10 research outputs found
The dramaturgy of the tragedies of John Webster and John Ford with special reference to their use of stage imagery.
PhDThe imagery of the plays of John Webster and John
Ford is not only verbal: in staging as well as language
these dramas display strongly imagistic, symbolic elements.
The purpose of this thesis is to examine the seven extant
tragedies of Webster and Ford from the point of view of
their total dramatic nature - to examine the staging,
costumes, hand and large properties, movement and gestures
as well as the verbal imagery, and the interplay of these
verbal and visual elements. The original appearance, of
these plays in their contemporary theatre, and the
dramatist's intentions for performance, can only be surmised.
The original stage directions are examined for
hints of the original presentation: these stage directions
may not always be authorial, but, especially in the case of
Ford, they seem to reveal the playwright's hand. The dialogue,
too, frequently implies particular gestures,
grouping or stage placement.
The visual imagery, it is here suggested, is created
by the dramatist for several purposes: a moral or ironical
point may be silently established; a chain of related
visual motifs may bind various actions and characters into
an organic union; a visualization may appeal outward to
other works of art or theatrical or non-dramatic conventions,
enlarging the immediate significance by this shorthand
reference; visual ceremonies may make concrete the more
ephemeral words and feelings of the characters.
Each of the tragedies is studied in a separate chapter,
in the following order: Webster's The White Devil, The
Duchess of Malfi, and Appius and Virginia (the authorship
of which is disputed); John Ford's The Broken Heart,
Love's Sacrifice, 'Tis Pity She's a Whore, and Perkin
Warbeck. A conclusion indicates the differences between
Webster's more overtly theatrical visualizations and Ford's
quiet tableaux.
The thesis is accompanied by illustrations which are
either explanatory or comparative
Recommended from our members
Review: Lal, Deepak. The poverty of “Development Economics.” 2d revised and expanded US edition.
The ‘end of AIDS’ project: Mobilising evidence, bureaucracy, and big data for a final biomedical triumph over AIDS
Efforts are currently underway by major orchestrators and funders of the global AIDS response to realise the vision of achieving an end to AIDS by 2030. Unlike previous efforts to provide policy guidance or to encourage ‘best practice’ approaches for combatting AIDS, the end of AIDS project involves the promotion of a clear set of targets, tools, and interventions for a final biomedical solution to the epidemic. In this paper, we examine the bureaucratic procedures of one major AIDS funder that helped to foster a common vision and mission amongst a global AIDS community with widely divergent views on how best to address the epidemic. We focus on the methods, movements, and materials that are central to the project of ending AIDS, including those related to biomedical forms of evidence and big data science. We argue that these approaches have limitations and social scientists need to pay close attention to the end of AIDS project, particularly in contexts where clinical interventions might transform clinical outcomes, but where the social, economic, and cultural determinants of HIV and AIDS remain largely intact and increasingly obscured
Highly active anti-retroviral treatment as a bridge towards education for all in sub-Saharan Africa
HIV/AIDS continues to pose serious challenges to the health and economic development of many low-resource countries. Over the last decade, the impact of HIV/AIDS has been well documente
Geometry-independent inclusion of basal myocardium yields improved cardiac magnetic resonance agreement with echocardiography and necropsy quantified left-ventricular mass
