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Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
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Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution
by Arianna Dolce
and Sara Della Torre
* [ORCID]
Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2023, 15(10), 2335; https://doi.org/10.3390/nu15102335 (registering DOI)
Received: 18 April 2023 / Revised: 12 May 2023 / Accepted: 13 May 2023 / Published: 16 May 2023
(This article belongs to the Special Issue Diet and Fertility Status: Relevance in Health and Disease)
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Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease and represents an increasing public health issue given the limited treatment options and its association with several other metabolic and inflammatory disorders. The epidemic, still growing prevalence of NAFLD worldwide cannot be merely explained by changes in diet and lifestyle that occurred in the last few decades, nor from their association with genetic and epigenetic risk factors. It is conceivable that environmental pollutants, which act as endocrine and metabolic disruptors, may contribute to the spreading of this pathology due to their ability to enter the food chain and be ingested through contaminated food and water. Given the strict interplay between nutrients and the regulation of hepatic metabolism and reproductive functions in females, pollutant-induced metabolic dysfunctions may be of particular relevance for the female liver, dampening sex differences in NAFLD prevalence. Dietary intake of environmental pollutants can be particularly detrimental during gestation, when endocrine-disrupting chemicals may interfere with the programming of liver metabolism, accounting for the developmental origin of NAFLD in offspring. This review summarizes cause–effect evidence between environmental pollutants and increased incidence of NAFLD and emphasizes the need for further studies in this field
As doces heresias de "La dolce vita"
No full textNuestro aprendizaje cultural, mediático y fílmico, como generación educada en un contexto sociocultural latino y esencialmente católico, intelectual, social, sexual y políticamente estigmatizado fue transfigurado por Federico Fellini en la película «La dolce vita». El autor analiza las claves proféticas, éticas, estéticas y cinéfilas de esta obra que considera la piedra angular de nuestra cultura cinematográfica. Para ello aborda cinco perspectivas en las que analiza lo que él llama las «doce herejías» del film.___________________________________The author analyses how Federico Fellini represents in «La dolce vita» the social, cultural, sexual and politic characteristics of a generation who has grown up in a strict latin and catholic context. Ethic, aesthetic and cinematographic keys of this film are analysed by the author using five dimensions. These keys are called by him the "twelve heresies" of "La dolce vita"
Cinematographic analysis of «La dolce vita»: the twelve heresies
No full textThe author analyses how Federico Fellini represents in «La dolce vita» the social, cultural, sexual and politic characteristics of a generation who has grown up in a strict latin and catholic context. Ethic, aesthetic and cinematographic keys of this fil
Il desiderio di potere e il potere del desiderio: la "catastrofe del colonialismo" in Wanting di Richard Flanagan
No full textWanting (2008), a moving novel by the Tasmanian writer Richard Flanagan, is a stern and provocative condemnation of what the author defines as “the catastrophe of colonialism”. The antipodean imperial adventure has, on the one hand, permanently affected the aboriginal people destroying their civilization and culture, while, on the other hand, has influenced the process of identity construction of a country which is still struggling to free itself from the national legend and its founding myths.
The article examines the innovative features of this ‘neo-Victorian’ text (an inadequate definition to represent its complexity and originality) which subverts the traditional genre of the historical novel in order to explore, through postmodern writing strategies, reworked to serve the writer’s postcolonial project, the “overlapping territories, intertwined histories” (Said 1993) generated by colonial expansion. Connecting stories which embrace the new and the old world, Flanagan questions the official version of the peaceful white settlement in Van Diemen’s Land and the myth of the “grand destinies and progressive hopes” of Victorian society, while reflecting on the power of words and on the responsibility of creative writing. Thanks to his delicate and participated work of rediscovery and rewriting of the past, which takes shape throughout the pages of the novel, Flanagan leads the reader towards a form of understanding and “empathic knowledge” (LaCapra 2014) aimed at urging the assumption of a shared responsibility
Lodovico Dolce tragediografo tra riscrittura dell'antico e traduzione
No full textLodovico Dolce between re-writing of the Ancient and translation
