230 research outputs found
Transformations Groups of the Andersson-Perlman Cone
No full text. An Andersson-Perlman cone is a certain subcone\Omega\Gamma K) of the symmetric cone\Omega of a Euclidean Jordan algebra. We exhibit a subgroup of the automorphism group of\Omega which operates transitively on \Omega\Gamma K) and show that \Omega\Gamma K) is a simply-connected submanifold of\Omega . 1. Introduction. Andersson-Perlman cones in the setting of Euclidean Jordan algebras (henceforth abbreviated as AP cones) were introduced by H. Massam and the author in [MN] as a generalization of certain cones defined by the statisticians S. A. Andersson and M. D. Perlman for real symmetric matrices [AP]. All mathematical results in [AP] were generalized in [MN] to the setting of Euclidean Jordan algebras, except the existence of transitive transformation groups which play a predominant role in the development in [AP]. In fact, the paper [MN] stresses a different, perhaps more direct approach to the description of Andersson-Perlman cones by employing Peirce decompositions and Frobeniu..
Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
No full textThe general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.Wilms tumor, while the most common pediatric kidney tumor, has a poorly understood etiology. Several recent studies have uncovered a role for loss of let-7 in its pathogenesis. One crucial mechanism through which let-7 expression is controlled is via the activity of the RNA-binding protein LIN28, which binds the precursor of let-7 and mediates the addition of a series of uridines to the 3′ end. This oligouridylation marks pre-let-7 for degradation by the exoribonuclease DIS3L2. Loss-of-function mutations in DIS3L2 lead to the Perlman congenital overgrowth syndrome, characterized by high neonatal mortality and, interestingly, a strong predisposition to Wilms tumor. Furthermore, DIS3L2 has been found to be deleted or mutated in some cases of sporadic Wilms tumor. The importance of let-7 in Wilms tumorigenesis and a purported role for DIS3L2 in the LIN28-let-7 pathway have led to speculation that aberrant let-7 expression underlies Wilms tumor susceptibility in DIS3L2-deficient contexts.
It is still unclear, though, how loss of DIS3L2 could lead to altered let-7 levels, as the uridylated pre-let-7 species that DIS3L2 degrades is believed to be a dead-end product that cannot be further processed by DICER into mature let-7. Thus far, regulation of mature let-7 levels by DIS3L2 has only been examined in a limited number of cell lines. To determine whether DIS3L2 regulation of let-7 differs in a broader set of cell types, we used genome-editing to knockout DIS3L2 in a wide-ranging panel of cell lines with differing levels of LIN28 expression. Consistent with prior reports, loss of DIS3L2 had no effect on mature let-7 expression in these cell lines.
However, it remained possible that the regulation of let-7 by DIS3L2 differed in cell populations relevant to Wilms tumor pathogenesis in vivo. Thus, to examine DIS3L2 function in these contexts, we used CRISPR-Cas9 to generate mouse lines harboring either Dis3l2-null alleles or mutations commonly observed in Perlman syndrome. Interestingly, Dis3l2 mutants recapitulated some aspects of Perlman syndrome, including neonatal mortality and genitourinary abnormalities, but not overgrowth or Wilms tumor. Moreover, the phenotype that results from the most common Perlman mutation is the same as that seen in the Dis3l2 loss-of-function mouse model, suggesting that the DIS3L2 mutations reported in Perlman syndrome are indeed loss-of-function.
Finally, we examined the molecular function of DIS3L2 in isolated primary nephron progenitor cells (NPCs), a likely cell of origin of Wilms tumors, from Dis3l2-null and wild-type embryos. Consistent with our findings in the cell lines, loss of DIS3L2 in NPCs does not affect let-7 expression or activity, yet leads to upregulation of Igf2, which is reported to be overexpressed in 70-80% of Wilms tumors. Therefore, Igf2 poses an attractive candidate for both overgrowth and oncogenesis associated with DIS3L2 loss
Massive Cellular Angiofibroma of the Vulva
No full textCellular angiofibromas of the vulva are uncommon, and usually small and circumscribed. A massive cellular angiofibroma extending into the pelvis is described.Peer reviewe
Report on the International Public Management Network Research Conference in Rio de Janeiro, Brazil
No full textThe paper reports on the 2004 Conference of the International Public Management Network "Third Generation Reform in Brazil and Other Nations: Achieving Governmental, Social and Economic Realignment" . The author, a rapporteur at that Conference, offers his view about the critical elements presented by the different speakers, and recaps some suggestions aimed at ensuring a higher success of reform of whatever generation
La théorie de Selig Perlman : une étude critique
