1,720,970 research outputs found
Pruritic papular eruption in HIV: A case successfully treated with NB-UVB
No full textAbstact Pruritic papular eruption (PPE) is a skin disease characterized by the eruption of itching papules on the extremities, face, and trunk; it is quite frequent in HIV-positive patients especially during the advanced immunosuppressive stage. PPE usually improves or heals when antiretroviral therapy restores the immune system function, but in some cases, it can take several months, and a symptomatic treatment for PPE is required. Systemic antihistamines, topical steroids, topical tacrolimus, itraconazole, pentoxyphilline, and ultraviolet B phototherapy have been proposed in cases of persisting PPE, but an elective treatment has not yet been found. We describe the case of a black patient affected by PPE, nonimproving with antiretroviral treatment, and resistant to topical steroids and oral antihistamines; a satisfactory and speedy result was achieved with narrow-band ultraviolet B phototherapy. © 2013 Wiley Periodicals, Inc
Photodynamic therapy: An option in mycosis fungoides
No full textBackground Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. Methods We retrospectively analysed MF patients treated with PDT over the last ten years. Each PDT protocol consisted of the appliance for 3 h under an occlusive film dressing on each lesion of a one-mm-thick layer of 16% methyl aminolaevulinate (MAL) 160 mg/g cream (Metvix®, Galderma, Paris, France). The cream was then removed and the skin was exposed to 630 nm red light from a diode lamp (Aktilite®, Galderma Benelux, Rotterdam, the Netherlands), with a total radiation dose of 37 J/cm2 for 9 mins. A protocol of one session every month was scheduled. The treated lesions were clinically examined, before each treatment. Results Four cases, three male and one female, had been treated with PDT. Two patch lesions on the plantar area, one leg and the pubic area were treated. The number of PDT sessions ranged from 4 to 9. Two complete remissions and two partial remissions were observed. A low-to-mild burning sensation was reported during the treatment, and persisted over the next day; no further side effects were observed. Conclusions Our series shows that PDT can be considered an effective second-line treatment in patients characterised by a disease located in difficult-to-treat anatomical areas such as the feet and the pubic area
Erythematous patches and pretibial ulcers: an uncommon presentation of cutaneous sarcoidosis
No full textLetter to the Edito
Peculiar features of non-melanoma skin cancers in organ transplant patients
Full text linkLe neoplasie cutanee non melanoma (NMSCs) hanno un’aumentata incidenza tra i pazienti trapiantati d’organo. L’obiettivo di questo studio è quello di comparare gli aspetti clinico-patologici dei NMSCs dei pazienti trapiantati con quelli dei soggetti immunocompetenti. A questo scopo abbiamo analizzato i NMSCs insorti tra i pazienti trapiantati dell’ Ambulatorio Pazienti Immunocompromessi della Dermatologia di Bologna (132 SCCs e 119 BCCs), nel periodo Gennaio 2013/Dicembre 2015, confrontandoli con un numero equivalente di NMSC (132 SCCs e 119 BCCs) insorti tra i pazienti immunocompetenti del Centro Tumori Cutanei della Dermatologia di Bologna. I pazienti trapiantati erano in media 12 anni più giovani al momento della diagnosi di NMSCs rispetto ai pazienti immunocompetenti; i tumori nei trapiantati erano più spesso multipli ed extracefalici. Una componente istologica a cellule fusate era più comune tra i CCSs dei pazienti trapiantati, una componente superficiale era invece più frequente tra i BCCs dei pazienti sottoposti a trapianto. Il decorso si è rivelato peggiore per gli SCCs dei pazienti trapiantati ma non per i BCCS. Questi risultati hanno un’implicazione diretta nella pratica clinica quotidiana. L’aumentata incidenza di NCSCs nei pazienti trapiantati e la loro distribuzione in sedi differenti rispetto ai soggetti immunocompetenti sottolineano l’importanza di un’attenta sorveglianza cutanea in questo gruppo di pazienti. Gli SCCs dei trapiantati, in particolare quelli a cellule fusate, dovrebbero richiedere un trattamento più aggressivo, che non è invece necessario per i BCCs. Infine i nostri dati sono a favore di una differente eziopatogenesi dei NMSCs nei trapiantati che potrebbero influenzare le future stategie di prevenzione e terapia.Non-melanoma skin cancers (NMSCs) are increased in organ transplant recipients The objective of this study is to compare clinicopathologic features of transplant and immunocompetent NMSCs. For this reason we have analyzed consecutive transplant NMSCs (132 SCCs, 119 BCCs) and immunocompetent NMSCs (132 SCCs, 119 BCCs) presenting between January 2013 and December 2015. Transplant patients were 12 years younger at time of NMSC diagnosis compared with immunocompetent individuals, and transplant tumors were often more multiple and extracephalic. Spindle cell morphology was more common in transplant SCCs, a superficial component was more common in transplant BCCs. Outcome was worse for transplant SCCs but not transplant BCCs. These findings have direct implications for clinical care. The increased frequency and distribution of transplant NMSCs underscore the importance of whole-body surveillance. Transplant SCCs, particularly those with diffuse spindle cell change, may require more aggressive management, whereas transplant BCCs do not. Finally, our data support differences in the pathogenesis of transplant NMSC, which may influence future preventive and therapeutic strategies
Keratosis lichenoides chronica mit untypischer klinischer Präsentation und variblen histopathologischen Merkmalen
No full text.N/
Erythema nodosum
No full textErythema nodosum is an acute inflammatory dermatosis characterized by painful nodules which are generally symmetrical and non ulcerative and are mainly located to the extensor surface of the lower legs. The nodules, due to septal panniculitis, are often accompanied by fever and resolve without permanent sequelae. Arthralgia occurs in more than 50% of patients and begins during the eruptive phase or precedes the eruption by 2-4 weeks. Erythema nodosum is presumed to be a hypersensitivity reaction and may occur in association with several systemic diseases or drug therapies, or it may be idiopathic. The most common cause of erythema nodosum is streptococcal infection in children and streptococcal infection and sarcoidosis in adults. Peak incidence occurs at age 18-34 years. Age and sex distributions vary according to etiology and race; women are affected more often than men. It is possible to distinguish between an acute and a chronic form of erythema nodosum; in the acute form, an early stage and a late stage can be detected, both clinically and histologically. Laboratory and instrumental examinations to be performed in case of erythema nodosum are varied and are intended to identify any underlying trigger disease. Erythema nodosum is a self-limited disease, so the therapy is often only symptomatic. Even if the erythema nodosum quickly responds to systemic steroids, in most cases their use is not recommended, nor necessary; is usually sufficient to use NSAIDs (eg, acetyl salicylic acid, ibuprofen, naproxen, indomethacin)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
- …