ObjectivesLeft-ventricular mass (LVM) is widely used to guide clinical decision-making. Cardiac magnetic resonance (CMR) quantifies LVM by planimetry of contiguous short-axis images, an approach dependent on reader-selection of images to be contoured. Established methods have applied different binary cut-offs using circumferential extent of left-ventricular myocardium to define the basal left ventricle (LV), omitting images containing lesser fractions of left-ventricular myocardium. This study tested impact of basal slice variability on LVM quantification.MethodsCMR was performed in patients and laboratory animals. LVM was quantified with full inclusion of left-ventricular myocardium, and by established methods that use different cut-offs to define the left-ventricular basal-most slice: 50% circumferential myocardium at end diastole alone (ED50), 50% circumferential myocardium throughout both end diastole and end systole (EDS50).ResultsOne hundred and fifty patients and 10 lab animals were studied. Among patients, fully inclusive LVM (172.6±42.3g) was higher vs. ED50 (167.2±41.8g) and EDS50 (150.6±41.1g; both P<0.001). Methodological differences yielded discrepancies regarding proportion of patients meeting established criteria for left-ventricular hypertrophy and chamber dilation (P<0.05). Fully inclusive LVM yielded smaller differences with echocardiography (Δ=11.0±28.8g) than did ED50 (Δ=16.4±29.1g) and EDS50 (Δ=33.2±28.7g; both P<0.001). Among lab animals, ex-vivo left-ventricular weight (69.8±13.2g) was similar to LVM calculated using fully inclusive (70.1±13.5g, P=0.67) and ED50 (69.4±13.9g; P=0.70) methods, whereas EDS50 differed significantly (67.9±14.9g; P=0.04).ConclusionEstablished CMR methods that discordantly define the basal-most LV produce significant differences in calculated LVM. Fully inclusive quantification, rather than binary cut-offs that omit basal left-ventricular myocardium, yields smallest CMR discrepancy with echocardiography-measured LVM and non-significant differences with necropsy-measured left-ventricular weight
Improved Left Ventricular Mass Quantification with Partial Voxel Interpolation – In-Vivo and Necropsy Validation of a Novel Cardiac MRI Segmentation Algorithm
Background—CMR typically quantifies LV mass (LVM) via manual planimetry (MP), but this approach is time consuming and does not account for partial voxel components - myocardium admixed with blood in a single voxel. Automated segmentation (AS) can account for partial voxels, but this has not been used for LVM quantification. This study used automated CMR segmentation to test the influence of partial voxels on quantification of LVM. Methods and Results—LVM was quantified by AS and MP in 126 consecutive patients and 10 laboratory animals undergoing CMR. AS yielded both partial voxel (ASPV) and full voxel (ASFV) measurements. Methods were independently compared to LVM quantified on echocardiography (echo) and an ex-vivo standard of LVM at necropsy. AS quantified LVM in all patients, yielding a 12-fold decrease in processing time vs. MP (0:21±0:04 vs. 4:18±1:02 min; pFV mass (136±35gm) was slightly lower than MP (139±35; Δ=3±9gm, pPV yielded higher LVM (159±38gm) than MP (Δ=20±10gm) and ASFV (Δ=23±6gm, both pPV and ASFV correlated with larger voxel size (partial r=0.37, pPV yielded better agreement with echo (Δ=20±25gm) than did ASFV (Δ=43±24gm) or MP (Δ=40±22gm, both pPV and ex-vivo results were similar (Δ=1±3gm, p=0.3), whereas ASFV (6±3g, P\u3c0.001) and MP (4±5 g, P=0.02) yielded small but significant differences with LVM at necropsy
Bassani e l’omosessualità
