1,721,198 research outputs found
Affiliations of ISGC participants
No full text<p>These are affiliation data of ISGC participants with enrichments from Marion Maisonobe. This dataset is one of the outcomes of the NETCONF research project : <a href="https://netconf-geoscimo.univ-tlse2.fr">https://netconf-geoscimo.univ-tlse2.fr </a></p>
International Suicide Genetics Consortium (ISGC) Acknowledgement.
No full textInternational Suicide Genetics Consortium (ISGC) Acknowledgement.</p
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Full text linkGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
ISGC International Sheep Genomics Consortium: Update PAGXXXIII 2020
No full textThe long-term goal…. develop underpinning resources for the sheep research community
-- resulted in continued improvement of the sheep genome assembly, and the development of low, medium and high-density Illumina SNP chips.
-- continued to make available whole genome sequence data to the community; captured via the Sheep Genomes Database, an initiative of the ISGC that extends the consortium’s recent achievement
Etherification of Bio-Based Furanic Compounds via Continuous Flow
No full textCurrently, the majority of energy is produced from oil, coal, and natural gas. Additionally, petroleumderived products account for the largest share of total final energy consumption. [1] This highlightsthe urgent need to reduce reliance on fossil fuels, in line with EU strategies aimed at tackling the growing challenges of plastic
pollution, climate change, and sustainability. As a result, in 2007 the International Energy Agency (IEA), introduced the concept of Biorefinery (Task 42): "Biorefinery is the sustainable transformation of biomass into a wide range of commercial products (food, feed, chemical products) and energy (fuels, energy and heat)".[2] The ultimate goal of the biorefinery is the transition from a fossil-based model to a more sustainable industry focused on the use of renewable feedstocks, while adhering to the principles of the circular economy.[3] In this perspective, the socalled Bio-Based Platform Chemicals play an important role. Bio-Based Platform Chemicals are biomass derived molecules that incorporate one or more chemical moieties that can be easily functionalized so to lead to a library of derivatives for the most disparate applications i.e. biofuels, intermediates for the production of compounds of industrial interest and monomers for the
synthesis of bio-based polymers.[4] From this premises, the presented work focuses on the functionalization of several furanic monomers easily derived from D-fructose. In particular, etherification of 5-hydroxymethylfurfural (HMF) and 2,5-bis(hydroxymethyl)furan (BHMF) via continuous-flow have been investigated so to synthetised 5,5 -[oxybis(methylene)]bis-2-furfural (OBMF) via HMF self-etherification ′ and a library of 2,5-bis(alkoxymethyl) furans (BAMFs), respectively. In both case studied, reaction conditions were optimized by evaluating the type and quantity of heterogeneous catalysts, the reaction media, as well
as flow and temperature. In terms of possible applications BAMFs have demonstrated to be good additives for biofuels, meanwhile OBMF is generating increasing interest due to its exploitation in the synthesis of macrocycles (16-crown-6) and as a precursor of polyurethanes, polyamides, and polyamines
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Mapping of ISGC SNP chip probes
No full textOvine SNP chips created by the International Sheep Genomics Consortium (ISGC, https://sheephapmap.org/) were mapped onto reference genomes. Results are reported per chip and include SNP_name, chrom, pos, ref_alt, flag, rsID.Probe sequences were taken from the Illumina manifests (ISGC_SheepLD2015_15K_20003262_A1, OvineSNP50_B, SheepHD_AgResearch_Cons_15041608_A) and mapped onto the Oarv3.1 (GCF_000298735.1) and the Rambouillet version 1 (GCF_002742125.1) and Rambouillet version 2 (GCA_016772045.1) reference genomes using bwa mem v0.7.17-r1188 with default settings. Only SNPs were mapped, indels were ignored.For each SNP a probe pair was constructed by using AlleleA_ProbeSeq and appending either the reference or the alternative allele. Only probe pairs where accepted that passed following filters.-both probes have no alternative mappings-both probes are mapped-one probe is mapped with 0 mismatches-both probes are not multi-mapped-no indels were allowed-both probes had to map in the same orientation-both probes had to map to the same position-mapped probes had between them exactly 1 mismatch, the SNP.Mapped SNPs got assigned to rsIDs via their Oarv3.1 position (ftp://ftp.ensembl.org/pub/release-100/variation/vcf/ovis_aries/ovis_aries.vcf.gz).Any data shared here is without warranty
of any kind and in no event shall the authors or copyright holders be
liable for any claim, damages or any liability.</div
- …
