4,466 research outputs found
The Predictive Value of Neutrophil/Lymphocyte Ratio for CK-MB Elevation in Myocardial Infarction: A Study in Syrian ACS Patients
No full textالمتلازمة الإكليليّة الحادّة هي داء قلبي وعائي شديد مترافق مع معدل وفيات مرتفع. ينتج الداء عادةً من تمزّق لويحة التصلّب العصيدي ممّا يؤدي إلى تشكّل الخثرة العصيديّة. تتضمن المتلازمة الإكليليّة الحادّة كل من الخناق غير المستقر واحتشاء العضلة القلبيّة. يسبّب احتشاء العضلة القلبيّة تنخّراً للعضلة القلبيّة بالتالي تحريض استجابة التهابيّة حادّة تساهم في تقدّم المرض. قلّةٌ فقط من الدراسات قد تحرّت القدرة التشخيصيّة لنسبة العدلات إلى اللمفاويات باعتباره مشعر مساعد رخيص الثمن وسهل الإجراء لتشخيص احتشاء العضلة القلبيّة، وذلك لوحده أو بالمشاركة مع الكرياتين كيناز MB. بالتالي تهدف الدراسة إلى تحديد القدرة التشخيصية لنسبة العدلات إلى اللمفاويات عند القبول كمشعر لاحتشاء العضلة القلبية عند مرضى المتلازمة الإكليلية الحادّة. شارك 89 مريضاً بالمتلازمة الإكليلية الحادة في هذه الدراسة المقطعيّة والذين تم قبولهم في وحدة الإسعاف ضمن مشفى الباسل بين شهري آذار 2023 وكانون الثاني 2024. تم تقسيم المرضى إلى مجموعة احتشاء العضلة القلبية (عدد 41) ومجموعة الخناق غير المستقر (عدد 48). تم مقارنة وتقييم الخصائص الأساسية إضافةً لعدد من المشعرات الخلوية الالتهابية (تعداد الكريّات البيضاء والعدلات واللمفاويات ونسبة العدلات إلى اللمفاويات) بين مجموعتي الدراسة. أظهرت نتائجنا أن قيم نسبة العدلات إلى اللمفاويات عند القبول كانت أعلى عند مجموعة الاحتشاء منها عند مجموعة الخناق غير المستقر (4.62 مقابل 2.56، P <0.01)، كما كانت القيم مرتبطة مع فعالية الكرياتين كيناز في مجموعة الاحتشاء (معامل الارتباط=0.45، P <0.01). وجد أن القيمة الحديّة 2.78 لنسبة العدلات إلى اللمفاويات عند القبول كان لها حساسية73% ونوعية62% في التنبؤ باحتشاء العضلة القلبية عند مرضى المتلازمة الإكليلية الحادة. كما كان من المثير للاهتمام أن مشاركة نسبة العدلات إلى اللمفاويات مع الكرياتين كيناز MB أدّت إلى زيادة الحساسية والنوعية إلى (88% و93% على التوالي) أي أفضل من استخدام المشعرين بشكل منفصل. يدّل ذلك إلى أن مشعراً تشخيصيّاً بسيطاً كنسبة العدلات إلى اللمفاويات يمكن أن يكون له دور كعامل مساعد في تشخيص احتشاء العضلة القلبيّة عند المرضى المصابين بالمتلازمة الإكليليّة الحادّة.Acute coronary syndrome (ACS) is a serious cardiovascular condition associated with a high mortality rate. It typically arises from the rupture of an atherosclerotic plaque leading to thrombus formation and encompasses unstable angina (UA) and myocardial infarction (MI). The latter results in myocardial necrosis, which triggers an acute inflammatory response that contributes to disease progression. Few studies have explored the diagnostic utility of the neutrophil-to-lymphocyte ratio (NLR) as a complementary, inexpensive, and easily performed test for diagnosing MI, either alone or in conjunction with creatine kinase-MB (CK-MB). Therefore, this study aimed to evaluate the diagnostic accuracy of admission NLR as a biomarker for MI in ACS patients. This cross-sectional study included 89 patients with ACS who were admitted to the emergency department of Al-Basel Hospital between March 2023 and January 2024. The patients were