2,754 research outputs found
MABS validation through repeated execution and data mining analysis
No full textAgent Based Modelling is the most interesting and advanced approach for simulating a complex system: in a social context, the single parts and the whole are often very hard to describe in detail. Besides, there are agent based formalisms which allow to study the emergency of social behaviour with the creation and study of models, known as artificial societies. Thanks to the ever increasing computational power, it's been possible to use such models to create software, based on intelligent agents, which aggregate behaviour is complex and difficult to predict, and can be used in open and distributed systems. Data mining is born in the last decades in order to help users in finding useful knowledge from the otherwise overwhelming amount of data available nowadays from the web and the data collected every day by companies. Data Mining techniques can therefore be the keystone to reveal non-trivial knowledge expressed by the initial assumption used to build the micro-level of the model and the structure of the society of agents that emerged from the simulation
Donkeys and Hares. The Enemy Warrior in the Early European Chronicles of the Conques
No full textThe Author scrutinizes the image of the enemy warrior in the early European chronicles of the Spanish conquest, within a historical-comparative approach. In the 16th century sources the image of the Indios fighting Europeans offers a very specific vision of this enemy. It was an image that had its roots in stereotypes of the past. But it had been reshaped into a new and original version. Solidarity between the devil and the Indios did not produce fearsome warriors. It was an image that did not have to hinder the expansion of European traffic
El Tlacuache Núm. 294 (2008). 294 Año 9 (2008) enero. El Tlacuache
No full textConservación de nuestro Patrimonio por Marco Antonio Santo. - Xochicalco Patrimonio Mundial por Marco Antonio Santos Ramírez
A distributed amplifier system for bilayer lipid membrane (BLM) arrays with noise and individual offset cancellation
No full textLipid bilayer membrane (BLM) arrays are required for high throughput analysis, for example drug screening or advanced DNA sequencing. Complex microfluidic devices are being developed but these are restricted in terms of array size and structure or have integrated electronic sensing with limited noise performance. We present a compact and scalable multichannel electrophysiology platform based on a hybrid approach that combines integrated state-of-the-art microelectronics with low-cost disposable fluidics providing a platform for high-quality parallel single ion channel recording. Specifically, we have developed a new integrated circuit amplifier based on a novel noise cancellation scheme that eliminates flicker noise derived from devices under test and amplifiers. The system is demonstrated through the simultaneous recording of ion channel activity from eight bilayer membranes. The platform is scalable and could be extended to much larger array sizes, limited only by electronic data decimation and communication capabilities
Riflessioni in tema di liberalizzazione e settore farmaceutico
No full textThis paper aims at analyzing the effects of recent liberal reforms in the pharmacy sector. After briefly examining several doctrine thesis concerning the debate on the legal status of the pharmaceutical public service, the author draws attention to the mainly significant issues linked to the ineluctable conflicts between health protection, service efficiency and profit expectations. In particular, regulatory aspects related to the market entry, to the pharmaceutical store management, and also to the drugs trade, are specifically examined, with the aim to overcome several critical issues, through a process of real liberalization
Dalla metafisica all'ontologia: storia di una trasformazione editoriale (secoli XVI-XVII)
No full textThe bibliographical history offers an interesting point of view for a better understanding
of the rise and development of ontology, as an autonomous discipline, in early
modern thought. After Luther’s interdict, the metaphysics was neglected in many protestant
academies and excluded from the disciplinary classifications (§§ 1-2). The return of
metaphysics, at the end of the 16th century, coincided, in many cases, with the affirmation
of the new scholastic paradigm of ontology (§ 3). An illustrious precedent of this paradigm
was constituted by the Jesuit Francisco Suárez and his Disputationes metaphysicae (§ 5).
The Jesuit models – not only that by Suárez, but also those by Benet Perera and Pedro da
Fonseca – represented the standard on which Calvinists and Lutherans built their own
metaphysics in an ontological way. This paper provides a conspicuous number of case
studies in which the passage from metaphysics to ontology becomes definitively clear: this
debate takes place throughout the first handbooks, treatises, magisterial and doctoral disputations
(§ 6) proposed by the Calvinist and Lutheran author
El Tlacuache Núm. 309 (2008). 309 Año 9 (2008) abril. El Tlacuache
No full textLa Mujer MesoamericanaLa Educación por Silvia Garza Tarazona. - El INAH recibe galardón en el marco de la XXXIII edición del tianguis Turístico Internacional de Acapulco po Vianey C. Arroyo
Stages for the More Sustainable Farm
No full textCurrently, agricultural farm units are faced with a double and most times contradictory challenge, in order to be successful: on the one hand the invested capital has to be profitable and the economic performance has to be maximised. On the other hand, given the socio-environmental situation, it is necessary to preserve and to protect the environment and natural resources. Given the potential conflict of the two aims, since the satisfaction of one implies the underperformance of the other (and vice versa), the question then is: which is the solution to choose? We intend, in this work, to formulate a farm plan with the purpose of reconciling the criteria of environmental sustainability with that of economic competitiveness. For this achievement we proceed to the comparative study of sustainability of different groups of farms identified in the study area (first evaluation cycle) through MESMIS (“Marco para la Evaluación de Sistemas de Manejo de Recursos Naturales Mediante Indicadores de Sustentabilidad” - Framework for Evaluation of Natural-Resource Systems Handling through Sustainability Indicators) methodology, that allowed to select the more sustainable group of farms. Based on the found potentialities and weakness on these production systems, we stepped to the planning of a production unit of bovine meat, which obeys simultaneously to economic and environmental objectives, using Multicriteria Decision. We finished the work with the sustainability evaluation between groups of farms identified previously and the planned farms (second evaluation cycle), based, again, in the MESMIS methodology, to confirm (or not) the greatest sustainability of the last ones. Analyses of the results allow us to confirm the greatest relative sustainability of the planned farm, for the diverse traced scenarios.Decision taking, planning, sustainability, Environmental Economics and Policy, Farm Management,
BAG3 in Tumor Resistance to Therapy. MC Turco: Corresoponding Author
No full textBAG3 is highly expressed across cancer types and its intracellular activity is critical for cancer cell survival. However, recent findings suggest that BAG3 can also modulate the tumor microenvironment to promote cancer progression and resistance to therapies, suggesting new ways to target this protein in cancer therapy
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