102,546 research outputs found
Sixty Years of Community: St. Olaf Catholic Parish in Eau Claire, Wisconsin, 1952-2012
No full textThis paper will explore how the parish community of St. Olaf in Eau Claire, Wisconsin, established in 1952, reflects the Roman Catholic Church, specifically at the local, state, and national levels in the United States. It will also discuss the various changes that have occurred in the past 60 years of its history in terms of the various locations of worship for the members, the growth of the community outreach programs, and the effects of the Second Vatican Council. This ecumenical council was a meeting of Catholic bishops from around the whole that brought reform to the Catholic Church and affected the relationship of the Catholic Church to the world. The parish at St. Olaf has grown from having only 125 families in 1952 to over 1,000 families in 2012
Screening of DTP Compound Libraries for CK2 Inhibitors with Focus on Natural Products
No full textVarious compound libraries of the Drug Therapeutic Program (DTP) of the NIH/NCI were screened against the catalytic subunit and the tetrameric holoenzyme of protein kinase CK2. Different IC50 values were obtained for the two CK2 molecules. In the case of nortangeretin, the IC50 value was 0.34 μM for the catalytic subunit and 15 μM for the holoenzyme. In the case of coumestrol, opposite results were obtained, i.e., high IC50 for the CK2α subunit (2.7 μM) and a lower IC50 value for the holoenzyme (0.19 μM). From the many compounds identified to inhibit CK2, we have selected 14 different compounds and listed them according to their CK2α/CK2 holoenzyme IC50 ratio. Four compounds were tested on a panel of seven cell lines revealing considerable differences in the degree of CK2 inhibition inside the cells.</p
Dissection of the dual function of the β-subunit of protein kinase CK2 (‘casein kinase-2’): a synthetic peptide reproducing the carboxyl-terminal domain mimicks the positive but not the negative effects of the whole protein
No full textThe dual function of the regulatory beta-subunit of protein kinase CK2 is highlighted by its ability to abolish calmodulin phosphorylation in contrast to its stimulatory effect on the phosphorylation of peptide substrates, Here we show that a synthetic peptide reproducing the C-terminal region of the beta-subunit (beta[170-215]) stimulates to a similar extent the phosphorylation of either the peptide substrate or calmodulin and also protects the catalytic alpha-subunit against thermal inactivation as efficiently as full-length beta-subunit. These data show that the positive and negative functions of the beta-subunit reside in physically separated domains and that the elements responsible for positive regulation are located in the C-terminal region
Northern Rover: The Life Story of Olaf Hanson
No full textFrom 1919 to 1970, Olaf Hanson was a trapper, fur trader, prospector, game guardian, fisherman, and road blasting expert in northeastern Saskatchewan. He told his life story to popular Saskatchewan author A. L. Karras, who wrote this historical memoir in the 1980s. In an uncompromising, straightforward style, Karras and Hanson reveal the geography, wildlife, natural history of the region as well as the business and social interactions between people. Their book offers a look at the vanished subsistence and commercial economy of the boreal forest, wound around a fascinating personal story of courage and physical stamina
Northern Rover: The Life Story of Olaf Hanson
No full textFrom 1919 to 1970, Olaf Hanson was a trapper, fur trader, prospector, game guardian, fisherman, and road blasting expert in northeastern Saskatchewan. He told his life story to popular Saskatchewan author A. L. Karras, who wrote this historical memoir in the 1980s. In an uncompromising, straightforward style, Karras and Hanson reveal the geography, wildlife, natural history of the region as well as the business and social interactions between people. Their book offers a look at the vanished subsistence and commercial economy of the boreal forest, wound around a fascinating personal story of courage and physical stamina
Synthesis of Triazenoazaindoles: a New Class of Triazenes with Antitumor Activity
No full textDespite improvements in the treatment and prevention of cancer, the number of new diagnoses continues to rise; this has fuelled substantial interest in the development of new and effective chemotherapeutic agents. Compounds of the triazene class, such as dacarbazine, have been used in the clinical management
of many cancer types including brain, leukemia, and melanoma. A new compound class bearing a triazenoazaindole
scaffold was synthesized with the aim of identifying new antiproliferative
agents. Compounds 5a–g and 6a–c were
