57,513 research outputs found
Traces and shards of self-injury: Strange accounting with “Author X”
No full textIn this strange account autoethnography, three or four authors explore their lived experiences with self-injury. Strange accounting is both a post-modern style of text, and a method for keeping identities concealed when risks and secrets are in play. Author X, a post-modern place-keeper for an anonymous author who may or may not have contributed to this manuscript, introduces a new dimension and layer of concealment. With Author X in-play and under erasure, the reader will never be sure if there were three or four authors on this manuscript. Through strange accounting, a post-structuralist/postmodernist frame will be applied to understanding the self-injury experience. We frame self-injury as a social practice and, for some, an everyday norm, while remaining acutely aware of the stigma surrounding the topic of self-injury. Each of us, coupled with Author X, provide the others cover to trace stories of self-injury through the literature, our flesh, and our lives
Effects of intravenous neuropeptide Y on insulin secretion and insulin sensitivity in skeletal muscle in normal rats.
No full textIntracerebroventricular administration of neuropeptide Y to normal rats induces a syndrome characterised by obesity, hyperinsulinaemia, insulin resistance and over expression of the adipose tissue ob gene. Little is known about the effect of circulating neuropeptide Y on glucose metabolism, insulin secretion and leptin. We therefore aimed to evaluate the effect of an intravenous infusion of neuropeptide Y on glucose disposal, endogenous glucose production, whole body glycolytic flux, and glucose storage as assessed during euglycaemic hyperinsulinaemic clamp. In addition, the insulin-stimulated glucose utilisation index in individual tissues was measured by the 2-deoxy-[1-3H]-glucose technique. The effect of neuropeptide Y on insulin secretion was evaluated by hyperglycaemic clamp. Infusion did not induce any change in endogenous glucose production during basal conditions or at the end of the clamp. Glucose disposal was significantly increased in the rats given neuropeptide Y compared with controls (27.8 +/- 1.3 vs 24.3 +/- 1.6 mg x min(-1) x kg(-1); p < 0.05) as was the glycolytic flux (18.9 +/- 1.6 vs 14.4 +/- 0.8 mg x min(-1) x kg(-1); p < 0.05), while glucose storage was comparable in the two groups. In skeletal muscle, the glucose utilisation index was increased significantly in rats given neuropeptide Y. The glucose utilisation index in subcutaneous and epididimal adipose tissue was not significantly different between the two groups. Plasma leptin was significantly increased by hyperinsulinaemia, but was not affected by neuropeptide Y infusion. Both the early and late phase of the insulin response to hyperglycaemia were significantly reduced by neuropeptide Y. In conclusion neuropeptide Y infusion may increase insulin-induced glucose disposal in normal rats, accelerating its utilisation through the glycolytic pathway. Neuropeptide Y reduces both phases of the insulin response to hyperglycaemia
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Relations between x-ray timing features and spectral parameters of galactic black hole x-ray binaries
No full textWe present a study of correlations between spectral and timing parameters for a sample of black hole X-ray binary candidates. Data are taken from GX
339-4, H 1743-322, and XTE J1650-500, as the Rossi X-ray Timing Explorer
(RXTE) observed complete outbursts of these sources. In our study we investigate outbursts that happened before the end of 2009 to make use of the high-energy coverage of the HEXTE detector and select observations that
show a certain type of quasi-periodic oscillations (type-C QPOs). The spectral parameters are derived using the empirical convolution model simpl to model the Comptonized component of the emission together with a disc blackbody for the emission of the accretion disc. Additional spectral features, namely a reflection component, a high-energy cut-off, and excess emission at 6.4 keV, are taken into account. Our investigations confirm the known positive
correlation between photon index and centroid frequency of the QPOs and reveal an anti-correlation between the fraction of up-scattered photons and the QPO frequency. We show that both correlations behave as expected in the “sombrero”
geometry. Furthermore, we find that during outburst decay the correlation between photon index and QPO frequency follow a general track, independent of individual outbursts
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Enhanced colour encoding of materials discrimination information for multiple view dual-energy x-ray imaging
