1,075 research outputs found
The impact of the COVID-19 pandemic on oral biopsies in the Brazilian National Health System
No full textN/
Internet dispute resolution.
No full textPhDThis thesis develops a model for the fair resolution of internet disputes. The internet
has the potential to lead to international~ cross-border disputes being a powerful
communications medium, that allows data exchanges in various media formats
between a wide range of different users situated in distant locations. It explores the
meaning of fairness for the resolution of such disputes.
This thesis refers to the existing literature examining the private international law
issues arising from cross-border interactions and transactions on the internet which
make litigation and enforcement more costly and lengthy.
For many disputes arising on the internet, alternative ways of resolving such
disputes have to be found. This thesis contains a detailed exploration of the use of
mediation and arbitration, using online technology. obviating the need for the
parties and lawyers to meet face-to-face and leading to more efficient information
processing, and thereby reducing cost and delay in dispute resolution.
Binding dispute resolution and enforceability in cross-border cases are important
for internet disputes and can be provided by online arbitration. Therefore, this thesis
proceeds to examines in great detail the legal issues surrounding online arbitration.
It looks at questions of due process in arbitration and covers the legal issues
surrounding business-to-consumer arbitration comparing the European approach to
that in the us. The thesis contains a detailed analysis of the Uniform Domain Name
Dispute Resolution Procedure (UDRP) and considers to what extent the dispute
resolution model established by the UDRP could or should sene as a model for
other types of internet disputes.
The conclusion from this examination of all aspects of internet dispute resolution is
a model of dispute resolution. which encourages the use of online arbitration for
internet disputes but, where there exists a substantial power imbalance between the
disputants (such as the traditional business-to-consumer paradigm), subjects
traditional commercial arbitration to more stringent due process standards for
disputes
Modelling large-deformation plasticity in metals with edge based smoothed finite element method
No full textThe problem of modelling plasticity in materials has been investigated for the past 200 years. Standard theories on yielding for metals go back to the era of Tresca(1864) and von Mises(1913). The rapid rise of the finite element method and new testing techniques in the last few decades led to further research. This thesis aims to model large-deformation plasticity in metals using the Bai-Wierzbicki material plasticity model to account for local- ization and the effect of the stress state in the material. Further, a new element technology, the edge-based smoothed finite element method(ES-FEM), is used to increase the accuracy and convergence rate of the numerical solution. The scope of this thesis is limited to plane stress and plane strain plasticity but can be extended to 3D problems. This technique is implemented in ABAQUS using a user element(UEL) subroutine written in FORTRAN 95. The results show that the ES-FEM element performs more accurately than the traditional finite element for large-deformation plasticity problems.https://github.com/arshdeep-brar/FN-ESFEM-uel Github link for the codeAerospace Engineerin
A Prospective Multicenter SPOG 2003 FN Study of Microbiologically Defined Infections in Pediatric Cancer Patients with Fever and Neutropenia.
No full textBACKGROUND
Fever and neutropenia (FN) often complicate anticancer treatment and can be caused by potentially fatal infections. Knowledge of pathogen distribution is paramount for optimal patient management.
METHODS
Microbiologically defined infections (MDI) in pediatric cancer patients presenting with FN by nonmyeloablative chemotherapy enrolled in a prospective multi-center study were analyzed. Effectiveness of empiric antibiotic therapy in FN episodes with bacteremia was assessed taking into consideration recently published treatment guidelines for pediatric patients with FN.
