1,655 research outputs found
Double-Effect Reasoning: From Jean Pierre Gury to Peter Knauer
No full textThe author argues in favor of the thesis proposed by Peter Knauer and others that double-effect reasoning, or the principle of double effect, changes in character from Aquinas\u27s initial formulation in his treatment of self-defense to the articulations offered by various manualists. However, Knauer and others fail to recognize that proportionalism is better understood as an extension of neo-Scholastic Jesuit manuals than as a recovery of Aquinas
Antifaschismus und Widerstand: Spuren in die Gegenwart (Vorwort zu Neuauflage von: Die unterbrochene Spur)
No full textThe Kurgans of Budzhak Explored by F. I. Knauer: History of Excavztion, Cartography and Modern State
No full textСтатья посвящена археологическй деяльности уроженца немецкой колонии Сарата в Буджаке и автору первых научных раскопок курганов этого региона — профессору киевского университета Святого Владимира Федору Ивановичу Кнауэру.The article is observed the archeological activity of the native of German colony of Sarata in Budzhak and the author of first excavations of the barrows of this region, Professor F. I. Knauer
"... unsere Kameradschaft auf Leben und Tod": Annke-Margarethe Knauer (1901-1987) und Alfred Hein (1894-1945)
No full text"... unsere Kameradschaft auf Leben und Tod" : Annke-Margarethe Knauer (1901- 1987) u. Alfred Hein (1894-1945). - In: Beuthener Geschichts- und Museumsverein: Mitteilungen des ... 48. 1987. S. 111-13
The Kurgans of Budzhak Explored by F. I. Knauer: History of Excavztion, Cartography and Modern State
No full textСтатья посвящена археологическй деяльности уроженца немецкой колонии Сарата в Буджаке и автору первых научных раскопок курганов этого региона — профессору киевского университета Святого Владимира Федору Ивановичу Кнауэру.The article is observed the archeological activity of the native of German colony of Sarata in Budzhak and the author of first excavations of the barrows of this region, Professor F. I. Knauer
3D Visualization - Using High Resolution Multi.Sensor Data
No full textThis is an approach creating a three dimensional virtual world by using high resolution multi-sensor data. The throne hall of Neuschwanstein castle was visualized three dimensional with the help of multi-sensor data records. The high resolution multi-sensor data was based on laser scanner data and panoramic/matrix camera images. It is illustrated how multi-sensor data can be processed, achieving impressive results. It is also presented the state of the art concerning technologies and software solutions and approaches for future activities
Characterization of cull sows harvested in the U.S.
No full textStalder, K.J.; Knauer, M.; Karriker, L.; Baas, T.J.; Johnson, C.; Serenius, T.; Layman, L.; Mabry, J. W.; McKean, J.D.. (2006). Characterization of cull sows harvested in the U.S.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/157430
Performance and economic evaluation of feeding cull sows
No full textFitzgerald, R.; Stalder, K.J.; Karriker, L.; Knauer, M.; Johnson, C.; Baas, T.J.; Layman, L.; Mabry, J. W.. (2006). Performance and economic evaluation of feeding cull sows. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/157432
Untersuchungen zur Bedeutung des Kern-Zytoplasma Transports für die biologische Funktion zellulärer Proteine
No full textThe thesis entitled „Investigations on the significance of nucleo-cytoplasmic transport for the biological function of cellular proteins" aimed to unreveal molecular mechanisms in order to improve our understanding of the impact of nucleo-cytoplasmic transport on cellular functions. Within the scope of this work, it could be shown that regulated nucleo-cytoplasmic transport of a subfamily of homeobox transcription factors controlled their intra- and intercellular transport, and thereby influencing also their transcriptional activity. This study describes a novel regulatory mechanism, which could in general play an important role for the ordered differentiation of complex organisms. Besides cis-active transport Signals, also post-translational modifications can influence the localization and biological activity of proteins in trans. In addition to the known impact of phosphorylation on the transport and activity of STAT1, experimental evidence was provided demonstrating that acetylation affected the interaction of STAT1 with NF-kB p65, and subsequently modulated the expression of apoptosis-inducing NF-kB target genes. The impact of nucleo-cytoplasmic