1,533 research outputs found
The thermal decomposition of diazirines: 3-(3-methyldiazirin-3-yl)propan-1-ol and 3-(3-methyldiazirin-3-yl)propanoic acid
No full textPT: J; CR: BIGOT B, 1978, J AM CHEM SOC, V100, P6575 BRIDGE MR, 1969, J CHEM SOC A, P91 CHURCH RFR, 1970, J ORG CHEM, V35, P2465 CLOSS GL, 1965, J AM CHEM SOC, V87, P4270 EFFIO A, 1980, J AM CHEM SOC, V102, P1734 FIGUERA JM, 1976, AN QUIM, V72, P737 FIGUERA JM, 1978, J CHEM SOC F1, V74, P809 FIGUERA JM, 1979, J PHOTOCHEM, V10, P473 FREY HM, 1963, J CHEM SOC, P3514 FREY HM, 1964, J CHEM SOC, P4700 FREY HM, 1965, J CHEM SOC, P1700 FREY HM, 1965, J CHEM SOC, P3101 FREY HM, 1966, J CHEM SOC A, P968 FREY HM, 1977, J CHEM SOC F1, V73, P2010 FREY HM, 1979, J CHEM SOC A, P1916 GANZER GA, 1986, J AM CHEM SOC, V108, P1517 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 LAL D, 1974, J AM CHEM SOC, V96, P6355 LIU MTH, 1972, INT J CHEM KINET, V4, P229 LIU MTH, 1972, J PHYS CHEM-US, V76, P797 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1982, CHEM SOC REV, V11, P127 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1984, TETRAHEDRON, V40, P887 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1986, J CHEM SOC PERK T 2, P211 LIU MTH, 1987, CHEM DIAZIRINES, V1, P111 MANSOOR AM, 1966, TETRAHEDRON LETT, P1753 MANSOOR M, 1967, THESIS U SOUTHAMPTON MOSS RA, 1984, TETRAHEDRON LETT, V25, P1023 NEUVARAND EW, 1967, J PHYS CHEM-US, V71, P1229 SCHMID P, 1979, INT J CHEM KINET, V11, P333 SHERIDAN RS, 1984, J AM CHEM SOC, V106, P436 SKELL PS, 1972, TETRAHEDRON, V28, P3571 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 VOIGT E, 1975, CHEM BER, V108, P3326; NR: 39; TC: 8; J9: J CHEM SOC PERKIN TRANS 2; PG: 7; GA: DD960Source type: Electronic(1
on the thermal decomposition of diazirines
No full textPT: J; CR: BIGOT B, 1978, J AM CHEM SOC, V100, P6576 BRADLEY GF, 1977, J CHEM SOC P2, P1214 BRUNNER J, 1980, J BIOL CHEM, V255, P3313 DIDERICH G, 1972, HELV CHIM ACTA, V55, P2103 FLEMING I, 1980, FRONTIER ORBITALS OR GRILLER D, 1982, J AM CHEM SOC, V104, P5549 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 LAHMANI F, 1976, J PHYS CHEM-US, V80, P2623 LANGANIS ED, 1983, J AM CHEM SOC, V105, P7457 LIU MTH, 1972, J PHYS CHEM-US, V76, P797 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1977, CAN J CHEM, V55, P3596 LIU MTH, 1982, CHEM SOC REV, V11, P127 MOORE CB, 1964, J CHEM PHYS, V41, P3504 SCHMITZ E, 1965, CHEM BER, V98, P2509 SCHMITZ E, 1967, CHEM BER, V100, P2093 SCHMITZ E, 1971, 23RD INT C PUR ALL C, V2, P283 SHEPARD RA, 1967, J ORG CHEM, V32, P3197 SHILOV AE, 1968, TETRAHEDRON LETT, P4177 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 SNYDER JP, 1972, TETRAHEDRON LETT, P4347 TAYLOR EC, 1979, CHEM REV, V79, P181 TURRO NJ, 1980, J AM CHEM SOC, V102, P7576 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754 VOIGT E, 1975, CHEM BER, V108, P3326 ZOLLINGER H, 1978, ANGEW CHEM INT EDIT, V17, P141; NR: 28; TC: 8; J9: J CHEM SOC PERKIN TRANS 2; PG: 4; GA: A2035Source type: Electronic(1
Effect of diazirine concentration on the reaction of 3-benzyl-3-chlorodiazirine with methanol
