4,581 research outputs found
Falling waters : reverie / John J. Fitzpatrick.
No full textFor piano.Caption title.Cover illustration: inset drawing of waterfalls, surrounded by pink flowers on a pink background / Starmer.Archived web conten
Dance of the golden rods [music] : schottische /
No full textCover title.; "To my esteemed friend Edward F. Murphy" -- Caption.; Originally published: The Wellington Music, 1905 ; Boston : Jos. M. Daly Music, 1907.; Also available online http://nla.gov.au/nla.mus-an5406334; N, MUSM 142235 ; A, MUSM 114023/34 ; N/A, MUS/E89/118.; N/A copy cropped to 33cm
Requirements for In-Situ Authoring of Location Based Experiences
No full textIn this paper we describe an investigation into the requirements for and the use of in-situ authoring in the creation of location based pervasive and UbiComp experiences. We will focus on the co-design process with users that resulted in a novel visitor experience to a historic country estate. This has informed the design of new, in-situ, authoring tools supplemented with tools for retrospective revisiting and reorganization of content. An initial trial of these new tools will be discussed and conclusions drawn as to the appropriateness of such tools. Further enhancements as part of future trials will also be described
The use of pH and kinetic isotope effects to probe the mechanism of D-amino acid oxidase
No full textVita.The mechanism of hog kidney D-amino acid oxidase with glycine, D-alanine and D-serine as substrates has been examined in detail using the methods of pH effects and primary, secondary and solvent kinetic isotope effects. Reduction of the enzyme-bound FAD requires that a group with a pK[a] value of 8.7 be unprotonated and that a group with a pK[a] of 10.7 be protonated. The DV/K[ser] value of 4.5 is pH-independent and intrinsic as confirmed by the primary deuterium isotope effect in the anaerobic rapid reaction and by the primary tritium isotope effect. With D-alanine, the pK[a] values are perturbed outwardly. The DV/Kaia value increases with decreasing pH, establishing that D-alanine is sticky. The effect of pH on the DV/K[ala] value is consistent with a model in which exchange with solvent of the proton from the group with pK[a] 8.7 is hindered and is catalyzed by H2O and OH- above pH 7. The intrinsic DV/K[ala] value of 5.8 with D-alanine was determined from the TV/K[ala] value at low pH. With glycine, the pH optimum is shifted and the DV/K[gly] value increases with increasing pH, consistent with fully reversible CH bond cleavage followed by a pH-dependent step. At high pH, the intrinsic DV/K[gly] value is 3.6 which was confirmed by the isotope effect on the limiting rate of reduction and by the TV/K[gly] value. No significant a-secondary, 13-secondary or solvent Kinetic isotope effects were observed at the conditions where CH bond cleavage is totally rate-determining. These results argue against a concerted mechanism for reduction. A protonated group with a pK[a] value of 10.5 is important for the reaction of reduced flavin enzyme:imino acid complex with oxygen. Consistent with the bimolecular reaction of oxygen with reduced enzyme being rate-limiting, no solvent isotope effects were observed on the V/K[O2] value. Significant solvent isotope effects on turnover with D-alanine as substrate are consistent with a single slow proton transfer which mediates a conformational change, permitting imino acid release
sj-pdf-2-cpx-10.1177_21677026221120230 – Supplemental material for Empirically Supported Principles of Change in Youth Psychotherapy: Exploring Codability, Frequency of Use, and Meta-Analytic Findings
No full textSupplemental material, sj-pdf-2-cpx-10.1177_21677026221120230 for Empirically Supported Principles of Change in Youth Psychotherapy: Exploring Codability, Frequency of Use, and Meta-Analytic Findings by Olivia M. Fitzpatrick, Evelyn Cho, Katherine E. Venturo-Conerly, Ana M. Ugueto, Mei Yi Ng and John R. Weisz in Clinical Psychological Science</p
sj-docx-1-cpx-10.1177_21677026221120230 – Supplemental material for Empirically Supported Principles of Change in Youth Psychotherapy: Exploring Codability, Frequency of Use, and Meta-Analytic Findings
No full textSupplemental material, sj-docx-1-cpx-10.1177_21677026221120230 for Empirically Supported Principles of Change in Youth Psychotherapy: Exploring Codability, Frequency of Use, and Meta-Analytic Findings by Olivia M. Fitzpatrick, Evelyn Cho, Katherine E. Venturo-Conerly, Ana M. Ugueto, Mei Yi Ng and John R. Weisz in Clinical Psychological Science</p
Fitzpatrick, Alison M. (Death, 1903-01-17)
No full textAddress: 2328 Glenway Ave.Age at death: 3 mo.Pg 6/1903/294/M W S/City/Dr.B. F. Lyle/John J. Radel/Carthage Rd.Original record filed in drawer labeled 'FISHER, D-FLEG'
Investigations of the kinetic and chemical mechanisms of tryptophan two-monooxygenase