transport on the regulation of apoptosis was underlined by showing that the evolutionary conservation of a NES within the anti-apoptotic protein survivin plays an essential role for its dual function in the inhibition of apoptosis and ordered cell division. Since survivin is considered a bona fide cancer therapy target, these results strongly encourage future work to identify molecular decoys that specifically inhibit the nuclear export of survivin as novel therapeutics. In order to further dissect the regulation of nuclear transport and to efficiently identify transport inhibitors, cell-based assays are urgently required. Therefore, the cellular assay Systems developed in this work may not only serve to identify synthetic nuclear export and Import inhibitors but may also be applied in systematic RNAi-screening approaches to identify novel components of the transport machinery. In addition, the translocation based protease- and protein-interaction biosensors can be applied in various biological Systems, in particular to identify protein-protein interaction inhibitors of cancer relevant proteins. In summary, this work does not only underline the general significance of nucleo-cytoplasmic transport for cell biology, but also demonstrates its potential for the development of novel therapies against diseases like cancer and viral infections.Die vorliegende Arbeit mit dem Titel „Untersuchungen zur Bedeutung des Kern- Zytoplasma Transports für die biologische Funktion zellulärer Proteine" hatte die Aufklärung molekularer Mechanismen des nukleozytoplasmatischen Transports zum Ziel, um so unser Verständnis von dessen Bedeutung für verschiedene zelluläre Funktionen zu vertiefen. Im Rahmen dieser Arbeit konnte gezeigt werden, daß der regulierte Kern-Zytoplasma Transport einer Unterfamilie der Homeobox Transkriptionsfaktoren deren intra- und interzellulären Transport und letztendlich deren transkriptionelle Aktivität beeinflussen konnte. Diese Studie beschreibt einen neuartigen Regulationsmechanismus, welcher für die geordnete Differenzierung komplexer Organismen eine allgemein wichtige Rolle spielen könnte. Neben cis-aktiven Transportsignalen können auch posttranslationelle Modifikation die Lokalisation und biologische Aktivität von Proteinen in trans beeinflussen. Im Rahmen dieser Arbeit konnte gezeigt werden, daß durch Acetylierung des Transkriptionsfaktors Stat1 dessen Interaktion mit NF-KB p65 verstärkt, und somit die subzelluläre Lokalisation und die DNA-Bindung von NF-KB sowie letztendlich die NF-KB kontrollierte Expression von Apoptose-induzierenden Zielgenen beeinflußt wurde. Des weiteren konnte gezeigt werden, daß die evolutionäre Konservierung eines nuklearen Exportsignals (NES) im anti-apoptotischen Protein Survivin für dessen duale Funktion, der Verhinderung von Apoptose und der geordneten Zellteilung, eine essentielle Rolle spielt. Diese Ergebnisse unterstützen den Ansatz, durch spezifische Inhibierung des Kern-Zytoplasma Transports von krankheitsrelevanten Proteinen neue Therapeutika zu entwickeln. Zur Umsetzung dieses Vorhabens wurden zelluläre Testsysteme entwickelt, welches es erlauben, spezifische Kerntransportinhibitoren zu identifizieren. Das Prinzip der nukleären Translokation konnte darüber hinaus zur Etablierung von Protease und Protein-Interaktions Biosensoren weiterentwickelt werden. Die vorliegende Arbeit unterstreicht nicht nur die allgemeine zellbiologische Bedeutung des nukleozytoplasmatischen Transports, sondern zeigt auch dessen Potential zur Entwicklung neuer Therapien gegen Krankheiten wie Krebs und virale Infektionen
Correction to: Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) (Breast Cancer Research and Treatment, (2019), 174, 2, (279-296), 10.1007/s10549-018-05071-1)
No full textThe article Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions), written by Christoph J Rageth, Elizabeth AM O’Flynn, Katja Pinker, Rahel A Kubik-Huch, Alexander Mundinger, Thomas Decker, Christoph Tausch, Florian Dammann, Pascal A. Baltzer, Eva Maria Fallenberg, Maria P Foschini, Sophie Dellas, Michael Knauer, Caroline Malhaire, Martin Sonnenschein, Andreas Boos, Elisabeth Morris, Zsuzsanna Varga, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on November 30, 2018 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on May 30, 2019 to © The Author(s) 2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons.org/licen ses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The original article has been corrected
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