1,354,457 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Defining the molecular basis of host range in Papaya ringspot virus (PRSV) Australia
No full textThe potyvirus Papaya ringspot virus (PRSV) is widespread throughout the world in cucurbits (such as zucchini, watermelon, pumpkin etc) and papaya (papaw). There are two serologically indistinguishable strains of PRSV, which can only be differentiated on the basis of host range. PRSV-P is able to infect both papaya and cucurbits whereas PRSV-W only infects cucurbits. Both infections drastically reduce the yield and market quality of the fruit. Australian isolates of PRSV-P and -W are very closely related and there is evidence that PRSV-P arose by mutation from PRSV-W. The aim of this project was to investigate the molecular basis of the host range difference between Australian isolates of PRSV-P and -W.
The close relationship between Australian PRSV-P and -W isolates at the molecular level made this an ideal system to investigate molecular host range determinants through the development of full-length infectious cDNA clones. Initially, the complete genomes of PRSV-P and -W were each incorporated into two overlapping clones; one included the CaMV 35S promoter fused to the 5' one third of the PRSV genome and the second included the 3' two thirds of the genome (including a 33 nucleotide poly(A) tail) fused to a CaMV35S terminator. Full-length clones could not be obtained from subcloning of these fragments due to apparent toxicity in E.coli. Several approaches were subsequently undertaken to overcome this problem. In an attempt to prevent transcription of potentially toxic sequences, a plant intron (St-Ls1 IV2 intron) was engineered into the first coding region (P1) of the PRSV-W genome. Although clones were obtained using this strategy these could not be effectively maintained in E.coli. An alternative strategy involved subcloning of the genome into a low copy number vector, pACYC177, to minimise expression of toxic sequences. Again this resulted in clones that produced very small colonies, which were hard to culture and which gave very low plasmid yields. These plasmids were also difficult to maintain in E. coli.
A final, successful strategy was developed using overlapping long distance PCR (OE-LD PCR) to generate full-length infectious PCR products of both PRSV-P (rPRSV-P) and -W (rPRSV-W) incorporating a CaMV 35S promoter and terminator. Infectious PCR products of both strains were inoculated onto squash cotyledons in vitro by microprojectile bombardment and subsequently mechanically inoculated to squash with greater than 86% efficiency. RPRSV-P subsequently infected papaya with 96% efficiency while, as expected, rPRSV-W was unable to infect papaya.
Once a system for generating infectious clones was developed, both sequence analysis and recombination of infectious clones was utilised to investigate the underlying host range mechanism. The complete genomes of PRSV-P and -W were sequenced and compared to each other and to five full- length sequences of overseas PRSV isolates that were available. Sequence analysis confirmed the close relationship between the Australian PRSV isolates (97.8% nucleotide and 98.4% amino acid identity over the whole genome), supporting the mutation theory between both Australian and Asian P and W pairs. However, there was no consistent amino acid difference over the whole genome that correlated with host range or a single site that could be implicated, suggesting that the mutation and possibly the position of the mutation is different at least between Asian and Australian isolates and potentially differs at each mutation event.
To better localise the P/W mutation within the PRSV genome, five different recombinant hybrid PRSVs (rhPRSV1-5) were generated in which 5', middle or 3' regions of the PRSV-P and -W genomes were exchanged. Infectivity of all hybrids was confirmed in squash, however, only hybrids including the 3' third of the PRSV-P genome were able to infect papaya, suggesting that this region encodes the papaya host range determinant. The region implicated encodes the genome-linked protein (VPg), NIa protease, replicase (NIb), coat protein (CP) and 3' UTR. While further identification of the host range determinants was not possible due to time constraints, based on studies with other potyviruses, there is a strong basis for implication of the VPg. Sequence analysis identified only 2 amino acid differences between the VPg of Australian PRSV-P and -W isolates in regions previously implicated in pathogenicity. These will be targeted for mutagenesis in ongoing studies.
Identification of the genes/sequences involved in the determination of host range in PRSV will provide valuable information as to the sequence of events that lead to infection and will lead to a better understanding of the significance of changing hosts in the molecular evolution of PRSV, an essential requirement for the development of long-term sustainable control strategies against PRSV
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
The Thursday Murder Club: Launching a megabrand author - a publishing case study
No full textIn 2020, the Christmas book charts in the UK made headlines: Barack Obama’s eagerly awaited autobiography, The Promised Land, was beaten to the top spot by The Thursday Murder Club by Richard Osman, a debut cosy crime novel set in a retirement village. Not only did Osman’s book beat the former US president’s expected bestseller, it also broke records, becoming the fastest-selling debut crime novel of all time. Although Osman has a certain level of fame in the UK from his TV appearances on shows such as Pointless, his celebrity status does not entirely explain the novel’s huge sales. This article tracks the acquisition, publication, and promotion journey of The Thursday Murder Club in order to understand the industry and cultural context of its success and to interrogate the role of celebrity in the creation of author brands. The findings suggest that the unexpected scale of the success of the book owed to a number of factors, including in-depth editing by the novel’s agent, editor, and author to tighten up the plot, an extensive and strategic promotional campaign, the pandemic (which drove interest in the book’s genre and themes), and the quality of the writing. We find that the book’s success was accentuated by Osman’s celebrity status rather than being entirely reliant on it. This research adds to the growing scholarship on celebrity authorship by means of an in-depth case study and provides insight into the processes behind publishing a ‘celebrity’ book and launching a megabrand author
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
BDNF/TrkB Signaling Inhibition Suppresses Astrogliosis and Alleviates Mechanical Allodynia in a Partial Crush Injury Model
No full textNeuropathic pain presents a formidable clinical challenge due to its persistent nature and limited responsiveness to conventional analgesic treatments. While significant progress has been made in understanding the role of spinal astrocytes in neuropathic pain, their contribution and functional changes following a partial crush injury (PCI) remain unexplored. In this study, we investigated structural and functional changes in spinal astrocytes during chronic neuropathic pain, employing a partial crush injury model. This model allowes us to replicate the transition from initial nociceptive responses to persistent pain, highlighting the relevance of astrocytes in pain maintenance and sensitization. Through the examination of mechanical allodynia, a painful sensation in response to innocuous stimuli, and the correlation with increased levels of brain-derived neurotrophic factor (BDNF) along with reactive astrocytes, we identified a potential mechanistic link between astrocytic activity and BDNF signaling. Ultimately, our research provides evidence that inhibiting astrocyte activation through a BDNF/TrkB inhibitor alleviates mechanical allodynia, underscoring the therapeutic potential of targeting glial BDNF-related pathways for pain management. These findings offer critical insights into the cellular and molecular dynamics of neuropathic pain, paving the way for innovative and targeted treatment strategies for this challenging condition.11Nsciescopuskc
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
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