3,985 research outputs found
Funktionelle Analyse von potententiell aktivierenden FGFR3 Mutationen
No full textAuthor Ingrid Hartl, MScAbweichender Titel laut Übersetzung der Verfasserin/des VerfassersDissertation Johannes Kepler Universität Linz 2022Arbeit nach Ablauf der Sperre auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Ledvice in rogovje srnjadi (Capreolus capreolus L.) kot bioindikatorja onesnaženosti okolja na Kozjanskem
No full textSrnjad je ena najprimernejših živalskih vrst za bioindikacijo onesnaženosti okolja. V pričujoči raziskavi so določili: (i) vsebnosti kovin v ledvicah 14 osebkov srnjadi, uplenjenih v letu 2005 na Kozjanskem(ii) vsebnosti kovin v ledvicah 35 osebkov srnjadi, uplenjenih v istem letu v Šaleški dolini(iii) nihajočo asimetrijo 4 merskih znakov rogovja 163 srnjakov, uplenjenih v obdobju 1975?2005 na Kozjanskem. Vsebnosti Pb, Hg in Asso bile v Šaleški dolini večje kot na Kozjanskem. Nasprotno se povprečne vsebnosti Cd v ledvicah mladičev srnjadi niso razlikovale, pri čemer so bile na Kozjanskem največje izmerjene vrednosti celo večje kot v Šaleški dolini in so v dveh vzorcih presegale zakonsko dopustne vrednosti. Kot reakcijsko bioindikacijo so uporabili merjenje nihajoče asimetrije (FA) rogovja. V retrospektivni študiji so ugotovili spreminjanje nihajoče asimetrije v obdobju 1975-2005, z viškom konec osemdesetih in na začetku devetdesetih let ter s kasnejšim upadom.Roe deer is one of the most suitable animal species for the bioindication of environmental pollution. The following aims were emphasised: (i) determinationof heavy metals in the kidneys of 14 roe deer, shot in 2005 in Kozjansko region(ii) the determination of heavy metals in the kidneys of 35 roe deer, shot in the same year in the Šalek Valley(iii) the measurement of fluctuating asymmetry (FA) of 4 antlers traits of 163 roe deer, shot in the period from 1975 to 2005 in Kozjansko region. Levels of Pb, Hg and As were higher in Šalek Valley than in Kozjansko region, but the average levels of Cd in roe deer offspring kidneys were not significantly different. The maximum measured levels in Kozjansko region were even higher than in Šalek Valley and two samples were exceeding legal allowable measurment levels. For testing a reactive bioindication we used a method of measuring the fluctuating asymmetry (FA) of roe deer antlers. In temporal comparison of the period 1975 to 2005 we have discovered a change of the oscillating asymmetry, with its maximum in the late 80\u27s and in the beggining of the 90\u27s and its posterior downturn
Aspects of Iwasawa theory over function fields
No full textWe consider -extensions of a global function field and study various aspects of Iwasawa theory with emphasis on the two main themes already (and still) developed in the number fields case as well. When dealing with the Selmer group of an abelian variety defined over , we provide all the ingredients to formulate an Iwasawa Main Conjecture relating the Fitting ideal and the -adic -function associated to and . We do the same, with characteristic ideals and -adic -functions, in the case of class groups (using known results on characteristic ideals and Stickelberger elements for -extensions). The final section provides more details for the cyclotomic -extension arising from the torsion of the Carlitz module: in particular, we relate cyclotomic units with Bernoulli-Carlitz numbers by a Coates-Wiles homomorphism
The thematic interpretation of plural nominalizations
No full textNominalizations, in German as well as in other languages, are systematically polysemous, a fact that has been widely discussed in the linguistic literature [...]. In this paper, I will discuss certain asymmetries concerning the interpretation of the postnominal genitive [...]