RESULTS
MDI were identified in a minority (22%) of pediatric cancer patients with FN. In patients with, compared to without MDI, fever (median, 5 [IQR 3-8] vs. 2 [IQR1-3] days, p < 0.001) and hospitalization (10 [6-14] vs. 5 [3-8] days, p < 0.001) lasted longer, transfer to the intensive care unit was more likely (13 of 95 [14%] vs. 7 of 346 [2.0%], p < 0.001), and antibiotics were given longer (10 [7-14] vs. 5 [4-7], p < 0.001). Empiric antibiotic therapy in FN episodes with bacteremia was highly effective if not only intrinsic and reported antimicrobial susceptibilities were considered but the purposeful omission of coverage for coagulase negative staphylococci and enterococci was also taken into account (81% [95%CI 68 - 90] vs. 96.6% [95%CI 87 - 99.4], p = 0.004) CONCLUSIONS: MDI were identified in a minority of FN episodes but they significantly affected management and the clinical course of pediatric cancer patients. Compliance with published guidelines was associated with effectiveness of empiric antibiotic therapy in FN episodes with bacteremia
Fn-Dps, a novel virulence factor of Fusobacterium nucleatum, disrupts erythrocytes and promotes metastasis in colorectal cancer
No full textFusobacterium nucleatum (Fn) is a critical colorectal cancer (CRC)-associated bacterium. DNA hunger/stationary phase protective proteins (Dps) are bacterial ferritins that protect DNA from oxidative stress. However, little is known about the regulatory roles of Fn-Dps towards host cellular functions. Here, we identified Fn-Dps from the culture supernatant of Fn by mass spectrometry, and prepared the recombinant of Fn-Dps protein. We show a novel virulence protein of Fn, Fn-Dps, which lyses and disrupts erythrocytes by the competition for iron acquisition. Also, Fn-Dps facilitates intracellular survival of Fn in macrophages by upregulating the expression of the chemokine CCL2/CCL7. In addition, Fn-Dps can elicit a strong humoral immune response, and mucosal immunization with Fn-Dps conferred protection against Fn in the intestinal tract. Moreover, a high level of anti-Fn-Dps antibody was prevalent in populations, and elevated anti-Fn-Dps antibody levels were observed in CRC patients. Furthermore, Fn-Dps promotes the migration of CRC cells via the CCL2/CCL7-induced epithelial-mesenchymal transition (EMT) and promotes CRC metastasis in vivo. Author summary Our previous studies have found that the CRC-associated bacterium Fn is a facultative intracellular bacterium. To date, the underlying mechanism by which Fn infection induces carcinogenesis remains largely unknown. Here, our findings revealed that Fn-Dps is a novel multifunctional Fn virulence factor that lyses and disrupts erythrocytes, enhances intracellular survival of Fn in macrophages, and promotes CRC metastasis. We also found that mucosal immunization with Fn-Dps conferred protection against Fn. A high level of serum anti-Fn-Dps antibody was prevalent in populations, and elevated anti-Fn-Dps antibody levels were observed in CRC patients. These findings reveal a novel Fn virulence factor that promotes tumor progression, providing a potential novel drug target for CRC treatment
„FN Serviss” Ltd. marketing communications in the context of the company’s reputation and image making
No full textOksana Kuļikova. Bakalaura darba „SIA „FN Serviss” mārketinga komunikācijas uzņēmuma reputācijas un tēla veidošanas kontekstā”.
Bakalaura darbā analizēta mārketinga komunikāciju izmantošana uzņēmuma reputācijas un tēla veidošanas procesā. Bakalaura darba mērķis ir, pamatojoties uz teorijā sniegtajām atziņām par mārketinga komunikācijām, izanalizēt konkrēta uzņēmuma - SIA „FN Serviss” mārketinga komunikāciju ietekmi uz uzņēmuma tēla un reputācijas veidošanu, kā arī izstrādāt priekšlikumus SIA „FN SERVISS” mārketinga komunikāciju pilnveidošanai.
Pirmajā darba nodaļā autore pēta mārketinga komunikāciju teorētiskos aspektus, otrajā daļā pēta SIA „FN Serviss” darbību, mērķauditoriju un izmantotās mārketinga komunikācijas, analizē to efektivitāti uzņēmuma reputācijas un tēla veidošanā. Trešajā nodaļā tiek apkopoti pētāmā uzņēmuma klientu aptaujas rezultāti, kā arī izstrādāti mārketinga komunikāciju pilnveidošanas virzieni uzņēmuma SIA „FN Serviss” reputācijas un tēla uzlabošanai un popularizēšanai.
