1,161 research outputs found
Five Decades of Transplant for AML
No full textBurnham Lecture Series: Five Decades of Transplant for AML, Jacob Rowe, MD, Chief - Department of Hematology and the Ann and Pinky Sohn Chair in Hemato-Oncology at the Shaare Zedek Medical Center, Jerusalem, and Emeritus Professor at the Technion Israel Institute of Technology, Haifa.
Objectives: Understanding of the historic hurdles in allogeneic transplantation that allowed the successes in current practice. Overcoming the age barrier in transplantation. Crucial role of supportive care in transplantation. Understanding that “everyone has a donor”
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Smith, George Rowe
No full textGeorge Rowe Smith, LL.B.
Central City, Kentucky
Heavyweight Boxing Championship \u2712; President Freshman Class; Varsity Track (1); Varsity Football (4) ; Union Literary Society; Democratic Club; Y. M. C. A. Cabinet; Prohibition Club.
If well thou hast begun, go on fore-right; It is the end that crowns us, not the fight. George R. began life in the Prep and has had many a delightful day since he could first call himself a Freshman. He admits that he is differently constituted from the rest since no one can hurt him. He has measured arms with some sturdy fighters but still holds his championship in boxing. His crowning glory came when he received his letter in football after many years of faithful toil.
-The Kentuckian, 1915---------------------------------
George Rowe Smith (January 16, 1890 - December 18, 1975) was born in Central City, Kentucky to George Smith and Martha Eleanor Rowe. Smith stayed in Lexington and entered into a law partnership with fellow class of 1915 student Jacob Owen Reynolds. Smith practiced law in Lexington for over 50 years before retiring in 1972. Smith was also involved in Lexington\u27s motel industry. He married twice--his wives were Ella Mae Clark and Mattie Stella Clark.https://uknowledge.uky.edu/klapp_1915/1029/thumbnail.jp
Efficacy and Safety Profile of Ivosidenib in the Management of Patients with Acute Myeloid Leukemia (AML): An Update on the Emerging Evidence
No full textGalia Stemer,1 Jacob M Rowe,2– 4 Yishai Ofran2,4 1Institute of Hematology, Ha’Emek Medical Center, Afula, Israel; 2Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel; 3Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel; 4The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, IsraelCorrespondence: Jacob M RoweDepartment of Hematology, Shaare Zedek Medical Center, Shmu’el Bait St 12, Jerusalem, 91031, IsraelTel +972-2-6555204Fax +972-2-6555755Email [email protected]: The isocitrate dehydrogenase enzyme, catalyzing isocitrate conversion to α-ketoglutarate (αKG) in both the cell cytoplasm and mitochondria, contributes to the production of dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as a reductive potential in various cellular processes. IDH1 gene mutations are revealed in up to 20% of the patients with acute myeloid leukemia (AML). A mutant IDH enzyme, existing in the cell cytoplasm and possessing neomorphic activity, converts αKG into oncometabolite R-2-hydroxyglutarate (R-2-HG) that accumulates in high amounts in the cell and inhibits αKG-dependent enzymes, including epigenetic regulators. The resultant alteration in gene expression and blockade of differentiation ultimately lead to leukemia development. Myeloid differentiation capacity can be restored by obstruction of the mutant enzyme, inducing substantial reduction in R-2-HG levels. Ivosidenib, a potent selective inhibitor of mutant IDH1, is a differentiating agent shown to be clinically effective in newly diagnosed AML (ND-AML) and relapsed/refractory (R/R) AML harboring this mutation. The drug is approved by the Food and Drug Administration (FDA) as a single-agent treatment for R/R AML. Significance of mutated IDH1 targeting and a potential role of ivosidenib in AML management, when used either as a single agent or as part of combination therapies, will be reviewed herein.Keywords: mutant IDH1, acute myeloid leukemia, ivosideni
Cervantes, Rowe, Venturi & Scott Brown; Manieras...