The present thesis consists in a precise and complete textual analysis of tragical production of Venetian playwright Lodovico Dolce (1508-1560), except his two last tragical works (Marianna and Troiane). Above all, I’ve studied well the first translation of the whole Senecan tragical corpus realized in a modern European language ever, published in Italian by Dolce in 1560 (Venezia, Sessa). Obviously, in the first chapter I’m concerned with the theory and practice of tragical poetry in Italy during the XVI century (in particular in the midst of the century), to contextualize the historical, political, anthropologi-cal, cultural position of Dolce and to underline what were his aesthetical ideas about the new tradition of tragical modern poetry. In the third chapter, I’m concerned with the various phenomenology of re-writing and translational theories and practices in the XVI century, with the goal to know what were the landmarks that Dolce chose for his theatrical texts, always result of a complex hypertextual activity, never original. The author, a poligrafo that was historic, comedian, satirical and epic poet, anthologist, translator, essayist, grammarian and editor and that asserted himself in the typographical world of Ve-nice, was also, although forced to work incredibly hard (and my research would show it) capable of do-ing authorial and autonomic literary choices, of finding personal dramatic and poetic strategies and of realizing a fundamental popularization of cultural contents (especially classical), otherwise not available for the majority of the people at that time
“Never-ending stories”: da "The Tempest" di William Shakespeare alle riletture e riscritture del grande classico nella letteratura caraibica
No full textShakespeare’s The Tempest (1611), despite the lightness of tone required by its romance genre, is a complex and many-sided play, an inexhaustible wealth of ideas to be explored and revisited in order to deal with questions which are still relevant and urgent in our contemporary society. The extraordinary number of critical re-readings and rewritings of The Tempest, which re-imagine the authoritative source text either celebrating or contesting it, is a clear sign of its power to engender a fruitful and provocative debate, which has guaranteed its constant “actualization” throughout the centuries. While literary critics have produced memorable pages investigating virtually every aspect of the play, this chapter, moving from an analysis of the romance which emphasises the richness of its suggestions and implications, intends to stimulate a reflection on the driving force exerted by the creative Word of the Bard, which is able to generate a dialogue that crosses sterile and fictitious barriers between worlds and cultures. Interesting expressions of such a debate are the innumerable and varied appropriations and transformations of The Tempest in Caribbean literature, which has turned the rewriting of the classics into a strategy of cultural decolonization, as in the following texts that will be taken into examamination: Aimé Césaire’s play Une tempête. D’après La Tempête de Shakespeare. Adaptation pour un théâtre nègre (1969), Edmund Kamau Brathwaite’s poem “Caliban” (1969), George Lamming’s novel Water With Berries (1971) and his collection of essays The Pleasures of Exile (1960). The closing part of this chapter is devoted to the analysis of Marina Warner’s Indigo (1992), a peculiar refashioning of the Shakespearean play overlapping feminist and postcolonial claims, a novel which could be included among the “Caribbean” rewritings, despite the British origins of the author, because of its fundamental preoccupations. Indigo is adopted as a significant example of the productive intertwinings of issues and claims generated by The Tempest, an immortal classic which has activated processes of cross-cultural fertilization transcending spatial and temporal boundaries
Survey Tingkat Pengetahuan Dan Sikap Pasien Kusta Tentang Perawatan Diri Di Desa Oeltua Wilayah Kerja Puskesmas Baumata Kecamatan Taebenu
No full textKusta merupakan penyakit infeksi yang kronik, yang disebabkan oleh mycrobakterium lepra yang bersifat intra seluler. Tujuan penelitianini adalah untuk mengidentifikasi pengetahuan dan sikap tentang perawatan diri penderita kusta. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan rancangan penelitian yaitu deskriptif melalui pendekatan survey untuk menjawab pertanyaan riset tentang tingkat pengetahuan dan sikap pasien kusta tentang perawatan diri di Wilayah Kerja Puskesmas Baumata. Populasi penelitian adalah semua penderita kusta yang ada di Desa Oeltua Wilayah Kerja Puskesmas Baumata Kecamatan Taebenu yang berjumlah 53 orang. Sampel dalam penelitian ini diambil dengan cara accidental sampling berjumlah 53 orang. Hasil penelitian mengenai pengetahuan dan sikap tentang perawatan diri penderita kusta di Desa Oeltua Kecamatan Taebenu diketahui bahwa terdapat 4 orang (7,54%) memiliki tingkat pengetahuan yang baik, 24 orang (4,29%) memiliki tingkat pengetahuan yang cukup dan yang memiliki tingkat pengetahuan kurang 25 orang (47,17%). Hasil penelitian mengenai sikap perawatan diri penderita kusta di Desa Oeltua Kecamatan Taebenu diketahiu bahawa terdapat 5 orang (9,43%) memiliki sikap baik, 18 orang (33,96) memiliki sikap cukup, 30 orang (56,61%) memiliki sikap kurang
I ragionamenti di Lodovico Dolce sulla Institution della vergine
