1,721,016 research outputs found
AKTIFITAS HEPATOPROTEKTIF EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) DILIHAT DARI RASIO BERAT HEPAR, NILAI SGPT-SGOT, DAN HISTOPATOLOGI HEPAR PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI CCL4
Get PDFHepar merupakan organ yang berperan dalam pengaturan homeostasis tubuh meliputi metabolisme, biotransformasi, sintesis dan imunologi. Penyebab penyakit hepar bervariasi, diantaranya adalah virus, obat-obatan, alkohol dan stress oksidatif yang merupakan faktor utama. Jumlah radikal bebas yang melebihi antioksidan menyebabkan terjadinya stres oksidatif. Sidaguri (Sida rhombifolia L.) mengandung senyawa fenol dan flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek hepatoprotektif ekstrak etanol daun sidaguri (EEDS) terhadap nilai SGPT-SGOT, gambaran histopatologi hepar tikus dan rasio berat hepar yang diinduksi carbon tetrachloride (CCl4). Dua puluh lima tikus dibagi menjadi 5 kelompok. Kelompok I merupakan kelompok normal yang hanya diberi makan dan minum, kelompok II merupakan kelompok kontrol yang diinjeksi CCl4 secara intraperitoneal dengan dosis 1 mL/KgBBdan kelompok (III, IV dan V merupakan kelompok perlakuan yang diberi EEDS peroral dengan dosis: 25, 50 dan 100 mg/KgBB) berturut-turut selama 21 hari. Pada hari ke 21 kelompok ini diinjeksi CCl4 1 mL/KgBB secara intraperitoneal 1 jam setelah perlakuan. Data rasio berat organ hepar dari masing masing kelompok dianalisis secara statistik menggunakan analisis varian (ANOVA), LSD post hoc test P<0,05 untuk menentukan perbedaan signifikan. Hasil penelitian menunjukkan bahwa rasio berat hepar pada kelompok II (kontrol) 216,52±15,04 berbeda signifikan dibandingkan dengan kelompok III, IV dan V berturut turut dengan nilai 436,56± 46,78; 438,86±44,79; dan 534,46±45,49. Hal ini menunjukkan bahwa pemberian EEDS dapat menaikkan rasio berat hepar. Data ini didukung dengan nilai SGPT dan SGOT yang berbeda bermakna dengan kelompok kontrol (p<0,05). Dilihat dari gambaran histopatologi hepar, pada  kelompok  II (kontrol), III, IV dan V berturut-turut tidak  menunjukkan adanya nekrosis karena CCl4. Kesimpulan dari penelitian ini bahwa EEDS dapat melindungi hepar berdasarkan rasio berat hepar dan nilai SGPT-SGOT, namun belum dapat disimpulkan bahwa EEDS memiliki efek hepatoprotektif dilihat dari gambaran histopatologi
Trend Studi Berkaitan dengan Ulcerative Colitis dan Genomik dari Tahun 2000-2023
Get PDFUlcerative Colitis (UC) merupakan suatu inflamasi kronis yang terjadi pada saluran cerna terutama pada rectum dan kolon. Gangguan genetik seperti aktivitas dari Nuclear Factor - Kappa Beta (NF-kB) menjadi salah satu penyebab UC. Analisa bibliometrik merupakan suatu metode yang dapat digunakan untuk mengidentifikasi frekuensi dan banyaknya kutipan dari suatu jurnal. Analisa ini dapat memberikan informasi terkait kredibilitas, kualitas dan dampak dari suatu karya ilmiah. Analisis bibliometrik dilakukan menggunakan VOSViewer version 1.6.16 dan perangkat Biblioshiny R. VOSViewer dan Biblioshiny merupakan dua program software digunakan untuk membuat dan menampilkan peta bibliometrik. Hasil yang diperoleh berupa jenis dokumen jurnal dengan bahasa inggris, kata kunci yang banyak digunakan berupa Ulcerative Colitis, peningkatan publikasi terkait Genomik pada UC, Amerika Serikat menjadi Negara yang paling banyak disitasi, Frontier menjadi sumber jurnal yang paling produktif, penulis dari negara-negara maju menjadi Negara yang paling tinggi dalam kolaborasi antar Negara baik Single Country Publications (SCP) dan Multiple Country Publications (MCP) terkait studi Genomik pada Ulcerative Colitis. Trend publikasi artikel terkait Studi Genomik pada UC dari tahun 2000 sampai 2023 yang semakin meningkat menggambarkan bahwa tersebut semakin diminati dan menarik untuk diteliti
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Tracking advances in precision medicine for osteoarthritis
Get PDFOsteoarthritis (OA) is a prevalent degenerative joint disease that significantly affects the quality of life for millions of individuals globally. As research in this area continues to grow, conducting a bibliometric study becomes essential to analyse publication trends, identify key focus areas and assess the overall impact of research on OA. This study aimed to undertake a comprehensive bibliometric analysis of the existing literature on OA, emphasising the urgency of understanding current trends and advancements in this field. Utilising databases such as Scopus, the number of publications, citation metrics and collaborative networks among researchers were evaluated. Findings indicated that "osteoarthritis" was the most frequently used keyword among the 1,911 unique keywords identified in analysis. Notably, a peak in studies related to precision medicine for OA in 2023 was observed, with a total of 127 publications projected for 2024. The International Journal of Molecular Sciences emerged as the most productive journal in this domain, publishing 17 documents specifically focused on precision medicine for OA. Furthermore, the United States was identified as the most cited country in this research area, accumulating a total of 3,953 citations. Among individual articles, The Lancet was recognised as the most cited source, with its article titled "Osteoarthritis" receiving 2,648 citations, underscoring its substantial influence on both clinical practice and further research in OA. The data also highlights that the United States leads in both single country publications (SCP) and multiple country collaborations (MCP), reflecting its extensive resources and commitment to advancing precision medicine initiatives. Given the increasing prevalence of OA and its associated healthcare burden, this bibliometric study is crucial for guiding researchers, clinicians and policymakers in developing effective interventions and improving patient outcomes. Through this analysis, we seek to promote collaboration and innovation in OA research, ultimately enhancing management strategies for this chronic condition. These collaborative efforts across various disciplines are crucial for developing effective interventions and improving outcomes for those affected by OA
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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