10 research outputs found
AN IMMEDIATE FIT AND ADJUSTABLE TRANSTIBIAL PROSTHETIC SYSTEM; A PROSPECTIVE FEASIBILITY AND EFFICACY STUDY
No full textINTRODUCTION
Limb loss rates globally are rising and there is a large unmet need for an affordable and accessible prosthetic system for this growing US and International population. The purpose of this prospective cohort study was to assess the feasibility and utility of a novel immediate fit modular prosthetic system (IFIT Prosthetics, LLC™ prosthesis) for transtibial amputees.
Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/32025/24442
How to cite: Dillingham T.R, Kenia J, Shofer F.S, Marschalek J. AN IMMEDIATE FIT AND ADJUSTABLE TRANSTIBIAL PROSTHETIC SYSTEM; A PROSPECTIVE FEASIBILITY AND EFFICACY STUDY. CANADIAN PROSTHETICS & ORTHOTICS JOURNAL, VOLUME 1, ISSUE 2, 2018; ABSTRACT, POSTER PRESENTATION AT THE AOPA’S 101ST NATIONAL ASSEMBLY, SEPT. 26-29, VANCOUVER, CANADA, 2018. DOI: https://doi.org/10.33137/cpoj.v1i2.32025
Abstracts were Peer-reviewed by the AOPA 2018 National Assembly Scientific Committee
The future of UK Antarctic science: strategic priorities essential needs and opportunities for international leadership
No full text• The Antarctic region has been experiencing rapid change in recent decades
due to human induced factors. Most notably, climate heating is causing ice
sheet melting, leading to sea level rise and disruption in global ocean heat
circulation, with far-reaching global consequences.
• At the same time, this region holds unique research potential that can help
address a range of critically important scientific priorities, including climate
change impacts, ecosystem protection, the likelihood of extra-terrestrial life
and monitoring of space debris.
• Due to its long and impressive record of Antarctic research and its scientific,
engineering and logistical capabilities in the region, the United Kingdom (UK)
is strategically well-positioned to lead or play a key role in the delivery of these
research priorities.
• To achieve this potential, the UK must act collectively and in partnership with
others, as the best and most urgent research benefits from collaboration,
cooperation and cost sharing. Crucially, it must mobilise experts both from
within the UK and internationally from a range of disciplines, including the
social sciences. In the twenty-first century, Antarctic research must not exist
within its own bubbl
Cultura de tecidos de plantas no apoio ao melhoramento genético vegetal e à produção massal de plantas
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Curso de Agronomia.O arroz (Oryza sativa) é uma gramínea pertencente à família Poacea. Juntamente com o milho e o trigo é o cereal de maior produção em nível mundial. Esse fator desperta interesse por parte de muitos países que investem em pesquisas para o desenvolvimento de cultivares com maior resistência a patógenos, pragas entre outros males que afetam negativamente a cultura. Presente em diversos países como constituinte básico da dieta populacional, o arroz deixa de ter apenas importância econômica, apresentando também uma forte importância cultural, como pode ser observado com maior intensidade em países asiáticos, China e Japão, por exemplo. Para que o Brasil permaneça competitivo no mercado mundial é preciso que pesquisas sejam desenvolvidas de forma contínua para que novos produtos sejam lançados frequentemente. Nesse âmbito entra o melhoramento genético e com ele a criação constante de novas ferramentas que auxiliam no desenvolvimento e aperfeiçoamento da cultura. O presente trabalho objetivou o estudo e a realização de um experimento relativo ao processo de obtenção de plantas duplo-haplóides de arroz através da cultura de anteras. O experimento foi realizado com o intuito de definir o melhor momento para a utilização das anteras, levando em conta o estágio de desenvolvimento das plantas de arroz e também dos micrósporos presentes nas anteras. A pesquisa consistiu do cultivo das anteras em meio de cultura N6 adicionado de diferentes concentrações de auxina 2,4-D (0,5; 2,0 e 4,0 mg/L). As anteras foram coletadas no estágio de emborrachamento da panícula, com 6 e 10 cm de distância entre o colar da folha bandeira e o colar da última folha, da linhagem SC 471. O estágio de desenvolvimento dos micrósporos presentes nas panículas do experimento foi determinado pela análise citológica em microscópio com diferentes períodos de maturação. Além, dos trabalhos com arroz, foram acompanhadas e desenvolvidas atividades visando à multiplicação de bananeiras, limpeza de vírus em citros e definição de novos protocolos para multiplicação, em ambiente asséptico, de diferentes espécies ornamentais. Os resultados alcançados serão importantes para futuras pesquisas pelo Laboratório de Biotecnologia, tanto para a obtenção de novas variedades pelo programa de melhoramento genético quanto para a obtenção de protocolos e multiplicação de mudas matrizes livres de vírus ou não de espécies de interesse do Estado de Santa Catarina
The future of UK Antarctic science: Strategic priorities, essential needs and opportunities for international leadership
No full text• The Antarctic region has been experiencing rapid change in recent decades due to human induced factors. Most notably, climate heating is causing ice sheet melting, leading to sea level rise and disruption in global ocean heat circulation, with far-reaching global consequences. • At the same time, this region holds unique research potential that can help address a range of critically important scientific priorities, including climate change impacts, ecosystem protection, the likelihood of extra-terrestrial life and monitoring of space debris. • Due to its long and impressive record of Antarctic research and its scientific, engineering and logistical capabilities in the region, the United Kingdom (UK) is strategically well-positioned to lead or play a key role in the delivery of these research priorities. • To achieve this potential, the UK must act collectively and in partnership with others, as the best and most urgent research benefits from collaboration, cooperation and cost sharing. Crucially, it must mobilise experts both from within the UK and internationally from a range of disciplines, including the social sciences. In the twenty-first century, Antarctic research must not exist within its own bubble