No full textLodovico Dolce (1508/1510-1568), a great humanist and scholar of the sixteenth century, was a multifaceted and multidimensional figure, a prolific writer with a restless and curious spirit, among the intellectuals who participated in the Querelle des Femmes during the Renaissance period. It is in this context that his treatise Dialogo di M. Lodovico Dolce della institution delle donne secondo li tre stati, che cadono nella vita humana is placed. The Dialogo is made up of three books, each of which presents his reasoning and rules of behaviour he proposes for the three phases of women's life, namely virgins, married women and widows. The aim of our intervention is to examine and highlight Dolce's arguments on the institution della vergine set out in the first book of the dialogue, as well as to present the female profile proposed by the author and the virtues that a young and single woman must have in sixteenth-century society.Lodovico Dolce (1508/1510-1568), grande umanista e studioso del Cinquecento, fu figura poliedrica e pluridimensionale, scrittore prolifico con spirito inquieto e curioso nonché tra gli intellettuali che parteciparono alla Querelle des Femmes durante il periodo del sedicesimo secolo. Proprio in questo ambito si colloca il suo trattato Dialogo di M. Lodovico Dolce della institution delle donne secondo li tre stati, che cadono nella vita humana. Il Dialogo è composto da tre libri, ognuno dei quali presenta i suoi ragionamenti e le regole di comportamento per le tre fasi della vita delle donne, cioè le vergini, le maritate e le vedove. L'obiettivo dell'intervento consiste nell'esaminare ed evidenziare i ragionamenti di Dolce sulla institution della vergine esposti nel primo libro del Dialogo; presentare il profilo femminile proposto e le virtù di cui deve essere dotata una donna giovane e nubile nella società cinquecentesca
Corrigendum: Platinated Nucleotides are Substrates for the Human Mitochondrial Deoxynucleotide Carrier (DNC) and DNA Polymerase γ: Relevance for the Development of New Platinum-Based Drugs (ChemistrySelect, (2016), 1, (4633-4637), 10.1002/slct.201600961)
No full textIn agreement with all authors of this paper the order of the authors and the contribution “Paola Lunetti[+], Alessandro Romano[+], Chiara Carrisi, Daniela Antonucci, Tiziano Verri, Giuseppe E. De Benedetto, Vincenza Dolce, Francesco P. Fanizzi, Michele Benedetti,* and Loredana Capobianco.* [+] These authors contributed equally to this paper. * Corresponding authors: Michele Benedetti and Loredana Capobianco, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce.” is corrected to read the original order of the first submitted version of the paper: “Chiara Carrisi[+], Alessandro Romano[+], Paola Lunetti, Daniela Antonucci, Tiziano Verri, Giuseppe E. De Benedetto, Vincenza Dolce, Francesco P. Fanizzi, Michele Benedetti,* and Loredana Capobianco.* [+] These authors contributed equally to this paper. * Corresponding authors: Loredana Capobianco and Michele Benedetti, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce.” For completeness the following individual contributions of the authors were added in the Supporting Information: “Author contributions: L.C., M.B., C.C., A.R. designed research; C.C., A.R., P.L. and D.A. performed research; L.C., M.B., C.C., A.R., V.D. and P.L. analysed data; F.P.F., A.R., L.C. and M.B. wrote the paper; L.C., M.B., T.V., G.D.B. and F.P.F. active discussion paper revision.”
Dolce stil novo
No full textDolce Stil Novo is a slightly unconventional kind of tone poem. As the title suggests, the main inspiration for the piece is the poetry of Dante Alighieri, especially that subset of it which belongs to his so-called Sweet New Style. While the three successive intermezzi are tied only obliquely to this subject, the first and final movements make direct reference to Dante\u27s Sweet New Style as found in the Vita Nuova, an autobiographical compilation of prose and verse. In this way, the piece is a reflection on Dante\u27s writings from two perspectives: that of the author (in the first and final movements) and that of the reader (in the middle movements). The narrative of the piece alternates between these perspectives in its three sections:
Section 1 Venus Tristior . A reader takes up the Vita Nuova and gets only about halfway through-not quite to Donne ch\u27 avete intelletto d\u27amore, the first poem written in the dolce stil novo. Without it being any kind of comment on the quality of the book, the reader eventually falls asleep.
Section 2 Piano Portrait, Commuting on a Pileated Woodpecker with Mild Psychosis, and The Surreal . The sleeping reader dreams of what has been read so far. In the dream, esoteric themes of the Vita Nuova play themselves out through an amalgam of eclectic memories and images taken from the reader\u27s own life. Gradually, the dream devolves into a nightmare, symbolizing the fall of man (which may be one of the allegorical meanings of the story of lost love that Dante tells in the Vita Nuova) .
Section 3 Beata Beatrix . Awaking to :finish the text, the reader is deeply moved by the account and especially by Dante\u27s reaction to the death of Beatrice. This leaves the reader thoughtful and filled with the peace of God
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