6 research outputs found
Development of a Reliable and Efficient 3D Calculation Model of a High-Rise Building Under Seismic Loading
No full textThis thesis research focusses on the development of a reliable and efficient 3D calculation model of an existing high-rise, reinforced concrete building in the Groningen area, in order to analyse the dynamic behaviour of the existing and subsequently retrofitted main bearing structure of this high-rise building. The assessment of the existing building is performed through a Non-Linear Time History analysis in Simulia Abaqus, in which cracking of concrete and yielding of reinforcement is taken into account. Multiple NLTH analyses are performed for optimisation of the 3D model in order to obtain correct results with a minimum amount of calculation costs. This optimisation process results in a clear understanding of the dynamic behaviour of the building and the main sensitivities of the model. The 3D model is verified by means of a simplified 1D beam type model, developed and analysed with the software package Matlab. This 1D model consists of three elements, corresponding to the three main structural parts of the building. Next to this, a ‘modal response spectrum analysis’ is performed for verification of the 3D model results.The seismic assessment of the building is performed according to the Near Collapse criterion of the NPR. The results show that the building meets this criterion, based on one record of the NPR. Since at least seven various records should be applied, it is possible that the building does not meet the Near Collapse criterion for one of these records. Also from a structural point of view, it is interesting to develop and analyse strengthening possibilities for this specific building. therefore, three strengthening proposals are developed and initially analysed with the 1D model in Matlab.Civil Engineerin
Approaches to Multispectral Real-Time Object Detection and Tracking with an Electro-Optical Surveillance System
No full textDe begeleider en/of auteur heeft geen toestemming gegeven tot het openbaar maken van de scriptie.
The supervisor and/or the author did not authorize public publication of the thesis.
Maternal and Early-Life Exposure to Antibiotics and the Risk of Autism and Attention-Deficit Hyperactivity Disorder in Childhood: a Swedish Population-Based Cohort Study
No full textIntroductionAntibiotics represent the most common type of medication used during pregnancy and infancy. Antibiotics have been proposed as a possible factor in changes in microbiota composition, which may play a role in the aetiology of autism and attention deficit/hyperactivity disorder (ADHD). Our aim was to investigate the association between maternal and early-life antibiotic use and autism and ADHD in childhood.MethodsThis Swedish nation-wide population-based cohort study included all first live singleton births (N = 483,459) between January 2006 and December 2016. The association of dispensed antibiotics with autism and ADHD in children aged = 1 antibiotic during the exposure period (from 3 months pre-conception to delivery), and 41.6% (n = 201,040) of the children received >= 1 antibiotic in early life (aged <= 2 years). Penicillin was the most prescribed antibiotic class (17.9% of mothers, 38.2% of children). Maternal antibiotic use was associated with an increased risk of autism [odds ratio (OR) = 1.16, 95% confidence interval (CI) 1.09-1.23] and ADHD (OR = 1.29, 95% CI 1.21-1.36) in childhood. Early-life exposure to antibiotics showed an even stronger association [autism (OR = 1.46, 95% CI 1.38-1.55); ADHD (OR = 1.90, 95% CI 1.80-2.00)]. Both maternal and childhood-exposure sub-analyses suggested a dose-response relationship.ConclusionMaternal and early-life antibiotic use was associated with an increased risk of autism and ADHD in childhood. However, differences were noted by exposure period and antibiotic classes. Plain Language SummaryAntibiotics are commonly prescribed to pregnant women, infants, and toddlers. Antibiotic use during pregnancy may alter the maternal microbiota, which can influence the microbial colonisation of the gastrointestinal system of the foetus. It has been claimed that antibiotic use during pregnancy may have an effect on the gut-brain axis and, as a result, neurodevelopment. Neurodevelopmental disorder (NDD) is a category of illnesses characterised by functional impairments that manifest early in development. The most frequent NDDs are autism and attention-deficit/hyperactivity disorder (ADHD). In this large Swedish nation-wide study, we assessed whether antibiotic use during pregnancy and/or early in life affects the risk of developing autism and ADHD. The study found that both maternal antibiotic usage, as well as early childhood antibiotic use, were associated with an increased risk of autism and ADHD in children. These associations were altered by the quantity, type, and timing of antibiotic exposure.Romina Fornes received funding from the "National Commission for Scientifc and Technological Research". CONICYT, scholarship program “Becas Chile, Postdoctorado en el extranjero”. RB was funded as a postdoctoral researcher by the Research Foundation—Flanders (FWO: 2019–2021, 12I6319N). We wish to acknowledge our gratitude to the thousands of people, physicians, and health care workers who contributed to the data collection, and the National Board of Health and Welfare for collecting the data
Psychiatrische aandoeningen bij mucoviscidose: een overzicht
No full textDe gemiddelde levensverwachting van patiënten met mucoviscidose is de laatste twintig jaar sterk toegenomen Dit leidt niet automatisch tot een even grote toename van de levenskwaliteit De intensieve therapieën en de beperkingen die de ziekte meebrengt vragen een sterke psychosociale aanpassing van de patiënt en zijn omgeving.
