2,884 research outputs found
C.A. Parker's Store
Photograph - A dog team and a loaded sled on Strathcona Street in front of C.A. Parker's store, Athabasca, Albert
Eigen schuld van de architect
Rede, uitgesproken bij het afscheid als buitengewoon hoogleraar in het bouw- en woning recht aan de Technische Hogeschool Delft op vrijdag 21 februari 1986 door prof.mr C.A. Adriaansens.Architectur
Brazilian Atlantic Forest Lato Sensu: The Most Ancient Brazilian Forest, And A Biodiversity Hotspot, Is Highly Threatened By Climate Change [mata Atlântica Lato Sensu: A Mais Antiga Das Florestas Brasileiras, E Um Hotspot De Biodiversidade, Está Altamente Ameaçada Pelas Mudanças Climáticas]
After 500 years of exploitation and destruction, the Brazilian Atlantic Forest has been reduced to less the 8% of its original cover, and climate change may pose a new threat to the remnants of this biodiversity hotspot. In this study we used modelling techniques to determine present and future geographical distribution of 38 species of trees that are typical of the Brazilian Atlantic Forest (Mata Atlântica), considering two global warming scenarios. The optimistic scenario, based in a 0.5% increase in the concentration of CO2 in the atmosphere, predicts an increase of up to 2 °C in the Earth's average temperature; in the pessimistic scenario, based on a 1% increase in the concentration of CO2 in the atmosphere, temperature increase may reach 4 °C. Using these parameters, the occurrence points of the studied species registered in literature, the Genetic Algorithm for Rule-set Predictions/GARP and Maximum entropy modeling of species geographic distributions/MaxEnt we developed models of present and future possible occurrence of each species, considering Earth's mean temperature by 2050 with the optimistic and the pessimistic scenarios of CO2 emission. The results obtained show an alarming reduction in the area of possible occurrence of the species studied, as well as a shift towards southern areas of Brazil. Using GARP, on average, in the optimistic scenario this reduction is of 25% while in the pessimistic scenario it reaches 50%, and the species that will suffer the worst reduction in their possible area of occurrence are: Euterpe edulis, Mollinedia schottiana, Virola bicuhyba, Inga sessilis and Vochysia magnifica. Using MaxEnt, on average, in the optimistic scenario the reduction will be of 20% while in the pessimistic scenario it reaches 30%, and the species that will suffer the worst reduction are: Hyeronima alchorneoides, Schefflera angustissima, Andira fraxinifolia and the species of Myrtaceae studied.703 SUPPL.697708Almeida, F.F.M., Carneiro, C.D.R., Origem e evolução da Serra do Mar (1998) Revista Brasileira de Geociências, 28 (2), pp. 135-150Behling, H., Negrelle, R.R.B., Late Quaternary tropical rain forest and climate dynamics from the Atlantic lowland in southern Brazil (2001) Quaternary Research, 56, pp. 87-101Brow Jr., K.S., Conclusion, synthesis and alternative hypotheses (1987) Biogeography and Quartenary history in Tropical America, pp. 175-196. , In WHITMORE, TC. and PRANCE, GT. (Eds.), Oxford Science PublicationsBush, M.B., Oliveira, P.E., The rise and fall of the Refugial Hypothesis of Amazonian speciation: A paleoecological perspective (2006) Biota Neotropica, 6 (1). , http://www.biotaneotropica.org.br/v6n1/en/abstract?point-of-view+bn00106 012006, Available fromCavalcanti, R.B., Joly, C.A., Biodiversity and Conservation Priorities in the Cerrado Region (2002) The Cerrados of Brazil. Ecology and Natural History of a Neotropical Savana, pp. 351-367. , In OLIVEIRA, PE. and MARQUIS, RJ. (Eds.), New York: Columbia Univesity PressChapman, A.D., Muñoz, M.E.S., Koch, I., Environmental information: Placing biodiversity phenomena in an ecological and environmental context (2005) Biodiversity Informatics, 2, pp. 24-41Costa, L.P., The historical bridge between the Amazon and the Atlantic Forest of Brazil: A study of molecular phylogeography with small mammals (2003) Journal of. Biogeography, 30 (1), pp. 71-86Elith, J., Graham, C.H., Anderson, R.P., Novel methods improve prediction of species' distributions from occurrence data (2006) Ecography, 29, pp. 129-151Fonseca, G.A.B., Small mammal species diversity in Brazilian tropical primary and secondary forests of different sizes (1989) Revista Brasileira de Zoologia, 6 (3), pp. 381-422(1998) Atlas da evolução dos remanescentes florestais e ecossistemas associados no domínio da Mata Atlântica no período 1990-1995, , Fundação S.O.S. Mata Atlântica and Instituto Nacional de Pesquisas Espaciais - INPE, São Paulo(1988) Mapa de Vegetação do Brasil, , Instituto Brasileiro de Geografia e Estatística - IBGE, Brasília, DF: IBGE(1993) Mapa de vegetação do Brasil, , http://mapas.sosma.org.br/, Instituto Brasileiro de Geografia e Estatística - IBGE, Rio de Janeiro, IBGE. Available from(2007) Climate change 2007: Mitigation - Contribution of Working group III to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, , International Panel on Climate Change - IPCC, Cambridge: Cambridge University PressJoly, C.A., Aidar, M.P.M., Klink, C.A., Evolution of the Brazilian phytogeography classification systems: Implications for biodiversity conservation (1999) Ciência e Cultura, 51 (5-6), pp. 331-348Klockow, D., Targa, H.J., Vautz, W., (1997) Air pollution and vegetation damage in the tropics - the Serra do Mar as an example, , Geesthacht, Germany: GKSS -Forschungszentrum Geesthacht. Final Report 1990-1996Klump, A., Domingos, M., Klump, G., Foliar nutrient contents in tree species of the Atlantic Rain Forest as influenced by air pollution from the industrial complex of Cubatão, SE-Brazil (2002) Water, Air, Soil Pollution, 133, pp. 315-333Laurance, W.F., Delamonica, P., Ilhas de sobrevivência (1998) Ciência Hoje, 24, pp. 26-31Ledru, M.P., Rousseau, D.D., Cruz Jr., F.W., Riccomini, C., Karmann, I., Martin, L., Paleoclimate changes during the last 100 ka from a record in the Brazilian Atlantic rainforest region and interhemispheric comparison (2005) Quaternary Research, 64, pp. 444-450Lyons, K.S., A quantitative assessment of the rate of range shifts of Pleistocene mammals (2003) Journal of Mammalogy, 84, pp. 385-402Martinez-Meyer, E., Peterson, A.T., Hargrove, W.W., Ecological niches as stable distributional constraints for Pleistocene extinctions and climate change projections for biodiversity (2004) Global Ecology and Biogeography, 13, pp. 305-314Myers, N., Mittermeier, R.A., Mittermeier, C.G., Fonseca, G.A.B., Kent, J., Biodiversity hotspots for conservation priorities (2000) Nature, 403, pp. 853-858Oliveira Filho, A.T., Fontes, M.A.L., Patterns of floristic differentiation among Atlantic forests in Southeastern Brazil, and the influence of climate (2000) Biotropica, 32 (4 B), pp. 793-810Oliveira, R.J., (2001) Análise da variação florístico-estrutural das florestas atlânticas no estado de São Paulo, Brasil, , Campinas: Biology Institute State University of Campinas. [PhD Thesis]Peterson, A.T., Shaw, J., Lutzomyia vectors for cutaneous leishmaniasis in Southern Brazil: Ecological niche models, predicted geographic distributions, and climate change effects (2003) International Journal for Parasitology, 33, pp. 919-931Peterson, A.T., Predicting species' geographic distributions based on ecological niche modeling (2001) The Condor, 103, pp. 599-605Peterson, A.T., Ball, L.G., Cohoon, K.C., Predicting distributions of Mexican birds using ecological niche modeling methods (2002) Ibis, 144, pp. 27-32Peterson, A.T., Papes, M., Eaton, M.U.I.R., Transferability and model evaluation in ecological niche modeling: A comparison of GARP and Maxent (2007) Ecography, 30 (4), pp. 550-560Peterson, A.T., Soberon, J., Sanchez-Cordero, V., Conservatism of ecological niches in evolutionary time (1999) Science, 285 (1265-1267)Phillips, S.J., Anderson, R.P., Schapire, R.E., Maximum entropy modeling of species geographic distributions (2006) Ecological Modelling, 190 (231-259)Ribeiro, M.C., Metzger, J.P., Martensen, A.C., Ponzoni, F.J., Hirota, M.M., The Brazilian Atlantic Forest: How much is left, and how is the remaining forest distributed? Implications for conservation (2009) Biological Conservation, 142, pp. 1141-1153Rizzini, C.T., (1997) Tratado de fitogeografia do Brasil, , 2 ed. Ambito Cultural Edições LtdaRochelle, A.L.C., (2008) Heterogeneidade ambiental, diversidade e estrutura da comunidade arbórea de um trecho da Floresta Ombrófila, , Campinas: Biology Institute, State University of Campinas. [MSc Thesis]Rodrigues, R.R., Martins, S.V., Gandolfi, S., (2007) High Diversity Forest Restoration in Degraded Areas: Methods and Projects in Brazil, , Hauppauge, New York: Nova Science PublishersSalis, S.M., Shepherd, G.J., Joly, C.A., Floristic comparison between mesophytic forests of the interior of the state of São Paulo, S.E. Brazil (1995) Vegetatio, 119, pp. 155-164Scudeller, V.V., Martins, F.R., FITOGEO - um banco de dados aplicado à Fitogeografia (2003) Acta Amazônica, 33 (1), pp. 9-21Sentelhas, P.C., Pereira, A.R., Angelocci, L.R., (2000) Meteorologia Agrícola, , 3 ed. Piracicaba, SP: ESALQ(2006) Sistema de informação ambiental do programa, , http://sinbiota.cria.org.br/, SinBiota, BIOTA/FAPESP. Available fromSiqueira, M.F., Peterson, A.T., Consequences of global climate change for geographic distributions of Cerrado tree species (2003) Biota Neotropica, 3 (2). , http://www.biotaneotropica.org.br/v3n2/pt/fullpaper?bn00803022003+en, Available from(2006) Sistema de Informação Distribuído para Coleções Biológicas: A Integração do Species Analyst e do SinBiota, , http://splink.cria.org.br/, SpeciesLink, Available fromStockwell, D.R.B., Noble, I., Induction of sets of rules from animal distribution data: A robust and informative method of data analysis (1992) Mathematics and Computer in Simulation, 33, pp. 385-390Stockwell, D.R.B., Peters, D.P., The GARP modeling system: Problems and solutions to automated spatial prediction (1999) International Journal of Geographic Information Science, 13, pp. 143-158Thomas, W.M.W., Carvalho, A.M.V., Amorim, A.M.A., Garrison, J., Arbeláz, A.L., Plant endemism in two forests in southern Bahia, Brazil (1998) Biodiversity and Conservation, 7, pp. 311-322Thomaz, L.D., Monteiro, R., Composição florística da Mata Atlântica de encosta da Estação Biológica de Santa Lúcia, município de Santa Teresa-ES (1997) Boletim do Museu de Biologia Mello-Leitão, Nova Série, 7, pp. 3-48Thompson, R.S., Mead, J.I., Late Quaternary environments and biogeography in the Great Basin (1982) Quaternary Research, 17, pp. 39-55Wells, P.V., Paleobiogeography of montane islands in the Great Basin since the last glaciopluvial (1983) Ecological Monographs, 53, pp. 341-38
Application Of Maldi-ms Analysis Of Rainforest Chemodiversity: A Keystone For Biodiversity Conservation And Sustainable Use
[No abstract available]471114821485http://www.cbd.int/gbo3/Lovelock, J.E., Hands up for the Gaia hypothesis (1990) Nature, 344, p. 100EDITORIAL (2011) Nature, 473, p. 254Metzger, J.P., Lewinsohn, T., Joly, C.A., Verdade, L.M., Rodrigues, R.R., Brazilian law: Full speed in reverse (2010) Science, 329, p. 276Godoy, R., Wilkie, D., Overman, H., Cubas, A., Cubas, G., Demmer, J., McSweeney, K., Brokaw, N., Valuation of consumption and sale of forest goods from a Central American rain forest (2000) Nature, 406, p. 62Castello, L., Viana, J.P., Watkins, G., Pinedo-Vasquez, M., Luzadis, V.A., Lessons from integrating fishers of arapaima in small-scale fisheries management at the Mamirauá Reserve, Amazon (2009) Environ. Manage., 43, p. 197http://www.unep.org/greeneconomy/Joly, C.A., Assis, M.A., Bernacci, L.C., Tamashiro, J.Y., Campos, M.C.R., Gomes, J.A.M.A., Lacerda, M.S., Belinello, R., Floristic and phytosociology in permanent plots of the Atlantic Rainforest along altitudinal gradient in southeastern Brazil (2012) Biota Neotrop., 12 (1). , http://www.biotaneotropica.org.br/v12n1/en/abstract?article+bn01812012012Manna, J.D., Reyzer, M.L., Latham, J.C., Weaver, C.D., Marnett, L.J., Caprioli, R.M., High-Throughput