86,835 research outputs found
The role of systemic statins in the inception and healing of apical periodontitis: a systematic review
No full textObjectives: Statins are a category of medications widely used to reduce plasma LDL-cholesterol levels, that also possess antibacterial, anti-inflammatory, and immunomodulatory action. The aim of this systematic review was to explore the effects of systemic statins therapy on the development and treatment of apical periodontitis (AP) on humans and animals. Material and methods: Three electronic databases (PubMed, Web of Science, and Scopus) and grey literature were searched from their inception until February, 20 2023 (PROSPERO CRD42021246231). For the quality assessment and risk of bias, different guidelines were used according to the typology of the studies considered (Animal Research Reporting of In Vivo Experiments, Newcastle–Ottawa Quality Assessment Form for Cohort Studies, Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool and Tool to assess risk of bias in cohort studies of CLARITY Group). Results: Seven hundred eleven records were screened, and six articles were included for this qualitative review. The eligible studies showed a moderate overall quality and risk of bias. Human patients in treatment with statins exhibited a higher healing rate of AP following root canal treatment. In experimental animal models, statins had a beneficial effect on the development of AP. Conclusions: Despite the limited number of studies and considering that most of them are on animals, our findings suggest that systemically administered statins make a positive contribution to prevent the development and help healing of AP. Clinical relevance: There is an increased evidence that a pharmacologic adjunct to endodontic treatment may be considered to enhance healing of AP. Among other medications, statins seem to have a positive impact on the disease
Prevalence of Apical Periodontitis in Patients with Autoimmune Liver Diseases on Immune Suppressants and Immune Modulators: A Cross-sectional Study
No full textIntroduction: Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated autoaggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of apical periodontitis (AP) in patients suffering from ALDs undergoing treatment with the immune suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid. Methods: The ALD group included 46 patients (11 men and 35 women, average age = 57.9 ± 11.8 years) and 1186 teeth. The control group included 50 healthy patients not taking any medications (15 men and 35 women, average age = 58.6 ± 10.4 years) and 1251 teeth. Demographic data and medical, pharmacologic, and dental history were recorded. Dental and radiographic examinations were performed. The presence of AP; the periapical index score; decayed, missing, and filled teeth; quality of restoration, and root canal treatment were evaluated. The influence of the medications the patients were taking on the prevalence of AP was also tested. Results: The prevalence of AP was significantly lower in ALDs than in the control group at the patient (P = .019) and tooth level (P = .014). Smoking and age were associated with a significant increase in AP in cases and controls (P = .045 and P = .001, respectively). In both groups, endodontically treated teeth showed a higher prevalence of AP. Conclusions: Considering the limitations because of the observational nature of the study, the patients affected by ALDs liver diseases and undergoing treatment with immune suppressors (often associated with immune modulators) were found to exhibit a lower prevalence of AP
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
PENGARUH METODE MATERNAL REFLEKTIF DENGAN TEKNIK PERDATI DAN TEKNIK MEMBACA IDEO-VISUAL TERHADAP PEMEROLEHAN PERBENDAHARAAN KATA ANAK TUNA RUNGU WICARA DI SURAKARTA
No full textMursiti : PENGARUH METODE MATERNAL REFLEKTIF DENGAN TEKNIK
PERDATI DAN TEKNIK MEMBACA IDEO-VISUAL TERHADAP
PEMEROLEHAN PERBENDAHARAAN KATA ANAK TUNARUNGU
WICARA DI SURAKARTA. Skripsi, Surakarta : Fakultas Keguruan dan Ilmu
Pendidikan Universitas Sebelas Maret Surakarta, Januari 2007.