categorized into two groups: MI (n = 41) and UA (n = 48). Baseline characteristics and specific inflammatory markers (WBC, neutrophils, lymphocytes, and NLR) were assessed and compared between the two groups. Our findings revealed that admission NLR values were significantly higher in the MI group compared to the UA group (4.62 vs. 2.56, P < 0.01). Moreover, NLR was significantly correlated with CK-MB activity in the MI group (r = 0.45, P < 0.01). A cutoff value of 2.78 for admission NLR yielded a sensitivity of 73% and a specificity of 62% for predicting MI in ACS patients. Notably, combining CK-MB and NLR measurements improved diagnostic performance, with a sensitivity of 88% and specificity of 93%. These findings suggest that a simple biomarker such as NLR could serve an adjunctive role in facilitating the diagnosis of MI in patients with ACS
A Response to “Patient’s Perceptions and Attitudes Towards Medical Student’s Involvement in Their Healthcare at a Teaching Hospital in Jordan: A Cross Sectional Study” [Response to Letter]
No full textHana Ahmad Taha,1–3 Mohammed Bassam Nawaiseh4 1Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan; 2Department of Family and Community Medicine, School of Medicine, The University of Jordan, Amman, 11942, Jordan; 3Department of Neurobiology, Caring Science and Society, Karolinska Institutet, Huddinge, 141 52, Sweden; 4Jordanian Royal Medical Services, Amman, 11855, JordanCorrespondence: Hana Ahmad Taha, Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, P. O. Box 330127, Zarqa, 13133, Jordan, Tel +962-5-3903333, Email [email protected]
A REMARK ON n− JORDAN HOMOMORPHISMS
No full textLet A and B be commutative algebras and n 2 an integer. Then each n− Jordan homomorphism h : A B is an n- homomorphism
RESEARCHING THE CAUSES FOR THE DEGRADATION OF WATERPROOFING MATERIALS ON THE ROOF OF THE INDUSTRIAL HALL A-PRINT WITH THE SUGGESTED RESTORATION
No full textV diplomskem delu smo obravnavali ravno streho, kot najzahtevnejši konstrukcijski element zgradbe, ki jo obravnavamo kot bazen. Ker je ravna streha podvržena izrazitemu toplotnemu delovanju, moramo upoštevati poleg hidroizolacije tudi toplotno izolacijo.
Pri izvedbi hidroizolacije pazimo na pravilno izbiro materialov, njihovo vgradnjo in skrbno izvedbo parne zapore. S stališča gradbene fizike delimo ravne strehe v osnovi na tople in hladne strehe. V delu je predstavljena topla ravna streha iz PVC-P hidroizolacije preplastena s poliuretansko hidroizolacijo. Preiskava je pokazala, da sanacija strehe s PVC-P membrano ni bila ustrezno izbrana.. Objekt leži v območju, kjer so pogosta neurja s točo, zato smo za sanacijo strehe izbrali kritino EPDM-Resitrix MB, ki je odporna na točo in ima dolgo življenjsko dobo.In this diploma thesis we researched the flat roof, as the most advanced construction element of a building. We regard it similar to a pool. Because this flat roof was subject to extreme heat exposure, we have to research the thermal insulation as well as the waterproofing materials.
