4,846 research outputs found
Esperienza e verità delle passioni: il Proust di Ernesto Grassi
No full textLa relazione analizza il rapporto istituito da Ernesto Grassi col pensiero di Proust, e il significato che questo rapporto ha assunto in relazione ad alcuni nodi teorici della prospettiva filosofica di Grassi: dal problema del tempo e della memoria a quello della metafora; dalla condanna del pensiero razionale al riscatto del mondo sensibile e alla valenza veritativa delle passioni. La relazione mostra così il ruolo importante svolto dal confronto con Proust, soprattutto nell’ultima fase della riflessione di Grassi, dove la lezione proustiana si salda con quella offerta dalla tradizione retorica dell’Umanesimo
John Anthony Grassi, S.J. (26 of 39)
No full textContains ALS: from E. Fenwick to G. Fenwick on occasion of New Year's Day 1/3/1815; to Grassi 1/12/1815; from Joseph Mobberly, SJ to Grassi recommending release of slaves 2/5/1815, on relations between St. Inigoes and St. George's Island 2/16/1815; from B. Fenwick to Grassi on celebration of end of War of 1812, disposal of items belonging to Literary Institute 2/20/1815; from Abp Carroll to Grassi in which former defends himself re preservation of Society property and Society interests in general, transfer of novitiate to Conewago, C. Neale's defects, Pasquet affair 2/21/1815; from E. Fenwick to Grassi on Pasquet 2/29/1815 [sic].*Former finding aid locations: 119_58_6; 204K1-204K7*This folder contains materials related to Jesuit slaveholding.We are in the dark as long as we keep slaved. Br. Joseph Mobberly, S. J. calculates the cost savings from emancipation, February, 5, 1815 [GSA58
Super Chern-Simons theory: Batalin-Vilkovisky formalism and A∞ algebras
No full textThis is a companion paper of a long work appeared in [C. Cremonini and P. Grassi, Pictures from super Chern-Simons theory, J. High Energy Phys. 03 (2020) 043JHEPFG1029-847910.1007/JHEP03(2020)043] discussing the super-Chern-Simons theory on supermanifolds. Here, it is emphasized that the Batalin-Vilkovisky formalism is naturally formulated using integral forms for any supersymmetric and supergravity models and we show how to deal with A∞ algebras emerging from supermanifold structures
Alex de Grassi
No full textPoster advertising Alex de Grassi with the original caption "Alex de Grassi; Windham Hill Records; (415) 329-0647" The poster includes a portrait of de Grassi and his instrument
Grassi (J.R.), Suggested refinement of Rorschach scoring, J. project. Techn., juin 1951
No full textAnzieu Didier. Grassi (J.R.), Suggested refinement of Rorschach scoring, J. project. Techn., juin 1951. In: Bulletin du groupement français du Rorschach, n°1, 1952. p. 22
La Fine del Potere Ottomano. L’ultimo sultano, l’ultimo califfo, gli ultimi gran visir
No full textContrariamente alla fine dell’Impero zarista, dell’Impero asburgico e di quello germanico, la fine dell’Impero ottomano sopravvenne dopo lunga e tortuosa agonia, prodotta principalmente dalle confliggenti ambizioni delle potenze che avevano vinto la Grande Guerra. A cento anni dall’abolizione del califfato (3 marzo 1924), Fabio L. Grassi ripercorre la storia ben poco conosciuta degli uomini che ressero e rappresentarono l’impero in quegli anni. L’autore ne illustra la vita, la carriera, le propensioni politiche, l’opera, le posizioni di volta in volta assunte, la loro sorte successiva, oltre che la loro dimensione culturale, morale e psicologica. Ciò che fecero e non fecero l’ultimo sultano, l’ultimo califfo e gli ultimi gran visir, ovvero i massimi rappresentanti della «Turchia legale», nelle loro relazioni da una parte con gli Alleati dall’altra con la «Turchia ribelle», costituisce un insieme complesso, ambiguo e in parte ancora misterioso.Contrary to the end of the Tsarist Empire, of the Habsburg Empire and of the Germanic, Empire, the end of the Ottoman Empire came after a long and torturous agony, caused mainly by the conflicting ambitions of the powers that had won the Great War. One hundred years after the abolition of the caliphate (3 March 1924), Fabio L. Grassi traces the scarcely story
known of the men who ruled and represented the empire in those years. The author illustrates their life, career and political propensities policies, their acts, the positions taken from time to time, theirs subsequent fate, as well as their cultural, psychological and moral dimension. What the last sultan, the last caliph and the last grand viziers, i.e. the highest representatives of «legal Türkiye», did and did not do, in their relations on the one hand with the AlliedPowers on the other with "rebel Türkiye", constitutes a
complex, ambiguous and partly still mysterious whole
Grassi (J.R.), Suggested refinement of Rorschach scoring, J. project. Techn., juin 1951
No full textAnzieu Didier. Grassi (J.R.), Suggested refinement of Rorschach scoring, J. project. Techn., juin 1951. In: Bulletin du groupement français du Rorschach, n°1, 1952. p. 22
Los mundos lejanos de Ángela Grassi: historia, leyenda y moral
