451 research outputs found
Analyzing Fatal Bird-Window Collisions Occurring on USU\u27s C&SS Building, Brigham City, Utah
No full textFatal bird window collisions are often overlooked as minimally damaging to bird populations or viewed as inevitable collateral damage of human habitat expansion. In reality, these unnecessary collisions are truly monumental in number, and prove to be a serious threat to bird populations, especially endangered bird species. In the United States alone it is estimated that between 365 - 988 million birds fatally collide with man-made windows annually. We are focusing our study on fatal bird-window collisions occurring on the Classroom and Student Services Building (C&SS building) at the USU campus in Brigham City, UT 84302. We have selected this building as a potential location for a high frequency of bird-window collision for its inclusion of multiple large windows. Several studies have indicated that window area was positively correlated with the amount of window strikes. The objective of the study is to: Investigate the number of fatal bird window collisions that occur on the C&SS building, then determine if it is larger than the expected number of fatal window collisions per month for a low-rise non-residential building. The expected number is between 0 – 6 collisions per month. The objective will be accomplished through a two-step method. First, we will be analyzing data obtained through the conduction of daily surveys of the C&SS building during the months of August through November of 2020. The surveys will be conducted by ourselves and USU faculty. We will be looking for bird-window collision evidence. Finally, we will be collating our survey data with survey data obtained in the in the years 2017-2019.https://digitalcommons.usu.edu/fsrs2020/1039/thumbnail.jp
The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts
No full textThe protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al
Managing the Later Stuart Press, 1662–1696
No full textThe system of pre-publication censorship laid down in 1662 finally collapsed when the Printing Act expired in 1695. Yet even in the interim censorship rarely took the form of a direct confrontation between a writer and the state. In practice, the authorities simply lacked the means to police a regime of censorship of the kind now associated with the impersonal agency of the state. More representative of the way in which the Stuarts managed the press is the career of George Larkin (c.1642–1707), a printer, bookseller, and author overlooked in standard accounts of the London literary underground. This chapter provides a case study of Larkin against the background of these legislative developments.</p
Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600–Mutant Stage III Melanoma
No full textPurpose Dabrafenib plus trametinib improved relapse-free survival (RFS) versus placebo (hazard ratio [HR], 0.47; P < .001) in patients with resected BRAF V600–mutant stage III melanoma (BRF115532; COMBI-AD; ClinicalTrials.gov identifier: NCT01682083). We present an updated RFS analysis on the basis of extended study follow-up and a cure-rate model analysis to estimate the fraction of patients expected to remain relapse free long term. Methods In this phase III trial, patients with resected BRAF V600–mutant stage III melanoma were randomly assigned to 12 months of adjuvant dabrafenib plus trametinib versus placebo. We report updated RFS (primary end point) and distant metastasis–free survival. RFS was also analyzed by subgroups defined by baseline disease stage (American Joint Committee on Cancer 7th and 8th editions), nodal metastatic burden, and ulceration status. The fraction of patients who remained relapse free long term was estimated using a Weibull mixture cure-rate model. Results At median follow-up of 44 months (dabrafenib plus trametinib) and 42 months (placebo), 3- and 4-year RFS rates were 59% (95% CI, 55% to 64%) and 54% (95% CI, 49% to 59%) in the dabrafenib plus trametinib arm and 40% (95% CI, 35% to 45%) and 38% (95% CI, 34% to 44%) in the placebo arm, respectively (HR, 0.49; 95% CI, 0.40 to 0.59). Distant metastasis–free survival also favored dabrafenib plus trametinib (HR, 0.53; 95% CI, 0.42 to 0.67). The estimated cure rate was 54% (95% CI, 49% to 59%) in the dabrafenib plus trametinib arm compared with 37% (95% CI, 32% to 42%) in the placebo arm. Subgroup analysis of RFS demonstrated similar treatment benefit regardless of baseline factors, including disease stage, nodal metastatic burden, and ulceration. Conclusion Longer follow-up confirmed RFS benefit with dabrafenib plus trametinib. Subgroup analysis suggested that dabrafenib plus trametinib benefited patients regardless of baseline factors
520: Analysis of the fetal growth trajectory improves risk stratification in growth-restricted fetuses
No full textDopamine restores reward prediction errors in old age
No full textSenescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value, resulting in an incomplete reward prediction error (RPE) signal in the nucleus accumbens, a brain region that receives rich input projections from substantia nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural connectivity between SN/VTA and striatum, measured by diffusion tensor imaging, was tightly coupled to inter-individual differences in the expression of this expected reward value signal. The dopamine precursor levodopa (L-DOPA) increased the task-based learning rate and task performance in some older adults to the level of young adults. This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
Phase transition in a chain of quantum vortices
No full textWe consider interacting vortices in a quasi-one-dimensional array of Josephson junctions with small capacitance. If the charging energy of a junction is of the order of the Josephson energy, the fluctuations of the superconducting order parameter in the system are considerable, and the Vortices behave as quantum particles. Their density may be tuned by an external magnetic field, and therefore one can control the commensurability of the one-dimensional vortex lattice with the lattice of Josephson junctions. We show that the interplay between the quantum nature of a vortex and the long-range interaction between the vortices leads to the existence of a specific commensurate-incommensurate transition in a one-dimensional vortex lattice. In the commensurate phase an elementary excitation is a soliton with energy separated from the ground state by a finite gap. This gap vanishes in the incommensurate phase. Each soliton carries a fraction of a flux quantum; the propagation of solitons leads to a finite resistance of the array. We find the dependence of the resistance activation energy on the magnetic field and parameters of the Josephson array. This energy consists of the above-mentioned gap, and also of a boundary pinning term, which is different in the commensurate and incommensurate phases. The developed theory allows us to explain quantitatively the available experimental data. [S0163-1829(99)00402-6]
712: Beyond preterm birth history and cervical length: analysis of routinely collected clinical data improves prediction of preterm delivery
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