No full textL'auteur analyse du point de vue méthodologique et du point de vue substantif la thèse exposée par Selig Perlman dans« A Theory of the Labor Movement ». Il en examine la consistance intrinsèque, l’utilité et les faiblesses. Il conclut que la théorie de Perlman est fondamentalement une apologie anti-marxiste dirigée principalement contre des propositions de Lénine. Une telle approche apporte une conception incomplète et normative du phénomène syndical. C'est pourquoi la thèse de Perlman demeure au niveau de généralisations dont l’utilité est limitée. En effet, considérant la base de la solidarité, les buts, les méthodes et les comportements syndicaux, elle ne fournit qu'une explication partielle, parfois subjective, des diverses composantes de faction syndicale.In this article, the author provides a systematic and detailed analysis of the theory of Selig Perlman, and submits it to a critical evaluation, both in terms of methodology and substance. The following is a brief outline of Perlman's approach.In his methodology, Perlman relies on three analytical elements: 1) three factors: the Power of subsistence of the capitalist system, the degree of influence of intellectuals upon organized labor, the level of maturity of the working class;2) three characteristics: the strength of the institution of private ownership, the degree of class consciousness among labor, the inadequacy of political tools;3) the psychology of manual labor.The essence of Perlman's theory may be outlined in the following manner. At the basis of labor solidarity is « the consciousness of scarcity of opportunity ». This explains why the role of trade unions is to control job opportunities; « job control » is based on « job interests ». For this purpose economic action, through collective agreements and strikes, appears to be the most effective approach. Political action may play, at best, a supplementary role. This approach is bound to lead to equality in industrial relations and to democratization in the economic structure; this may be attained without going through class warfare and without introducing a socialist or a communist system.A critical analysis of Perlman's theory brings out a number of points of methodological character:a) Essentially, the theory is an anti-Marxist apology of the stability of the capitalist system, mainly directed against the position of Lenin. At the basis of the divergence between Perlman and Lenin is the different evaluation of the role of the « intelligentsia ».b) Despite Perlman's claim to the contrary, he provides only a partial definition of trade unionism. This definition presents a scheme for a specific functional model; only through extension by means of a normative projection it becomes a general model for a true trade unionism.c) The analytical variables are not independent one from another, and because of this their interrelation cannot be significant. The three factors are defined, in part, each one by means of the others. The three characteristics are a descriptive elaboration of the three factors within the American context. Psychological categories are implicit in the definition of the third factor.d) The depreciatory concept of the « intelligentsia » reflects a subjective and biased approach to the problem of leadership in trade unionism. According to Perlman's definition, leaders who rose from the ranks of labor represent the concept of a « stable and responsible » trade unionism; in contrast, intellectuals, that is, « educated non-manualists », who enter the labor world introduce with them radicalism and revolutionary program of action, or advocate political action within trade unionism, in terms of Perlman's definition.With regard to the substance of Perlman's theory, this writer suggests the following points for consideration:a) The psychological approach ( « the consciousness of scarcity of opportunities »), despite some inconsistencies in definition and despite the fact that it may be regarded as typical for a particular group only, provides room for some useful generalizations; yet these generalizations are of limited character and cannot lead to theoretical conclusions. They reflect one element in workers' motivation to join the union and to support its activities. This element, in itself, cannot explain the process of labor organization, nor the occupational and territorial differentiation in the degree of unionization. Moreover, its origin is in the assumption of a state of chronic underemployment — a condition which is least favorable to labor solidarity.b) The concept of « job control » is related exclusively to occupational goals.c) Perlman sees in the joint system of control the most advantageous alternative; in his view, the autonomous system of control has no advantages, and control by external factors has an entirely secondary significance. By emphasizing collective negotiations he grossly underrestimates the importance of various forms of mutual assistance. Also, Perlman was not able, unfortunately, to provide a clear distinction between political activities of non-occupational character (revolutionary and other) and the utilization of political levers as a supplementary tool in realization of occupational and semi-occupational goals.d) The idealistic concept of « parity » in industrial relations cannot be ignored. Its eventual realization will call for a framework different from that provided by Perlman; under modem conditions the solution for existing problems often cannot be found on local level and has to rely on the dynamic intervention of a new interested party — the state
2016 HWW Alternative Academic (Alt-Ac) Career Summer Workshop: The Non-Academic Job Search with Karen Kelsky, author of "The Professor Is In"
No full textKaren Kelsky, author of The Professor Is In, will give you practical, hands-on guidance on crafting a compelling, persuasive resume and cover letter. In the afternoon, you’ll benefit from insider knowledge that can help you learn how to apply the art of brand development to your own career. For more information: http://theprofessorisin.com/ Humanities Without Walls is a consortium of 15 universities across the Midwestern United States, based at the Illinois Program for Research in the Humanities at the University of Illinois at Urbana Champaign, and funded by a grant from the Andrew W. Mellon Foundation. For more information, visit: http://www.humanitieswithoutwalls.illinois.ed
Perlmann Family Collection 1863-1979 Bulk dates: 1940-1979
