20 research outputs found
Design and Implementation of a Web Application for Office Space Allocation
No full textTato bakalářská práce se věnuje návrhu a implementaci webové aplikace pro efektivní obsazování míst v kancelářích, reagující na potřeby firem v éře flexibilních pracovních režimů a rostoucích nákladů na kancelářské prostory. Práce analyzuje stávající řešení a identifikuje klíčové firemní procesy, na jejichž základě stanovuje požadavky na aplikaci. Dle sepsaných požadavků je dále součástí práce návrh, implementace a testování webové aplikace v PHP Symfony. Cílem je poskytnout řešení pro zvýšení efektivity využití kancelářských prostor, snížení nákladů a zvýšení produktivity.This bachelor thesis focuses on the design and implementation of a web application for efficient office staffing, responding to the needs of companies in an era of flexible working schedules and rising office space costs. The thesis analyses existing solutions and identifies key business processes to determine the requirements for the application. According to the written requirements, the work also includes the design, implementation and testing of a web application in PHP Symfony. The aim is to provide a solution to increase the efficiency of office space utilization, reduce costs and increase productivity
FTIR SPECTROSCOPY OF CRYOGENIC AEROSOLS
No full text T.A. Dunder and R.E. Miller, Molecular Spectroscopy Symposium, Columbus, 1989.Author Institution: Department of Chemistry, University of North CarolinaCryogenic aerosols are generated via homogeneous nucleation in a flowing mixture of condensible and non-condensible gases at low temperature. FTIR spectra of the resulting cryo-cloud display features due to the interaction of scattering and absorption processes. Mie scattering calculations used in conjunction with the FTIR results indicate the spectra are highly sensitive to the particle size distribution. Compelling spectroscopic evidence indicates that aerosol, formed in cold He at 95K, is in the high temperature cubic phase despite a solid-solid phase transition to the orthorhombic phase observed at 133K in the bulk solid. Mixed aerosols, composed primarily of Xe, provide the opportunity to observe diffusion in micro-particles and afford a gas-phase analogy to matrix isolation. Moreover, competition between homogeneous and heterogeneous nucleation is readily studied in these mixed systems
FTIR SPECTROSCOPY OF AEROSOLS
No full text J. K. Messer and F.C. De Lucia, Phys. Rev. Lett. 53, 2555 (1984).Author Institution: Dept. of Chemistry, University of North CarolinaAn experimental technique has been developed for the study of large clusters (aerosols) whose sizes are in the micron regime. The method is a variant of the technique developed by De Lucia1 in which the gas of interest is injected into a helium-filled, liquid nitrogen cooled gas cell wherein rapid collisional cooling occurs. The diffusion time to the cell walls greatly exceeds the cooling time, such that the gas is ``diffusion trapped'' and may homogeneously condense to form clusters. The FTIR spectroscopy of the clusters reveals scattering and absorbance features. With the assumption of spherical clusters, Mie theory calculations have been performed using the bulk optical constants of the materials. From this analysis the size distribution has been determined. Results for , and will be discussed, as well as applications of the technique to atmospheric studies
Characterization of 45 cases of congenital lung malformation and association of inflammation with symptomatology
No full textAbstract
Lung development begins during week 4 of pregnancy and continues through fetal development until early infancy. Various malformations can develop during the fetal period. There is histology overlap in several of them and partly joint etiology has been suggested as the cause of malformation. Early surgery has been supported after the diagnosis of a local pulmonary malformation due to potential malignancy risk and an increased lung infection risk. However, the evidence supporting surgery for asymptomatic patients is scarce. This comprehensive single-center study in a tertiary children’s hospital included all 45 surgically treated patients at any age between 1986 and 2015. The study population consisted of 45 patients. Histology, preoperative symptoms, and radiological and operative findings were systematically reevaluated. Small cyst type congenital pulmonary airway malformation (CPAM) was the most common type of detected congenital lung malformation. There were no malignant or premalignant findings. Of all the patients, 23 (48.9%) were asymptomatic at the time of surgery. However, histology showed that four out of them (18%) had ongoing inflammation. Overall, one third of patients (n = 15, 34%) presented to have inflammation histologically. While chronic inflammation results in alveolar fibrosis, a high reported inflammation rate (34%) supports early malformation excision, regardless of the symptoms.Abstract