In this essay the author analyzes the presence of homosexuality, as well as its symbolic equivalents of injured or diminished virility, in Giorgio Bassani’s narrative. In this direction, the most significant texts are considered The Gold Rimmed Glasses (where the tragic hero is an homosexual), Behind the Door and The Heron, but also the figure of Alberto (and somewhat of the protagonist and narrator) in The Garden of the Finzi-Contini and of Barilari in One night in ‘43 are the subject of thematic interpretation. The author claims that homosexual identity is not investigated itself and ontologically legitimized by Bassani, but takes the value of a metaphor for exclusion, even a violent one, as the one that struck, at the same time, Jewish identity after the enactment of Racial Laws in Italy. From this point of view, the doubt on the “conformity” of his own sexuality, the fear this sexuality would meet the regime’s propaganda stereotypes, or (in Behind the Door) the liberating projection of these stereotypes on an antagonistic character and alter ego seem to inhabit the protagonists of the aforementioned novels and short stories and produce, with their diverted or evaded questions, the agony of false consciousness.In questo saggio l’autore analizza la presenza dell’omosessualità, nonché dei suoi equivalenti simbolici della virilità lesa o diminuita, nella narrativa di Giorgio Bassani. In tale direzione, i testi bassaniani più significativi vengono considerati Gli occhiali d’oro (in cui il tragico protagonista è un omosessuale), Dietro la porta e L’airone, ma anche la figura di Alberto (e, in parte, dello stesso protagonista) nel Giardino dei Finzi-Contini e quella di Barilari in Una notte del ’43 sono oggetto di interpretazione tematica. L’autore del saggio cerca di mostrare che l’identità omosessuale non è da Bassani indagata in sé e legittimata ontologicamente, ma assume un puro valore di metafora dell’esclusione, anche violenta, quella che parallelamente colpì l’identità ebraica dopo l’emanazione delle leggi razziali in Italia. Secondo questa angolazione di lettura, il dubbio sulla “conformità” della propria sessualità, il timore di un’omologazione di essa agli stereotipi della propaganda di regime o (in Dietro la Porta) la proiezione liberatoria di questi ultimi su un personaggio antagonistico / alteregoico, sembrano abitare i protagonisti dei romanzi e dei racconti succitati e produrre, coi loro interrogativi deviati o elusi, i tormenti della falsa coscienza
Myocardial Extracellular Volume Expansion And The Risk Of Recurrent Atrial Fibrillation After Pulmonary Vein Isolation
Objectives This study tested whether myocardial extracellular volume (ECV) is increased in patients with hypertension and atrial fibrillation (AF) undergoing pulmonary vein isolation and whether there is an association between ECV and post-procedural recurrence of AF. Background Hypertension is associated with myocardial fibrosis, an increase in ECV, and AF. Data linking these findings are limited. T1 measurements pre-contrast and post-contrast in a cardiac magnetic resonance (CMR) study provide a method for quantification of ECV. Methods Consecutive patients with hypertension and recurrent AF referred for pulmonary vein isolation underwent a contrast CMR study with measurement of ECV and were followed up prospectively for a median of 18 months. The endpoint of interest was late recurrence of AF. Results Patients had elevated left ventricular (LV) volumes, LV mass, left atrial volumes, and increased ECV (patients with AF, 0.34 ± 0.03; healthy control patients, 0.29 ± 0.03; p < 0.001). There were positive associations between ECV and left atrial volume (r = 0.46, p < 0.01) and LV mass and a negative association between ECV and diastolic function (early mitral annular relaxation [E′], r = -0.55, p < 0.001). In the best overall multivariable model, ECV was the strongest predictor of the primary outcome of recurrent AF (hazard ratio: 1.29; 95% confidence interval: 1.15 to 1.44; p < 0.0001) and the secondary composite outcome of recurrent AF, heart failure admission, and death (hazard ratio: 1.35; 95% confidence interval: 1.21 to 1.51; p < 0.0001). Each 10% increase in ECV was associated with a 29% increased risk of recurrent AF. Conclusions In patients with AF and hypertension, expansion of ECV is associated with diastolic function and left atrial remodeling and is a strong independent predictor of recurrent AF post-pulmonary vein isolation. © 2014 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION PUBLISHED BY ELSEVIER