2,480 research outputs found
Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units : a comparison of two large cohorts
No full textPublisher Copyright: © 2021, The Author(s).Background: Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients. Methods: This was a post hoc analysis of two cohorts of adult ICU patients admitted between May 1–15, 2002 (SOAP study, n = 3147), and May 8–18, 2012 (ICON audit, n = 4601 admitted to ICUs in the same 24 countries as the SOAP study). ARDS was defined retrospectively using the Berlin definitions. Values of tidal volume, PEEP, plateau pressure, and FiO2 corresponding to the most abnormal value of arterial PO2 were recorded prospectively every 24 h. In both studies, patients were followed for outcome until death, hospital discharge or for 60 days. Results: The frequency of ARDS requiring mechanical ventilation during the ICU stay was similar in SOAP and ICON (327[10.4%] vs. 494[10.7%], p = 0.793). The diagnosis of ARDS was established at a median of 3 (IQ: 1–7) days after admission in SOAP and 2 (1–6) days in ICON. Within 24 h of diagnosis, ARDS was mild in 244 (29.7%), moderate in 388 (47.3%), and severe in 189 (23.0%) patients. In patients with ARDS, tidal volumes were lower in the later (ICON) than in the earlier (SOAP) cohort. Plateau and driving pressures were also lower in ICON than in SOAP. ICU (134[41.1%] vs 179[36.9%]) and hospital (151[46.2%] vs 212[44.4%]) mortality rates in patients with ARDS were similar in SOAP and ICON. High plateau pressure (> 29 cmH2O) and driving pressure (> 14 cmH2O) on the first day of mechanical ventilation but not tidal volume (> 8 ml/kg predicted body weight [PBW]) were independently associated with a higher risk of in-hospital death. Conclusion: The frequency of and outcome from ARDS remained relatively stable between 2002 and 2012. Plateau pressure > 29 cmH2O and driving pressure > 14 cmH2O on the first day of mechanical ventilation but not tidal volume > 8 ml/kg PBW were independently associated with a higher risk of death. These data highlight the continued burden of ARDS and provide hypothesis-generating data for the design of future studies.Peer reviewe
Designing a graphical interface for creativity support tools for designers: a case study
No full textThis study proposes a co-designing, iterative methodology to design graphical user interface for creativity support tools for designers. Given the high level of expectation from designers, the interface quality was one of the most challenging aspects of the work, in conjunction with the utility of the functionalities. An iterative design and evaluation process was used to create the icon-based interface, during which the needs of the designers and the functionalities of the system were integrated until a complete operational prototype emerged. This process provided three sequential prototypes. In order to achieve this, we derived qualitative and quantitative results from various methods: creative sessions, semantic and emotional evaluations, questionnaires, semidirective interviews, subjective performance assessments, longitudinal tests, and focus group assessments. Finally, our iterative design and evaluation process can be considered to be a very efficient means of integrating end users’ spontaneous feedback about icon redesigns in the early phases of development. The design outcome enabled the end users to ensure that key features of the creativity support tool were both usable and appealing
Author Attributions in Medieval Text Collections: An Exploration
No full textThis article examines the role and function of author attributions in multi-text manuscripts containing Dutch, English, French or German short verse narratives. The findings represent one strand of the investigations undertaken by the cross-European project ‘The Dynamics of the Medieval Manuscript’, which analysed the dissemination of short verse narratives and the principles of organisation underlying the compilation of text collections. Whilst short verse narratives are more commonly disseminated anonymously, there are manuscripts in which authorship is repeatedly attributed to a text or corpus. Through six case studies, this article explores medieval concepts of authorship and how they relate to constructions of authority, whether regarding an empirical figure or a literary construction. In addition, it looks at how authorship plays a role in manuscript compilation, and at the effects of attributions (by author and/or compiler) on reception. The case studies include manuscripts from the thirteenth to fifteenth centuries, produced in a range of social and cultural contexts, and featuring some of the most important European authors of short verse narratives: Rutebeuf, Baudouin de Condé, Der Striker, Konrad von Würzberg, Willem of Hildegaersberch, and Geoffrey Chaucer. The preliminary findings contribute to our understanding of author attributions in text collections from across northern Europe and point towards future lines of enquiry into the role of authorship in medieval textual dissemination
Le voyage au service d’une peinture de la France et des Français : Maxime Du Camp en Hollande
No full textThis article aims to study the travelogue En Hollande (1859), written by the French author and photographer Maxime Du Camp. This travel document deals with a two weeks journey that Du Camp made in Holland in the winter of 1857. The article particularly examines the way Du Camp has painted the picture of France and the French people, while travelling through different regions of the Netherlands. The article presents in detail some cultural, religious and political aspects of the French identity and culture Du Camp reflects upon in his text
The Reynaert story as a vehicle for intellectual recreation: The case of the Grooten ende nieuwen Reinart de voss
