829 research outputs found
Kosciusko [music] /
No full textFor voice and piano.; Cover title.; "Introduced & sung by Miss Nella Webb."; Cover carries portraits of Nella Webb (by Rudolph Buchner), Charles Vaude and Moritz Lutzen.; Words printed as text on p. [4].; "During Moritz Lutzen's visit to Australia he offered a prize for the best lyric, by an Australian author to be set to music by himself. The prize was awarded to Charles Vaude, for his lyric 'Kosciusko,' and Miss Nella Webb produced this song with instantaneous success."--P. [4].; Also available online http://nla.gov.au/nla.mus-an8393500; 1913, by Victor J. Draper, Sydney.; NLA's NL copy from the collection of Keith Watson. ANL
Letter containing inquiry regarding the ethnic identity of the descendents of Georg Moritz Oppenheim.
No full textLetter from Wilhelm Gehlig to Rabbi Dr. Freudenthal in Nuremberg with a genealogical question regarding Georg Moritz Oppenheim. Of particular interest to the author is to determine whether Oppenheim's descendents are "rein jüdischen Blutes (=of pure Jewish blood)."Robert Singermandigitize
Conventional and circular economy compliant modification strategies for recycled polypropylene
No full textAuthor Moritz MagerMasterarbeit Universität Linz 2021Arbeit gesperr
Conventional and circular economy compliant modification strategies for recycled polypropylene
No full textAuthor Moritz MagerMasterarbeit Universität Linz 2021Arbeit gesperr
Hayo Haya Maaseh [= Once upon a time]
No full textAnthology of East European Jewish folklore, with introduction and sources. The anthology includes: songs, tales, traditions, customs, jokes, proverbs, riddles. Authored by Chaim Ben Zion Elon-Baranik (born 1901). Published immediately after the Second World War. Illustrations by Moritz Oppenheimer, L. Pilichowski, Yosef Budko, E.M. Lilien (his signature in print). Most of the illustrations are printed on separated chrome paper, on one side of the page. Folklore publishing, Tel Aviv. HaIvri press, Jerusalem. 22 em. [1],303, [3] pages. Excellent condition. Chipped top of spine. . '... Olb price140-160This is a hardbound book (hard cover)Language note: HebrewChaim Ben Zion Elon-Barani
Karl Philipp Moritz\'s essays: language, arts, philosophy (selection, introduction, translation and notes)
No full textApós mais de duzentos anos, o interesse pela obra de Karl Philipp Moritz (15 de setembro de 1756 26 de junho de 1793) só tem aumentado. Diferentes autores como Herman Hesse e Walter Benjamin, e, mais recentemente, Hans Joachin Schrimpf, Tzvetan Todorov, Peter Szondi, Arno Schmidt e Peter Handke têm escrito ressaltando a importância e a fecundidade desse autor. Moritz pode ser considerado um dos autores inaugurais do romantismo alemão. Este mestrado em filosofia, área de estética, pretende, por meio de seleção, tradução e introdução dos textos de Karl Philipp Moritz, contribuir para a valorização dessa importante obra em nossa cultura. Os textos selecionados são de teoria da linguagem, estética e filosofia.After over two hundred years, the concern for the works of Karl Philipp Moritz (September 15th 1756 June 26th 1793) has increased steadily. Different authors such as Herman Hesse and Walter Benjamin and more recently Hans Joachin Schrimpf, Tzvetan Todorov, Peter Szondi, Arno Schmidt and Peter Handke have written on the relevance and fecundity of this author. Moritz can be said to be one of the inaugural authors of German Romanticism. This Masters in Philosophy, in the Aesthetics field, intends, by means of selection, translation and introduction of Karl Philipp Moritz texts, to contribute to the appreciation of this important work in our culture. The selected texts belong to the fields of Language Theory, Aesthetics and Philosophy
Survival : 1933-1945.