No full textVitaMajor subject: BiochemistryIn title, there are numeralsThe flavoprotein tryptophan 2-monooxygenase (TMO) from the plant pathogen Pseudomonas syringae pv. savastanoi catalyzes the oxidative decarboxylation of tryptophan to indole-3-acetamide, carbon dioxide and water. TMO is involved in the bacterial production of auxin. The enzyme was overexpressed in and purified to homogeneity from E coli. Steady state and rapid reaction kinetic methods were used to study the reaction with L-tryptophan at pH 8.3 and 25 ����C. The reduction of TMO by L-tryptophan was consistent with equilibrium binding of substrate followed by two reversible steps. The first step was isotope sensitive with a rate constant of 115 s e c 1, while the second had a rate constant of 2.5 s e c 1. Indole-pyruvate was formed with a rate constant of 107 sec*1, consistent with all of the chemistry occurring during the isotope sensitive step. Oxygen reacted with the reduced enzyme oxidized substrate complex with a rate constant of 195 mM*1 sec*1. The rate constant for product release was calculated to be 14.9 sec*1. The substrate's amino group and a group on the enzyme with a pKa of 6.0 had to be protonated; deprotonation of a group on the enzyme with a pKa of 10 increased activity. Deprotonation of a group with a pKa of 8.5 resulted in an increase in V/K02(met) value but had no effect on V/K02(trp) ���� r V/K02(phe)- Deprotonation of a group on the enzyme increased Vmax; the pKa of this group was 6.3 with L-methionine, 7.7 with L-phenylalanine and 8.5 with Ltryptophan. DV/K(trp) values were small, consistent with a high forward commitment. At high or low pH the ����V/Kmet value was 5.2. The ����V/Kala value at pH 8.3 was 5.3. The P����V/Kala value was 0.96����0.04; this is inconsistent with a hydride transfer mechanism. DVmax values with Ltryptophan and L-phenylalanine at pH 8.3 were small, consistent with product release being rate limiting
Efficacy of Laser Resurfacing and Facial Plastic Surgery Using Age, Glogau, and Fitzpatrick Rating
No full textBackground:. To assess clinical outcomes based on established rating scales in patients who underwent treatment for rhytids using laser resurfacing with and without facial plastic surgery.
Methods:. Retrospective case review of 48 patients treated by the senior author (J.E.B) between 2009 and 2016. Three reviewers assigned ratings to a total of 48 patients using estimated age and Fitzpatrick, Modified Fitzpatrick, and Glogau scales. Reviewers were blinded to patient demographics and before and after photographs. Patients elected to receive laser-only treatment or combination laser plus facial plastic surgery. Participants included forty-eight patients were selected on the basis that they had either laser treatment alone or laser plus facial plastic surgery and pre- and postoperative photographs.
Results:. Patients with higher Fitzpatrick scores had a greater reduction in Glogau score (ß = 1.66; SE = 0.59; P < 0.01). With respect to modified Fitzpatrick scores after surgery, patients with higher Glogau scores of 3 or 4 before surgery (P < 0.01) had higher scores after surgery ((ß = 0.07; SE = 0.02; P < 0.01). For estimated age, the average change was -1.7 years after laser resurfacing (P = 0.038; 95% CI, 2.96–3.06 years) and -2.07 years when combined with surgery (P = 0.01; 95% CI, 2.89–3.19 years).
Conclusions:. Patients with Fitzpatrick scores of 3, 4, 5, younger patients, and those with less rhytids before surgery tended to have lower Glogau scores after surgery. These findings provide insight on an approach to treating ethnic skin and aging face concerns
‘Enacted in the destiny of sedentary peoples’: racism, discovery and the grounds of law
No full textWhilst the racial, and racist, basis of the doctrine of discovery is a modern innovation, the doctrine owes much to its pre-modern forms and ethos. The finding and settlement of putatively unknown lands has long been attended with mythic and religious justification and with rituals of appropriation all of which strikingly resemble modern practice. Similarity in this case, however, serves to dramatize difference. What marks modern discovery of the occidental variety is the displacement of the mythic and religious by a combination of racism and legalism. The story of that displacement is told here along with an analysis of the poverty, not to say vacuity, of the doctrine of discovery as a justification for imperial appropriation. Since the story is told in broadly historical terms, its conception of the modern relies on the temporal ‘depth’ which historians usually attribute to this term, the discoveries of Columbus here providing something of a benchmark. But this account of the doctrine of discovery is not an antiquarian exercise, not a tale told in a now entirely discovered world, the unfolding of which may have had its reasons for regret but is now decidedly done with. Rather, this account is modern also in the sense of having current significance, of discovery’s still being an impelling force in the treatment of peoples supposedly once discovered and in the self-identity of those who would claim to have once discovered them, an identity which extends to the grounding of the discoverer’s law. Following the preponderant legal authority on discovery, my ‘case’ study here will come from the history of the United States. The parallels with the Australian situation are, it would seem, close
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