Quantification of Bioactive Lipids by MALDI Mass Spectrometry: Application to Prostaglandins (2011) Anal. Chem., 83, p. 6683Joly, C.A., Rodrigues, R.R., Metzger, J.P., Haddad, C.F.B., Verdade, L.M., Oliveira, M.C., Bolzani, V.S., Biodiversity Conservation Research, Training, and Policy in São Paulo (2012) Science, 328, p. 1358De Vos, R.C.H., Moco, S., Lommen, A., Keurentjes, J.J.B., Bino, R.J., Hall, R.D., Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry (2007) Nat. Protoc., 2, p. 778Taiz, L., Zeiger, E., (2006) Plant Physiology, , Sinauer Associates, Inc: Sunderland, USAYamazaki, Y., Urano, A., Sudo, H., Kitajima, M., Takayama, H., Yamazaki, M., Aimi, N., Saito, K., Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants (2003) Phytochemistry, 62, p. 461http://ir.tevapharm.com/preview/phoenix.zhtml?c=73925&p= irol-reportsAnnualKnochenmuss, R., Zenobi, R., MALDI ionization: The role of in-plume processes (2003) Chem. Rev., 103, p. 441Zenobi, R., Knochenmuss, R., Ion formation in MALDI mass spectrometry (1998) Mass Spectrom. Rev., 17, p. 337Tholey, A., Heinzle, E., Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives (2006) Anal. Bioanal. Chem., 386, p. 24Armstrong, D.W., Zhang, L.K., He, L., Gross, M.L., Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry (2001) Anal. Chem., 73, p. 3679Perrings, C., Duraiappah, A., Larigauderie, A., Mooney, H., The Biodiversity and Ecosystem Services Science-Policy Interface (2011) Science, 331, p. 113
C.A. McGill, March 23, 1918
Portrait of C.A. McGill. Written on verso: With love from C.A. McGill Monrovia, Liberia, March 23rd, 1918.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the National Endowment for Humanities - Humanities Collections and Reference Resources Implementation Project Grant in supporting the processing and digitization of a number of its major archival collections as part of the project: Spreading the Word: Expanding Access to African American Religious Archival Collections at the Atlanta University Center Robert W. Woodruff Library.</em
Floristic And Structural Differences, Between Two Altitudinal Quotas, Of The Submontane Atlantic Rainforest Within The Serra Do Mar State Park, Municipality Of Ubatuba/sp, Brazil [diferenças Florísticas E Estruturais Entre Duas Cotas Altiduninais Da Floresta Ombrófila Densa Submontana Atlântica, Do Parque Estadual Da Serra Do Mar, Município De Ubatuba/sp, Brasil]
This study presents a comparative analyzes of two areas of Atlantic Rain Forest, in the municipality of Ubatuba (SP), Brazil, and tests the hypothesis that floristic composition and phytosociological structure change along an altitudinal gradient. Two 1-ha plots were installed, respectively, at 190 (PLOT G) and 350 m (PLOT I) above see level, and within these plots all individuals with DBH ≥ 4.8 cm were sampled, measured and identified. In total we found 252 species, belonging to 134 genera and 53 families, diversity H' of 4.425 nats/individual, and 103 species (41% of total) common to both plots. But, among the 10 top species in Absolute Dominance only two: Cryptocarya mandioccana and Sloanea guianensis were found in both plots. In PLOT G we found 1496 individuals distributed in 152 species, 101 genera and 41 families, with H' = 3.961 nats/individual and 48 exclusive species (32%). In PLOT I we found 1993 individuals distributed in 203 species, 111 genera, 50 families, with H' = 4.339 nats/individual and 100 exclusive species (49%). Supporting our hypothesis, the comparative analyzes showed that there are significant differences in density (p < 0.01, t = 7.10), richness (p < 0.01, t = 7.76) and volume (p = 0.02, t = 2.44), between the two sampled areas. The pattern here observed shows that the plot installed closer to the middle of the Serra do Mar slope (350 m) presented a higher number of individuals, higher richness and higher scores of volume, when compared to that closer to the base of the slope (190 m).112123137Aiba, S., Kitayama, K., Structure, Composition And Species Diversity In An Altitude Substrate Matrix Of Rain Forest Tree Communities On Mount Kinabalu, Borneo (1999) Plant Ecol, 140 (2), pp. 139-157. , Http://Dx.Doi.Org/10.1023/A:1009710618040Aiba, S., Kitayama, K., Takyu, M., Habitat Associations With Topography And Canopy Structure Of Tree Species In A Montane Forest On Mount Kinabalu (2004) Borneo. Plant Ecol, 174 (1), pp. 147-161. , Http://Dx.Doi.Org/10.1023/B:Vege.0000046059.92806.49An Update Of The Angiosperm Phylogeny Group Classification For The Orders And Families Of Flowering Plants: Apg Ii (2003) Bot. J. Linn. Soc, 141 (4), pp. 399-436. , Http://Dx.Doi.Org/10.1046/J.1095-8339.2003.T01-1-00158.X, Angiosperm Phylogeny Group - Apg IiAssis, M.A., (1999) Florística E Caracterização Das Comunidades Vegetais Da Planície Costeira De Picinguaba, , Ubatuba - Sp. Tese De Doutorado, Universidade Estadual De Campinas, CampinasAssis, M.A., Prata, E.M.B., Pedroni, F., Sanchez, M., Eisenlohr, P.V., Martins, F.R., Santos, F.A.M., Joly, C.A., Florestas De Restinga E De Terras Baixas Na Planície Costeira Do Sudeste Do Brasil: Vegetação E Heterogeneidade Ambiental (2011) Biota Neotrop, 11 (2). , Http://Www.Biotaneotropica.Org.Br/V11n2/Pt/Abstract?Article+Bn02111022011Ayres, M., Ayres Jr., M., Ayres, D.L., Santos, A.S., (2000) Bioestat 2.0: Aplicações Estatísticas Nas Áreas De Ciências Biológicas E Médicas, , Sociedade Civil Manirauá/Cnpq, BelémBarbosa, J.P.M., Utilização De Método De Interpolação Para Análise E Espacialização De Dados Climáticos: O Sig Como Ferramenta (2006) Cam. Geog, 9 (17), pp. 85-96Bernacci, L.C., Franco, G.A.D.C., Árbocz, G.F., Catharino, E.L.M., Durigan, G., Metzger, J.P., O Efeito Da Fragmentação Florestal Na Composição E Riqueza De Árvores Na Região Da Reserva Morro Grande (Planalto De Ibiúna, Sp) (2006) Rev. Inst. Florest, 18 (1), pp. 121-166(2008) Lista Oficial De Espécies Ameaçadas De Extinção No Brasil, , Http://Www.Biodiversitas.Org.Br/Florabr/Grupo3fim.Asp, Biodiversitas, Disponível Em, Último Acesso Em 28/04/2011(2008) Secretaria Do Meio Ambiente - Sma. Resolução Sma 08: Fixa a Orientação Para O Reflorestamento Heterogêneo De Áreas Degradadas E Dá Providências Correlatas, , Brasil, Diário Oficial Do Estado De São Paulo, Brasília, Df, 31 Jan. 2008Campos, M.C.R., Tamashiro, J.Y., Assis, M.A., Joly, C.A., Florística E Fitossociologia Do Componente Arbóreo Da Transição Floresta Ombrófila Densa Das Terras Baixas - Floresta Ombrófila Densa Submontana Do Núcleo Picinguaba/Pesm, Ubatuba, Sudeste Do Brasil (2011) Biota Neotrop, 11 (2). , Http://Www.Biotaneotropica.Org.Br/V11n2/Pt/AbstrAct?Inventory+Bn02311022011Carvalho, D.A., Oliveira Filho, A.T., van den Berg, E., Fontes, M.A.L., Vilela, E.A., Marques, J.J.G.S.M., Carvalho, W.A.C., Variações Florísticas E Estruturais Do Componente Arbóreo De Uma Floresta Ombrófila Alto-Montana Às Margens Do Rio Grande, Bocaina De Minas, Mg, Brasil (2005) Acta Bot. Bras, 19 (1), pp. 91-109. , Http://Dx.Doi.Org/10.1590/S0102-33062005000100010Catharino, E.L.M., Bernacci, L.C., Franco, G.A.D.C., Durigan, G., Metzger, J.P., Aspectos Da Composição E Diversidade Do Componente Arbóreo Das Florestas Da Reserva Florestal Do Morro Grande, Cotia, Sp (2006) Biota Neotrop, 6 (2). , Http://Www.Biotaneotropica.Org.Br/V6n2/Pt/Fullpaper?Bn00306022006+Pt, Último Acesso 28/04/2011Cesar, O., Monteiro, R., Florística E Fitossociologia De Uma Floresta Sobre A Restinga Em Picinguaba (Parque Estadual Da Serra Do Mar) Município De Ubatuba (1995) Sp. Naturalia, 20 (1), pp. 21-35Cielo, F.R., Gneri, M.A., Martins, F.R., Position On Slope, Disturbance, And Tree Species Coexistence In A Seasonal Semideciduous Forest In Se Brazil (2007) Plant Ecol, 190 (2), pp. 189-203. , Http://Dx.Doi.Org/10.1007/S11258-006-9200-X(2000) Avaliação E Ações Prioritárias Para a Conservação Da Biodiversidade Da Mata Atlântica E Campos Sulinos, , Conservation International Do Brasil, Fundação Sos Mata Atlântica, Fundação Biodiversitas, Instituto De Pesquisas Ecológicas, Secretaria Do Meio Ambiente Do Estado De São Paulo, Instituto Estadual De Florestas-Mg, Mma/Sbf, BrasíliaDelprete, P.G., Ixora (2008) Flora Fanerogâmica Do Estado De São Paulo, 5, pp. 354-358. , M.G.L. Wanderley, G.J. Shepherd, T.S. Melhem & A.M. Giulietti, Coords, Instituto De Bota^nica, São PauloFurlan, A., Monteiro, R., Cesar, O., Timoni, J.L., Estudos Florísticos Das Matas De Restinga De Picinguaba (1990) Sp. Publ. 