130,759 research outputs found
The Eighth Session of the CCLCS (1987): Context, Meaning, Interpretation
No full textFrom first paragraph: Osma sjednica Centralnog komiteta Saveza komunista Srbije (održana 23. i 24. septembra 1987.) bila je značajan događaj u povijesti ne samo Saveza komunista Srbije, nego i same Srbije, te za sam raspad socijalističke (i svake druge) Jugoslavije. Iako bi bilo pogrešno tvrditi da je s njom započeo raspad Jugoslavije, njen je ishod dao značajan doprinos onome što će kasnije – četiri godine nakon njenog održavanja – prerasti u konflikt, koji će onemogućiti miran rasplet jugoslavenske krize. Ona je zato - prije svega zbog onog što joj je slijedilo – postala simbol kraja jedne epohe i početka druge, koju je sve do 2000. simbolizirao njen glavni predstavnik, Slobodan Milošević
Dietary compounds as potential modulators of microRNA expression in psoriasis.
No full textNutrigenomic DNA reprogramming in different chronic diseases and cancer has been assessed through the stimulation of gene expression and mRNA synthesis versus DNA silencing by CpG DNA modification (methylation); histone modification (acetylation, methylation) and expression of small noncoding RNAs, known as microRNAs (miRNAs). With regard to the specific nutrigenomic effects in psoriasis, the influence of specific diets on inflammatory cell signaling transcriptional factors such as nuclear factor (NF)-κB and Wnt signaling pathways, on disease-related specific cytokine expression, pro/antioxidant balance, keratinocyte proliferation/apoptosis and on proliferation/differentiation ratio have been documented; however, the influence of dietary compounds on the balance between 'good and bad' miRNA expression has not been considered. This review aims to summarize knowledge about aberrant microRNAs expression in psoriasis and to emphasize the potential impact of some dietary compounds on endogenous miRNA synthesis in experimental conditions in vivo and in vitro. Among the aberrantly expressed miRNAs in psoriasis, one of the most prominently upregulated seems to be miR-21. The beneficial effects of phenolic compounds (curcumin and resveratrol), vitamin D, methyl donors, and omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) are discussed. Highly expressed miR-155 has been downregulated by flavonoids (through a quercetin-rich diet) and by vitamin D. Quercetin has been effective in modulating miR-146a. On the other hand, downregulated miR-125b expression was restored by vitamin D, Coenzyme Q10 and by microelement selenium. In conclusion, the miRNA profile, together with other 'omics', may constitute a multifaceted approach to explore the impact of diet on psoriasis prevention and treatment
Problems of Early Post-Communist Transition Theory: from Transition from to Transition to
No full textThe paper critically assesses the main approaches developed within the theories of post-communist transitions in the 1990s by looking at early works of Przeworski, Fukuyama, Vanhanen and Schoepflin. The author argues that the post-communist transition theories departed from the original understanding of transition, as developed by O’Donnell and Schmitter in the 1980s. Instead of focusing on explaining the past, the post-communist transition theories constructed themselves as primarily normative, ie. forward-looking. They adopted key elements of ‘objectivist’ and normative approaches in analyzing political actions. In order to emphasise this anticipatory approach to analyzing political and economic transformations, the new ‘transitologists’ described transition as ‘transitiion to democracy’, rather than ‘transition from authoritarianism’. The author argues that some of the (self-admitted) failures of anticipatory transition theories in predicting events that led to 1989 in Eastern Europe were primarily due to their ‘objectivist’ approach in analyzing political actions
Discussion on the Comments of Slobodan K. Milonjic on the article entitled "Adsorption of strontium on different sodium-enriched bentonites" by Sanja R. Marinovic, Marija J. Ajdukovic, Natasa P. Jovic-Jovicic, Tihana M. Mudrinic, Bojana N. Nedic-Vasiljevi
No full textA thorough discussion on the Comments on the article "Adsorption of strontium on different sodium-enriched bentonites", by Sanja R. Marinovic, Marija J. Ajdukovic, Natasa P. Jovic-Jovicic, Tihana M. Mudrinic, Bojana N. Nedic-Vasiljevic, Predrag T. Bankovic and Aleksandra D. Milutinovic-Nikolic published in the Journal of the Serbian Chemical Society, Volume 82, Issue 4, Pages: 449-463 (2017), given as Letter to the Editor by S. K. Milonjic, is provided in this letter. The authors of the commented paper have considered all the comments, and responded to each of them, point by point
Automatic prediction of falls via heart rate variability and data mining in hypertensive patients: The SHARE project experience
No full textAccidental falls in elderly is a major problem. This paper presents the preliminary results of a retrospective study investigating association between Heart Rate Variability (HRV) measures and risk of falling, analyzing 168 clinical 24- hour ECG recording from hypertensive patients, 47 of them experienced at least one fall in the three months before/after the registration. Several HRV patterns, based on 68 linear and non-linear HRV measures, were analyzed in relation to falls using advanced statistical and data mining methods. The results demonstrated that there is a significant association between a depressed HRV and the risk of falling, suggesting that a depressed HRV could be a new independent risk factor for falls with an odds ratio of 5.12 (CI 95% 1.42-18.41; p<0.01)
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Multiple eruptive squamous cell carcinomas: a possible clinical sign in melanoma patients treated with vemurafenib
No full textCroatia and the European Union: a long delayed journey
No full textThe accession talks with the European Union, which Croatia begun in October 2005, have been described as an opportunity for a complete transformation of Croatian society. As of 2000, membership of the EU has been described as being of strategic importance, to be compared only with the 1992 international recognition of Croatia. Membership of the EU is seen as the end of ‘second transition’ (from nationalism and isolation of the 1990s to a modern, European state) and as an opportunity to increase a level of de facto sovereignty of the new state over its domestic affairs. Accordingly, in the last five years, the official narrative has been radically changed, whereas Tudjmanists have been marginalised. In addition, Croatian domestic politics has changed to become co-operative with ethnic minorities. The article analyses this transformation by placing it in the context of the EU-Croatian relations
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