Tujuan penelitian adalah untuk mengetahui berpengaruh atau tidaknya, teknik
perdati ( 1 X ) terhadap pemerolehan perbendaharaan kata (Y), untuk mengetahui
berpengaruh atau tidaknya teknik membaca ideo-visual ( 2 X ) terhadap pemerolehan
perbendaharaan kata (Y), dan untuk mengetahui berpengaruh atau tidaknya teknik
perdati ( 1 X ) dan teknik membaca ideo-visual ( 2 X ) terhadap pemerolehan
perbendaharaan kata (Y) di SLB-B YRTRW Surakarta kelas D5. Teknik perdati dan
teknik membaca ideo-visual sebagai variabel bebas, pemerolehan perbendaharaan
kata sebagai variabel terikat.
Populasi penelitian adalah seluruh siswa kelas D5 SLB-B YRTRW Surakarta
tahun pelajaran 2006/2007 sebanyak 8 siswa. Dalam penelitian ini semua populasi
dijadikan sampel sebanyak 8 siswa. Teknik pengumpulan data menggunakan metode
observasi pada variabel teknik perdati, untuk variabel teknik membaca ideo-visual
dan variabel pemerolehan perbendaharaan kata menggunakan tes. Sebelum dilakukan
penelitian maka perlu dilakukan uji validitas yaitu korelasi product moment untuk
instrumen observasi, dan uji validitas point berserial untuk tes.
Untuk mencari pengaruh antara teknik perdati dan teknik membaca ideo-visual
terhadap pemerolehan perbendaharaan kata menggunakan teknik analisis regresi
ganda. Dari hasil analisis data menggunakan teknik analisis regresi ganda diperoleh
koefisien yang mana
tab xy r r > untuk
1 X terhadap Y yaitu sebesar 0,7662 > 0.707,
untuk
2 X terhadap Y yaitu sebesar 0,7537 > 0.707 dan untuk
1 X dan
2 X terhadap
Y diperoleh
hit
F > tab F atau 21,1360 > 5,79 dengan db=2 vs 5 dk pembilang=1 dan dk
penyebut=5 dengan N=8 dan taraf signifikansi 5%. Sehingga diperoleh kesimpulan
bahwa, teknik perdati ( 1 X ) dan teknik membaca ideo-visual ( 2 X ) secara bersama-
sama mempengaruhi pemerolehan perbendaharaan kata (Y), yakni sebesar 89,43%
dari teknik perdati 45,75%, dan teknik membaca ideo-visual 43,68%. Sedangkan
berdasarkan persamaan regresi Y = -28,0250 + 1,0358 X1 + 0,9359 X2 artinya dapat
disimpulkan bahwa rata-rata peningkatan/ penurunan pemerolehan perbendaharaan
kata (Y) diperkirakan sebesar 1,0358 untuk setiap peningkatan/ penurunan satu unit
teknik perdati (X1) dan 0,9359 untuk setiap peningkatan/ penurunan satu unit teknik
membaca ideo-visual (X2)
Clinical management of external cervical resorption: A systematic review
No full textThis review investigated whether any therapeutic options influenced the outcome of treatment for teeth with external cervical resorption. Out of 870 articles identified by an electronic search, 60 clinical case reports and six case series were included. No randomised clinical trials were found. Risk of bias was assessed using Joanna Briggs Institute's tools. External surgical intervention was the preferred method of accessing the lesions. Removal of resorptive tissue was most often achieved mechanically. Bioactive endodontic cements were the preferred materials for restoring teeth. The outcome measures were based on clinical and radiographic parameters. Of the cases included in the review, no specific treatment approach had a superior outcome in relation to Heithersay's classification. Furthermore, due to the absence of randomised clinical trials, and the low level of evidence associated with case reports/case series, it was not possible to define the optimum clinical treatment for external cervical resorption
Proresolving Mediators in Endodontics: A Systematic Review
No full textIntroduction: Proresolving lipid mediators are specialized molecules (SPMs) involved in the active resolution of the inflammatory process by regulating tissue homeostasis. The aim of this study was to investigate the scientific literature to assess the potential of SPMs as an adjunct in the treatment of endodontic infection. Methods: Three electronic databases (PubMed, Web of Science, and Scopus) were searched from their inception until February 2020 (PROSPERO CRD42020164743). Supplemental research was performed by screening the references of the relevant studies eligible for inclusion. A quality assessment of animal studies was performed using the Animal Research: Reporting of In Vivo Experiments guidelines, whereas the Systematic Review Centre for Laboratory animal Experimentation Risk of Bias tool was used to assess the risk of bias. Results: A total of 3295 records were screened, and 