99 research outputs found
Access and use of the Internet in the libraries of Lahore, Pakistan
Get PDFThis study is to find out the level of the Internet access in libraries, its uses by library staff and the problems regarding access and use of Internet in libraries of Lahore, Pakistan. The research is based on primary data. A structured questionnaire survey was conducted by (n=75) 48 academic libraries (university and college), 21 special libraries, five public libraries and one school library in the city of Lahore. Findings of the study may be useful for policy makers to understand the status of the Internet access and its need as well as for library schools to revise the curriculum to improve the Internet skills of future librarians
The Relationship between Wastewater Toxic Substances and Alzheimer’s disease
No full textabstract: Alzheimer’s disease (AD) is a neurodegenerative disease resulting in loss of cognitive function and is not considered part of the typical aging process. Recently, research is being conducted to study environmental effects on AD because the exact molecular mechanisms behind AD are not known. The associations between various toxins and AD have been mixed and unclear. In order to better understand the role of the environment and toxic substances on AD, we conducted a literature review and geospatial analysis of environmental, specifically wastewater, contaminants that have biological plausibility for increasing risk of development or exacerbation of AD. This literature review assisted us in selecting 10 wastewater toxic substances that displayed a mixed or one-sided relationship with the symptoms or prevalence of Alzheimer’s for our data analysis. We utilized data of toxic substances in wastewater treatment plants and compared them to the crude rate of AD in the different Census regions of the United States to test for possible linear relationships. Using data from the Targeted National Sewage Sludge Survey (TNSSS) and the Centers for Disease Control and Prevention (CDC), we developed an application using R Shiny to allow users to interactively visualize both datasets as choropleths of the United States and understand the importance of this area of research. Pearson’s correlation coefficient was calculated resulting in arsenic and cadmium displaying positive linear correlations with AD. Other analytes from this statistical analysis demonstrated mixed correlations with AD. This application and data analysis serve as a model in the methodology for further geospatial analysis on AD. Further data analysis and visualization at a lower level in terms of scope is necessary for more accurate and reliable evidence of a causal relationship between the wastewater substance analytes and AD.
GitHub Repository: https://github.com/komal-agrawal/AD_GIS.gi
Understanding the effect of confinement in scanning spreading resistance microscopy measurements
Get PDFScanning spreading resistance microscopy (SSRM) is a powerful technique for quantitative two-and three-dimensional carrier profiling of semiconductor devices with sub-nm spatial resolution. However, considering the sub-10 nm dimensions of advanced devices and the introduction of three-dimensional architectures like fin field effect transistor (FinFET) and nanowires, the measured spreading resistance is easily impacted by parasitic series resistances present in the system. The limited amount of material, the presence of multiple interfaces, and confined current paths may increase the total resistance measured by SSRM beyond the expected spreading resistance, which can ultimately lead to an inaccurate carrier quantification. Here, we report a simulation assisted experimental study to identify the different parameters affecting the SSRM measurements in confined volumes. Experimentally, the two-dimensional current confinement is obtained by progressively thinning down uniformly doped blanket silicon on insulator wafers using scalpel SSRM. The concomitant SSRM provides detailed electrical information as a function of depth up to oxide interface. We show that the resistance is most affected by the interface traps in case of a heterogeneous sample, followed by the intrinsic resistance of the current carrying paths. Furthermore, we show that accurate carrier quantification is ensured for typical back contact distances of 1 μm if the region of interest is at least nine times larger than the probe radius. © 2020 Author(s)
Geobacter sulfurreducens inner membrane cytochrome transcriptional and phenotypic data
No full textThe data files include raw data as well as analyzed results for transcriptional analysis of WT G. sulfurreducens and mutant lacking BccR (GSU0598) under fumarate vs iron citrate growth conditions. This dataset also includes the phenotypic data files for experiments associated with this project.Geobacter sulfurreducens utilizes extracellular electron acceptors such as Mn(IV), Fe(III), syntrophic partners, and electrodes that vary from +0.4 to −0.3 V vs. Standard Hydrogen Electrode (SHE), representing a potential energy span that should require a highly branched electron transfer chain. Here we describe CbcBA, a bc-type cytochrome essential near the thermodynamic limit of respiration when acetate is the electron donor. Mutants lacking cbcBA ceased Fe(III) reduction at −0.21 V vs. SHE, could not transfer electrons to electrodes between −0.21 and −0.28 V, and could not reduce the final 10% – 35% of Fe(III) minerals. As redox potential decreased during Fe(III) reduction, cbcBA was induced with the aid of the regulator BccR to become one of the most highly expressed genes in G. sulfurreducens. Growth yield (CFU/mM Fe(II)) was 112% of WT in ∆cbcBA, and deletion of cbcL (an unrelated bc-cytochrome essential near −0.15 V) in ΔcbcBA increased yield to 220%. Together with ImcH, which is required at high redox potentials, CbcBA represents a third cytoplasmic membrane oxidoreductase in G. sulfurreducens. This expanding list shows how metal-reducing bacteria may constantly sense redox potential to adjust growth efficiency in changing environments.Office of Naval Research: N00014-16-1-2194, and N00014-18-1-2632.Joshi, Komal; Chan, Chi Ho; Bond, Daniel R. (2021). Geobacter sulfurreducens inner membrane cytochrome transcriptional and phenotypic data. Retrieved from the University Digital Conservancy, https://doi.org/10.13020/5AMD-ZW33
Heme-oxygenase-1 Induction Improves Type-1 Cardiorenal Syndrome Only In Mice With Impaired AngII-induced Lymphocyte Activation (SCID Mice)
No full textRational: The absence of lymphocyte activity protects SCID mice from AngII-induced hypertension facilitating blood pressure-induced sodium excretion, possibly via the stimulation of eNOS- and COX-2-dependent pathways. Type-1 cardiorenal syndrome (CRS-1), characterized by acute kidney dysfunction secondary to deterioration in cardiac function, is caused by renal arteriolar vasoconstriction, mediated by the activation of renin-angiotensin and sympathetic nervous systems (RAAS, SNS). Heme Oxygenase-1 (HO-1) induction improves renal function, but not renal vasoconstriction, in AngII-induced hypertension, and causes the desensitization of vascular smooth muscle to phenylephrine.