No full textEl artículo aborda la figura intelectual del angloestadounidense Colin Rowe, de una forma fragmentada, incidiendo en algunos aspectos que han marcado hitos en la historiografía y la interpretación arquitectónica del siglo XX. Se establece una reflexión sobre la presencia de Rowe en la actualidad, entre las generaciones de estudiantes que cursan arquitectura para seguidamente establecer algunas cuestiones consideradas de relevancia. La innovación en los mecanismos interpretativos de este autor, muy avanzados, que permiten una comprensión muy significativa en tiempos posteriores, tales como los conceptos de transparencia literal, transparencia fenomenal, son analizados como influencias en el curso del tiempo, apertura de nuevas posibilidades. El espacio geográfico y cultural de Italia, es otra de las fuentes en la obra de Rowe sobre la que se reflexiona en una perspectiva que introduce la imagología como un estadio previo de los mecanismos con los que diferentes culturas son visualizadas, interpretadas y recibidas. Una centralidad que no debía evitarse, es el concepto del aprovechamiento del manierismo como una metáfora que se traslada a lo contemporáneo, para de un modo perspicaz alumbrar comparaciones e interpretaciones arquitectónicas que resultan muy novedosas en su momento y alumbran su propio futuro. Una especulación comparada entre Rowe y Venturi, con la interpretación de algunas obras de éste último, nos sitúa en la continuidad y recuperación actual que el manierismo como heterodoxia puede aportar en el abordaje presente de la arquitectura. Finalmente, contextualizar a Rowe en el ámbito español, era necesario por enriquecer las teselas del mosaico de sus geografías transitadas.The article addresses the intellectual !gure of the Anglo-American Colin Rowe, in a fragmented
way, focusing on some aspects that have marked milestones in the historiography and architectural
interpretation of the 20th century. A re#ection is established on Rowe ‘s presence today, among the
generations of students who study architecture, to then establish some issues considered relevant.
e innovation in the interpretive mechanisms of this author, very advanced, which allow very
signi!cant advances in later times, such as the concepts of literal transparency, phenomenal
transparency, are analyzed as in#uences on the course of time and opening of new possibilities. e
geographical and cultural space of Italy is another source in Rowe ‘s work that is re#ected on in a
perspective that introduces imagology as a previous stage of the mechanisms with which di%erent
cultures are visualized, interpreted and received. A centrality that should not be avoided is the
concept of using mannerism as a metaphor that is transferred to the contemporary, to illuminate
in a perceptive way architectural comparisons and interpretations that are very novel at the time
and illuminate their own future. A comparative speculation between Rowe and Venturi, with the
interpretation of some of the latter’s works, places us in the continuity and current recovery that
mannerism as heterodoxy can contribute to the present approach to architecture. Finally,
contextualizing Rowe in the Spanish context was necessary to enrich the tiles of the mosaic of his
traveled geographiesO artigo aborda a !gura intelectual do anglo-americano Colin Rowe, de forma fragmentada,
enfocando alguns aspectos que marcaram marcos na historiogra!a e interpretação arquitetônica do
século XX. Estabelecese uma re#exão sobre a presença de Rowe hoje, entre as gerações de estudantes
que estudam arquitetura, para então estabelecer algumas questões consideradas relevantes. A
inovação nos mecanismos interpretativos deste autor, muito avançados, que permitem avanços
muito signi!cativos em tempos posteriores, como os conceitos de transparência literal, transparência
fenomenal, são analisadas como in#uências no curso do tempo e abertura de novas possibilidades.
O espaço geográ!co e cultural da Itália é outra fonte da obra de Rowe que se re#ete numa perspectiva
que introduz a imagologia como etapa prévia dos mecanismos com os quais as diferentes culturas
são visualizadas, interpretadas e recebidas. Uma centralidade que não deve ser evitada é o conceito
de utilizar o maneirismo como metáfora que se transfere para o contemporâneo, para iluminar de
forma perspicaz comparações e interpretações arquitetónicas muito inovadoras na época e que
iluminam o seu próprio futuro. Uma especulação comparativa entre Rowe e Venturi, com a
interpretação de algumas obras deste último, colocanos na continuidade e na recuperação actual de
que o maneirismo enquanto heterodoxia pode contribuir para a abordagem actual da arquitectura.
