35,275 research outputs found
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings
No full textCharacterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or domains linked by short, potentially flexible, sequences of amino acid residues. The use of NMR-derived residual dipolar couplings (RDCs), in magnetically aligned media, to evaluate interdomain motion is established but only for two-domain proteins. We focused on the three N-terminal domains (called CCPs or SCRs) of the important complement regulator, human factor H (i.e., FH1-3). These domains cooperate to facilitate cleavage of the key complement activation-specific protein fragment, C3b, forming iC3b that no longer participates in the complement cascade. We refined a three-dimensional solution structure of recombinant FH1-3 based on nuclear Overhauser effects and RDCs. We then employed a rudimentary series of RDC data sets, collected in media containing magnetically aligned bicelles (disklike particles formed from phospholipids) under three different conditions, to estimate interdomain motions. This circumvents a requirement of previous approaches for technically difficult collection of five independent RDC data sets. More than 80% of conformers of this predominantly extended three-domain molecule exhibit flexions of <40°. Such segmental flexibility (together with the local dynamics of the hypervariable loop within domain 3) could facilitate recognition of C3b via initial anchoring and eventual reorganization of modules to the conformation captured in the previously solved crystal structure of a C3b:FH1-4 complex.</p
Microvelia isa ZETTEL 2012
No full textMicrovelia isa ZETTEL, 2012 PHL P h i l i p p i n e n: Northern Mindanao, Camiguin, Mambajao/ Dagoocan Spring, 2 Ex., 14.II.2007, leg. Zettel H.Published as part of Heiss, Ernst, Eckelt, Andreas, Lederwasch, Manfred & Unterasinger, Romed, 2022, Die Heteropterensammlung Ernst Heiss im Tiroler Landesmuseum Ferdinandeum. Teil IX: Gerromorpha II: Familien Mesoveliidae, Hebridae, Hydrometridae, Hermatobatidae, Veliidae, pp. 149-173 in Linzer biologische Beiträge 54 (1) on page 156, DOI: 10.5281/zenodo.750725
EF EK P EMB ER IA N EK ST R A K D A U N SIN G K O N G ( Mani ho t escul ent a ) T E R H A D A P P R O SE S P E N Y E MB U H A N L U K A G I N G I V A T I K U S (R at t us norv egi cus )
No full textLuka yang timbul akibat perawatan jaringan lunak dan jaringan keras rongga
mulut diharapkan dapat sembuh secara fisiologis dengan melalui beberapa fase
penyembuhan luka. Proses ini dimulai dari munculnya sel-sel radang sebagai tanda
inflamasi, diikuti adanya perbaikan jaringan ikat dan akhirnya terbentuk epitel baru
yang menutupi daerah luka. Luka di rongga mulut sering mengganggu serta
menimbulkan rasa tidak nyaman. Luka tersebut seringkali terbuka karena letaknya
yang sulit dijangkau sehingga penanganannya sulit. Luka yang terbuka rentan terkena
kontaminasi bakteri dapat menaikkan respon sel radang sehingga inflamasi menjadi
semakin lama dan penyembuhan luka terhambat. Oleh karena itu, dicari upaya untuk
menekan fase inflamasi agar luka segera mengalami proses penyembuhan.
Obat kimia yang digunakan sebagai standar penilaian efek obat sejenis
antiinflamasi adalah Aspirin. Aspirin merupakan derivat asam salisilat yang memiliki
efek luas sebagai antiinflamasi, analgesik dan antipiretik. Aspirin dan derivat - derivat
asam salisilat yang lain memiliki efek samping terhadap organ dalam tubuh. Hal ini
yang mendasari pencarian bahan-bahan alami sebagai obat. Salah satu tanaman obat
yang telah lama digunakan masyarakat adalah daun singkong (Manihot esculenta).
Tujuan penelitian ini adalah untuk mengetahui potensi pemberian ekstrak daun
Singkong (Manihot esculenta) dalam meningkatkan proses penyembuhan luka
gingiva tikus. Penelitian merupakan penelitian jenis eksperimental laboratoris dengan
rancangan penelitian the posttest only control group design. Hewan coba yang
digunakan dalam penelitian ini adalah tikus Wistar jantan berjumlah 27 ekor yang
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Fully Turbulent Mean Velocity Profile for Purely Viscous non-Newtonian Fluids
No full textThe characteristic near wall behavior of turbulent flow of purely-viscous non-Newtonian fluids is discussed for both power-law (P.-L.) and Herschel-Bulkley (H.-B.) rheological models. A proper scaling is presented for H.-B. fluids to establish an analogy with power-law fluids with same flow index. To provide reference data for turbulent flow of non-Newtonian fluids, DNS simulations of power-law fluids are conducted in a rectangular channel for a large range of power-law indices ( = 0.5, 0.69, 0.75, 0.9, 1, 1.2). The DNS data show that the mean velocity profile in the viscous and logarithmic layers follow expressions of the form and respectively, where shows a logarithmic dependency on the flow index.Comparison with some experimental data shows the above formulation to be valid for Reynolds numbers (based on shear velocity) as high as 1000
Loss of <i>sema3fb</i> disrupts ISA migration.