No full textPT: J; CR: GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1985, J ORG CHEM, V50, P3218 LIU MTH, 1985, TETRAHEDRON LETT, V26, P3071 LIU MTH, 1986, J CHEM SOC PERK T 2, P1233 LIU MTH, 1986, J PHYS CHEM-US, V90, P75 LIU MTH, 1987, CHEM DIAZIRINES, V1, CH5 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TOMIOKA H, 1986, J CHEM SOC CHEM COMM, P1364; NR: 11; TC: 5; J9: J CHEM SOC PERKIN TRANS 2; PG: 3; GA: L7207Source type: Electronic(1
Substituent and temperature effects on the reactions of benzylchlorocarbene with alcohol
No full textPT: J; CR: DOLBY LJ, 1966, J ORG CHEM, V31, P110 FRENKING G, 1984, TETRAHEDRON, V40, P2123 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, UNPUB GRILLER D, 1982, J AM CHEM SOC, V104, P5549 GRILLER D, 1984, J AM CHEM SOC, V106, P198 KIRMSE W, 1971, CARBENE CHEM KIRMSE W, 1981, J AM CHEM SOC, V103, P5935 LIU MTH, 1984, J CHEM SOC CHEM COMM, P1062 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 MARCH J, 1985, ADV ORG CHEM, P244 MOSS RA, 1975, CARBENES, V1 MOSS RA, 1975, CARBENES, V2 MOSS RA, 1983, TETRAHEDRON LETT, V24, P685 MUROV SL, 1973, HDB PHOTOCHEMISTRY, P147 PLATZ MS, 1982, J AM CHEM SOC, V104, P6494 SCHLOSSER M, 1967, CHEM BER, V100, P3901 SCHMID GH, 1978, J ORG CHEM, V43, P777 SENTHILNATHAN VP, 1980, J AM CHEM SOC, V102, P7637 TANAKA R, 1971, TETRAHEDRON, V27, P2651 TOMIOKA H, 1983, J AM CHEM SOC, V105, P5053 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TOMIOKA H, 1984, J CHEM SOC CHEM COMM, P476 TOMIOKA H, 1984, TETRAHEDRON LETT, V25, P4413 WARNER P, 1984, J ORG CHEM, V49, P3666 WARNER PM, 1984, J AM CHEM SOC, V106, P5366 WRIGHT BB, 1984, J AM CHEM SOC, V106, P4175; NR: 27; TC: 9; J9: J CHEM SOC PERKIN TRANS 2; PG: 8; GA: D7012Source type: Electronic(1
A convenient synthesis of some arylated phenylsulfonylacetonitriles and ethyl cyanoacetates using organoiron complexes.
No full textA general method for the synthesis of some arylated phenylsulphonylacetonitriles 6a–g, 10a, b and 16 and ethyl cyanoacetates 7a-d and 11a, b is described. Nucleophilic substitution of the cyclopentadienyliron complexes of chloroarenes 1a–g with phenylsulphonylacetonitrile 2 or ethyl cyanoacetate 3 in the presence of potassium carbonate in DMF, at room temperature under a nitrogen atmosphere gave cyclopentadienyliron complexes of arylated phenylsulphonylacetonitriles 4a–g, 8a, b and 15 and ethyl cyanoacetates 5a–d and 9a, b in very good yields (71–94%). Photolysis of these complexes liberated the arenes (70–91%). To demonstrate the versatility of this methodological approach, reactions of both carbon nucleophiles 2, 3 with dimethyl chlorobenzene complexes 1h, j gave the desired products 8a, 9a, 12 and 13 without significant steric effect. This synthesis is advantageous over all those previously reported and should be a practical route to a variety of alkanoic acid and heterocyclic precursors
1950 U.S.Census Idaho, Steven B. Perkins and Steven D. Perkins
No full textText document crop of 1950 U.S. Census, Idaho, Steven B. Perkins and Steve D. Perkin
Perkins, D. C.