8 articles meeting the criteria were included for this qualitative review. The eligible studies showed a high to moderate overall quality and a low to moderate risk of bias. SPMs positively affected the development of pulpitis and apical periodontitis in experimental animal models. The early treatment of pulpitis with the topical application of SPMs was beneficial to control inflammation within 24 hours from contamination. In addition, SPMs delivered within the root canals after disinfection were found effective in promoting periapical healing. Conclusions: Our findings suggest that SPMs may play a role in the inception and treatment of pulpal-periapical diseases, and they should be considered for future research for developing new therapeutics as an adjunct to endodontic treatment
Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review
No full textBiologic medications (BMs) are increasingly used for the management of systemic chronic inflammatory diseases. These diseases are often associated with a higher prevalence of apical periodontitis (AP) and periodontitis (P). The purpose of this systematic review was to ascertain the interactions between AP and/or P and BMs. The review was registered in the PROSPERO database (CRD42017054756). Electronic searches were performed on Pubmed Medline, Scopus and The Web of Science from their inception through to 20 March 2018. The references of the articles selected were checked. The keywords were chosen based on a pilot search, which aimed to find the most frequently prescribed BMs. The included studies were appraised qualitatively using appropriate tools. Thirty-five articles met the inclusion criteria, comprising 16 non-randomized clinical studies, 12 in vivo animal studies and 7 case reports. Quality of information was assessed as high in 18 articles, moderate in 16 articles and low in 1 article. BMs in patients suffering from chronic inflammatory diseases seems to inhibit the progression of AP and P, and to enhance the healing response to periodontal and endodontic treatment. A healthier condition of the periodontal tissues seems to be associated with a better response of the patient to BMs therapy
Ribavirin and interferon-alpha combination therapy vs interferon-alpha alone in the retreatment of chronic hepatitis C: a randomized clinical trial
No full textPrevalence of apical periodontitis in patients with inflammatory bowel diseases: a retrospective clinical study
No full textAim We evaluated the prevalence of apical periodontitis (AP) and the oral health status in patients with inflammatory bowel diseases (IBDs) treated with immunomodulators, with particular attention to biologic medications (BMs). Methods One hundred ten patients, 49 men and 61 women (average age, 46 ± 13.8 years), from the Gastroenterology Unit of the University Hospital with IBDs who were treated with BMs or corticosteroids were included in the study. One hundred ten patients who registered for a dental check-up at the Dental Clinic were matched for age, sex, and physical characteristics with the study group without systemic diseases and not taking medications who were the control. Patients underwent a complete oral, dental, and radiographic examination. Decayed, missing, and filled teeth and periapical index score indexes were recorded. Student t test, χ2, and Mann-Whitney U test were used as appropriate. Results The prevalence of AP was 64% in IBD patients and 59% in the control; according to the gender-stratified analysis, the difference was not significant among the male groups, whereas the number of teeth with AP was significantly higher in female patients with IBDs than in the controls (P ≤ .05). The prevalence of AP in patients treated with BMs was 65%; women showed 69% higher risk for AP and presented a significantly higher number of teeth with AP (P ≤ .05). Decayed, missing, and filled teeth index was similar in both groups, whereas patients with IBDs had a higher periapical index score than the controls. Conclusions Women with IBDs and taking immunomodulators had a higher prevalence of AP. All patients with IBDs had larger lesions than healthy subjects. These data emphasize the influence of the status of the immune system in the onset of AP and the need for further studies to confirm these findings
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