1,720,996 research outputs found
Synaptotagmin–Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Detection of Trace Gases from Fermentation Processes using Photoacoustic Spectroscopy and Pronton-Transfer-Reaction Mass Spectrometry
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19620.pdf (Publisher’s version ) (Open Access)This thesis presents novel interdisciplinary Physics - Biology research work that employed Photoacoustic Spectroscopy and Proton-Transfer-Reaction Mass Spectrometry. Both techniques were used in biological studies of trace gasses emitted by crop plants and fruit under stress situations. The findings of this research bring to light essential new features in plant physiology. A line tuneable (5 - 8 ?m) infrared CO-laser based photoacoustic detector was adapted to achieve fast, non-invasive and highly sensitive on-line monitoring of biological processes. The set-up was used to study alcoholic fermentation and concomitant processes in seedlings of various crop plants, notably of rice and wheat (Chapters 2, 3, and 4). If a large number of gases are monitored by the photoacoustic method, the time resolution of the system becomes very low. In addition, there is great interest in trace gases that cannot be monitored by photoacoustics. To overcome these drawbacks, a Proton-Transfer-Reaction Mass Spectrometer (PTR-MS) was designed, constructed and optimized. In Chapter 5 this PTR-MS is described together with its use in monitoring emission of various compounds (aldehydes, alcohols, acids, esters and C-6 compounds) related to fermentation and to fruit aroma and flavour, released by four apple cultivars under short anaerobic and post-anaerobic conditions. Detection limits similar to those reported in the literature were achieved with this system. For the first time, a comparison between PTR-MS and laser photoacoustics was made in order to ensure that fragmentation processes occurring during the PTR-MS measurements do not disturb the assignment of the ion-signals to the neutral compounds of interest. Simultaneous monitoring of alcoholic fermentation products from young rice plants by both methods gave comparable results for acetaldehyde. The preliminary results show that application of PTR-MS detectors in fruit storage opens new possibilities for revealing the kinetics of metabolic processes relevant to storage conditions, fruit quality and basic physiologyNijmegen, 11 april 2005Promotores : Parker, D.H., Jackson, M.B. Co-promotor : Harren, F.J.M.126 p
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II
No full textHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. We reported recently that complexin II, a protein involved in neurotransmitter release, is depleted from both the brains of mice carrying the HD mutation and from the striatum of post mortem HD brains. Here we show that this loss of complexin II is recapitulated in PC12 cells expressing the HD mutation and is accompanied by a dramatic decline in Ca2+-triggered exocytosis of neurotransmitter. Overexpression of complexin II (but not complexin I) rescued exocytosis, demonstrating that the decline in neurotransmitter release is a direct consequence of complexin II depletion. Complexin II depletion in the brain may account for some of the abnormalities in neurotransmission associated with HD
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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