When waterproofing a roof, we have to be cautious about choosing the right materials, building them in and the right placement of a vapour barrier. Building engineering physics separate two kinds of flat roofs, the cold and the warm roof. The flat roof presented in this diploma thesis is a warm roof, consisting of PVC-P waterproofing membranes, covered with a layer of polyurethane liquid waterproofing material. The research showed that the restoration of the roof with the PVC-P membrane wasn’t adequately chosen. The building is located in a place, where hailstorms are not an uncommon phenomenon, that is why we have chosen to restore the roof with the membrane EPDM – Resitrix MB, that is resistant to hail and has a long lifespan
Deliberalization in Jordan the roles of Islamists and U.S.-EU assistance in stalled democratization
No full textDespite some political openings in Jordan during the 1980s, the democratization process is presently stalled. What explains the lack of continuous democratization in Jordan while democratic transitions in many other countries around the world have taken place? This study seeks to understand the reasons behind stalled democratization in Jordan by analyzing three variables: the nature of the opposition movement; the role of domestic and international events in shaping opposition-regime interactions; and the role of U.S.-European Union (EU) assistance to Jordan. The major finding of this study is that democratization in Jordan has stalled due to the regime's policy of preventing political opportunities to maintain the status quo backed by the U.S. and the EU. Political inclusion of the Muslim Brotherhood (MB) will bode well for Jordan's democratic progress. The MB's strategic behavior has withstood an Islamist radicalization in light of repression and unpopular western policy. Nevertheless, neither the U.S. nor the EU pushed for more liberalization, which enables the MB to gain political access. The U.S. and the EU opted for a realist approach, focusing on security in Jordan. This thesis proposes a rethinking of assistance to Jordan based on a burden sharing between the U.S. and the EU.Approved for public release; distribution is unlimited.German Army authorhttp://archive.org/details/deliberalization10945529
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Rights for LGBTQ persons: MB v Secretary of State for Work and Pensions
No full textIn the case of MB v Secretary of State for Work and Pensions[Case C-451/16] [2018] Pens. L.R. 17, the European Court of Justice (‘CJEU’) determined that the requirement of the Gender Recognition Act 2004 (‘GRA 2004’), which required trans persons to annul their marriage before they would be granted a full Gender Recognition Certificate in their new sex (prior to same-sex marriage being legalised in 2013), which was also necessary to claim state pension benefits for women from the age of 60, contravened Article 4 Council Directive 79//7/EEC non-discrimination provisions. The consequence of the GRA 2004 provisions meant that many individuals never obtained gender recognition certificates as they did not want to annul their marriages. This subsequently meant that they could not exercise the right to claim the state pension at the lower age of 60 previously given to women (where men had to wait until 65). The far reaching judgment from the CJEU demonstrates again that the expanding nature of EU family law. The concept of EU citizenship is leading to an ever greater array of rights being given to EU citizens. Following Brexit UK citizens will no longer be able to benefit from such interventions from the CJEU
Investigations of Lipid Droplets Role in Attenuating Chemotherapeutic Responses to 5-FU in Cancer Cells in vitro
No full textCancer has been considered as a main cause of death worldwide. Despite the effectiveness of traditional anticancer therapies such as 5-Flurouracil (5-FU), poor therapeutic outcomes are reported in many cases, due to tumor recurrence and chemoresistance. Intracellular lipid accumulation as lipid droplets (LDs) is now a well-recognized hallmark of cancer. However, the influence of LDs accumulation in cancer progression and treatment remains to be elucidated. Adjuvant use of non-chemotherapeutic drugs (e.g. NSAIDs and corticosteroids) with anticancer drugs to manage cancer related symptoms, may though serve as factors modulating the therapeutic response to anticancer agents via LDs related mechanisms. The aim of this study is to evaluate possible strategies influencing chemoresistance by attenuating LDs biogenesis and function. LDs levels in eight human cancer cell lines were measured. The existence of correlation between the cellular levels of LDs and cytotoxicity of ten chemotherapeutic agents was evaluated. A moderate correlation between basal LDs levels and the half inhibitory concentration (IC50) values of 5-FU on selected cell lines was established (r2= 0.5235). Nevertheless, LDs levels were significantly elevated following exposure to 5-FU. A549 human lung cancer cells showed the highest increase in LD accumulation (***P >0.001) compared to their basal levels of LDs. LDs levels were also assessed following exposure to 5-FU in the presence of sub-lethal doses of celecoxib (CXB), dexamethasone (DEX), and simvastatin (SMV). Interestingly, CXB and DEX exposure to 5-FUtreated cells resulted in an alleviation in the antiproliferative activities of 5-FU in MDA-MB-468 and HCT116 but not in A549 cells. While, SMV exposure to 5-FU-treated cells resulted in reduced antiproliferative activities of 5-FU in MDA-MB-468 only. These results strongly suggest that increased LDs levels caused by CXB, DEX, and SMV may contribute in the development of a resistance mechanism exist only in some cancer types, which therefore, attenuates responses to 5- FU. The inhibition of phospholipid metabolism by DEX, as well as the inhibition of 3-hydroxy-3- methylglutaryl-CoA reductase (HMGCR) by SMV were expected to result in the up regulation of triacylglycerol (TAG), leading to LDs accumulation. This study highlights the importance of assessing drug-drug interaction before designing integrated therapy regimens for cancer patients receiving 5-FU treatment. Further studies are needed to discover the role of TAG inhibition on the sensitivity of cancer cells against 5-FU
Receiver Windowing Design for Narrowband Interference Mitigation in MB-OFDM UWB System
No full textIn 2005, the WiMedia Alliance working with the European Computer Manufacturers Association (ECMA) announced the establishment of the WiMedia MB-OFDM (Multiband Orthogonal Frequency Division Multiplexing) UWB radio platform as their global UWB standard. It was also chosen as the physical layer (PHY) of high data rate wireless specifications for high speed Wireless USB (W-USB), Bluetooth 3.0 and Wireless High-Definition Media Interface (HDMI). However, due to the low power and wide bandwidth nature of UWB systems, in-band narrowband interference (NBI) may hinder the receiver performance. This thesis presents an analysis of NBI impact on the MB-OFDM system for UWB communication. The intent of our analysis is to provide practical solutions for interference mitigation under different NBI models. In our work, a new receiver windowing for zero padding (ZP) OFDM system is proposed to reduce NBI spreading in the MB-OFDM UWB system. Simulations demonstrate the effectiveness of windowing under different NBI models.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells
No full textIntroduction After the onset of bone metastasis, tumor cells appear to modify surrounding microenvironments for their benefit, and particularly, the levels of circulating fibroblast growth factor (FGF) 23 in patients with tumors have been highlighted. Materials and methods We have attempted to verify if human breast carcinoma MDA-MB-231 cells metastasized in the long bone of nu/nu mice would synthesize FGF23. Serum concentrations of calcium, phosphate (Pi) and FGF23 were measured in control nu/nu mice, bone-metastasized mice, and mice with mammary gland injected with MDA-MB-231 cells mimicking primary mammary tumors. Results and conclusions MDA-MB-231 cells revealed intense FGF23 reactivity in metastasized lesions, whereas MDA-MB-231 cells cultured in vitro or when injected into the mammary glands (without bone metastasis) showed weak FGF23 immunoreactivity. Although the bone-metastasized MDA-MB-231 cells abundantly synthesized FGF23, osteocytes adjacent to the FGF23-immunopositive tumors, unlike intact osteocytes, showed no FGF23. Despite significantly elevated serum FGF23 levels in bone-metastasized mice, there was no significant decrease in the serum Pi concentration when compared with the intact mice and mice with a mass of MDA-MB-231 cells in mammary glands. The metastasized femora showed increased expression and FGFR1 immunoreactivity in fibroblastic stromal cells, whereas femora of control mice showed no obvious FGFR1 immunoreactivity. Taken together, it seems likely that MDA-MB-231 cells synthesize FGF23 when metastasized to a bone, and thus affect FGFR1-positive stromal cells in the metastasized tumor nest in a paracrine manner
ASIC FFT processor for MB-OFDM UWB system
No full textThe physical layer (PHY) standard of Multi-band Orthogonal Frequency Division Multiplexing (MB-OFDM) Ultra Wideband (UWB) system was defined by ECMA International. In this standard, the data sampling rate from the analog-to-digital converter to the physical layer is up to 528 Msample/s. Therefore, it is a challenge to realize the physical layer of the UWB system-especially the components with high computational complexity in Very Large Scale Integration (VLSI) implementation. Fast Fourier Transform (FFT) block is one of these components. FFT plays an important role in Multi-band OFDM UWB system, which is the demodulation block of OFDM signals. The purpose of this project is to design an Application Specific Integrated Circuit (ASIC) FFT solution for this system. The specification is defined from the system analysis and literature research. All the design choices and considerations are concluded and explained.Based on the algorithm and architecture analysis, a novel Radix22Parallel processor is proposed, which is a small-area and low-power-consumption solution for MB-OFDM UWB system. Both Field Programmable Gate Array (FPGA) and ASIC targeted synthesis results of this architecture are presented.Electrical Engineering, Mathematics and Computer Scienc
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