Get PDFThis study sets out to uncover the ideological and formal keys of the literary work published by Ángela Grassi (1823-1883) in the form of press articles. Of her extensive production, which appeared in various magazines of her time, particularly women’s magazines, we have annotated over fifty articles published in El Correo de la Moda, the magazine to which Grassi contributed most assiduously from 1866 onwards, and which she ran from 1867 until her death. Her work, romantic in nature, escapes the reality of her age in historical or legendary times in which she looks for useful models for moral education; all wrapped in a rich literary style.El presente estudio se propone descubrir las claves ideológicas y formales en que se funda la obra literaria publicada por Ángela Grassi (1823-1883) bajo la forma de artículos en prensa. De su extensa producción, aparecida en las diversas revistas de su tiempo, en especial en las femeninas, hemos acotado más de medio centenar de artículos publicados en El Correo de la Moda, la revista en que la autora colaboró más asiduamente desde 1866 y que dirigió desde 1867 hasta su muerte. Su obra, de estirpe romántica, se aleja de la realidad de su época para huir hacia tiempos históricos o legendarios en los que busca modelos útiles para una enseñanza moral; todo ello revestido de una gran riqueza literaria
Improving drug efficacy and specificity by innovative drug delivery approaches
No full textThe limited efficacy of current therapeutic approaches for a number of socially relevant human diseases requires the exploration of alternative and more effective therapeutic strategies. In this regard, the researchers have pursued on one hand the identification of novel and more effective therapeutic molecules and on the other the optimization of drug delivery systems.
So far, many therapeutic molecules, especially those used as anticancer drugs, are plagued by a low therapeutic index being the efficacious dose very close to the lethal one; moreover, they often lack any specificity of action. This aspect can be improved by the use of drug delivery systems composed of different drug carriers including lipids and polymers. The carriers, often in the shape of nanoparticles , can be loaded by the therapeutic molecule and directed against the target cells via the presence of targeting moieties allocated on the nanoparticle surface.
The specificity of the complex carrier/drug can be further improved by the use of therapeutic molecules preferentially/exclusively active on the target diseased cells. Molecules active against diseased-associated target (oncogenes etc) may hit the diseased cells leaving healthy cells substantially unaffected. In this regard, in the last three decades, nucleic acid based drugs (NABDs) have emerged as an attractive and novel alternative with great therapeutic potential. NABDs, which include antisense oligonucleotides, decoys, aptamers, triple helix forming oligonucleotides, DNAzymes, Ribozymes and small interfering RNAs, have been shown to be able to efficiently and specifically counteract pathological gene expression in many different experimental systems. Notably as they can be engineered to hit virtually any cell target, their potential applicability is very broad.
Despite NABD broad potential applicability, their use in the clinic is limited by the lack of optimal delivery systems. Due to their hydrophilic nature, NABDs cannot efficiently cross cellular membrane for which appropriate carriers are needed. Moreover, their instability in serum requires a proper protection to prevent a fast degradation which would invariably lead to the abrogation of any significant therapeutic effect.
The present special issue will be focused on the critical description of some aspects related to the optimization of drug delivery with a particular emphasis on NABD; despite this, a discussion about the possibility to use/adapt NABD developed delivery systems for more conventional drugs, is also present.
The papers of Chan et al., of Marrache et al, of Schaffert et al., Jung et al. and Grassi et al. describe different delivery approaches for NABD and other commonly used therapeutic molecules for several pathological conditions. In the paper of Chan et al. attention is given to liposome and polymeric based delivery systems with regard to DNA enzymes; the described studies offer perspectives on future methodologies for improved DNAzyme delivery and utility as novel drugs. Marrache et al. describe the use of nanoparticles (made by polymer, liposome and other delivery agents), as delivery devices which can be engineered to load multiple drugs with varied physicochemical properties, contrast agents, and cellular or intracellular component targeting moieties. Schaffert et al draw their attention on the description of delivery systems based on the polycation linear polyethylenimine, where peptide based ligands are attached to the polycation via heterobifunctional polyethylene glycol linker molecules. Conjugate synthesis, in vitro testing and in vivo cancer models in rodents are discussed. Jung et al describe the employment of the thermo sensitive pluronic-based core/shell nanoparticles, formed using various strategies such as self-assembly and temperature induced-phase transition. Particular emphasis is given to the use of the nanoparticles for tumor targeting, stimulated release of proteins, and cancer imaging capabilities. Grassi et al, beside discussing the above mentioned delivery systems, for most of the different types of NABDs, draw their attention on the complex situation of NABD delivery to the arteries describing the advantages and dis-advantages of three different administration routes i.e. systemic, perivascular and intravascular.