Pētījuma periods – 2002. - 2009. gads. Darba apjoms 86 lapaspuses, tajā ir 19 attēli, 9 tabulas un 1 pielikums.
Atslēgvārdi: mārketinga komunikācijas, uzņēmuma reputācija, uzņēmuma tēls, reklāma, sabiedriskās attiecības.Oksana Kuļikova. Bachelor work ““FN Serviss” Ltd. marketing communications in the context of the company's reputation and image making”.
Thesis analyzes the use of marketing communications company's reputation and image making process. Bachelor's work is based on the theory's knowledge of marketing communications, to analyze a particular company – “FN Serviss” Ltd. marketing communications impact on the company's image and reputation building, and to develop proposals for “FN Services” Ltd. marketing communications development.
In the first chapter the author examines the theoretical aspects of marketing communications, the second part examines the “FN Serviss” Ltd. operation targeting and marketing communication used, analyze the effectiveness of the company's reputation and image. The third chapter summarizes the researched company’s customer survery results, as well as to develop marketing communications development directions of the company “FN Serviss” Ltd. reputation and image improvement and promotion.
The study period - 2002 - 2009. 86 amount of work pages, there are 19 images, 9 tables and 1 attachment.
Keywords: marketing communication, company reputation, company image, advertising, public relations
Instrucción de armamento individual fn scar y el desarrollo profesional de los cadetes de cuarto año de infantería de la Escuela Militar de Chorrillos "Coronel Francisco Bolognesi" 2022
No full textEsta investigación tuvo como objetivo determinar la relación que existe entre la instrucción de armamento individual FN Scar y el desarrollo profesional de los cadetes de Cuarto Año de Infantería de la Escuela Militar de Chorrillos "Coronel Francisco Bolognesi" 2022. Como metodología es descriptivo de enfoque cuantitativo, tipo de investigación fue básico, método descriptivo, alcance descriptivo-correlacional, diseño no experimental de carácter transversal, la población estuvo conformada por 109 cadetes de Cuarto Año de Infantería y la muestra fue probabilístico de tipo aleatorio resultando 86 cadetes; se optó como técnica e instrumento de recolección de datos la encuesta y el cuestionario de escala de Likert. Se obtuvo por resultados que la mayoría de los cadetes de Cuarto Año de Infantería siendo el 79.07% (68/86) tienen un nivel alto sobre la instrucción de armamento individual FN Scar. De esta manera, se puede observar que el 87.21% (75/86) de los cadetes de Cuarto Año de Infantería tienen un nivel alto sobre el desarrollo profesional. Se concluye que hay una relación directa ya que tienen un coeficiente de Rh0 de Spearman es 0.668, existe una correlación positiva moderada. Además, el nivel de significancia es 0.000 es menor que 0.05 (0.000 < 0.05).; por lo tanto, se rechaza la hipótesis general nula y se acepta la hipótesis general alterna, esto indica que si existe una relación directa y significativa entre la instrucción de armamento individual FN Scar y el desarrollo profesional de los cadetes de Cuarto Año de Infantería de la Escuela Militar de Chorrillos "Coronel Francisco Bolognesi" 2022
The urban environment : agendas and problems
No full textThe United Nations estimate that by 2025 there will be around 5 billion people living in urban areas, more than the total world population 20 years ago. Currently, the developed nations are the most urbanised with, on average around three-quarters of their population living in cities, but this is changing. Increased levels of economic growth, of migration, of population expansion and, in some cases, of unprecedented industrial growth, mean that Asia and Africa will be the regions most radically affected by urban development over the next twenty years. Increasing debate on issues of urban sustainability has led to the consolidation of environmental agendas and the definition of a specific body of problems and policy issues on two levels. The first involves green agenda problems occupying the concerns of many in the developed nations such as global warming, ozone-layer depletion, loss of bio-diversity, deforestation, and the exhaustion of non-renewable resources. For the developing world, however, these global environmental problems are less immediate than the need to resolve acute problems relating to poverty and the so-called brown agenda problems