No full textAutobiography in German, French and English with illustrations by the author and reproductions of photos and documents.Family history in Becherbach, Germany going back to the 18th century. The author's father Ludwig David Moritz served in World War One. He got married to Klara Kaufmann in 1929. Birth of their sons Alfred and Ernst. Rise of Nazism. In 1936 Alfred was enrolled in the public school of Becherbach. Confrontation with anti-Jewish laws and regulations. Celebration of Jewish holidays with the maternal Kaufmann family in Cologne. Night of the November pogrom in 1938 and arrest of his father. Ludwig Moritz was taken to Dachau concentration camp, where he was interned for three months. His sons Alfred and Ernst were taken to safety by their uncle Hermann Wolf in Luxemburg. His parents followed after the release of their father from Dachau. German invasion of Belgium, Luxemburg and France in 1940. Escape to Southern France. Ludwig Moritz was interned in the camp Les Milles near Aix en Provence. Alfred and Ernst were enrolled in the local public school in St. Lizaigne. Life in hiding in Issoudun, where their father's brother had a clothes business. Alfred and Ernst were sent to the Jewish children relief organization OSE (Oeuvre de Secours de l'Enfance). With support of the French resistence movement new identity cards were issued for the two siblings, which stated them being of French descendent. Life in hiding in the countryside of Vernoux/Vivarais. They were enrolled in a public school and in the local Catholic sunday school of Vernoux. End of the war and final reunion with their parents.The architect Alfred Moritz was born in Becherbach, Germany. He survived the war in hiding in the French countryside and was reunited with his parents after the war. The author lived in the United States.Synopsis in fileMoses familyDijonLyonEmigration and immigration, 1933-1945, LuxemburgEmigration and immigration, 1933-1945, FranceEmigration and immigration, after 1945, United StatesFrench Resistance movements, WarGermany, history, 1933-1945Holocaust, survivorsMilliner
Using multi-parametric imaging and multi-nuclear cardiac magnetic resonance to investigate novel treatment strategies for heart failure
No full textHeart failure (HF) remains the leading cause for hospitalisation in patients over the age of 65 years in industrialised nations. Furthermore, prognosis of HF remains poor and lags behind the improvements observed for similar chronic conditions like cancer, despite efforts for new therapies. However, these therapies are mostly available for patients with HF and a reduced ejection fraction (HFrEF), whereas prognostically relevant therapies for patients with HF and a preserved ejection fraction (HFpEF) have been absent for more than 20 years and this only changed very recently with the results of the EMPEROR-preserved trial investigating treatment with empagliflozin (10 mg once daily) in patients with HFpEF. Equally, a significant improvement of quality of life and physical limitations has been shown for patients with HFpEF following treatment with dapagliflozin in PRESERVED-HF.
An increasing amount of evidence describes more subtypes of the complex and rather arbitrarily classified syndrome of HF and thus, there is a growing need for comprehensive, non-invasive imaging techniques to identify and individually phenotype patients affected. Furthermore, the same approach could be used to assess novel treatments as well as identify treatment responders, further tailoring individual patient management and aid efforts to improving prognosis. Additionally, use of a model imaging technique may lower the exponential costs of drug development by reducing the numbers of subjects needing to be enrolled and increasing reproducibility of findings.
Cardiovascular magnetic resonance (CMR) fulfils many of the demands for a model imaging technique in the context of HF-phenotyping and -drug development. Firstly, CMR is the gold standard method to assess cardiac structure and function. More importantly, it allows examination of imaging and metabolic parameters alike and, with novel techniques like dynamic nuclear polarisation (i.e. hyperpolarized MR spectroscopy), even direct assessments of molecular cellular pathways. Thirdly, HF is a syndrome affecting multiple organ systems and thus, has complex and incompletely understood links in need of exploration. MR offers the possibility of multi-organ assessment in the same session and therefore, is perfectly placed to gather information on the biological interplay in HF.
The underlying mechanism for the observed benefits of sodium glucose like transporter 2 inhibitors (SGLT2i) like empagliflozin in HFrEF are not yet understood. One of the leading hypotheses brought forward was that SGLT2i may induce changes in myocardial substrate selection via increased availability of ketone bodies which may serve as an additional energy source for the failing heart. Thus, I sought to investigate whether empagliflozin treatment (10mg per day) would enhance myocardial energetics in patients with HFrEF (phosphocreatine to adenosine triphosphate ratio, PCr/ATP). In this randomised controlled trial (RCT), patients did not improve measures of resting or dobutamine stress myocardial energetics (Chapter 3) and empagliflozin treatment neither altered a panel of 19 serum metabolites assessed by targeted metabolomic analysis. However, there were interesting changes to the amount of triglycerides stored in the heart, myocardial cell volume and hypertrophy as well as markers of fibrosis and quality of life (QoL). This exemplifies the usefulness of CMR in the interrogation of novel treatments and likewise emphasises that the broad range of indications for SGLT2i (diabetes, chronic kidney disease, heart failure) is possibly mirrored by a multi-organ rather than a single cardio-specific effect in patients with HFrEF.