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Erratum: Future temperature extremes will be more harmful: A new critical factor for improved forecasts (Int. J. Environ. Res. Public Health 2019, 16 (20), 4015)
The authors would like to correct the names and surnames of both authors of their previous paper [1] as follows: Costas A. Varotsos1,2,* and Yuri A. Mazei2 Therefore, to cite this paper please use the correct reference as follows: Varotsos, C.A.; Mazei,Y.A. Future Temperature Extremes Will Be More Harmful: A New Critical Factor for Improved Forecasts. Int. J. Environ. Res. Public Health 2019, 16 (20), 4015. © 2020 by the author. Licensee MDPI, Basel, Switzerland
Skeleton-based design and simulation flow for Computation-in-Memory architectures
Memristor-based Computation-in-Memory is one of the emerging architectures proposed to deal with Big Data problems. The design of such architectures requires a radically new automatic design flow because the memristor is a passive device that uses resistance to encode its logic value. This paper proposes a design flow for mapping parallel algorithms on the CIM architecture. Algorithms with similar data flow graphs can be mapped on the crossbar using the same template containing scheduling, placement, and routing information; this template is named skeleton. By configuring such a skeleton with different pre-designed circuits, we can build CIM implementations of the corresponding algorithms in that class. This approach does not only map an algorithm on a memristor crossbar, but also gives an estimation of its performance, area, and energy consumption. It also supports user-defined constraints and parallel SystemC simulation. Experimental results demonstrate the feasibility and the potential of the approach.Accepted Author ManuscriptComputer EngineeringQuantum & Computer EngineeringFTQC/Bertels La
Thoughts about cancer stem cells in solid tumors
Cancer chemotherapy efficacy is frequently impaired by either intrinsic or acquired tumor resistance. A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue cells. In recent years, the cancer stem cell (CSC) theory has changed the classical view of tumor growth and therefore the therapeutic perspective. Overcoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. On the other hand, the identification of CSCs in vivo and in vitro relies on specific surface markers that should allow the sorting cancer cells into phenotypically distinct subpopulations. In the present review, recent papers published on CSCs in solid tumors (breast, prostate, brain and melanoma) are discussed, highlighting critical points such as the choice of markers to sort CSCs and mouse models to demonstrate that CSCs are able to replicate the original tumor. A discussion of the possible role of aldehyde dehydrogenase and CXCR6 biomarkers as signaling molecules in CSCs and normal stem cells is also discussed. The author believes that efforts have to be made to investigate the functional and biological properties of putative CSCs in cancer. Developing diagnostic/prognostic tools to follow cancer development is also a challenge. In this connection it would be useful to develop a multidisciplinary approach combining mathematics, physics and biology which merges experimental approaches and theory. Biological models alone are probably unable to resolve the problem completely
Letter from unknown writer to Jesse L. Boyce
Letter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
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