Lung development begins during week 4 of pregnancy and continues through fetal development until early infancy. Various malformations can develop during the fetal period. There is histology overlap in several of them and partly joint etiology has been suggested as the cause of malformation. Early surgery has been supported after the diagnosis of a local pulmonary malformation due to potential malignancy risk and an increased lung infection risk. However, the evidence supporting surgery for asymptomatic patients is scarce. This comprehensive single-center study in a tertiary children’s hospital included all 45 surgically treated patients at any age between 1986 and 2015. The study population consisted of 45 patients. Histology, preoperative symptoms, and radiological and operative findings were systematically reevaluated. Small cyst type congenital pulmonary airway malformation (CPAM) was the most common type of detected congenital lung malformation. There were no malignant or premalignant findings. Of all the patients, 23 (48.9%) were asymptomatic at the time of surgery. However, histology showed that four out of them (18%) had ongoing inflammation. Overall, one third of patients (n = 15, 34%) presented to have inflammation histologically. While chronic inflammation results in alveolar fibrosis, a high reported inflammation rate (34%) supports early malformation excision, regardless of the symptoms
ACUTE APPENDICITIS IN PREGNANCY – DIAGNOSTIC AND THERAPEUTIC CHALLENGES
No full textBackground: Acute appendicitis during pregnancy is one of the most common non-obstetric surgical conditions in pregnant women. However, due to the ambiguous symptoms that may be presented, an accurate diagnosis can be delayed or misinterpreted as a result of pregnancy-related changes.
Aim: The aim of this article is to highlight the challenges involved in diagnosing and treating acute appendicitis in pregnant women.
Methods: A review of scientific articles published on Google Scholar and PubMed from 2015 to 2025.
Results: Acute appendicitis in pregnancy presents with identical symptoms or mimics several other diseases, not only obstetric conditions. Surgical treatment is recommended, but there are no clear guidelines favoring either laparoscopic or open methods. Magnetic resonance imaging (MRI) is the most accurate imaging modality for diagnosing acute appendicitis. Laboratory diagnostics do not provide definitive evidence for appendicitis in pregnancy.
Conclusion: It is essential to be aware of the numerous ways acute appendicitis can present in pregnancy and to remain critical of an initially proposed diagnosis. The choice of surgical treatment largely depends on the experience and skill of the physician. Therefore, continuous education is necessary to understand the challenges associated with this condition
THE IMPACT OF HYPERURICEMIA ON CARDIOVASCULAR RISK. REVIEW OF THE EXISTING LITERATURE
No full textObjectives: The aim of the current work was to assess, following analysis of existing and widely available literature, whether increased levels of uric acid in blood serum have an impact on increased cardiovascular risk, and is urate-lowering treatment beneficial.
Materials and Methods: A review was conducted using the PubMed database, limited to full-text, freely available publications from the past 10 years. The analysis focused primarily on randomized controlled trials, meta-analyses, and systematic reviews related to hyperuricemia and cardiovascular risk.
Results: The evidence indicates a consistent association between hyperuricemia and increased cardiovascular risk, including higher all-cause and cardiovascular mortality. Although threshold values for hyperuricemia varied across studies, cardiovascular risk was shown to rise even with levels above 5 mg/dl. SGLT2 inhibitors demonstrated both urate-lowering and cardioprotective effects. In contrast, traditional xanthine oxidase inhibitors (e.g., allopurinol, febuxostat) did not show a significant benefit in reducing cardiovascular events.
Conclusions: Hyperuricemia is an independent risk factor for the increase in mortality and other adverse cardiovascular outcomes. SGLT2 inhibitors have shown to be promising in improving cardiovascular prognosis, while xanthine oxidase inhibitors presented no advantages. Further research in this subject is suggested
INNOVATIONS IN OBESITY TREATMENT – GLP – 1 PHARMACOTHERAPY AND BARIATRIC SURGERY
No full textBackground: Obesity is a growing global health challenge requiring effective, long - term treatment strategies. This paper focus on two leading innovations: GLP - 1 receptor agonists and bariatric surgery. GLP - 1 - based pharmacotherapy, including agents like semaglutide and tirzepatide, has shown impressive weight loss outcomes by regulating appetite and glucose metabolism. Meanwhile, bariatric procedures such as sleeve gastrectomy and gastric bypass remain the most effective interventions for severe obesity, offering sustained weight reduction and improvement of metabolic comorbidities. By comparing the efficiency, safety, and indications of both approaches, this paper show how pharmacological and surgical treatments can work synergistically to improve patient outcomes in obesity management.