of air and water pollution, inadequate waste management, the lack of basic services and green areas, declining infrastructure, and poor housing conditions, as well as issues of health, crime, violence, and social exclusion. It is now a commonly held belief that the green agenda cannot be addressed until the urgent problems of urban social deprivation and inequalities are resolved. This paper reviews the scale and character of contemporary urbanisation and the rapid growth of cities, particularly within the developing nations, and examines associated implications with respect to the physical arrangement of cities, their resource consumption and their environmental impact
Empleo del fusil scar fn y el desempeño en la instrucción de las marchas de campaña de los cadetes de cuarto año de la Escuela Militar de Chorrillos "CFB", 2024
No full textEl propósito de este estudio consistió en determinar la relación que existía entre el empleo del
FN-Scar y el desempeño en la instrucción de las marchas de campaña de los cadetes de Cuarto
Año de la Escuela Militar de Chorrillos "Coronel Francisco Bolognesi", 2024. Esta
investigación se situó dentro del ámbito de la investigación básica, adoptando un enfoque
descriptivo-correlacional y empleando un método hipotético-deductivo, con un diseño no
experimental y transversal, con énfasis cuantitativo. Se implementó una encuesta como técnica
de recolección de datos mediante la aplicación de un cuestionario. La población de interés
estuvo conformada por 219 cadetes de Cuarto Año, de los cuales se extrajo una muestra
representativa de 140 cadetes para llevar a cabo el estudio. Los resultados presentados en la
Tabla 6 indicaron que, de un total de 140 cadetes evaluados, la mayoría (83 cadetes, que
representaron el 59.3% del total) alcanzó un alto desempeño en las marchas de campaña al
emplear el FN-Scar. En contraste, solo un pequeño número (8, es decir, 5.7%) presentó un
desempeño medio, y ningún cadete mostró un desempeño bajo. La prueba de correlación de
Spearman mostró un coeficiente de 0.729, indicando una correlación positiva alta entre el
empleo del FN-Scar y el desempeño en la instrucción de las marchas de campaña, lo que
permitió concluir que existía una relación directa y significativa entre estas variables
Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study
No full textArticle first published online: 15 JAN 2013 Pour consulter la version éditeur DOI: 10.1002/jbmr.1742A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range, as measured with dual-energy X-ray absorptiometry (DXA). Separately measuring the cortical and trabecular FN compartments and combining the results would likely be a critical aspect of enhancing the diagnostic capabilities of a new technique. Because the cortical shell determines a large part of FN strength a novel quantitative ultrasound (QUS) technique that probes the FN cortical compartment was implemented, aimed at testing the sensitivity of the method to variations of FN cortical properties and FN strength. Nine femurs (women, mean age 83 years) were subjected to QUS to measure the through transmission time-of-flight (TOF) at the FN and mechanical tests to assess strength. Quantitative computed tomography (QCT) scans were performed to enable analysis of the dependence of TOF on bone parameters. DXA was also performed for reference. An ultrasound wave propagating circumferentially in the cortical shell, which TOF was not influenced by the properties of the trabecular compartment Q3, was measured in all specimens. Averaged TOF for nine FN measurement positions/orientations was significantly correlated to strength (R² = 0.79) and FN cortical QCT variables: total BMD (R² = 0.54); regional BMD in the inferoanterior (R² = 0.90) and superoanterior (R² = 0.57) quadrants; and moment of inertia (R² = 0.71). The results of this study demonstrate that QUS can perform a targeted measurement of the FN cortical compartment. Because the method involves mechanical guided waves, the QUS variable is related to the geometric and material properties of the cortical shell (cortical thickness, tissue elasticity, and porosity). This work opens the way to a multimodal QUS assessment of the proximal femur, combining our approach targeting the cortical shell with the existing modality sensitive to the trabecular compartment. In vivo feasibility of our approach has to be confirmed with experimental data in patients
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