No full textThis thesis reports an investigation into dual-energy X-ray discrimination techniques. These techniques are designed to provide colour-coded materials discrimination information in a sequence of perspective images exhibiting sequential parallax. The methods developed are combined with a novel 3D imaging technique employing depth from motion or kinetic depth effect (KDE). This technique when applied to X-ray images is termed KDEX imaging and was developed previously by the university team for luggage screening applications at security checkpoints. A primary motivation for this research is that the dual-energy X-ray techniques, which are routinely incorporated into ‘standard’ 2D luggage scanners, provide relatively crude materials discrimination information. In this work it was critical that robust materials discrimination and colour encoding process was implemented as the sequential parallax exhibited by the KDEX imagery may introduce colour changes, due to the different X-ray beam paths associated with each perspective image. Any introduction of ‘colour noise’ into the resultant image sequences could affect the perception of depth and hinder the ongoing assessment of the potential utility of the dual-energy KDEX technique. Two dual-energy discrimination methods have been developed, termed K-II and W-E respectively. Employing the total amount of attenuation measured at each energy level and the weight fraction of layered structures, a combination of the K-II and the W-E techniques enables the computation and extraction of a target objects’ effective atomic number (Zeff) and its surface density (ρS) in the presence of masking layers
Diagnostic mutation analysis in hypertrophic cardiomyopathy by DNA resequencing array
No full textPurpose: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease (1/500) characterized by a remarkable clinical and genetic heterogeneity. More than 450 different pathogenic mutations in at least 20 genes have been identified so far. Genetic testing for HCM has a growing impact on the medical management of patients and their families, however routine diagnostic mutation analysis by classical methods remains very time-consuming and expensive.
Methods: We have developed a 30 Kbp HCM-DNA-resequencing-array (CustomSeq Affymetrix) for all exons (n=160), splice-sites and 5'-UTR of 12 HCM genes, which we currently use for mutation analysis in clinical practice. This HCM-array is very efficient to detect single nucleotide substitutions accounting for up to 86% of all HCM mutations. Actually it does not detect small indels.
Results: We analysed 115 patients from 5 different centres. Overall, we identified 30 different single nucleotide substitutions in the coding regions or splice sites of MYH7, MYBPC3, TNNT2, TNNI3, TPM1 and MYL3 in 42 patients (37%). Twelve variants were reported as known mutations and 14 were novel changes not found in a control population study (>200 chromosomes). Furthermore, we identified 4 known SNPs/variants previously reported as mutations for HCM.
Conclusions: Our DNA resequencing array appears to date as the most rapid and cost-effective technology for mutation screening in HCM. Further improvement of the software may detect small insertions/deletions in the future. The HCM-array provides a first attempt of high throughput sequencing methodology which will further develop and probably become the method of choice for routine molecular diagnosis of heterogeneous disorders such as HCM
Student Project: Replication of Author, Author, & Author (201X, JDM, Study X) - Template
No full textThis project is an independent replication of Author, Author, & Author (201X, study X) conducted as part of the Hagen Cumulative Science Project
Author headings for the official publications of the State of Kansas
No full textIncludes bibliographical references (page x).This list of author headings covers all official agencies as found in the laws of the territory and the laws of the state of Kansas from May 30, 1854 through July 1955; also agencies created by Executive Order, and administrative divisions, or boards, created within a department of the state. Agencies included are:
1. All departments, bureaus, divisions, commissions, courts, legislative bodies and special committees created by the laws or joint resolutions of the territory or state of Kansas, or by Executive Order*
2. Subdivisions of the respective departments, bureaus, commissions and committees even though not expressly created by acts of the legislature, but which are included in the official reports of the agencies*
3. Legislative bodies and their committees, if created by law, or if their reports were published.
4. Societies supported wholly, or in part, by the state.
5. All state and territorial institutions (including educational, charitable, correctional and penal)
Securing XML documents with author-X
No full textAuthor-X is a Java-based system that addresses the security issues of access control and policy design for XML document administration. Author-X supports the specification of policies at varying granularity levels and the specification of user credentials as a way to enforce access control. Access control is available according to both push and pull document distribution policies, and document updates are distributed through a combination of hash functions and digital signature techniques. The Author-X approach to distributed updates allows a user to verify a document's integrity without contacting the document server
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