No full textA) Lateral confocal time-lapse images from 25–29 hpf double transgenic Tg(kdrl:mCherry;fli1a:nEGFP) endothelial cells (magenta) and nuclei (white). The location of the horizontal myoseptum (green dashed line) and DLAV (blue dashed line) are noted to highlight ISA growth over time. Scale bar, 50 μm. B) Average ISA Sprout Length at 30-minute intervals from 25–29 hpf: WT vs sema3fbca305 at 25.0 hpf, p = 0.474; at 25.5 hpf p = 0.262; at 26.0 hpf p = 0.081; at 26.5 hpf *p = 0.023; at 27.0 hpf *p = 0.020; at 27.5 hpf **p = 0.030; at 28.0 hpf **p = 0.008; at 28.5 hpf **p = 0.007; at 29.0 hpf *p = 0.024. C-E) Quantification of ISA migration speeds (μm/min). C) At 26–27 hpf WT = 0.15 μm/min and sema3fbca305 = 0.12 μm/min, p = 0.157. D) At 27–28 hpf WT = 0.19 μm/min and sema3fbca305 = 0.13 μm/min, *p = 0.020. E) At 28–29 hpf: WT = 0.16 μm/min and sema3fbca305 = 0.19 μm/min, p = 0.461. B-E) N = 2; WT = 7 embryos (n = 33 ISAs) and sema3fbca305 = 7 embryos (n = 35 ISAs), Unpaired t-test with Welch’s correction. F-H) Lead angioblast distance from DA at 1hr intervals. F) At 27 hpf mean distance from DA: WT = 55.12±14.06 μm and sema3fbca305 = 47.18±5.75 μm, *p = 0.030. G) At 28 hpf mean distance from DA: WT = 71.57±15.47 μm and sema3fbca305 = 55.47±9.65 μm, ***p = 0.0008. H) At 29 hpf mean distance from DA: WT = 85.19±18.03 μm and sema3fbca305 = 68.36±16.64 μm, **p = 0.008. F-H) N = 1: WT = 4 embryos (20 ISAs) and sema3fbca305 = 3 embryos (15 ISAs), Unpaired t-test with Welch’s correction. I) Lateral confocal images of 30hpf double transgenic Tg(kdrl:mCherry;fli1a:nEGFP) endothelial cells (ECs, magenta) and nuclei (white). EC nuclei clumps (blue arrows/arrowheads) are noted. Scale bar, 100 μm. Inset: Schematics show method for measuring distance between EC nuclei and highlight EC nuclei clumps in ISAs. J) Number of EC nuclei (angioblasts) per ISAs at 30 hpf. WT (mean of 3 nuclei/ISA), heterozygous (het) sema3fbca305/+ (3 nuclei/ISA), and homozygous (hom) sema3fbca305 (3 nuclei/ISA). K) Quantification of inter-endothelial nuclei spacing per ISA at 30 hpf. WT (mean 28±13 μm), het sema3fbca305/+ (23±13μm), and hom sema3fbca305 (22±14 μm), ***p = 0.0002 and ****p2), het sema3fbca305/+ (mean 60±24 μm2), and hom sema3fbca305 (mean 56±23 μm2),**p = 0.0069 and ****psema3fbca305/+ = 19 embryos (n = 190 ISAs), and homsema3fbca305 = 11 embryos (n = 110 ISAs),. 2-Way ANOVA Tukey’s multiple comparisons test Error bars = ±SD.</p
A Detailed Analysis of Contemporary ARM and x86 Architectures
No full textRISC vs. CISC wars raged in the 1980s when chip area and processor design complexity were the primary constraints and desktops and servers exclusively dominated the computing landscape. Today, energy and power are the primary design constraints and the computing landscape is significantly different: growth in tablets and smartphones running ARM (a RISC ISA) is surpassing that of desktops and laptops running x86 (a CISC ISA). Further, the traditionally low-power ARM ISA is entering the high-performance server market, while the traditionally high-performance x86 ISA is entering the mobile low-power device market. Thus, the question of whether ISA plays an intrinsic role in performance or energy efficiency is becoming important, and we seek to answer this question through a detailed measurement based study on real hardware running real applications. We analyze measurements on the ARM Cortex-A8 and Cortex-A9 and Intel Atom and Sandybridge i7 microprocessors over workloads spanning mobile, desktop, and server computing. Our methodical investigation demonstrates the role of ISA in modern microprocessors? performance and energy efficiency. We find that ARM and x86 processors are simply engineering design points optimized for different levels of performance, and there is nothing fundamentally more energy efficient in one ISA class or the other. The ISA being RISC or CISC seems irrelevant
Konsep Tasawuf Abdurrahman Al-Tha’alibi dalam Tafsir Al-Jawa>hir Al-H{isa>n fi> Tafsi>r al-Qur’a>n
No full textThis article discusses some of the Sufism concepts, al-walayah, al-khalwah, al-dhikr, al-tafakkur and al-tawakkal according to Al-Tha'alibi, Muslim scholar from Algeria in the 8th and 9th centuries in Tafsi>r Al-Jawa>hir al-H{isa>n fi> Tafsi>r al-Qur'a>n. Using the descriptive-analytic method, this literature study found that Al-Tha'alibi in his tafsir in interpreting the verses was influenced by Sufi scholars who supported the Sunni Sufi concept, namely the Sufi way of life guided by al- Qur`an, Hadith, and the journey of life of the Companions and Salaf al-Ummah. As a Sufi and 'a>lim fi> al-di>n, Al-Tha'alibi certainly practiced the Sufi life patterns according to what he believed, namely the Sunni Sufi which was different from the Sufi understanding practiced by the majority of the Algerian population at that time which was considered to have come out of many demands Islam. It is caused by political, economic, and social conditions that are unstable and have a significant impact on the religious life of the Algerian population, especially in the understanding and practice of Sufism
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Ilyodromus stanleyanus King 1855, n. sp.
