1,721,036 research outputs found
Sclerosing 'mucinous' blue naevus
No full textAbundant mucin deposition is an unusual finding in melanocytic naevi. We describe the first example, to our knowledge, of a sclerosing blue naevus with an abundant mucinous stroma in two unrelated patients. This uncommon variant of blue naevus should be differentiated from desmoplastic-neurotropic melanoma, in which the presence of mucin stromal deposition is a more typical finding
Cutaneous Merkel cell carcinoma: A case study
No full textThe clinical, histological, immunohistochemical and ultrastructural study of a case of trabecular carcinoma of the skin (Merkel cell tumor) is reported. The tumor involved medium and deep dermis, spared characteristically the epidermis and was constitued by cells in insular and trabecular arrangements. Immunohistochemical findings (PAP) showed neuron-specific-enolase, cytokeratin type intermediate filaments and neurofilaments in the cytoplasm of tumor cells. The Authors demonstrate that the keratin filaments were those of simple epithelia. Ultrastructural studies showed the presence of neurosecretory-type dense-core granules and characteristic paranuclear whorls of intermediate filaments
Applicazioni delle tecniche immunoistochimiche nello studio dei tumori cutanei: strategie, possibilità e limiti.
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