As it was unclear until very recently if patients with HFpEF would equally benefit from treatment with SGLT2i, I further integrated a HFpEF cohort into the RCT and investigated the identical variety of parameters as for the HFrEF patients (Chapter 4). Similarly to the findings in the HFrEF cohort (Chapter 3), I could not observe any changes to myocardial energetics (resting PCr/ATP as primary endpoint) or whole-body substrate usage (targeted metabolomics). Interestingly, I detected certain similarities nevertheless as myocardial triglycerides reduced in the treatment arm but not in the placebo group. Furthermore, systolic function (peak circumferential and radial strain) and measures of pulmonary function improved. This was also paralleled by a numerically improved walking distance in the six-minute walk test (6MWT) and increased QoL (assessed by the Kansas City Cardiomyopathy Questionnaire; KCCQ). The present results reinforce the need for mechanistic experiments in human subjects in-vivo, as they highlight the disparity of results from animal models that previously showed a metabolic effect following treatment with SGLT2i. Furthermore, more research is needed into effects of drugs in different HFpEF subtypes (e.g. diabetic, obese) to improve risk stratification and adequate treatment.
To explore novel, non-pharmacological treatments targeting unique subgroups under the ‘HFpEF-umbrella’, I aimed to explore whether a lifestyle intervention of weight loss is an effective treatment for patients with obesity and HFpEF (Chapter 5). Accordingly, I enrolled patients with a clinical diagnosis of HFpEF and observed cardio-metabolic effects following 10 weeks of a very low energy diet (VLED). Assessments included exercise CMR and dobutamine stress phosphorus magnetic resonance spectroscopy (31P-MRS). While cardiac energetics at rest or during dobutamine stress did not change, prognostic serum markers (n-terminal pro-BNP; NT-proBNP) and symptom burden (New York Heart Association; NYHA) improved significantly and cardiac structure (LV-mass) as well as function (diastolic function on echo and RV function at rest and during exercise) ameliorated. The results emphasise that lifestyle treatments in select patient groups are underutilised yet cost-efficient, safe and successful. Furthermore, the obesity paradox (describing the observation that mild obesity appears to be protective in HF) may not equally apply to the group of severely obese HFpEF patients (BMI>30 kg/m2) and thus, this should be investigated in larger trials.
Finally, I was interested to examine the feasibility of CMR in the context of early (phase IIa) cardio-metabolic drug development. In Chapter 6, I enrolled 22 patients with type 2 diabetes (T2D) but no underlying HF and investigated the effects of ninerafaxstat, a novel drug intended to enhance myocardial substrate metabolism via restoring metabolic flexibility in the heart. Here I show that the drug’s proposed mechanism of action can indeed be successfully investigated by using [1-13C]pyruvate hyperpolarized MRS. The pyruvate dehydrogenase (PDH) flux was improved in the majority of subjects (7/9). Furthermore, this resulted in significantly improved PCr/ATP and reduced myocardial steatosis. Diastolic function and early LV-filling also improved following drug treatment for 4 or 8 weeks. Based on these results, hyperpolarized MRS is a suitable tool to investigate the mechanism of action in early drug development in humans with reduced sample sizes. The broader implication is certainly that, similar to treatments for immune modulation (e.g. canakimumab), patient selection is key for metabolic assessments in clinical trials.