Organotin and osmoregulation: quantifying the effects of environmental concentrations of sediment-associated tri-n-butyltin and triphenyltin on osmoregulatory processes in the European flounder Platichthys flesus (L)
No full textThe disruption of physiological and morphological aspects of osmoregulatory processes in freshwater-adapted 0-group European flounders, Platichthys flesus (L.), caused by exposure to environmental concentrations (150 ng triorganotin g-1 dry weight sediment) of sediment-associated tri-o-butyltin chloride (TBTCl) and triphenyltin chloride (TPhTCl), was examined and quantified. Radiotracers were used to measure hydromineral fluxes, the water balance and passive sodium efflux of chronically (35 days) exposed fish. The water permeabilities of exposed flounders varied during the course of the experiment and were significantly lower than the corresponding controls, that did not change significantly with time. It was found that the maximum change in water permeability of TBTCl- and TPhTCl exposed fish occurred after 14 days and 21 days, respectively; thereafter there was an increase towards control values, suggesting adaptation to compensate for the effects of the organotin exposure. Drinking rates increased significantly in both organotin groups buturine production rates did not change. The effects of organotin exposure on the passive sodium efflux and Na+/K+-ATPase activity showed an inverted relationship in the TBT group, where the Na7K+-ATPase activity was reduced and the passive sodium efflux was increased. TPhT had no inhibitory effect on Na7K+-ATPase activity and the passive sodium efflux increased only gradually. The overall effect of these changes in these components of hydromineral regulation was to reduce the mean blood osmolalities of the organotin groups compared to the control values.The effects of chronic exposure to sediment-associated triorganotin compounds during sea water adaptation was examined and quantified by measuring the active sodium efflux, Na+/K+-ATPase activity and structural changes to the gill epithelium usually encountered in euryhaline fish during adaptation to sea water. Following the transfer to seawater, the Na+/K+-ATPase activity and the active sodium efflux were decreased in the TBT group but increased significantly in both the TPhT and control groups. Similarly, the morphological changes to the gill epithelium, involving chloride cell distribution, associated with sea water adaptation, took place in the control group and only partially in the TPhT group but were significantly inhibited or delayed in the TBT group. The exposure to organotin caused the mean blood osmolalities in fish of the TBT and TPhT to rise beyond the expected values that were observed in the control group. The results presented in this study lead to the conclusion that tri-tt-butyltin chloride and triphenyltin chloride in sediments are capable of significantly disrupting both the physiological as well as morphological components of osmoregulatory functions of an estuarine fish, at concentrations currently found in local sediments
Structural gravity models of international trade: environment and competition
No full textThis dissertation contributes to two frontiers of research in structural gravity models of international trade: (i) the impact of international trade on the environment, in particular with respect to climate change, and (ii) the effect of market power on international trade and welfare gains from trade. After an introductory overview, chapter two examines the general equilibrium effect of liberalizing trade in the European Union (EU) on CO2 emissions and welfare. Chapter three presents estimates of the magnitude of carbon leakage as a consequence of emission reduction commitments under the Kyoto Protocol. Chapter four develops a parsimonious quantitative general equilibrium model of world trade and examines the welfare effects of trade (de)liberalization under modes of imperfect competition.Author Mag. Anton Hartl, MScDissertation Johannes Kepler Universität Linz 202
Reference priors in non-normal location problems
No full textBayesian Statistics;Statistical Distribution
Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei
No full textTwo distantly related classes of cylindrical chaperonin complexes assist in the folding of newly synthesized and stress-denatured proteins in an ATP-dependent manner. Group I chaperonins are thought to be restricted to the cytosol of bacteria and to mitochondria and chloroplasts, whereas the group II chaperonins are found in the archaeal and eukaryotic cytosol. Here we show that members of the archaeal genus Methanosarcina co-express both the complete group I (GroEL/ GroES) and group II ( thermosome/prefoldin) chaperonin systems in their cytosol. These mesophilic archaea have acquired between 20 and 35% of their genes by lateral gene transfer from bacteria. In Methanosarcina mazei Go1, both chaperonins are similarly abundant and are moderately induced under heat stress. The M. mazei GroEL/ GroES proteins have the structural features of their bacterial counterparts. The thermosome contains three paralogous subunits, alpha, beta, and gamma, which assemble preferentially at a molar ratio of 2: 1: 1. As shown in vitro, the assembly reaction is dependent on ATP/Mg2+ or ADP/Mg2+ and the regulatory role of the beta subunit. The co-existence of both chaperonin systems in the same cellular compartment suggests the Methanosarcina species as useful model systems in studying the differential substrate specificity of the group I and II chaperonins and in elucidating how newly synthesized proteins are sorted from the ribosome to the proper chaperonin for folding
ASCB Award Essays (F. Ulrich Hartl is the corecipient of the 2017 E. B. Wilson Medal awarded by the American Society for Cell Biology.)
No full textProtein folding in the cell was originally assumed to be a spontaneous process, based on Anfinsen's discovery that purified proteins can fold on their own after removal from denaturant. Consequently cell biologists showed little interest in the protein folding process. This changed only in the mid and late 1980s, when the chaperone story began to unfold. As a result, we now know that in vivo, protein folding requires assistance by a complex machinery of molecular chaperones. To ensure efficient folding, members of different chaperone classes receive the nascent protein chain emerging from the ribosome and guide it along an ordered pathway toward the native state. I was fortunate to contribute to these developments early on. In this short essay, I will describe some of the critical steps leading to the current concept of protein folding as a highly organized cellular process
Neutral Point Substitution Patterns in the Grasshopper <i>Podisma</i> and the Fruit Fly <i>Drosophila</i>
No full text<p>Frequency of the different point substitutions in <i>Podisma</i> (black) and <i>Drosophila</i> (grey) (data from Petrov and Hartl [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030022#pgen-0030022-b009" target="_blank">9</a>]) expressed as a percentage of the average substitution rate.</p
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