screened against a panel of human tumor cell lines, and two of them, 5e and 5 f, showed cytotoxicity (GI50 range: 2.2–8.2 mm) in all cell lines. These two compounds even maintained their cytotoxicity in some multidrug-resistant cell lines. Flow cytometry analysis demonstrated their ability to induce cell death by apoptosis with involvement of lysosomes
Portrait of author Olaf Ruhen, Bathurst, New South Wales, 1975 [picture] /
No full textTitle from inscription.; Inscription: 'Author Olaf Ruen [i.e. Ruhen], Bathurst, NSW, 1975"--Lower left.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3697108; Purchased from the photographer, 2006
Analysing the performance of the OLAF framework in the context of identifying music in movies
No full textThis paper presents the findings of a benchmark performed on the audio fingerprinting framework OLAF in the context of movie music. The goal is to find a music identification framework suitable for automatically identifying a song from a movie clip. This research aims to find how well OLAF performs in this context with regard to the criteria determined in the benchmark and to see if the performance can be increased. The OLAF framework makes use of parameters, which are individually tweaked and benchmarked with synthesised data. These findings are then combined to find a set of parameters that is used to perform this same benchmark on real clips from movies. The found parameter setup slightly increased the performance, going from 1 true positive and 133 false negatives in the original setup to 5 true positives, 3 false positives and 126 false negatives.CSE3000 Research ProjectComputer Science and Engineerin
Análisis de Erwin Olaf y sus series fotográficas
No full textErwin Olaf es un autor dedicado tanto a la fotografía, como a la creación de vídeos y a la publicidad. A través de un estudio de este polémico fotógrafo, podremos conocer su vida, obra y técnica.
Este trabajo, que incluye una breve introducción a su obra mediante su biografía y evolución artística, se centra sobre todo en el análisis de sus series personales dentro del gran abanico de proyectos que el autor lleva a cabo, y en relación a esas series, se detallarán otros elementos técnicos de gran importancia como la iluminación, la composición, las poses, la importancia del color o la del Photoshop y el significado de la serie en sí, que tendrá mucho que ver con las vivencias de Olaf.
Tras el estudio teórico, se presenta una interpretación de sus fotografías mediante cuatro series. Estas series de cosecha propia estarán basadas en otras cuatro de Erwin Olaf que se convirtieron en un punto de inflexión en la trayectoria de su obra, tanto artísticamente como en el aspecto más técnico.Erwin Olaf is an author dedicated to photography, videos and advertising. Through a study of this controversial photographer, we can know his life, work and technique.
This work, which includes a brief introduction to his work through his biography and artistic development, focuses mainly on the analysis of their personal series within the wide range of projects that the author carried out, and in relation to such series, will detail other important technical elements such as lighting, composition, poses, the importance of color or Photoshop and significance of the series itself, which have much to do with the experiences of Olaf.
After the theoretical study, an interpretation of his photographs is presented through four series. My series will be based on four more of Erwin Olaf became a turning point in the course of his work, both artistically and in the technical aspect.Grado en Comunicación Audiovisual. Universidad de Extremadur
The location of OLAF in the multi-level governance system
No full textAutor opracowania stawia sobie za cel zbadanie usytuowania OLAF-u w systemie wielopoziomowego
zarządzania UE (Multi-level Governance – MLG) wraz z określonymi interinstytucjonalnymi
zależnościami i konsekwencjami takiego usytuowania, przy założeniu, że OLAF
nie jest klasyczną instytucją ponadnarodową. Skoro OLAF jako agent i supervisor posiada
kompetencje kontrolne nad instytucjami ponadnarodowymi, w tym nad swoim mocodawcą,
jakim jest ponadnarodowa Komisja Europejska, to mało prawdopodobne jest, aby był także
instytucją ponadnarodową.
W badaniach wykorzystano dwa narzędzia teoretyczno-metodologiczne: Principal/Agent
Theory oraz Principal/Supervisor/Agent Theory.The author of the study aims to investigate the location of OLAF in the multi-level governance
system (MLG) of the European Union with specific interinstitutional consequences of
such location, assuming that OLAF is not a classical supranational institution. If OLAF as an
agent and supervisor has control powers over supranational institutions, including its principal,
a supranational European Commission, it is unlikely that it would also be a supranational institution.
Two theoretical and methodological tools were used in this research: Principal/Agent Theory
and Principal/Supervisor/Agent Theory
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