2,812 research outputs found
Uncoupling of Behavioral and Metabolic Twenty-Four-Hour Rhythms in Reindeer (Current Biology, Meier et al. 2024): Actigraphy data
No full text<p>Raw reindeer actigraphy data collected and analysed in the course of the study "Uncoupling of Behavioral and Metabolic Twenty-Four-Hour Rhythms in Reindeer" (Current Biology, Meier et al. 2024). Details on data processing and plotting can be found in the published article. Further information and codes can be requested from the first author Sara A. Meier.</p>
Interferon type I gene expression in chronic hepatitis C
No full textHepatitis C virus (HCV) frequently causes chronic liver disease. The cause of viral persistence might be an inappropriate type I interferon (IFN) induction. To analyze the host's IFN response in chronic hepatitis C, we measured the transcription level of type I IFN genes as well as type I IFN-regulated genes in liver tissue and corresponding blood samples from patients with chronic hepatitis C, nonviral liver diseases, and a suspected but later excluded liver disease. Competitive and real-time RT-PCR assays were used to quantify the messenger RNA (mRNA) levels of all known IFN-α, IFN-β, and IFN-λ genes and those of some IFN-regulated genes. We failed to detect any hepatic type I IFN mRNA induction, although liver tissue of chronic hepatitis C patients contained high numbers of some type I IFN-inducible effector mRNA molecules. Analysis of peripheral blood samples, however, showed a clear type I IFN induction. Parallel experiments employing HCV replicon cell lines revealed that replication of HCV RNA is not sufficient to induce any type I IFN nor to induce directly type I IFN-regulated genes such as MxA. In conclusion, our data provide evidence for the absence of an induction of type I IFN genes by HCV in the human liver and argue for a further development of type I IFN-based therapies.</p
Cwbr Author Interview: Nature\u27s Civil War: Common Soldiers And The Environment In 1862 Virginia
No full textInterview with Kathryn Shively Meier, Assistant Professor of History at Virginia Commonwealth University Interviewed by Michael Frawley
Civil War Book Review (CWBR): Today the Civil War Book Review is proud to speak with Kathryn Shively Meier, an Assistant professor of History at Virginia Commonwealth University, and discuss her recent book Nature\u27s Civil War: Common Soldiers and the Environment in 1862 Virginia. Thank you for joining us today. Kathryn Shively Meier (KM): Thank you for having me
On a semiparametric survival model with flexible covariate effect.
No full textA semiparametric hazard model with parametrized time but general covariate dependency is formulated and analyzed inside the framework of counting process theory. A profile likelihood principle is introduced for estimation of the parameters: the resulting estimator is n1/2-consistent, asymptotically normal and achieves the semiparametric efficiency bound. An estimation procedure for the nonparametric part is also given and its asymptotic properties are derived. We provide an application to mortality data.
Meier Shfeyah signing ceremony
No full textThe Meir Shfeyah Youth Village was founded following World War One as an orphanage for girls. Boys were accepted shortly thereafter. Located in the Jewish colony of Meir Shfeyah, near Zikron Ya’akov, the facility was situated on the site of previous youth facilities. The American Jewish Joint Distribution Committee, or JDC, funded the orphanage through its Palestine Orphan Committee until 1925 when Junior Hadassah, a division of Hadassah for young, unmarried women, took over the responsibility after several years of supporting individual orphans. Meir Shfeyah Youth Village, alternately known as Meir Shfeyah Children's Village, became Junior Hadassah’s largest fundraising project. Junior Hadassah financed the institution’s expenses for three decades until turning over primary responsibility to the State of Israel’s Department of Agriculture in 1958. Although Junior Hadassah merged with other Hadassah divisions in 1967, Hadassah continued to provide support to the Meir Shfeyah Youth Village, which still exists today as a residential, comprehensive high school with an agricultural focus.Hadassah National President Miriam Freund signing a contract for the shikun [housing] at Meier ShfeyahDigital imageDigital finding aid
Max Weber et l’Antiquité
No full textCette contribution est la traduction française d’un article publié en 1988 par Christian Meier, intitulé « Max Weber und die Antike ». L’auteur se propose d’évaluer l’apport des travaux de Max Weber dans le domaine de l’histoire ancienne et des sciences de l’Antiquité. Après avoir interrogé la place accordée à l’Antiquité dans l’œuvre du savant allemand, depuis son habilitation sur L’histoire agraire romaine (1891) jusqu’à son essai sur La Ville (rédigé entre 1911 et 1914, publié en 1921), Christian Meier souligne l’originalité de la démarche historienne de Weber, centrée sur la question de la spécificité de la civilisation gréco-romaine au sein de l’histoire universelle. Il montre comment les recherches de Weber dans ce domaine, fondées à la fois sur l’analyse croisée de facteurs concrets et la mise en œuvre d’une approche comparatiste, constituent le point de départ d’une théorie globale de la société antique. C’est en cela que réside, selon Christian Meier, toute l’actualité de l’œuvre de Weber, que l’on peut compter parmi les historiens de l’Antiquité de premier plan.This contribution is the French translation of an article published in 1988 by Christian Meier, entitled “Max Weber und die Antike”. The author aims at evaluating the contribution of Max Weber’s work to classical studies and ancient history. Christian Meier underlines the importance of Antiquity within the German scholar’s writings, from the habilitation thesis on Roman Agrarian History (1891) to the essay on The City (composed between 1911 and 1914, published in 1921). He also emphasises the originality of Weber’s historical approach, centred on the specificity of Graeco-Roman civilisation within universal history. Christian Meier shows how Weber’s research on this issue, by combining the cross-analysis of concrete factors with a comparatist perspective, provides a sound basis for a global theory of ancient society. Therein lies, according to Christian Meier, the current relevance of Weber’s work as a major ancient historian
MSO915480 Supplemental Material - Supplemental material for Evaluation of the ‘ring sign’ and the ‘core sign’ as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis
No full textSupplemental material, MSO915480 Supplemental Material for Evaluation of the ‘ring sign’ and the ‘core sign’ as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis by Nelly Blindenbacher, Eveline Brunner, Susanna Asseyer, Michael Scheel, Nadja Siebert, Ludwig Rasche, Judith Bellmann-Strobl, Alexander Brandt, Klemens Ruprecht, Dominik Meier, Jens Wuerfel</p
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
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