6 research outputs found
The Reality Of The Process Of Detecting Athletically Gifted Students In The Half-long Running Activity (1500 Meters.3000 Meters) A Field Study Of The Relationship Between Permanence And Speed Among Athletic Talented Students In The Intermediate Stage
No full textThe study aims to identify the relationship between endurance quality and speed in light of the process of detecting sports talent in the middle-distance specialty and for this purpose, we used the descriptive approach on a sample of 245 students were deliberately selected. To collect data we used a proxy test tool to measure endurance and the 70 meter running test to measure speed. After collecting the results and processing them statistically, it was found that there is a correlation between endurance quality and speed in light of the sports talent detection process. The statistical results showed that there is a correlative relationship between endurance and speed in young middle-distance runners in athletics, so the results of the physical tests confirmed the contribution of early detection of gifted young people of exceptional physical quality
E-MRS symposium N: “Synthesis, processing and characterization of nanoscale multi functional oxide films V”
No full textThis symposium followed directly from extremely successful symposia on the same theme held at the Spring E-MRSmeeting in previous years (2006, 2009, 2011, and 2013). The theme is interdisciplinary, and drew together scientists and engineers interested in thin film and device fabrication, characterization, and applications, together with theoreticians and modellers.
Symposium sessions filled the whole week of the E-MRS meeting, and we learnt much about novel growth and processing methods for oxides; structuring and manipulation for nanotechnology; doping effects, and the influence ofmicrostructure, stress, defects, and interfaces. There were presentations on ionic conductivity, photoactivity, sensing, and electrochemical properties; piezoelectric, thermoelectric, thermochromic, photoelectric, and photonic applications; and on ferroelectrics, multiferroics and magnetic oxide-based films. This illustrates the vast range of interest in oxides, oxide-based thin films, and device structures.
At the start of theweekwe found that our symposium had been ‘upgraded’ to one of the larger presentation venues within the Lille Grand Palais, and we were very happy to see that most of the sessions did, indeed, attract large numbers of participants. Questions and discussions following presentationswere informed, and often animated. Poster sessions also offered opportunities for discussion and debate. We thank all of the E-MRS organisers for their support and guidance, which contributed to a very smooth-running symposium; and also
those who assisted by chairing sessions and assessing posters at the conference. Once again, the symposium proceedings are published in collaboration with thin solid films, and we are extremely grateful to Elsevier, and the editorial team, for their considerable assistance in the Editorial process. We also thank authors and reviewers for their hard and efficient work
Calpastatin prevents Angiotensin II–mediated podocyte injury through maintenance of autophagy
No full textInternational audienceThe strong predictive value of proteinuria in chronic glomerulopathies is firmly established as well as the pathogenic role of angiotensin II promoting progression of glomerular disease with an altered glomerular filtration barrier, podocyte injury and scarring of glomeruli. Here we found that chronic angiotensin II-induced hypertension inhibited autophagy flux in mouse glomeruli. Deletion of Atg5 (a gene encoding a protein involved autophagy) specifically in the podocyte resulted in accelerated angiotensin II-induced podocytopathy, accentuated albuminuria and glomerulosclerosis. This indicates that autophagy is a key protective mechanism in the podocyte in this condition. Angiotensin-II induced calpain activity in podocytes inhibits autophagy flux. Podocytes from mice with transgenic expression of the endogenous calpain inhibitor calpastatin displayed higher podocyte autophagy at baseline that was resistant to angiotensin II-dependent inhibition. Also, sustained autophagy with calpastatin limited podocyte damage and albuminuria. These findings suggest that hypertension has pathogenic effects on the glomerular structure and function, in part through activation of calpains leading to blockade of podocyte autophagy. These findings uncover an original mechanism whereby angiotensin II-mediated hypertension inhibits autophagy via calcium-induced recruitment of calpain with pathogenic consequences in case of imbalance by calpastatin activity. Thus, preventing a calpain-mediated decrease in autophagy may be a promising new therapeutic strategy for nephropathies associated with high renin-angiotensin system activity
Effect of interface roughness and well width on differential reflection dynamics in InGaAs/InP quantum wells
No full textWe have observed differential reflection dynamics in In0.518Ga0.492As/InP multiple quantum wells, using the pump-probe technique, and examined the photoluminescence spectra to determine the interface quality for the samples studied. Our results show that the interface quality and well width of the quantum wells (QWs) strongly influence the differential reflection dynamics. The experimental results provide a direct evidence to demonstrate that photoexcited carrier diffusion in cap layer and barriers along the direction perpendicular to sample surface plays a dominant role in determining the differential reflection dynamics of the QWs. (C) 1998 American Institute of Physics.Physics, AppliedSCI(E)2ARTICLE197-997
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
No full textThe glomerulus is a highly specialized capillary tuft, which under pressure filters large amounts of water and small solutes into the urinary space, while retaining albumin and large proteins. The glomerular filtration barrier (GFB) is a highly specialized filtration interface between blood and urine that is highly permeable to small and midsized solutes in plasma but relatively impermeable to macromolecules such as albumin. The integrity of the GFB is maintained by molecular interplay between its 3 layers: the glomerular endothelium, the glomerular basement membrane and podocytes, which are highly specialized postmitotic pericytes forming the outer part of the GFB. Abnormalities of glomerular ultrafiltration lead to the loss of proteins in urine and progressive renal insufficiency, underlining the importance of the GFB. Indeed, albuminuria is strongly predictive of the course of chronic nephropathies especially that of diabetic nephropathy (DN), a leading cause of renal insufficiency. We found that high glucose concentrations promote autophagy flux in podocyte cultures and that the abundance of LC3B II in podocytes is high in diabetic mice. Deletion of Atg5 specifically in podocytes resulted in accelerated diabetes-induced podocytopathy with a leaky GFB and glomerulosclerosis. Strikingly, genetic alteration of autophagy on the other side of the GFB involving the endothelial-specific deletion of Atg5 also resulted in capillary rarefaction and accelerated DN. Thus autophagy is a key protective mechanism on both cellular layers of the GFB suggesting autophagy as a promising new therapeutic strategy for DN.</p
Genetic and pharmacological inhibition of microRNA-92a maintains podocyte cell cycle quiescence and limits crescentic glomerulonephritis
No full textCrescentic rapidly progressive glomerulonephritis (RPGN) represents the most aggressive form of acquired glomerular disease. While most therapeutic approaches involve potentially toxic immunosuppressive strategies, the pathophysiology remains incompletely understood. Podocytes are glomerular epithelial cells that are normally growth-arrested because of the expression of cyclin-dependent kinase (CDK) inhibitors. An exception is in RPGN where podocytes undergo a deregulation of their differentiated phenotype and proliferate. Here we demonstrate that microRNA-92a (miR-92a) is enriched in podocytes of patients and mice with RPGN. The CDK inhibitor p57Kip2 is a major target of miR-92a that constitutively safeguards podocyte cell cycle quiescence. Podocyte-specific deletion of miR-92a in mice de-repressed the expression of p57Kip2 and prevented glomerular injury in RPGN. Administration of an anti-miR-92a after disease initiation prevented albuminuria and kidney failure, indicating miR-92a inhibition as a potential therapeutic strategy for RPGN. We demonstrate that miRNA induction in epithelial cells can break glomerular tolerance to immune injury