No full textIn the seventeenth century Den grooten ende nieuwen Reinart de voss was written, a Dutch adaptation of the first part of the Low German Reynke de vos that had been published by Ludwig Dietz in Rostock in 1539. The anonymous author transposed the Low German text into Dutch iambic verses and added an enormous commentary, the most learned commentary in the whole European Reynaert tradition. This article studies the relation between Den grooten ende nieuwen Reinart de voss and its source, its properties, and its literary and cultural context. At the end the results are put in a European perspective
Icon and spirituality
No full textThe thesis interprets the icon Transfiguration by Theofan the Greek. It collects the information needed for the interpretation. The first part is devoted to the meaning of a religious picture - an icon in the context of historical development of Byzantine art and Christian thinking. It presents Theofan the Greek as the author of the icon and the doctrine about the uncreated nature of the Light of Tabor, that emerged in his time and might have influenced his work. The second part is devoted to the nterpretation of the Transfiguration icon. It consist of an explication of the biblical texts which are related to the Transfiguration and reflects other possible resources of depiction: apocryphal texts and liturgy. The conclusion of the thesis holds the interpretation of the icon
The impact of extracerebral organ failure on outcome of patients after cardiac arrest : An observational study from the ICON database
No full textPublisher Copyright: © 2016 The Author(s).Background: We used data from a large international database to assess the incidence and impact of extracerebral organ dysfunction on prognosis of patients admitted after cardiac arrest (CA). Methods: This was a sub-analysis of the Intensive Care Over Nations (ICON) database, which contains data from all adult patients admitted to one of 730 participating intensive care units (ICUs) in 84 countries from 8-18 May 2012, except admissions for routine postoperative surveillance. For this analysis, patients admitted after CA (defined as those with "post-anoxic coma" or "cardiac arrest" as the reason for ICU admission) were included. Data were collected daily in the ICU for a maximum of 28 days; patients were followed up for outcome data until death, hospital discharge, or a maximum of 60 days in-hospital. Favorable neurological outcome was defined as alive at hospital discharge with a last available neurological Sequential Organ Failure Assessment (SOFA) subscore of 0-2. Results: Among the 469 patients admitted after CA, 250 (53 %) had had out-of-hospital CA; 210 (45 %) patients died in the ICU and 357 (76 %) had an unfavorable neurological outcome. Non-survivors had a higher incidence of renal (43 vs. 16 %), cardiovascular (56 vs. 45 %), and respiratory (62 vs. 48 %) failure on admission and during the ICU stay than survivors (all p < 0.05). Similar results were found for patients with unfavorable vs. favorable neurological outcomes. In multivariable analysis, independent predictors of ICU mortality were renal failure on admission, high admission Simplified Acute Physiology Score (SAPS) II, high maximum serum lactate levels within the first 24 h after ICU admission, and development of sepsis. Independent predictors of unfavorable neurological outcome were mechanical ventilation on admission, high admission SAPS II score, and neurological dysfunction on admission. Conclusions: In this multicenter cohort, extracerebral organ dysfunction was common in CA patients. Renal failure on admission was the only extracerebral organ dysfunction independently associated with higher ICU mortality.Peer reviewe
Elbphilharmonie: Re-designing an Icon for Hamburg
No full textAnalysis of the Elbphilharmonie project in Hamburg, designed by Herzog & de Meuron, which is currently under construction. My re-design addresses the project's iconic status and cost escalations, and its significance to the people of Hamburg, in an attempt to turn a failed Global Icon into a Local Icon.Follow The MoneyDesign As PoliticsArchitecture and The Built Environmen
Circulating in Commonplaces: Harriet Beecher Stowe’s Celebrity Status in the Netherlands
No full textThis article questions the supposed pervasive celebrity of the American author Harriet Beecher Stowe in Europe in the nineteenth century, and investigates her authorial status in the Netherlands in the mid-1850s. To what extent could she be considered a celebrity in the Netherlands in this period? The article pays attention both to the institutional and to the ideological situation, which can either facilitate or hinder the development of a so-called “celebrity society,” and shows that textual representations of Stowe did indeed circulate, but that this circulation did not take on the massive scale that seems necessary for a celebrity status. Whereas Uncle Tom’s Cabin was, by Dutch standards, an incredible success, journalists were only marginally aware of the authorial figure of Stowe herself. This was in part a result of the lack of a professional literary and journalistic infrastructure in the Netherlands. From an ideological point of view, the phenomenon of literary celebrity was a controversial one in the nineteenth-century Netherlands, hampering the emergence of a celebrity society. Together, these findings help us to consider the existence of a possible “transatlantic” Stowe cult in a different light: in the peripheral Netherlands, such a cult did not emerge easily
‘Ow god, die snobs zien ons weer aan voor een levend laboratorium’ Participatief internetonderzoek over/met Marokkaans-Nederlandse jongeren
No full textThis article covers participatory Internet research strategies with Moroccan-Dutch youth. As the Internet is not a singular entity, informants were stimulated to research with the author the variety of their digital experiences by inviting them to draw an Internet map. Additionally, inviting informants to save and select instant messaging conversation transcripts enabled the collection of non-publicly accessible Internet communication. Not only do these strategies facilitate a bridging of the gap between researchers and informants, they are also useful to make informed decisions about what to include and exclude in the study of digital culture
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