Objectives: We evaluated whether AngII resistant SCID mice develop CRS-1 as occurs in control mice, and the differential effects of HO1 induction on renal hemodynamics in CRS-1.
Methods: Post ischemic heart failure was induced in C57 and SCID mice by left anterior coronary artery ligation. Mice were divided in 4 groups: sham, myocardial infarction (MI), MI treated with cobalt protoporphyrin (CoPP), an inducer of HO-1, in the presence and absence of HO activity inhibitor, stannous mesoporphyrin (SnMP). All mice underwent echocardiography (ejection fraction, EF) and renal echoDoppler (arterial pulsatility index, K-PI) examination 30 days after surgery.
Results: EF was significantly reduced both in control and SCID mice after MI (C57: sham 0.60±0.07, MI 0.45±0.04, p<0.05; SCID: sham 0.60±0.06, MI: 0.46±0.1, p<0.01). K-PI was significantly increased in MI groups compared to sham groups (C57: sham 0.98±0.05, MI 1.12±0.11, p<0.05; SCID: sham 0.72±0.08, MI 1.37±0.37, p<0.05). HO1 induction improved renal vasoconstriction only in SCID mice (SCID K-PI: MI+CoPP 0.9±0.19 p<0.5çC57 K-PI: MI+CoPP 1.05±0.15, n.s.). In SCID mice SnMP reversed the effect of CoPP on renal vasoconstriction.
Conclusion: CRS-1 is similar in SCID and control mice and is associated with increased renal arterial resistance. HO-1 induction improves renal vasoconstriction only in SCID (AngII resistant) mice with CRS-1, suggesting that increased HO-1 activity cannot protect the kidney from AngII-induced lymphocyte activation, but only from SNS-induced vasoconstriction.
Author Disclosures: P. Pesce: None. D. Sacerdoti: None. S.R. Monu: None. K. Sodhi: None. M. Boldrin: None. N.G. Abraham: None.
Key Words: Angiotensin II • Renal circulation • Heart failur
Synthesis of Organic–Inorganic Nanohybrids-Based Polymeric Nanocomposites
No full textOrganic–inorganic nanohybrids-based polymer nanocomposites are made up of two different components, and these hybrids attained great attention over last decades due to their diversified framework and fascinating features. These nanohybrids possess synergistic characteristics of both organic and inorganic substances. Different synthetic routes are used to synthesize these materials with enhanced morphology, tunable features, and fine nanostructures. This chapter focuses on various synthetic routes for fabrication of organic–inorganic-based nanopolymeric composites. Synthetic strategies and protocols of different routes have been described in details. We have also discussed the advantages and limitations of all synthetic methods in details.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Aerospace Manufacturing Technologie
Fuzzy reliability analysis of the washing system in a paper plant using the TBFLT technique
No full text
Purpose
The purpose of this paper is to analyze the reliability of the washing system in a paper plant in a more promising way under vague environment by reducing the accumulating phenomenon of fuzziness and accelerating the computation process using the Tω (weakest t-norm) based fuzzy lambda-tau (TBFLT) technique.
Design/methodology/approach
This paper presents a unified approach for analyzing the fuzzy reliability of the washing system under vague environment. This approach applies the TBFLT technique which uses triangular fuzzy numbers for incorporating data uncertainty, fault tree and lambda-tau method for finding system failure rate and repair time mathematical expressions while simplified Tω-based arithmetic operations are applied for computing various reliability parameters of the system. The effectiveness of the TBFLT technique has been demonstrated by analyzing fuzzy reliability of the system using five different techniques including TBFLT. Moreover, this paper applies extended Tanaka’s (1983) approach to rank the critical components of the system.
Findings
The TBFLT technique has the advantage of low computation complexity in comparison to other techniques and effectively reduces the accumulating phenomenon of fuzziness. This main finding verifies the conclusion made by Chen (1994).
Originality/value
The author has suggested a simple and more applicable technique for analyzing the fuzzy reliability of any complex process industrial system under vague environment. The effectiveness of the technique has been demonstrated by computing various reliability parameters of the washing system of a paper plant.
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Studies On Process Development for the Production Of Lipase
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
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