The papers of Lico et al, Pagliari et al and Castronovo et al report the use of “living delivery systems” and describe the influences of nano-systems on NABD. Lico et al. focus their attention on the use of a different approach for NABD delivery based on plant viruses which have a size particularly suitable for nanoscale applications and can offer several advantages being structurally uniform, robust, biodegradable and easy to produce. Pagliari et al. continue the description of “living vector” reporting the possible and very innovative use of stem cells as delivery devices for therapeutic molecules to the injured myocardium. Finally, in the paper of Castronovo et al., a completely innovative point of view about NABD complexation in nano-carriers is provided. The author show that the functionality of NABD in nano-systems is highly dependent upon the local density, molecular flexibility and network of weak interactions between adjacent molecules. The understanding of these properties can enable the development of powerful molecular tools for nano-medicine.
In conclusion, whereas the developmental process of many delivery systems is still at the beginning, other delivery strategies are closer to possible applications. Regardless of the fact that the delivery systems are used for NABD or clinically available drugs, we believe the target tissue will mainly determine the nature of the optimal strategy. Despite the delivery issue can and should be further optimized, the encouraging results displayed so far in different experimental models using NABD or clinically used drugs, fully justify further economic and scientific efforts
Selective and Efficient Reduction of Nitrobenzene to Aniline catalyzed by AuNPs Embedded in a Nanoporous Crystalline Polymeric Support
No full textCongresso Divisione Chimica Industriale
Salerno, Settembre 2015
Selective and Efficient Reduction of Nitrobenzene to Aniline catalyzed
by AuNPs Embedded in a Nanoporous Crystalline Polymeric Support
Annarita Noschese1*, Antonio Buonerba1, Carmine Capacchione1, Stefano Milione1, Alfonso Grassi1
1 - Dipartimento di Chimica e Biologia, Università degli Studi di Salerno, Via Giovanni Paolo II - 84084 Fisciano (SA), Italy, and CIRCC-Bari, Italy
Abstract
Supported Gold Nanoparticles (AuNPs) efficiently catalyze both oxidation and reduction reactions. E.g. aerobic oxidation of alcohols and cross coupling reactions of alcohols leading to esters, amide, imine have been widely and successfully explored [1]. On the other side the reduction of nitroarenes to anilines using NaBH4, H2, silanes, formic acid, CO/H2O is a benchmark reaction for testing their catalytic performances in reduction reactions [2].
During reaserch efforts many supports have been exploited (carbon based supports, polymers, inorganic oxides) but their role is still under discussion. A semicrystalline porous polymeric support, consisting of syndiotactic polystyrene-co-cis-1,4-polybutadiene [3] has been successfully tested in our group and the AuNPS embedded in this polymer matrix (AuNPs-sPSB) were investigated in the reduction of nitrobenzene to aniline. The polymorphic behaviour of the host polymer matrix has been studied to optimize the catalyst performances. The nanoporous crystalline forms of the sPSB matrix, namely and , allowed a total conversion of nitrobenzene in 40 min at room temperature, with 100% selectivity in aniline. On the contrary the not permeable crystalline form gave a less reactive and selective catalyst; actually azobenzene and azoxybenzene were detected as intermediates compounds providing information on the cascade of the reduction reactions and the global reaction mechanism. Among the catalysts to date reported in the literature, the AuNPs-sPSB catalyst showed the highest activity (TOF=6000 h-1). The catalyst is very stable under the reaction conditions and reusable for at least three times without loss of catalytic activity.
Keywords: Gold Nanoparticles, Polymeric Matrix, Reduction.
* Corresponding author: [email protected]
References
[1] A. Corma, H. Garcia, Chem. Soc. Rev. 37 (2008) 2096
[2] S. Fountoulaki, V. Daikopoulou, P. L. Gkizis, I. Tamiolakis, G.S. Armatas, I. N. Lykakis, ACS Catal. 4 (2014) 3504; X. Liu, S. Ye, H.-Q. Li, Y.-M. Liu, Y. Cao, K.-N. Fan, Catal. Sci. Technol. 3 (2013) 3200; L. He, L.-C. Wang, H. Sun, J. Ni, Y. Cao, H.-Y. He, K.-N. Fan, Angew. Chem. Int. Ed. 48 (2009) 9538.
[3] A. Buonerba, C. Cuomo, S. Ortega Sánchez, P. Canton, A. Grassi, Chem. Eur. J. 18 (2012) 709; A. Buonerba, A. Noschese, A. Grassi, Chem. Eur. J. 20 (2014) 5478
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