4,394 research outputs found
Correction: Dermal Exposure Assessment to Pesticides in Farming Systems in Developing Countries: Comparison of Models. Int. J. Environ. Res. Public Health 2015, 12, 4670–4696
No full textWe wish to make the following changes to the published article [1], agreed upon by all authors. Claudia R. Binder has withdrawn her co-authorship. The corrected author list should therefore read: Camilo Lesmes-Fabian.[...
Die Ringer-Kunst des Fabian von Auerswald /
No full textIn portfolio."Gedruckt zu Wittemberg durch Hans Lufft. M.D.XXXIX."--Colophon.85 full-page woodcuts by Lucas Cranach the Younger, representing the author in his 85 wrestling positions.Facsimile of the edition of 1539 with title: Ringen Kunst: fünff und achtzig Stücke, zu Ehren Kurfürstlichen Gnaden zu Sachsen [etc.] Durch Fabian von Auerswald zugericht.Mode of access: Internet
A Survey of Pyridoxal 5′-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis
Get PDFThe B6 vitamer pyridoxal 5′-phosphate (PLP) is a co-factor for proteins and enzymes that are involved in diverse cellular processes. Therefore, PLP is essential for organisms from all kingdoms of life. Here we provide an overview about the PLP-dependent proteins from the Gram-positive soil bacterium Bacillus subtilis. Since B. subtilis serves as a model system in basic research and as a production host in industry, knowledge about the PLP-dependent proteins could facilitate engineering the bacteria for biotechnological applications. The survey revealed that the majority of the PLP-dependent proteins are involved in metabolic pathways like amino acid biosynthesis and degradation, biosynthesis of antibacterial compounds, utilization of nucleotides as well as in iron and carbon metabolism. Many PLP-dependent proteins participate in de novo synthesis of the co-factors biotin, folate, heme, and NAD+ as well as in cell wall metabolism, tRNA modification, regulation of gene expression, sporulation, and biofilm formation. A surprisingly large group of PLP-dependent proteins (29%) belong to the group of poorly characterized proteins. This review underpins the need to characterize the PLP-dependent proteins of unknown function to fully understand the “PLP-ome” of B. subtilis
Vitamin B6 metabolism in microbes and approaches for fermentative production
No full textVitamin B6 is a designation for the six vitamers pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate, and pyridoxamine. PLP, being the most important B6 vitamer, serves as a cofactor for many proteins and enzymes. In contrast to other organisms, animals and humans have to ingest vitamin B6 with their food. Several disorders are associated with vitamin B6 deficiency. Moreover, pharmaceuticals interfere with metabolism of the cofactor, which also results in vitamin B6 deficiency. Therefore, vitamin B6 is a valuable compound for the pharmaceutical and the food industry. Although vitamin B6 is currently chemically synthesized, there is considerable interest on the industrial side to shift from chemical processes to sustainable fermentation technologies. Here, we review recent findings regarding biosynthesis and homeostasis of vitamin B6 and describe the approaches that have been made in the past to develop microbial production processes. Moreover, we will describe novel routes for vitamin B6 biosynthesis and discuss their potential for engineering bacteria that overproduce the commercially valuable substance. We also highlight bottlenecks of the vitamin B6 biosynthetic pathways and propose strategies to circumvent these limitations. (C) 2016 Elsevier Inc. All rights reserved
Fabian lernt "schwimmen"
No full textMit der Absicht, eine Brücke zwischen deutschsprachiger Literatur und Humanistischer Psychologie zu konstruieren, geht die vorliegende Arbeit der Frage nach, ob es möglich ist, eine fiktive Person, die vor dem Hintergrund der Weltwirtschaftskrise von 1929 im Verlauf einer Romanhandlung arbeitslos geworden ist, durch Anwendung einer humanistischen Therapieform wieder in die Arbeitswelt zu integrieren. Die fiktive Person ist Jakob Fabian aus Erich Kästners neusachlichem Zeitroman Fabian. Die Geschichte eines Moralisten, erschienen 1931, und bei der humanistischen Therapieform handelt es sich um den „Klientenzentrierten Ansatz“ nach Carl Rogers. Die zentrale Forschungsfrage wird in zwei großen Schritten beantwortet: Im ersten Schritt werden themenrelevante Aspekte hinsichtlich Roman, Autor sowie Protagonist erläutert und analysiert, bis die Romanfigur Jakob Fabian zum Klienten Jakob Fabian wird und ein Anamnesebericht über diesen vorliegt. Basierend darauf, werden mit dem Ergebnis der beruflichen Rehabilitation im zweiten Schritt klientenzentriert-orientierte Therapiegespräche in einem realen Setting durchgeführt und transkribiert. Das Konzept dieser Arbeit kann als Modell auf weitere Arbeitslosenromane der Weimarer Republik angewendet werden. Zusätzlich besteht auch die Möglichkeit, das Setting an Beratungssituationen anzupassen.With the intention of constructing a bridge between German literature and “Humanistic Psychology”, the present thesis analyses the question, whether it is possible to reintegrate a fictitious man into the working environment by applying a humanistic type of therapy, who, against the background of the world economic crisis of 1929, in the course of a novel's plot has lost his job. Jakob Fabian is the fictional character in Erich Kästner’s new objectivity period novel Fabian. The story of a moralist, pub-lished in 1931, and the humanistic therapeutic method is the Rogerian Client-centered approach. The core issue is answered in two major steps: In the first step, issue-specific aspects regarding novel, author and protagonist are explained and analysed until the fictional character Jakob Fabian turns into the client Jakob Fabian and until an anamnesis report is available. Based on this, with the outcome of vocational rehabilitation in the second step, client-centred-oriented therapy sessions are conducted in a real setting and transcribed. The concept of this work can also be used as a model for other novels about unemployment during the Weimar Republic. In addition, it is also possible to adjust the setting of advisory situations
JBR_2018_supp_071218 – Supplemental material for Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice
No full textSupplemental material, JBR_2018_supp_071218 for Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice by Amanda M. Maple, Rachel K. Rowe, Jonathan Lifshitz, Fabian Fernandez and Amelia L. Gallitano in Journal of Biological Rhythms</p
A two‐step evolutionary process establishes a non‐native vitamin B6 pathway in <i>Bacillus subtilis</i>
No full textJunges Wasser in einem hoch-gelegenen Einzugsgebiet: zeitliche Variabilität und Verhältnis zu meteorologischen und glazial-hydrologischen Proxies des Klimawandels
No full textauthor: Fabian MaierAbweichender Titel laut Übersetzung des VerfassersMasterarbeit University Innsbruck 201
Junges Wasser in einem hoch-gelegenen Einzugsgebiet: zeitliche Variabilität und Verhältnis zu meteorologischen und glazial-hydrologischen Proxies des Klimawandels
No full textauthor: Fabian MaierAbweichender Titel laut Übersetzung des VerfassersMasterarbeit University Innsbruck 201
- …