INC.71111Levy, D., Larson, M.G., Vasan, R.S., Kannel, W.B., Ho, K.K., The progression from hypertension to congestive heart failure (1996) JAMA, 275, pp. 1557-1562Weber, K.T., Cardiac interstitium in health and disease: The fibrillar collagen network (1989) J Am Coll Cardiol, 13, pp. 1637-1652Frustaci, A., Caldarulo, M., Buffon, A., Bellocci, F., Fenici, R., Melina, D., Cardiac biopsy in patients with "primary" atrial fibrillation. Histologic evidence of occult myocardial diseases (1991) Chest, 100, pp. 303-306Ling, L.H., Kistler, P.M., Ellims, A.H., Diffuse ventricular fibrosis in atrial fibrillation: Noninvasive evaluation and relationships with aging and systolic dysfunction (2012) J Am Coll Cardiol, 60, pp. 2402-2408Diez, J., Querejeta, R., Lopez, B., Gonzalez, A., Larman, M., Martinez Ubago, J.L., Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients (2002) Circulation, 105, pp. 2512-2517Kim, R.J., Fieno, D.S., Parrish, T.B., Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function (1999) Circulation, 100, pp. 1992-2002Mewton, N., Liu, C.Y., Croisille, P., Bluemke, D., Lima, J.A., Assessment of myocardial fibrosis with cardiovascular magnetic resonance (2011) J Am Coll Cardiol, 57, pp. 891-903Rudolph, A., Abdel-Aty, H., Bohl, S., Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling (2009) J Am Coll Cardiol, 53, pp. 284-291Puntmann, V.O., Jahnke, C., Gebker, R., Usefulness of magnetic resonance imaging to distinguish hypertensive and hypertrophic cardiomyopathy (2010) Am J Cardiol, 106, pp. 1016-1022Brilla, C.G., Funck, R.C., Rupp, H., Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease (2000) Circulation, 102, pp. 1388-1393Querejeta, R., Lopez, B., Gonzalez, A., Increased collagen type i synthesis in patients with heart failure of hypertensive origin: Relation to myocardial fibrosis (2004) Circulation, 110, pp. 1263-1268Rossi, M.A., Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans (1998) J Hypertens, 16, pp. 1031-1041Jerosch-Herold, M., Sheridan, D.C., Kushner, J.D., Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy (2008) Am J Physiol Heart Circ Physiol, 295, pp. 1234-H1242Broberg, C.S., Chugh, S.S., Conklin, C., Sahn, D.J., Jerosch-Herold, M., Quantification of diffuse myocardial fibrosis and its association with myocardial dysfunction in congenital heart disease (2010) Circ Cardiovasc Imaging, 3, pp. 727-734Flett, A.S., Hayward, M.P., Ashworth, M.T., Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: Preliminary validation in humans (2010) Circulation, 122, pp. 138-144Ugander, M., Oki, A.J., Hsu, L.Y., Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology (2012) Eur Heart J, 33, pp. 1268-1278Iles, L., Pfluger, H., Phrommintikul, A., Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping (2008) J Am Coll Cardiol, 52, pp. 1574-1580Wong, T.C., Piehler, K., Meier, C.G., Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality (2012) Circulation, 126, pp. 1206-1216Coelho-Filho, O.R., Mongeon, F.P., Mitchell, R., The role of transcytolemmal water exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease (2013) Circ Cardiovasc Imaging, 6, pp. 134-141Chobanian, A.V., Bakris, G.L., Black, H.R., The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report (2003) JAMA, 289, pp. 2560-2572Levy, D., Labib, S.B., Anderson, K.M., Christiansen, J.C., Kannel, W.B., Castelli, W.P., Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy (1990) Circulation, 81, pp. 815-820Mongeon, F.P., Jerosch-Herold, M., Coelho-Filho, O.R., Blankstein, R., Falk, R.H., Kwong, R.Y., Quantification of extracellular matrix expansion by CMR in infiltrative heart disease (2012) J Am Coll Cardiol Img, 5, pp. 897-907Neilan, T.G., Coelho-Filho, O.R., Shah, R.V., Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: Relationship to aging and cardiac dimensions (2013) J Am Coll Cardiol Img, 6, pp. 672-683Ho, C.Y., Abbasi, S.A., Neilan, T.G., T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy (2013) Circ Cardiovasc Imaging, 6, pp. 415-422Cleland, J.G., Daubert, J.C., Erdmann, E., The