1,721,013 research outputs found
Evaluation of health outcomes in elderly patients with asthma and COPD using disease-specific and generic instruments: the Salute Respiratoria nell'Anziano(Sa.R.A.) Study.
No full textMild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction.
No full textFrom Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines to current clinical practice : an overview of the pharmacological therapy of stable chronic obstructive pulmonary disorder.
No full textUse of antibiotics in elderly patients with exacerbated COPD: the OLD-chronic obstructive pulmonary disease study.
No full text
Evaluation of health outcomes in elderly patients with asthma and COPD using disease-specific and generic instruments: the Salute Respiratoria nell'Anziano(Sa.R.A.) Study.
No full textMild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction.
No full textAlpha-1 Antitrypsin Deficiency: Current Perspective from Genetics to Diagnosis and Therapeutic Approaches.
No full textAdiponectin and bone mass density The InCHIANTI study
No full textIntroduction Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans The data on this Issue however are biased by small study sample size and lack of controlling for body composition Methods We used data from the third follow-up of the InCHIANTI study which included measurements of BMD using quantitative CT of the tibia and of body composition using bioimpedenziometry Serum adiponectin was measured using radioimmunoassay We excluded participants with diabetes hyperthyroidism using hormone replacement or corticosteroid therapy We evaluated the correlation of adiponectin with total trabecular and cortical BMD using Pearson s coefficient and linear regression models to estimate the association between adiponectin and BMD controlling for potential confounders (age body mass index alcohol intake fat mass smoking) Results Our sample was made up of 320 men (mean age 67 years SD 158 range 29-97 years) and 271 postmenopausal women (mean age 76 years SD 82 range 42-97 years) In men serum adiponectin was not independently associated with BMD In women after correction for potential confounders adiponectin was associated with total (beta= -0626 P<0 001) trabecular (beta= -0696 P<0 001) and cortical (beta= -1076 P=0001) BMD Conclusion Our results show that adiponectin is Inversely associated with bone mass in women Further studies are needed to confirm these findings prospectively and then to clarify the explanatory mechanisms (C) 2010 Elsevier Inc All rights reserve
Effect of ghrelin on bone mass density: The In Chianti study
No full textIntroduction: Ghrelin is a stomach secreted hormone, believed to play an important role in energy balance and in food intake. Experimental studies have shown a positive effect of ghrelin on bone metabolism, but both in vivo and clinical findings have been contradictory. We aimed to investigate the effect of ghrelin on volumetric BMD in a large cohort of elderly subjects. Methods: We have studied 401 women (mean age 75.1 years, range 65-94) and 306 men (mean age 73.9 years, range 65-94) from the InChianti study, which included measurements of BMD using quantitative CT of the tibia and of body composition using bio impedancemetry. Serum ghrelin was measured using ELISA. We excluded participants with diabetes, hyperthyroidism, using hormone replacement or glucocorticoid therapy. We evaluated the correlation of ghrelin with total, trabecular, and cortical BMD using Pearson's coefficient, and linear regression models to estimate the association between ghrelin and BMD controlling for potential confounders. Results: In women, after correction for potential confounders, ghrelin was associated with trabecular BMD (beta = 7.08, P < 0.02), but not with total or cortical BMD. In men, adjusted multivariable models showed a nearly significant association between serum ghrelin and trabecular BMD (beta = 4.99, P = 0.069) and no association with either cortical or total BMD. Conclusions: Serum ghrelin is positively correlated with trabecular BMD in a cohort of elderly healthy Italian women. The fact that trabecular is more metabolically active than cortical bone and the larger number of females might explain this selective association. (C) 2011 Elsevier Inc. All rights reserved
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