No full textPhotograph from the C.R. Savage Portrait Studio. Name associated with the photograph: D. C. Perkin
Enantioselective Synthesis Of A-hydroxysilanes By Bioreduction Of Aroyltrimcthylsilanes
No full textAromatic acylsilanes [Ar-CO-SiMe3; Ar = C6H5,4-ClC6H4, 2-, 3- and 4-OMeC6H4, 3,4-(OMe)2C6H3 and 3,4-OCH2OC6H3] were reduced by baker's yeast to optically active a-silyl alcohols in 20-70% yield and 43-88% ee. Comments are made on the influence of silicon in this bioreduction reaction. © The Royal Society of Chemistry 1999.2131333137Fleming, I., A. Barbero and D. Walter, Chem. Rev., , 1997, 97, 2063Chan, T.H., And D. Wang, Client. Rev., , 1992, 92, 995Crump, R.A., I. Fleming, J. H. M. Hill, D. Parker, N. L. Reddy and D. Waterson,./ Chem. Soc., Perkin Trans, , . /, 1992, 3277Bassindale, A.R., A. G. Brook, P. F. Jones and J. M. Lennon, Can. J. Chem., , 1975, 53, 332Buynak, J.D., J. B. Strikland, T. Hurd and A. Pan, J. Chem. Soc., Chem. Commun., , 1989, 89Buynak, J.D., J. B. Strikland, G. W. Lamb, D. Khasnis, S. Modi, D. Williams and H. Zhang, J. Org. Chem., , 1991, 56, 7076Sakaguchi, K., H. Mano and Y. Ohfune, Tetrahedron Lett., , 1998,39,4311Soderquist, J.A., C. L. Anderson, E. I. Miranda and I. Rivera, Tetrahedron Lett., , 1990,31,4677MacLeod, R., H. Presser, L. Fikentscher, J. Lanyi and H. S. Mosher, Biochemistry, , 1964,3,838Czuc, R., Glanzer, B., Chem. Rev., , 1991, 91, 49Yamazaki, Y., Kobayashi, H., Chem. Express, , 1993,8, 97Corey, E.J., Seebach, D., Angew. Chem., Int. Ed. EngL, , 1965, 4, 1075Brook, A.G., J. M. DufT, P. F. Jones and N. R. Davis, J. Am. Chem., , Soc., 1967, 89, 431Corey, E.J., D. Seebach and R. Freedman, J. Am. Chem. Soc., , 1967,89,434Sorrilha, A.E.P., M. Marques, I. Joekes, P. J. S. Moran and J. A. R. Rodrigues, BioMed. Chem. Lett., , 1992, 2, 191Kreutz, O.C., P. J. S. Moran and J. A. R. Rodrigues, Tetrahedron, , Asymmetry, 1997, 8, 2649Trost, B.M., J. L. Belletire, S. Godleski, G. J. D. Peddle, N. V. Schwanz and C. M. Warner, J. Org. Chem., , 1986,51,2370Biernbaum, M.S., Mosher, H.S.J., J. Org. Chem., , 1971,36,3168J. Am. Chem. Soc., , 1971,93,6221Eichberger, G., K. Faber and H. Griengl, Monatsh. Chem., , 1985, 116, 1233Wendhausen, R., P. J. S. Moran, I. Joekes and J. A. R. Rodrigues, J. Mol. Catal. B: Enzym., , 1998, 5, 69Brook, A.G., Adv. Organomel. Cliem., , 1968, 7, 95Brook, A.G., M. A. Quigley, G. J. D. Peddle, N. V. Schwartz and C. M. Warner, J. Am. Chcm. Soc., , 1960, 82, 5102Page, P.C.B., S. S. Klair and S. Rosenthal, Chcm. Soc. Rc\:, 1990, 19, 147A. Ricci and A. Degl'Innocenti, , Synthesis, 1989, 647Cirillo, P.F., Panek, J.S., Tetrahedron Lett., , 1991,32,457Fleming, I., In Comprehensive Organic Chemistry, Ed. D. Barton and W. D. Ollis, Pergamon Press, Oxford, , 1979, vol. 3, p. 541Squillacoteand, M.E., Neth, J.M., / Am. Chcm. Soc., , 1987,109,198Kitching, W., H. A. Olszowy and