476 research outputs found
Natural history of HIV infection : progression in disease; specialty session
No full textMeeting: International Conference on AIDS, 5th, 4-9 June, 1989, Montreal, QC, CAPresenters: Robert J. Biggar, Stanley H. Weiss, Peter A. Selwyn, Aggrey Anzala, James J. Goedert, Randall A. Coate
Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men
No full textCaussy D, Goedert JJ, Palefsky J, et al. Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men. International Journal of Cancer. 1990;46(2):214-219
Oxygen and carbon stable isotope analysis of samples from the Columbia River
No full textOxygen and carbon stable isotope analysis of samples from the Columbia Rive
Markers of risk in HIV-1
No full textKrämer A, Biggar RJ, Goedert JJ. Markers of risk in HIV-1. The New England journal of medicine. 1990;322:1886
Prevalence of Toscana and Sicilian phlebovirus antibodies in classic Kaposi’s sarcoma cases and control subjects in Sicily
No full textUrinary neopterin concentrations and T-cell subset data in HIV-1 infection
No full textReibnegger G, Fuchs D, Goedert JJ, et al. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 1990;68(1):43-48.We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression
Mass Occurrences of the Brachiopod Halorella in Late Triassic Methane-Seep Deposits, Eastern Oregon
No full textThe temporally and geographically scattered Phanerozoic record of methane-seep deposits hampers reconstruction of
the evolution of life in chemosynthesis-based ecosystems. Unlike modern, Cenozoic, and late Mesozoic seeps, many
of the known older seep deposits are typified by assemblages with profuse rhynchonellide brachiopods. Late Triassic
(Norian) limestone bodies in eastern Oregon are enclosed in deep-water strata, extend laterally for up to a few hundred
meters, and contain the dimerelloid rhynchonellide Halorella in rock-forming quantities. The analysis of two large
limestone bodies in the Rail Cabin Member of the Vester Formation exposed near Graylock Butte, Grant County,
Oregon, fosters the reconstruction of the paleoenvironmental setting of these unusual Halorella deposits, resulting
in the first recognition of Triassic methane-seep deposits. The faunal assemblage includes few fossils other than
Halorella. Although occasionally found at seeps, the recognized nuculanids are not seep-endemic bivalves. A
Nucinella-like bivalve and a possible permophorid bivalve were likely endemic to this chemosynthesis-based environment;
related bivalves lived at Jurassic and Cretaceous seeps. The superabundant, mostly articulated brachiopod
shells are enclosed in a variety of micrites, including peloidal to clotted micrite. Early fibrous cement, forming banded
and botryoidal crystal aggregates, preferentially occurs at the margin of the large limestone bodies but is scarce overall.
Peloidal to clotted micrite and banded and botryoidal cement are common constituents of methane-seep limestones.
Their negative d13C values as low as 36‰ reveal that carbonate formation was induced by the oxidation of methane.
The presence of pyrobitumen (i.e., metamorphosed crude oil) in the limestones may indicate that the seepage fluids
contained oil in addition to methane. Apart from the diagnostic 13C-depleted carbonate phases, mud injections recognized
in one of the two limestone bodies also bear testament to former seepage activity
Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific
No full textKrämer A, Biggar RJ, Hampl H, et al. Immunologic markers of progression to acquired immunodeficiency syndrome are time-dependent and illness-specific. American Journal of Epidemiology. 1992;136(1):71-80.Since prevalent cohorts may be biased by the duration of human immunodeficiency virus (HIV) infection (onset bias), it is useful to assess the potential predictive value of markers in incident cohorts of HIV-positive subjects for whom the date of seroconversion is known or can reliably be estimated. Of 131 homosexual men with HIV-1 seroconversion from New York City and Washington, DC, who were evaluated annually beginning in 1982, 60 developed acquired immunodeficiency syndrome (AIDS) by the end of 1989. The prognostic significance of immunologic markers (proportion of CD4+ T-lymphocytes, neopterin, ß2-microglobulin, serum interferon, and anti-p24 antibody) and of a virologic marker (HIV p24 antigen) was determined using measurements made at defined time intervals after the known or estimated date of HIV seroconversion. When measurements made 3 years after seroconversion were used, all markers except anti-p24 antibody were found to be significant estimators of AIDS risk in univariate analyses. In multivariate Cox regression modeling, the maximum information was obtained by including neopterin, interferon, and the CD4+ T-lymphocyte proportion. The predictive value of markers after HIV seroconversion could change considerably from one interval to another. Elevated levels of ß2-microglobulin and neopterin significantly predicted the development of Kaposi‘s sarcoma. These two markers were highly correlated (r=0. 74). The authors conclude that immunologic markers can be important for an HIV staging system for estimating prognosis and facilitating early therapeutic intervention in HIV-positive patients
No evidence of HTLV-I infection in intravenous drug abusers in West Germany
No full textKrämer A, Goedert JJ, Blattner WW, Marcus U. No evidence of HTLV-I infection in intravenous drug abusers in West Germany. Journal of Acquired Immune Deficiency Syndromes. 1988;1(2):163-164
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