216 research outputs found
The quest for Brazilian space research
No full textThis paper describes how QUEST(1) (QUaternion ESTimator algorithm) influenced Brazilian space research activities. Indeed, we present a short survey paper on researches in attitude determination and propagation in Brazil arising from the influence of the author of QUEST. We show how Brazilian researchers started implementing QUEST, tasting it, and later deriving other applications based on it. Some Brazilian researchers worked out further investigations through direct interaction with the QUEST author, Dr. Malcolm Shuster, addressing attitude alignment and calibration problems. Further related researches show the influence of Dr. Shuster's work on Brazilian space research.Inst Nacl Pesquisas Espaciais, POB 515, BR-12245970 Sao Jose Dos Campos, SP, BrazilSao Paulo State Univ, UNESP, Dept Math, BR-12500000 Guaratingueta, SP, BrazilSao Paulo State Univ, UNESP, Dept Math, BR-12500000 Guaratingueta, SP, Brazi
Response
No full textReply to Cantor, Alan B and Shuster, Jonathan J 'Re: Dangers of Using "Optimal" Outpoints in the Evaluation of Prognostic Factors,' Journal of the National Cancer Institute, (1994) 86 (23): 1798-1799. Correspondence referring to the article 'Dangers of Using "Optimal" Outpoints in the Evaluation of Prognostic Factors' http://repository.essex.ac.uk/2512
Central Management of Research Misconduct in the USA and Canada
No full textThis paper proposes major changes in how research misconduct cases should be managed in the USA and Canada. Specifically, I advocate for centralized oversight that completely removes research institutions from this role in order to: mitigate institutional conflicts of interest, standardize definitions of research misconduct, better preserve confidentiality of complainants (those alleging misconduct), ensure that cases are not screened for rejection, mobilize a review panel of experts who are free of conflicts of interest, avoid inappropriate collective punishment of institutions, and ultimately save resources as compared to current decentralized systems. Two cases which this author, as complainant, alleged research misconduct (in the USA and Canada) demonstrate clearly how far institutional Research Integrity Officers can go to prevent an impartial expert review. Given that our institutions and scientific community rightly have zero tolerance for research misconduct, the current decentralized practice should be a grave concern to those who hope to trust in proper oversight. A discussion follows, including comments on new directives for 2025 from the US Office of Research Integrity and the implications of high-profile cases. I conclude with details as to how cases might be brought to justice under the proposed centralized process
The Asp84GIu variant of the melanocortin 1 receptor (MC1R)is associated with melanoma
No full textMelanocyte stimulating hormone (MSH) plays an important role in determining the cutaneous response to ultraviolet radiation and may also influence melanoma progression. We have previously shown that variants of the melanocortin receptor present on melanocytes, MC1R, are associated with sun sensitivity and red hair in a UK population and therefore now consider the gene as a candidate for melanoma susceptibility. We have compared the frequency of known MC1R variants in the second and seventh transmembrane domains in 43 melanoma cases and 44 controls. MC1R variants were more common in cases than controls (?2 = 6.75, 1 d.f.; P = 0.0094) with a relative risk to carriers of variant alleles compared with normal homozygotes of 3.91 (95% c.l.: 1.48-10.35), and a population risk attributable to carriers of 34.6% (95% c.i. 10.7-52.1%). The Asp84Glu variant was only present in melanoma cases and appears to be of particular significance. The contribution of variant MC1R alleles was largely independent of skin type. Variants of the MC1R gene are likely to be causally associated with the development of melanoma
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