1,721,041 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
1 Prognostic factors and outcome of patients with lymphoproliferative disorders who receive treatment with chimeric antigen receptor T-cells
Full text linkEl mal pronòstic dels pacients amb limfoma difús de cèl·lules B grans en recaiguda o refractari ha millorat significativament des de la incorporació de la teràpia de cèl·lules T-CAR. Tot i aquests enormes avenços, aproximadament el 60% dels pacients infosos progressaran, cosa que s'associa amb una mitjana de supervivència aproximada de 6 mesos i taxes de resposta a les estratègies de rescat inferiors al 25%. Finalment, la teràpia amb limfòcits T-CAR no està exempta de toxicitat a curt i/o llarg termini que disminueix la supervivència d'alguns pacients. En conjunt, no hi ha dubte que una acurada selecció de pacients és clau per identificar quins candidats tenen una probabilitat més gran de beneficiar-se d'aquesta teràpia. Aquesta Tesi Doctoral està composta per tres estudis clínics que analitzen dades de vida real de les teràpies T-CAR axi-cel i tisa-cel. En tots ells es va observar un perfil de seguretat similar al dels assajos pivotals, encara que un ús més freqüent de tocilizumab i corticoides va conduir a una menor incidència de síndrome d'alliberament de citocines (SAC) i neurotoxicitat (NT) greus. Entre els productes, els pacients tractats amb axi-cel van presentar taxes més altes de SAC i NT que els receptors de tisa-cel, cosa que va portar a un major ús d'agents immunosupressors, hospitalització i infeccions. Els pacients amb LDH sèrica elevada, més de 2 línies de tractament prèvies o aquells amb mal estat general van presentar un risc més gran de SAC i/o NT greu. Pel que fa a l'eficàcia, les taxes de resposta i els resultats de supervivència van ser comparables als dels assaigs pivotals. No hi va haver diferències significatives en la supervivència entre tots dos productes a l'anàlisi per intenció de tractar modificat. Entre les característiques prèvies al tractament associades amb eficàcia, identifiquem que nivells elevats de LDH i volum metabòlic tumoral, juntament amb un estat general deteriorat, es van associar a una pitjor supervivència lliure de progressió. L'avaluació de resposta al mes post-infusió va predir els resultats de la teràpia T-CAR i va identificar els pacients en remissió parcial amb alt risc de progressió. En conclusió, els tres estudis que integren aquesta tesi doctoral van aconseguir identificar variables que, abans o després de la infusió de limfòcits T-CAR, són capaços de predir el resultat dels pacients que reben aquestes teràpies.El pronóstico sombrío de los pacientes con linfoma difuso de células B grandes en recaída o refractario ha mejorado significativamente desde la incorporación de la terapia de células T-CAR. A pesar de estos enormes avances, aproximadamente el 60% de los pacientes infundidos progresarán, lo que se asocia con una mediana de supervivencia aproximada de 6 meses y tasas de respuesta a las estrategias de rescate inferiores al 25%. Finalmente, la terapia con linfocitos T-CAR no está exenta de toxicidad a corto y/o largo plazo que disminuye la supervivencia de algunos pacientes. En conjunto, no cabe duda de que una cuidadosa selección de pacientes es clave para identificar qué candidatos tienen una mayor probabilidad de beneficiarse de esta terapia. Esta Tesis Doctoral está compuesta por tres estudios clínicos que analizan datos de vida real de las terapias T-CAR axi-cel y tisa-cel. En todos ellos se observó un perfil de seguridad similar al de los ensayos pivotales, aunque un mayor uso de tocilizumab y corticoides condujo a una menor incidencia de síndrome de liberación de citocinas (SLC) y neurotoxicidad (NT) graves. Entre los productos, los pacientes tratados con axi-cel presentaron tasas más altas de SLC y NT que los receptores de tisa-cel, lo que llevó a un mayor uso de agentes inmunosupresores, hospitalización e infecciones. Los pacientes con LDH sérica elevada, más de 2 líneas de tratamiento previas o aquellos con mal estado general presentaron un mayor riesgo de SLC y/o NT grave. En cuanto a la eficacia, las tasas de respuesta y los resultados de supervivencia fueron comparables a los de los ensayos pivotales. No hubo diferencias significativas en la supervivencia entre ambos productos en el análisis por intención de tratar modificado. Entre las características previas al tratamiento asociadas con eficacia, identificamos que niveles elevados de LDH y volumen metabólico tumoral, junto a un estado general deteriorado, se asociaron a una peor supervivencia libre de progresión. La evaluación de respuesta al mes post-infusión predijo los resultados de la terapia T-CAR e identificó a los pacientes en remisión parcial con alto riesgo de progresión. En conclusión, los tres estudios que integran esta tesis doctoral lograron identificar variables que, antes o después de la infusión de linfocitos T-CAR, son capaces de predecir el resultado de los pacientes que reciben estas terapias.The dismal prognosis of patients with relapsed/refractory large B-cell lymphoma has significantly improved since the advent of CAR T-cell therapy. Despite these enormous advances, approximately 60% of infused patients will eventually progress, which is associated with a median overall survival of 6 months and response rates to salvage strategies inferior to 25%. Finally, CAR T-cell therapy is not devoid of short and/or long-term toxicity that diminish the survival of some patients. Altogether, it is beyond doubt that a careful patient selection is key to identify which candidates have a higher chance of benefitting from CAR-T therapy. The Doctoral Thesis presented herein is composed by three clinical studies analyzing real-world data of axi-cel and tisa-cel CAR-T therapies. In all of them, a similar safety profile to the pivotal trials was observed, although a higher use of tocilizumab and steroids led to a lower incidence of severe CRS and ICANS. Among products, patients treated with axi-cel had higher rates of CRS and ICANS then tisa-cel recipients, leading to an increased use of immunosuppressive agents, hospital stay and infections. Patients with increased serum LDH, more than 2 prior lines of treatment or those harboring a poor PS presented an increased risk of severe CRS and/or ICANS. Regarding efficacy, the response rates and survival outcomes were comparable to the pivotal trials. There were no significant differences in survival between both products in the modified intention to treat analysis. Among pretreatment characteristics associated with efficacy, we identified high LDH levels, TMTV values and a poor PS to be associated with a worse PFS. The 1-month post-infusion assessment was predictive of CAR T-cell outcomes and identified patients in partial remission at high risk of disease progression. In conclusion, the three studies that represent the body of this doctoral thesis accomplished to identify variables that prior or after CAR-T infusion are able to predict the outcome of patients receiving these therapies
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