effect of cardiac resynchronization on morbidity and mortality in heart failure (2005) N Engl J Med, 352, pp. 1539-1549Tsang, T.S., Gersh, B.J., Appleton, C.P., Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women (2002) J Am Coll Cardiol, 40, pp. 1636-1644Vaziri, S.M., Larson, M.G., Benjamin, E.J., Levy, D., Echocardiographic predictors of nonrheumatic atrial fibrillation the Framingham Heart Study (1994) Circulation, 89, pp. 724-730Kuwahara, F., Kai, H., Tokuda, K., Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats (2002) Circulation, 106, pp. 130-135Shinbane, J.S., Wood, M.A., Jensen, D.N., Ellenbogen, K.A., Fitzpatrick, A.P., Scheinman, M.M., Tachycardia-induced cardiomyopathy: A review of animal models and clinical studies (1997) J Am Coll Cardiol, 29, pp. 709-715He, X., Gao, X., Peng, L., Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7 (2011) Circ Res, 108, pp. 164-175Swartz, M.F., Fink, G.W., Sarwar, M.F., Elevated pre-operative serum peptides for collagen i and iii synthesis result in post-surgical atrial fibrillation (2012) J Am Coll Cardiol, 60, pp. 1799-1806Dahlof, B., Devereux, R.B., Kjeldsen, S.E., Cardiovascular morbidity and mortality in the Losartan Intervention for Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol (2002) Lancet, 359, pp. 995-1003Levy, D., Garrison, R.J., Savage, D.D., Kannel, W.B., Castelli, W.P., Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study (1990) N Engl J Med, 322, pp. 1561-1566Bluemke, D.A., Kronmal, R.A., Lima, J.A., The relationship of left ventricular mass and geometry to incident cardiovascular events: The MESA (Multi-Ethnic Study of Atherosclerosis) study (2008) J Am Coll Cardiol, 52, pp. 2148-2155Anversa, P., Ricci, R., Olivetti, G., Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: A review (1986) J Am Coll Cardiol, 7, pp. 1140-1149Gardin, J.M., Arnold, A., Gottdiener, J.S., Left ventricular mass in the elderly the Cardiovascular Health Study (1997) Hypertension, 29, pp. 1095-1103Armstrong, A.C., Gidding, S., Gjesdal, O., Wu, C., Bluemke, D.A., Lima, J.A., LV mass assessed by echocardiography and CMR, cardiovascular outcomes, and medical practice (2012) J Am Coll Cardiol Img, 5, pp. 837-848Lang, R.M., Bierig, M., Devereux, R.B., Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology (2005) J Am Soc Echocardiogr, 18, pp. 1440-1463Missouris, C.G., Forbat, S.M., Singer, D.R., Markandu, N.D., Underwood, R., MacGregor, G.A., Echocardiography overestimates left ventricular mass: A comparative study with magnetic resonance imaging in patients with hypertension (1996) J Hypertens, 14, pp. 1005-1010MacEira, A.M., Prasad, S.K., Khan, M., Pennell, D.J., Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance (2006) J Cardiovasc Magn Reson, 8, pp. 417-426Messroghli, D.R., Radjenovic, A., Kozerke, S., Higgins, D.M., Sivananthan, M.U., Ridgway, J.P., Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart (2004) Magn Reson Med, 52, pp. 141-146Lee, J.J., Liu, S., Nacif, M.S., Myocardial T1 and extracellular volume fraction mapping at 3 tesla (2011) J Cardiovasc Magn Reson, 13, p. 75Polimeni, P.I., Extracellular space and ionic distribution in rat ventricle (1974) Am J Physiol, 227, pp. 676-683Jellis, C., Wright, J., Kennedy, D., Association of imaging markers of myocardial fibrosis with metabolic and functional disturbances in early diabetic cardiomyopathy (2011) Circ Cardiovasc Imaging, 4, pp. 693-702Flett, A.S., Sado, D.M., Quarta, G., Diffuse myocardial fibrosis in severe aortic stenosis: An equilibrium contrast cardiovascular magnetic resonance study (2012) Eur Heart J Cardiovasc Imaging, 13, pp. 819-826Schneider, M.P., Hua, T.A., Bohm, M., Wachtell, K., Kjeldsen, S.E., Schmieder, R.E., Prevention of atrial fibrillation by renin-angiotensin system inhibition: A meta-analysis (2012) J Am Coll Cardiol, 55, pp. 2299-2307Yusuf, S., Teo, K., Anderson, C., Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: A randomised controlled trial (2008) Lancet, 372, pp. 1174-118