Por !m, contextualizar Rowe no contexto espanhol foi necessário para enriquecer os azulejos do
mosaico das suas geogra!as viajada
Plasmodium falciparum:Rosettes do not protect merozoites from invasion-inhibitory antibodies
No full textRosetting is a parasite adhesion phenotype associated with severe malaria in African children. Why parasites form rosettes is unknown, although enhanced invasion or immune evasion have been suggested as possible functions. Previous work showed that rosetting does not enhance parasite invasion under standard in vitro conditions. We hypothesised that rosetting might promote invasion in the presence of host invasion-inhibitory antibodies, by allowing merozoites direct entry into the erythrocytes in the rosette and so minimising exposure to plasma antibodies. We therefore investigated whether rosetting influences invasion in the presence of invasion-inhibitory antibodies to MSP-1. We found no difference in invasion rates between isogenic rosetting and non-rosetting lines from two parasite strains, R29 and TM284, in the presence of MSP-1 antibodies (P = 0.62 and P = 0.63, Student's t test, TM284 and R29, respectively). These results do not support the hypothesis that rosettes protect merozoites from inhibitory antibodies during invasion. The biological function of rosetting remains unknown
Reiley, Joseph (Death, 1903-12-26)
No full textAddress: Ohio Maternity HospitalAge at death: 9 daysPg 130/554/1903/M WS/City/Dr. James W. Rowe/Jacob F. Eyrich/City CemeteryOriginal record filed in drawer labeled 'REIK-REMY'
McMullen, Oliver (Death, 1904-02-22)
No full textAddress: Ohio Maternity HospitalAge at death: 14 days609/Pg. 29/1904/M W S/City/Dr. James W. Rowe/Jacob Eyrich/City CemeteryOriginal record filed in drawer labeled 'MCLAUGHLIN, P-MACK, R'
Mueller, David (Death, 1908-11-04)
No full textAddress: 1716 Hughes St.Age at death: 2 Mos 9days75/Pg. 131/1908/M W S/B. P. - City/Dr. Jas. W. Rowe/Jacob F. Eyrich/Carthage Rd.Original record filed in drawer labeled 'MUELLER-MULLER'
Behaviour of buried pipelines subjected to external loading.
Get PDFThe research presented in this Thesis was carried out at the University of Sheffield under
the supervision of Dr I. C. Pyrah and Dr W. F. Anderson, and Mr G. Leach at British Gas
Engineering Research Station (ERS). The research was financially supported by a British
Gas Research Scholarship and by the Overseas Research Students Awards Scheme.
The Author would like to express his sincere gratitude to his supervisors for their invaluable
help, guidance and encouragement during the development of the research.
The Author is also grateful to Dr S. R. Mi for his interest and assistance throughout the
research. Special thanks also go to Dr S. J. Wheeler for his supervision during the first year
of the research and sound advice in the initial stage of the work.
The Author would like to express his gratitude to all members of the geotechnics group at
the University of Sheffield for the useful discussions and comments. Special thanks and
appreciation are extended to the staff at the ERS, particularly Mr E. Middleton for
providing the data of the field tests and constructive comments.
The laboratory tests were performed at ERS Soils Laboratory for which the Author is
thankful to the laboratory staff. The Author must also thank British Gas for providing the
computer hardware and software for performing the numerical analyses, and the printing
facilities to produce the Thesis. Thanks also go to Mr D. Reay and Mr B. Bellwood at the
Gas Research Centre of British Gas for ensuring continuous financial support throughout
the award period.
Finally, the Author wishes to thank his family and friends for their endless support and
encouragement throughout the period of study in the UK. Without them, this Thesis may
never have been completed
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