42 research outputs found
Hverdagsliv på barnevernsinstitusjon - Hvordan beskriver ansatte opplevelsen av boforhold og omsorgspraksis for barn i alderen 2-12 år ved en barnevernsinstitusjon?
No full textDenne masteroppgaven fokuserer på de unike omsorgsutfordringene og boforholdene for barn i alderen 2-12 år som bor på en akutt barnevernsinstitusjon i Norge, og tar for seg ansattes perspektiver og erfaringer. Jeg har opplevd at det er lite diskusjon både i fagmiljøet og på politisk nivå rundt barn i alderen 2-12 år som bor på barnevernsinstitusjon. Dette har skapt en interesse for å lære mer rundt det generelle livet for et barn som bor på institusjon. Problemstillingen i oppgaven er:
Hvordan beskriver ansatte opplevelsen av boforhold og omsorgspraksis for barn i alderen 2-12 år ved en barnevernsinstitusjon?
Teoretisk bygger oppgaven på tilknytningsteori, traumebevisst omsorg og hverdagsperspektiv på barn for å forstå hvordan ansattes omsorgspraksis formes og hvordan barnas behov og atferd kan forstås innenfor institusjonens rammer. Jeg har benyttet en kvalitativ tilnærming, og oppgaven er basert på fire individuelle semistrukturerte intervjuer med de ansatte på en akutt institusjon. Det er brukt tematisk analyse på intervjuene.
Funnene fra de tematiske analysene av intervjudataene avdekker tre hovedtemaer: 1) Normal hverdag i unormal kontekst 2) Profesjonell omsorg og 3) Barns tidligere opplevelser.
I det første temaet beskriver ansatte hvordan de prøver å skape en så normal hverdag som mulig for barna, til tross for den unormale konteksten av et institusjonsopphold. De fremhever viktigheten av rutiner og forutsigbarhet, som bidrar til å gi barna en følelse av sikkerhet og stabilitet. Ansatte møter utfordringer med å balansere mellom å opprettholde en hverdagslig normalitet og samtidig håndtere de spesifikke behovene som følger av barnas ofte komplekse og traumatiske bakgrunner. Det neste temaet fokuserer på hvordan de ansatte navigerer mellom å være mange ansatte som skal ha et foreldreansvar sammen og hvordan de skal ta vare på barnas individuelle behov. Det tredje temaet utforsker hvordan barnas historier og tidligere opplevelser påvirker deres oppførsel og interaksjon i institusjonen
Surface-roughness fractality effects in electrical conductivity of single metallic and semiconducting films
No full textSurface-roughness effects in electrical conductivity of thin metallic and semiconducting films with self-affine fractal surfaces are considered in the framework of the Born approximation. The surface roughness is described by the k-correlation model, and is characterized by the roughness exponent H (0≤H≤1), the in-plane correlation length ξ, and the rms roughness amplitude Δ. In the case of metallic films the conductivity is shown to increase monotonically with H increasing from H=0 to H=1 and with decreasing ratio Δ/ξ. For semiconducting quantum wells the conductivity shows a peculiar interplay of quantum-mechanical effects and scattering due to surface roughness
ORIGINAL RESEARCH—ED PHARMACOTHERAPY: Sildenafil Citrate Response Correlates with the Nature and the Severity of Penile Vascular Insufficiency
No full text908: Assessment of the Utility of Alpha Adrenergic Blockade in the Treatment of Post-Orgasmic Pain
No full textp53-Associated Parkin-like cytoplasmic protein (Parc) short-interfering RNA (siRNA) alters p53 location and biology of Peyronie's disease fibroblasts
No full textOBJECTIVE • To evaluate the impact of p53-associated Parkin-like cytoplasmic protein (Parc) short-interfering RNA (siRNA) on the location of p53 as well as the biology of Peyronie's disease (PD) plaque-derived fibroblasts after Parc knockdown. PATIENTS AND METHODS • Plaque tissue was excised from men with stable PD undergoing penile reconstructive surgery and used to produce cultured PD plaque-derived fibroblasts. • Immunofluorescence (IF) and reverse transcription-polymerase chain reaction (RT-PCR) were then used to define the location of p53 and Parc before and after siRNA. • Nuclear fractionation studies were used to assess the chronology of translocation of p53 from cytoplasm to nucleus on Parc knockdown. • The terminal transferase dUTP Nick end labelling (TUNEL) assay was used to assess the apoptotic indices of the PD fibroblasts after Parc knockdown. RESULTS • IF and PCR showed high cytoplasmic levels of p53 and Parc before siRNA. On IF, there was little or no p53 present within the nucleus before Parc knockdown. • After Parc siRNA, IF showed translocation of p53 to the fibroblast nucleus, while Parc levels dropped significantly, but what Parc remained was confined to the cytoplasm with none present in the nucleus. • Nuclear fractionation studies using RT-PCR confirmed this translocation phenomenon and showed the chronology of the event. All p53 had moved from the cytoplasm to the nucleus within 16 h of Parc siRNA. • On TUNEL assay, apoptotic indices increased dramatically after Parc siRNA. CONCLUSIONS • These data prove that Parc is a cytoplasmic anchor for p53 in PD plaque-derived fibroblasts and may be the primary cause of the stabilization and defunctionalization of p53 in these cells. • These findings support Parc as a novel target for PD pharmacotherapy, perhaps using human siRNA technologies once commercially available.
© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL
Strategi Pertahanan Laut Nusantara Dalam Mewujudkan Indonesia Sebagai Poros Maritim Dunia
No full textAbstrak – Poros Maritim Dunia (PMD) mulai dicetuskan sejak terpilihnya Joko Widodo sebagai Presiden RI pada tahun 2014, beberapa hal yang dijadikan dasar untuk menjadikan Indonesia sebagai poros maritim dunia diantaranya letak geografis Indonesia yang berada pada persilangan samudera Hindia dan samudera Pasifik serta antara benua Asia dan benua Australia. Posisi Indonesia yang strategis tersebut tentu berkepentingan untuk ikut menentukan masa depan kawasan samudera Pasifik dan samudera Hindia agar kedua kawasan tersebut tetap damai dan aman bagi pengguna jalur perdagangan dunia. Dalam rangka mewujudkan Indonesia sebagai poros maritim dunia, maka TNI AL sebagai komponen utama pertahanan negara di laut mempunyai peran penting untuk menjaga kepentingan bangsa Indonesia di laut dan menjamin keamanan bagi para pengguna laut. Melalui strategi pertahanan laut nusantara (SPLN) yang dimiliki oleh TNI AL sejak tahun 2004 perlu diketahui sejauh mana SPLN dapat mewujudkan lima pilar utama yang terdapat pada poros maritim dunia. Dengan menggunakan metode kualitatif fenomenologis, penulis mmemperoleh data melalui wawancara langsung kepada beberapa narasumber terkait dengan sejauh mana SPLN dapat mewujudkan poros maritim dunia yang hasilnya dapat disimpulkan bahwa SPLN tidak sepenuhnya dapat mewujudkan poros maritim dunia karena tujuan SPLN hanya untuk operasi pengendalian laut dan penangkalan, sehingga diperlukan adanya penyempurnaan SPLN dan kerjasama antar kementerian dan lembaga terkait untuk mewujudkan lima pilar utama poros maritim dunia.Kata Kunci: Strategi, Pertahanan Negara di Laut, Poros Maritim Dunia Abstract - The World Maritime Axis (WMA) began to be initiated since the election of Joko Widodo as President of the Republic of Indonesia in 2014, a number of things that became the basis for making Indonesia as the WMA, including Indonesia's geographical location in the Indian Ocean and Pacific Ocean crossing and between the Asian continent and the Australian continent. Indonesia's strategic position is certainly of interest to determine the future of the Pacific and Indian oceanic regions so that the two regions remain peaceful and safe for users of world trade routes. In order to realize Indonesia as a WMA, the Navy as a major component of the country's defense at sea has an important role to play in safeguarding the interests of the Indonesian people at sea and ensuring security for marine users. Through the Archipelago Sea Defense Strategy (ASDS) owned by the Indonesian Navy since 2004, it is necessary to know the extent to which the ASDS can realize the five main pillars contained in the WMA. By using phenomenological qualitative methods, the author obtains data through direct interviews with several informants related to the extent to which the ASDS can realize the WMA, the results of which can be concluded that ASDS cannot fully realize the WMA because the purpose of ASDS is only for sea control and deterrence operations, so required improvement of ASDS and cooperation between relevant ministries and institutions to realize the five main pillars of the WMAKeywords: Strategy, State of Defense at Sea, World Maritime Axi
AI-08 Characterization of human age-associated B cells (ABCs) in normal and lupus peripheral blood
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