The MLL recombinome of acute leukemias in 2017
No full text\ua9 The Author(s) 2018.Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients
The KMT2A recombinome of acute leukemias in 2023
No full textChromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 2003 and 2022. Genomic breakpoints within the KMT2A gene and the involved translocation partner genes (TPGs) and KMT2A-partial tandem duplications (PTDs) were determined. Including the published data from the literature, a total of 107 in-frame KMT2A gene fusions have been identified so far. Further 16 rearrangements were out-of-frame fusions, 18 patients had no partner gene fused to 5’-KMT2A, two patients had a 5’-KMT2A deletion, and one ETV6::RUNX1 patient had an KMT2A insertion at the breakpoint. The seven most frequent TPGs and PTDs account for more than 90% of all recombinations of the KMT2A, 37 occur recurrently and 63 were identified so far only once. This study provides a comprehensive analysis of the KMT2A recombinome in acute leukemia patients. Besides the scientific gain of information, genomic breakpoint sequences of these patients were used to monitor minimal residual disease (MRD). Thus, this work may be directly translated from the bench to the bedside of patients and meet the clinical needs to improve patient survival. © 2023, The Author(s)
The principles of screen design for computer-based learning materials.
No full textThe critical interface between learners and computer-based learning materials is the
screen. If the display of learning is not effective then learning will be hindered.
Screen design is therefore an important element in the design of computer-based
learning.
This research investigated the three fundamental screen design elements of
text, colour and graphics. A review of literature, experimental design and a limited
survey of computer-based learning materials provided the background for this
research. The experimental materials reflected the results of the review and survey
by using representative subjects, providing a learning focus and employing computerbased materials. Two experiments were undertaken. The Colour and Graphics
experiments considered the effects of a number of variables on learners' behaviour
which included: the use of colour; the size and type of graphics; the learner's prior
knowledge of tutorial subject; and the complexity of the display.
The results of this research showed that colour is a powerful motivating force
as long as it is not used excessively. This was identified as the use of more than
seven colours. Graphics can be used more extensively in current computer-based
learning materials and users preferred representational graphics occupying a quarter
to a half of the screen. However, learners were not prepared to make the effort to
either use analogical graphics to make links with their prior knowledge or to extract
information contained in the structure and form of logical graphics. Subjects were
motivated by representational graphics.
Learners' behaviour in relation to the various screen displays they
encountered was affected by their prior knowledge of the tutorial content. This was
apparent in their choice of options (additional modules) within the tutorial, their
methods of interacting with the material and their responses to individual displays
DeepMIP-Miocene: experimental design for model simulations of the Miocene Climatic Optimum (MioMIP2)
No full textThe Miocene Epoch, between the hot house climate of the Eocene and the more moderate warm climate of the Pliocene, has emerged as an important paleoclimate MIP target due to its dynamic nature, global warmth, and reconstructed atmospheric CO2 concentrations. Miocene CO2 estimates are as low as 300-600 ppmv and as high as 800-1,100 ppmv. The formalized Miocene Model Intercomparison (MioMIP2) aims to address questions about the mechanisms driving observed climatic changes and tipping points seen in the geological record and improve confidence in the ability of climate models to predict future climates and constrain climate sensitivity. Through alignment with PlioMIP and DeepMIP Eocene efforts, a coordinated MioMIP effort will allow for cross-time-period studies that sample the full range of Shared Socioeconomic Pathway paleo analogues. Building on MioMIP1, the Miocene community has been developing the experimental design for MioMIP2. The MioMIP1 effort was an ensemble of opportunity whereby the models, boundary conditions, and reference datasets were different between the modeling groups. MioMIP2 will be the first formal Miocene MIP with common boundary conditions and will target the Miocene Climatic Optimum (MCO; 16.75-14.5 Ma). We present the experimental design for coordinated "Core" MCO simulations and sensitivity studies. This community effort synthesizes paleogeography, icesheet, and vegetation boundary conditions based on the latest available literature and will use geological data synthesized by the companion MioOcean effort to evaluate the simulations.</p
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
No full textDocument recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press