Aim: The aim of this article is to highlight the challenges involved in treating obesity especially using GLP - 1 receptor agonists and bariatric surgery.
Methods: A review of scientific articles published on ResearchGate and PubMed from 2013 to 2025.
Results: Both GLP - 1 receptor agonists and metabolic surgery were found to be effective in reducing body weight and improving metabolic health in obese patients. Treatment with GLP - 1 analogs such as liraglutide or semaglutide led to moderate weight loss, typically between 5–15% of initial body weight. These medications also improved blood sugar control and lipid levels. Metabolic surgery, including sleeve gastrectomy and gastric bypass, resulted in greater weight reduction - often 25 - 35%, and more significant improvement in conditions like type 2 diabetes and hypertension. Interestingly, GLP - 1 levels tend to rise after surgery, suggesting that hormonal changes may partly explain the effectiveness of surgical interventions. In summary, both approaches show clear benefits, with surgery providing stronger effects, while GLP - 1 therapy offers a less invasive option.
Conclusion: GLP - 1 receptor agonists and metabolic surgery are methods to cure obesity and both of these methods are effective. GLP - 1 therapies offer a non - invasive option with metabolic benefits, while surgery provides greater and more sustained weight loss. The rise in GLP - 1 levels after surgery suggests shared mechanisms. Choosing the right approach should be based on individual patient needs and clinical factors
Neuroprotective effect of berberine based on the Alzheimer’s disease model
No full textBerberine, an isoquinoline alkaloid, is a substance used in traditional East Asian folk medicine. It is naturally found in many plant species, especially those of the Berberis genus. It has multifaceted anti-inflammatory and neuroprotective properties. The ageing population is currently affected by the growing prevalence of neurodegenerative diseases, the most common of which is Alzheimer’s disease. Berberine provides multidirectional protective and therapeutic effects against pathological neuronal changes. Its application reduces the synthesis of amyloid-β and tau protein plaques. In addition, it exhibits an effect typically associated with drugs currently used to treat this disease – cholinesterase inhibition. It has been shown that the use of berberine reduces inflammation in nervous tissue, inhibits apoptosis mechanisms and promotes neuronal repair processes. However, further preclinical studies are required to assess its efficacy and toxicity
Extrapolation in the development of paediatric medicines: examples from approvals for biological treatments for paediatric chronic immune-mediated inflammatory diseases
No full textDENGUE: A GLOBAL HEALTH CHALLENGE - CURRENT VIEWS ON PATHOGENESIS, DIAGNOSIS, TREATMENT AND PREVENTION
No full textBackground: Dengue is a global threat expanding its geographic reach and spreading to a growing world population. Up to 3 billion people are at risk. Dengue virus infection can be asymptomatic or sparse, but can also cause dengue hemorrhagic fever and dengue shock syndrome.
Aim: The purpose of this article is to highlight the challenges of effective treatment, multi-pronged prevention and safe immunoprophylaxis of dengue virus.
Methods: A review of scientific articles published on PubMed and Google Scholar from 2020 to 2025.
Results: Due to the number and complexity of dengue serotypes, as well as the antibody-dependent amplification mechanism characteristic of this virus, creating a universal, effective and safe vaccine is a difficult task. It is all the more important because of the lack of specific treatment, which is so necessary in the case of a severe course of the disease in the form of hemorrhagic fever or shock syndrome. It is also necessary to control vectors through chemical, biological and environmental methods.
Conclusion: Dengue is now a serious global public health threat that requires urgent action. Key areas for further research and development include a better understanding of pathogenesis, especially in the context of symptomatic DENV infections, and increased work on a variety of treatment and control options, as well as the development of a universal, safe and effective vaccine. The ultimate goal is to reduce the threat of the disease worldwide