To summarise, this Thesis examines cardio-metabolic effects of different pharmacological and lifestyle treatments in distinct populations and further demonstrates the suitability of CMR as an investigational tool for drug development. While the results underpin the importance of substrate selection and implications on cardiac structure and function, improved patient selection is key for demonstrating these effects with statistical significance. Furthermore, refuting the ‘fuel hypothesis’ theory as the main contributor to SGLT2i’s mode of action, I provide evidence for multi-organ effects of SGLT2i being likely responsible for the benefits observed in HF. Secondly, I add to the existing evidence that intentional weight loss is a safe and effective treatment in obese HFpEF patients
From « reminiscences » to « poetic pictures » : Sturm und Drang and sentimental trend in Karl Philipp Moritz’ work
No full textLa découverte d’œuvres du Sturm und Drang et de la tendance sentimentale (allemande et anglaise) fut pour le jeune K. Ph. Moritz une expérience déterminante, aussi bien pour le développement de sa personnalité que pour ses débuts comme écrivain. Nous avons entrepris d’étudier les différentes « traces » laissées par cette littérature dans les écrits de l’auteur, ainsi que leur évolution, notamment dans le cadre d’une pratique de l’intertextualité transformant de simples « réminiscences » littéraires en procédés d’écriture maîtrisés, voire même en « tableaux poétiques ». Nous analysons tout d’abord la réception du Sturm und Drang et de la tendance sentimentale par Anton Reiser (« double » du jeune Moritz) comme lecteur, poète et spectateur, réception « mise en scène » par l’auteur dans son roman autobiographique Anton Reiser. Nous tentons ensuite de montrer comment Moritz, entre 1780 et 1790, prend de la distance avec « l’enthousiasme » caractérisant sa réception de jeunesse de ces courants, sur lesquels il pose désormais un regard « éclairé » et objectif, depuis son point de vue d’écrivain, de critique littéraire et de psychologue empirique des « Lumières tardives », rejetant l’outrance dans le tragique, critiquant la Schwärmerei et observant les « maladies de l’âme ». Enfin, nous consacrons notre dernière partie au point de vue « esthétique » depuis lequel Moritz considère certaines œuvres du « temps des génies » (particulièrement Les Souffrances du jeune Werther), qui trouvent également leur place dans la théorie littéraire de l’auteur (exposée dans plusieurs écrits publiés après son séjour en Italie, entre 1792 et 1794), et dans sa pratique de la description de paysages.To discover works from the Sturm und Drang (« Storm and stress ») movement and from the sentimental trend (German and British) was a determining experience to the young Karl Philipp Moritz, for the development of his personality as well as for the beginning of his career as a writer. The present study aims at researching the « traces » left by this literature in Moritz’ work, and their evolution, in particular through intertextuality, which transforms simple literary « reminiscences » into mastered literary techniques, even into « poetic pictures ». First we analyse the reception of the Sturm und Drang and of Sentimentalism by Anton Reiser (« double » of Moritz in his youth) as reader, poet and spectator, reception « represented » by Moritz in his autobiographical novel Anton Reiser. We then examine how the author, between 1780 and 1790, distances himself from his former « enthusiastic » reception of those literary trends: from now on, he considers them from his « enlightened » and objective point of view as a novelist, a dramatist, a critic and an empirical psychologist of the « Late Enlightenment », rejecting excesses in tragedy, criticising the Schwärmerei and studying the « diseases of the soul ». The last part of our study is devoted to the « aesthetic » point of view, from which Moritz considers some works from the sentimental trend and from the Sturm und Drang (in particular The Sorrows of the Young Werther), which have also found a place in the literary theory of the author (expounded in several writings published between 1792 and 1794, after Moritz’ stay in Italy) and in his pratice of landscape description
Models for XFL: Naming Functions in Binaries with Extreme Multi-label Learning
No full text<p>The models and PSQL tables accompanying the paper <a href="https://arxiv.org/abs/2107.13404" target="_blank" rel="nofollow noreferrer noopener"><em>XFL: Naming Functions in Binaries with Extreme Multi-label Learning</em></a> by James Patrick-Evans, Moritz Dannehl and Johannes Kinder, which has been presented at the <a href="https://sp2023.ieee-security.org/index.html" target="_blank" rel="nofollow noreferrer noopener">IEEE Symposium on Security & Privacy 2023</a>.<br><br>The repository to use these artifacts is available <a href="https://github.com/lmu-plai/xfl" target="_blank" rel="noopener">on github</a>.<br>Read the <a href="https://github.com/lmu-plai/xfl/tree/main/xfl-r/README.md" target="_blank" rel="noopener">README</a> of XFL refactoring for more details.</p>
<p> </p>
<p>Please cite the paper as</p>
<div>
<pre><code>@inproceedings{oakland23-xfl,
author = {James Patrick-Evans and Moritz Dannehl and Johannes Kinder},
title = {{XFL}: Naming Functions in Binaries with Extreme Multi-label Learning},
booktitle = {Proc. IEEE Symp. Security and Privacy (S\&P)},
pages = {1677-1692},
publisher = {IEEE},
year = {2023},
doi = {10.1109/SP46215.2023.00096},
}</code></pre>
</div>
<p> </p>
<p>Please cite the record as:</p>
<div>
<pre><code>@misc{artifacts-xfl,
author = {Tristan Benoit},
title = {{Models for XFL}: Naming Functions in Binaries with Extreme Multi-label Learning},
publisher = {Zenodo},
year = {2024},
doi = {10.5281/zenodo.10733597},<br> url = {https://doi.org/10.5281/zenodo.10733597},
note = {Available at \url{https://doi.org/10.5281/zenodo.10733597}}<br>} </code></pre>
</div>
- …