No full textThe Perlmann Family Collection consists of papers of members of the Perlmann and related families, including the Spiero and Jolowicz families. It includes genealogy and biographies of these families and also of members of the related Lewald and Simson families. Some material on the city of Königsberg is also present. The collection consists of correspondence, genealogical research, family trees, biographies, articles, newspaper clippings, official documents, a few postcards and photographs, a memorial book and a few pamphlets.Herbert Perlman (born Perlmann) was born in 1886 in Königsberg, Prussia (now Kaliningrad, Russia), where his grandfather Heymann (also called Heimann or Heinrich) had been a rabbi. Herbert Perlman was the son of Eli (also Ely or Elias) Perlmann and his wife Luise (or Louise) Perlmann née Jolowicz and became a businessman and insurance agent. In 1939 he left Königsberg for England; in 1941 he came to the United States. After first settling in Alexandria, Louisiana, he later moved to Chicago, Illinois, where he married Lilian Philipps in 1949. He died in Chicago in 1980.Sabine Gova (born Spiero) was born in 1901, the daughter of the author, professor and literary historian Heinrich Spiero and his wife Olga née Jolowicz. During the time of Nazi Germany Heinrich Spiero was for a number of years the president of the Reichsverband nichtarischer Christen, later the Paulus-Bund. His daughter Sabine became an art historian and lived in Paris after 1933 until she fled from occupied France to Casablanca in the summer of 1940. By the late 1940s she had come to the United States where at one point she worked as a translator with the Research Committee of the United Nations and later became a professor of art history in Jersey City and New York. By 1968 she had returned to France, where she died in 1980.8-page inventory.Photographs removed to Photograph CollectionProcesseddigitize
"2016 HWW Alternative Academic (Alt-Ac) Career Summer Workshop: The Non-Academic Job Search with Karen Kelsky, author of ""The Professor Is In"""
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Previous issue date: 2016-07-25Karen Kelsky, author of The Professor Is In, will give you practical, hands-on guidance on crafting a compelling, persuasive resume and cover letter. In the afternoon, you’ll benefit from insider knowledge that can help you learn how to apply the art of brand development to your own career. For more information: http://theprofessorisin.com/ Humanities Without Walls is a consortium of 15 universities across the Midwestern United States, based at the Illinois Program for Research in the Humanities at the University of Illinois at Urbana Champaign, and funded by a grant from the Andrew W. Mellon Foundation. For more information, visit: http://www.humanitieswithoutwalls.illinois.ed
Understanding the use and disclosure of natural products by cancer patients
No full textBackground: Although cancer patients frequently use natural products (NP) to complement conventional oncology treatments and often do not disclose NP use to their healthcare providers, NP use initiated after diagnosis and the biopsychosocial determinants of NP use and disclosure have not been investigated. Purpose: The study purpose was to determine prevalence, patterns, and disclosure of NP use by cancer patients, and apply the Self-Regulation Model (SRM) to understand these behaviors. Methods: Analysis of a sub-set of the data from a cross-sectional survey of 1,226 cancer patients at a NCI–designated comprehensive cancer center within a 12-month period. Descriptive statistics were used for patterns of NP use and disclosure. Survey results were assigned to categories within the SRM and sequential bivariate correlations were performed through the model's dual-arm structure. Results: Among patients with a cancer diagnosis (64.6% female, 87% white, 72.8% married, 75.3% age 50+), 74.1% reported current use of 1 or more NP and 28.2% (n=346) indicated they initiated NP use after being diagnosed with cancer. Female sex (χ2=20.00, p<.001) and higher level of education (χ2=22.41, p=.004) were significantly associated with current NP use. Of the 28.2% (n=346) who initiated NP use post-diagnosis, 55.8% listed one or more NP among the top five CAM therapies that provided the most benefit. Green tea (EGCG, pills)(n=65), multivitamin/mineral (n=56), and selenium (n=18) were most commonly reported to be most beneficial. SRM Illness Representations (IR) dimensions Consequences (rs =.176, p=.014) and Desire to Avoid Suffering (rs =.157, p=.030) were very weakly positively correlated with the coping strategy of Continuation of NP Use. Consequences (rs =.214, p=.003) and Cure/Control (rs =.226, p=.002) positively correlated with disclosure of NP use. Negative (scared, afraid) (rs =-.435, p<.001) and Neutral (rs =-.548, p<.001) emotional IR dimensions and Disclosure were negatively correlated. Disclosure and Illness Outcomes (Treatment and Cancer Status) (rs =-.173, p=.016) were negatively correlated. Conclusions: NP use, post diagnosis initiation of use, and belief of benefit, were high among cancer patients surveyed. Multiple aspects of the SRM were found to be predictive of NP use and disclosure.Ph.D.Includes bibliographical referencesby Joshua M. Kotfil
Game Over
No full textIn the case of Perlman v. Catapult Entertainment, the Ninth Circuit applied the hypothetical test regarding the assumability of patent licenses under Section 365(c) of the Bankruptcy Code. This Note argues that trustees should have recourse to the law of unjust enrichment when a debtor is unable to assume a patent license under the hypothetical test
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