1,031 research outputs found
Cisplatin-based chemotherapy of testicular cancer - Two decades after a major breakthrough
No full textTwo decades ago the introduction of cisplatin-based combination chemotherapy has dramatically improved the prognosis of patients with metastatic testicular cancer, At present 3 cycles of cisplatin, etoposide and bleomycin are considered as standard treatment for good-risk metastatic disease. Outside of clinical trials patients in the intermediate and poor prognosis categories should receive 4 cycles of this standard regimen, Clinical trials currently evaluate the role of high-dose chemotherapy in first-line treatment of high-risk patients and in the salvage setting, Post-chemotherapy resection of tumor residuals remains an important part of therapy. Attention should be focused on long-term toxicity of therapy and the occurrence of late relapse
Internet bančništvo za podjetja s poudarkom na rešitvah e-plačilnih sistemov : diplomsko delo
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Conventional gamma and high energy probe for radioguided dissection of metastases in a patient with recurrent thyroid carcinoma with Tc-99m-MIBI and F-18-FDG
No full textConventional gamma and high energy probe for radioguided dissection of metastases in a patient with recurrent thyroid carcinoma with Tc-99m-MIBI and F-18-FDG
No full textIdentification of the proton M1 spin-flip transition in
No full textThe lifetime 146+13−16 fs of the excited state of 87Rb at 845 keV was measured by the Doppler-shift attenuation method (DSAM). It corresponds to a reduced transition strength of B(M1)⏐↓⏐=0.644+0.075−0.053 μ2N=0.36+0.04−0.03 W.u. for the M1 transition to the 32− ground state. Comparison to the value of B(M1)↑⏐=0.34(5) μ2N measured previously in (γ,γ′) [Käubler et al., Phys. Rev. C 65, 054315 (2002)] pins down the spin assignment Jπ=12− to the excited state at 845 keV. Together with its known angular momentum quantum number l=1, the 12−→32− transition can be identified as the proton 2p1/2→2p3/2 spin-flip transition
Ritzenthaler, Edward Jack (Birth, 1881-02-08)
No full textAddress: 54 Clay St.852/Pg 89/1881/M W/Ger./Gerl/Mrs. Becker, Mid.Original record filed in drawer labeled 'RIS-ROBINSON, J'
Dell, Oscar Martin (Birth, 1885-06-28)
No full textAddress: Pulte - N. Fairmount3513/Pg 204/1885/M W/Ger./Gerl/Rosalie Alex, Mid.Original record filed in drawer labeled 'DEAN, J-DELM'
A single EGF-like motif of laminin is responsible for high affinity nidogen binding
No full textA major nidogen binding site of mouse laminin was previously localized to about three EGF-like repeats (Nos 3-5) of its B2 chain domain III [M. Gerl et al. (1991) Eur. J. Biochem., 202, 167]. The corresponding cDNA was amplified by polymerase chain reaction and inserted into a eukaryotic expression vector tagged with a signal peptide. Stably transfected human kidney cell clones were shown to process and secrete the resulting fragment B2III3-5 in substantial quantities. It possessed high binding activity for recombinant nidogen in ligand assays, with an affinity comparable with that of authentic laminin fragments. In addition, complexes of B2III3-5 and nidogen could be efficiently converted into a covalent complex by cross-linking reagents. Proteolytic degradation of the covalent complex demonstrated the association of B2III3-5 with a approximately 80 residue segment of nidogen domain G3 to which laminin binding has previously been attributed. The correct formation of most of the 12 disulfide bridges in B2III3-5 was indicated from its protease resistance and the complete loss of cross-reacting epitopes as well as of nidogen-binding activity after reduction and alkylation. Smaller fragments were prepared by the same recombinant procedure and showed that combinations of EGF-like repeats 3-4 and 4-5 and the single repeat 4 but not repeats 3 or 5 possess full nidogen-binding activity. This identifies repeat 4 as the only binding structure. The sequence of repeat 4 is well conserved in the human and in part in the Drosophila laminin B2 chain.(ABSTRACT TRUNCATED AT 250 WORDS
Gamma-ray angular distribution in Coulomb excitation experiments at intermediate energies as a signature of electromagnetic and nuclear forces in peripheral collisions
No full textIn Coulex experiments at intermediate beam energies be sides electromagnetic forces the nuclear interaction may occur. These two excitation mechanisms result in emission of gamma-rays with a characteristic angular distribution W(theta). Measurement of W(theta) was performed at the RISING fast beam set-up to probe the electromagnetic-nuclear interface. Unexpectedly large hadronic-like contribution was observed when high Z projectiles were used
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