55 research outputs found
NovoPen Echo® insulin delivery device
No full textJacob Hyllested-Winge,1 Thomas Sparre,2 Line Kynemund Pedersen2 1Novo Nordisk Pharma Ltd, Tokyo, Japan; 2Novo Nordisk A/S, Søborg, Denmark Abstract: The introduction of insulin pen devices has provided easier, well-tolerated, and more convenient treatment regimens for patients with diabetes mellitus. When compared with vial and syringe regimens, insulin pens offer a greater clinical efficacy, improved quality of life, and increased dosing accuracy, particularly at low doses. The portable and discreet nature of pen devices reduces the burden on the patient, facilitates adherence, and subsequently contributes to the improvement in glycemic control. NovoPen Echo® is one of the latest members of the NovoPen® family that has been specifically designed for the pediatric population and is the first to combine half-unit increment (=0.5 U of insulin) dosing with a simple memory function. The half-unit increment dosing amendments and accurate injection of 0.5 U of insulin are particularly beneficial for children (and insulin-sensitive adults/elders), who often require small insulin doses. The memory function can be used to record the time and amount of the last dose, reducing the fear of double dosing or missing a dose. The memory function also provides parents with extra confidence and security that their child is taking insulin at the correct doses and times. NovoPen Echo is a lightweight, durable insulin delivery pen; it is available in two different colors, which may help to distinguish between different types of insulin, providing more confidence for both users and caregivers. Studies have demonstrated a high level of patient satisfaction, with 80% of users preferring NovoPen Echo to other pediatric insulin pens. Keywords: NovoPen Echo®, memory function, half-unit increment dosing, adherence, children, adolescents 
Insulin Degludec in Clinical Practice: A Review of Japanese Real-World Data
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Dissertationis academicæ, de papismo paganizante, pars prior; quam, ex suffragio ampliss Senatus. Philosoph. Regiæ Academiæ Upsaliensis, præside ... Erico Alstrin ... in audit. Gust maj. die XXIII. Decemb. an. MDCCXXVIII. placidæ eruditorum disquisitioni submittit Jacobus Winge, Westro-gothus. [Elektronisk resurs]
No full textTopographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis
No full textAbstractObjective: The extracellular matrix glycoprotein tenascin (TN) is upregulated in articular cartilage with severe osteoarthritis (OA). This study gives a detailed description of TN expression in areas of articular cartilage from femoral heads with mild OA showing structural lesions and in structurally normal areas of the same femoral heads compared with normal cartilage and cartilage with severe OA.Methods: Immunohistochemical evaluation was performed on cryosections stained with antibodies against TN. Sections were selected as follows: from each macroscopically normal femoral head (n=6) a normal central and peripheral biopsy; from each femoral head with macroscopically mild OA (n=8) a central biopsy that showed structural lesions and a peripheral normal biopsy; from each femoral head with severe OA (n=9) a central and a peripheral biopsy with structural lesions. Central biopsies represent load bearing areas, whereas peripheral biopsies are non-load bearing.Results: Central cartilage with mild OA contains significantly higher levels of TN in the superficial zone than structurally normal, peripheral cartilage from the same femoral heads. Normal cartilage and cartilage with severe OA do not display this topographic variation. Central cartilage with mild OA shows significantly higher levels of TN than normal, central cartilage. Peripheral, normal cartilage with mild OA shows significantly less TN than peripheral cartilage with severe OA.Conclusions: In femoral heads with mild OA, TN is accumulated in areas displaying structural damage. This proposes mild OA to be a localized disorder. Extreme caution is necessary for sampling of articular cartilage, especially from joints with mild OA
Diabetes management and daily functioning burden of non-severe hypoglycemia in Japanese people treated with insulin
No full textA Review of 25 Yearsʼ Experience with the NovoPen® Family of Insulin Pens in the Management of Diabetes Mellitus
No full textDissertatio Græcorum antiquorum culturam cum Romanorum breviter comparans. Cujus partem priorem ... publico examini modeste subjiciunt mag. Jacobus Hagberg ... et Isacus M. Winge Holmiensis. In audit. Gust. d. IV Junii MDCCCX., P. 1 [Elektronisk resurs]
No full textDissertatio de situ Reidgothiæ. Cujus partem priorem ... præside ... Jac. Fredr. Neikter ... pro gradu philosophico p. p. Gustavus Adolphus Winge ... Sudermannus. In audit. Gust. maj. d. X. Maji MDCCXCIV. H. C. [Elektronisk resurs]
No full textComparison of Preference for NovoPen® 4 With Previous Insulin Pen Treatments After 12 Weeks in Adult Patients With Type 1 and Type 2 Diabetes: A Multicenter Observational Study
No full textPhenylalanine Hydroxylase RNAi Knockdown Negatively Affects Larval Development, Molting and Swimming Performance of Salmon Lice
Get PDFPhenylalanine hydroxylase (PAH) is a crucial enzyme involved in tyrosine biosynthesis, having roles in neurological and physiological processes. The purpose of PAH has received little attention in crustaceans despite extensive investigations in other arthropods. Here, we characterize the PAH gene for the first time in the parasite Lepeophtheirus salmonis, a copepod that is responsible for huge economic losses in salmonid fish farming. Phylogenetic and sequence analyses confirmed that LsPAH is closely related to the metazoan PAH with conserved ACT regulatory and catalytic domains. Temporal expression patterns revealed that LsPAH is expressed throughout all developmental stages peaking during the copepodite stages, suggesting an essential role in developmental physiology. We used RNAi to knockdown LsPAH expression in the nauplius I stage to study developmental function during the larval stages. PAH knockdown impaired larval development, molting and swimming ability with severe morphological defects. This study provides insight into the role of PAH in copepods and demonstrates the importance of this metabolic gene in salmon louse growth and development.publishedVersionCopyright © 2020 Guragain, Sporsheim, Skjesol, Båtnes, Olsen, Bones and Winge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
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