G. M. Drew, J. Org. Chcm., , 1982, 47,5155Prelog, V., Pure Appl. Chem., , 1964, 9, 119Benner, S.A., E444xperientia, , 1982,38, 633P. Deslongchamps, Stereoelectronic Effects in Organic Chemistry, Pergamon Press, Oxford, 1983, p. 340Linderman, R., Ghannam, A., J. Am. Chem. Soc., , 1990, 112, 2392Linderman, R.J., A. Ghannam and I. Badejo, J. Org. Chem., , 1991, 56,5213Brook, A.G., J. Am. Chem. Soc, , 1958,80, 1886Yamamoto, K., S. Suzuki and J. Tsuji, Tetrahedron Lett., , 1980, 21, 1653Capperucci, A., A. Degl'Innocenti, C. Facgi and A. Ricci, J. Org. Chem., 1988,53,3612.Seebach, D., H. F. Leitz and V. Ehrig, Chem. Der., 1975,108, 1924
Structural studies of saccharides and glycopeptides in aqueous solution by 1H NMR spectroscopy
No full textThe first part of this thesis describes the use of hydroxy protons for 1H NMR conformational studies of saccharides and small glycopeptide performed in aqueous solution. The conformations of the disaccharide b-D-GlcpNAc-(1®4)-b-D-GlcNAc and of the glycoside b-D-Galp-(1®3)-a-D-GalpNAc-O-Me have been investigated and compared to those of the amino acid linked counterparts b-D-GlcpNAc-(1®4)-b-D-GlcNAc-N-Asn and b-D-Galp-(1®3)-a-D-GalpNAc-O-Ser. For this, the hydroxy proton chemical shifts, vicinal coupling constants, temperature coefficients, exchange rates with water and NOEs were measured. The V[b-D-Galp-(1®3)-a-D-GalpNAc-(1®]THPGY glycopeptide was also investigated. Information about hydrogen bonding interactions and hydration could be obtained. The second part of this thesis describes the 1H NMR studies of the solution conformation of the conotoxin contulakin-G and five analogues. The five analogues had different biological activities, all being less active than contulakin-G. The conformational studies were performed in an attempt to correlate the structure to the activity. Contulakin-G is a 16 amino acid O-glycosylated glycopeptide, which originally was isolated from the venom of the Cone snail Conus geographus. It has the sequence ZSEEGGSNAT*KKPYIL with the disaccharide b-D-Galp-(1®3)-a-D-GalpNAc attached to the threonine residue in position 10. It has entered phase II clinical trials for short-term management of post-operative pain. The five analogues are the non-glycosylated peptide, one glycopeptide with the monosaccharide a-D-GalpNAc attached to Thr10, one with the disaccharide attached at Ser7, and two enantiomeric analogues where the disaccharide was attached at the L-Ser10 and D-ser10 residues, respectively. The NMR studies showed that in all compounds, the peptide predominantly existed in extended conformations. Transient populations of folded conformations were found in the glycosylated peptides. The two most active compounds, contulakin-G, and the (D-Ser10) glycosylated analogue, displayed some similar conformational features
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