No full textIlyodromus stanleyanus (King, 1855) (Figs 2–4) * 1855 Candona stanleyana n. sp. —King: 66, pl. 10 fig h. nov. comb. 1889 Herpetocypris stanleyana (King) —Sars: 35, 41. nov. comb. v 1894 Ilyodromus stanleyanus (King) —Sars: 39–41, pl. 5 figs 3 a–e.Published as part of Shearn, Rylan, Halse, Stuart, Koenders, Annette, Schön, Isa & Martens, Koen, 2014, Redescriptions of six species of Ilyodromus Sars, 1894 (Crustacea, Ostracoda, Cyprididae) from New Zealand and Eastern Australia, pp. 101-145 in Zootaxa 3878 (2) on page 104, DOI: 10.11646/zootaxa.3878.2.1, http://zenodo.org/record/22745
DIALEKTIKA KENABIAN DAN KEILAHIAN ISA AL-MASIH : PERSPEKTIF TASAWUF IBN ‘ARABI
No full textIsa Al-Masih atau Yesus Kristus dalam teologi Islam maupun Kristen menjadi fokus perdebatan selama berabad-abad terkait dengan kenabian dan keilahiannya. Kenabian Isa Al-Masih yang diunggulkan dalam teologi Islam menjadi kritik atau antitesis dari keilahian Al-Masih dalam teologi Kristen. Keduanya merupakan aspek dasar dalam memahami Isa namun masih sering tidak dapat dipertemukan dikarenakan teologi Islam maupun Kristen yang cenderung dogmatis dan apologis.
Ibn ‘Arabi yang merupakan seorang sufi sekaligus teolog memiliki pandangan tersendiri terkait dengan kenabian dan keilahian Isa. Penelitian ini berpijak pada pertanyaan bagaimana konsep kenabian dan keilahian dalam tasawuf Ibn ‘Arabi. Dari keduanya akan dilihat apakah ada suatu sintesis yang mendamaikan kenabian dan keilahian Isa tersebut. Urgensi penelitian ini terletak pada sintesis konsep kenabian dan keilahian Isa Al-Masih berdasarkan tasawuf Ibn ‘Arabi yang diharapkan dapat menjadi sebuah kontribusi pemikiran tasawuf untuk menghasilkan suatu titik temu atau pandangan alternatif dalam diskursus teologi Islam-Kristen.
Hal tersebut dilakukan dengan menelaah kitab-kitab Ibn ‘Arabi yang menyinggung tentang Isa seperti Fus}u>s} al-Hikam, Futu>h}a>t al-Makkiyyah dan Tarjuma>n al-Asywa>q. Penelitian ini menggunakan pendekatan filosofis dengan metode deskriptif-analisis untuk menelaah secara dialektis kitab-kitab tersebut agar ditemukan konsep kenabian dan keilahian Isa dalam kerangka tasawuf Ibn ‘Arabi. Jika kenabian Isa berupa tesis sedangkan antistesisnya adalah keilahiannya, maka meniscayakan adanya sintesis dari keduanya. Sehingga penelitian ini sampai pada sintesis dari kenabian dan keilahian Isa Al-Masih yang digali berdasarkan tasawuf Ibn ‘Arabi tersebut.
Penelitian ini akhirnya menemukan hal-hal berikut. Pertama, tesis keilahian Isa Al-Masih menurut Ibn ‘Arabi, yakni bahwa Isa Al-Masih adalah ru>h}ullah (Roh Allah) dan kalimatullah (Firman Allah), sedangkan antitesis berupa kenabian Isa adalah ‘abdullah (Hamba Allah) dan syahi>d (Saksi). Kedua, sintesis antara kenabian dan keilahian Isa Al-Masih adalah Kha>tam al-Auliya>’ (Penutup Para Wali) yang terkait dengan konsep kewalian menurut Ibn ‘Arabi
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