In dit artikel wordt het voorkomen van psychiatrische aandoeningen bij patiënten met mucoviscidose beschreven Er is hierover veel inconsistentie in de literatuur Veel heeft te maken met de methodologie van de studies Als algemeen besluit kan gesteld worden dat het psychosociale functioneren van de patiënten vrij gelijklopend is met dat van de algemene bevolking tot de ziekte ernstiger wordt Toch is er evidentie dat de prevalentie van een aantal psychiatrische symptomen en stoornissen significant gestegen is Er is een duidelijke evolutie in de aard van de psychiatrische symptomatologieën volgens de leeftijdscategorie Bij kinderen komen voornamelijk gedragsstoornissen en een verstoord eetgedrag voor Bij adolescenten en volwassenen is voornamelijk het voorkomen van angstsymptomen en klinische depressies significant verhoogd in vergelijking met de algemene bevolking evenals de symptomen passend bij atypische eetstoornissen.
Ook het opvolgen en behandelen van de geestelijke gezondheid zou dus deel moeten uitmaken van de totale aanpak van de ziekte
Kirmen Uribe and Translation: An endless journey.
No full textAssuming that Kirmen Uribe is a social agent in the sub- field of Basque literature in translation, this work analyses the translator’s translation habitus, basing its analysis on the sociological foundations of translation. Consequently, the Ondarroa writer’s ideas about, perceptions of and attitudes towards translation are examined, as well as his reflections on his translation experiences. Likewise, following the line of research in translation studies termed “fictional turn”, there will be an explanation of how Uribe represents his translation habitus by means of the principal character/ translator in the novel Mussche. In order to do so, use is made of a personal interview with the author, his texts and articles by various translators about their experience in the translation process, as well as questionnaires that some of these translators filled out for this analysis. We will go over the relationship of the texts translated by Uribe, as well as his reason for doing so, how he has participated in translating his texts, in which form he puts himself and relates as a Basque writer by means of translation (at home and abroad), which positions both he and his translators adopt as regards bridge languages and what they contribute to the writer- translator relationship. It is worth highlighting that both the author and his translators emphasise the human side of the relationship, and that is, precisely, one of the questions which stands out in the novel Mussche; we will, therefore, try to describe the reflection of reality and fiction.Paper prepared within the projects IT 1047-16 (Basque government) and FFI2017-84342-P (MINECO) developed by the level A consolidated research group MHLI (Memoria Historikoa Literatura Iberiarretan / Memoria Histórica en las Literaturas Ibéricas / Historical Memory in Iberian Literatures)
Maternal and early-life exposure to antibiotics and the risk of autism and attention-deficit hyperactivity disorder in childhood : a Swedish population-based cohort study
No full textAbstract: IntroductionAntibiotics represent the most common type of medication used during pregnancy and infancy. Antibiotics have been proposed as a possible factor in changes in microbiota composition, which may play a role in the aetiology of autism and attention deficit/hyperactivity disorder (ADHD). Our aim was to investigate the association between maternal and early-life antibiotic use and autism and ADHD in childhood.MethodsThis Swedish nation-wide population-based cohort study included all first live singleton births (N = 483,459) between January 2006 and December 2016. The association of dispensed antibiotics with autism and ADHD in children aged = 1 antibiotic during the exposure period (from 3 months pre-conception to delivery), and 41.6% (n = 201,040) of the children received >= 1 antibiotic in early life (aged <= 2 years). Penicillin was the most prescribed antibiotic class (17.9% of mothers, 38.2% of children). Maternal antibiotic use was associated with an increased risk of autism [odds ratio (OR) = 1.16, 95% confidence interval (CI) 1.09-1.23] and ADHD (OR = 1.29, 95% CI 1.21-1.36) in childhood. Early-life exposure to antibiotics showed an even stronger association [autism (OR = 1.46, 95% CI 1.38-1.55); ADHD (OR = 1.90, 95% CI 1.80-2.00)]. Both maternal and childhood-exposure sub-analyses suggested a dose-response relationship.ConclusionMaternal and early-life antibiotic use was associated with an increased risk of autism and ADHD in childhood. However, differences were noted by exposure period and antibiotic classes. Plain Language SummaryAntibiotics are commonly prescribed to pregnant women, infants, and toddlers. Antibiotic use during pregnancy may alter the maternal microbiota, which can influence the microbial colonisation of the gastrointestinal system of the foetus. It has been claimed that antibiotic use during pregnancy may have an effect on the gut-brain axis and, as a result, neurodevelopment. Neurodevelopmental disorder (NDD) is a category of illnesses characterised by functional impairments that manifest early in development. The most frequent NDDs are autism and attention-deficit/hyperactivity disorder (ADHD). In this large Swedish nation-wide study, we assessed whether antibiotic use during pregnancy and/or early in life affects the risk of developing autism and ADHD. The study found that both maternal antibiotic usage, as well as early childhood antibiotic use, were associated with an increased risk of autism and ADHD in children. These associations were altered by the quantity, type, and timing of antibiotic exposure
