1,499 research outputs found
Mitochondrial genome reversion after mitochondrial replacement occurs by a haplogroup-independent mechanism
No full text<p>Raw NGS sequence data (FASTQ data) and analytical pipeline (full analytical pipeline for the analysis of mtDNA from FASTQ to annotated variant call data). Data and pipeline available upon request (unrestricted after publication) via email with corresponding authors (detailed below).</p>
<p>Please email Dr Gavin Hudson for access - [email protected] and Prof Mary Herbert.</p>
Erratum to: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos (Nature Cell Biology, (2018), 20, 2, (144-151), 10.1038/s41556-017-0017-8)
No full textIn the version of this Letter originally published, an author error led to the affiliations for Brendan Payne, Jonathan Coxhead and Gavin Hudson being incorrect. The correct affiliations are: Brendan Payne:3Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.6Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 6 and subsequent existing affiliations have been renumbered. Jonathan Coxhead:11Genomic Core Facility, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 11 and subsequent existing affiliations have been renumbered. Gavin Hudson:3Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. In addition, in Fig. 2d, the numbers on the x-axis of the left plot were incorrectly labelled as negative; they should have been positive. These errors have now been corrected in all online versions of the Letter
Letter from J. E. Gavin to Louis C. Cramton regarding Sale of Bright Angel Trail
No full textLetter from J. E. Gavin to Louis C. Cramton regarding the Bright Angel Trail controversy, including newspaper clipping
Letter from B. F. Gavin (for Carl Hayden) to Stephen Mather, National Park Service
No full textLetter from Mrs. B. F. Gavin to Stephen Mather regarding the sale of Bass properties to the Santa Fe Railroad Company
Working for Equality: The Narrative of Harry Hudson
No full text“When I went to work for Lockheed-Georgia Company in September of 1952 I had no idea that this would end up being my life’s work.” With these words, Harry Hudson, the first African American supervisor at Lockheed Aircraft’s Georgia facility, begins his account of a thirty-six-year career that spanned the postwar civil rights movement and the Cold War.Hudson was not a civil rights activist, yet he knew he was helping to break down racial barriers that had long confined African Americans to lower-skilled, nonsupervisory jobs. His previously unpublished memoir is an inside account of both the racial integration of corporate America and the struggles common to anyone climbing the postwar corporate ladder. At Lockheed-Georgia, Hudson went on to become the first black supervisor to manage an integrated crew and then the first black purchasing agent. There were other “firsts” along the path to these achievements, and Working for Equality is rich in details of Hudson’s work on the assembly line and in the back office. In both circumstances, he contended with being not only a black man but a light-skinned black man as he dealt with production goals, personnel disputes, and other workday challenges.Randall Patton’s introduction places Hudson’s story within the broader struggle of workplace desegregation in America. Although Hudson is frank about his experiences in a predominantly white workforce, Patton notes that he remained “an organization man” who “expressed pride in his contributions to Lockheed [and] the nation’s defense effort.”https://digitalcommons.kennesaw.edu/facbooks2015/1005/thumbnail.jp
Letter from J. E. Gavin (for Senator Hayden) to Roy W. James, Michael Hanley and H. A. Montgomery
No full textLetter from J. E. Gavin on behalf of Carl Hayden writing in regards to the insurance claims filed with the National Park
The first statewide, open access dataset tracking public records requests in New Jersey
No full textState freedom of information laws are vital mechanisms for providing public access to government records and supporting civic engagement through the effectuation of a public policy of transparency at the state level within the United States, not unlike their federal counterpart, the Freedom of Information Act (FOIA). New Jersey state law facilitates public access to government records under the Open Public Records Act (OPRA). Codified at N.J.S.A. 47:1A-1 et seq., OPRA applies to state, county and local public authorities but exempts the judicial and legislative branches from its disclosure requirements. Since OPRA took effect in 2002, it has been difficult to track the full extent of law's impact across New Jersey's 21 counties, 565 municipalities, and numerous state agencies, school districts and independent authorities, all of which must individually respond to requests under the law. To the best of the author's knowledge, no official source has compiled detailed metadata tracking the content and disposition of OPRA requests at the state, regional and municipal levels within New Jersey using individual requests, and authorities rarely proactively disclose their responses to requests they receive, necessitating further data collection to support research into the impacts of this law. This article presents the OPRAmachine dataset: data containing detailed metadata on public records requests submitted to state & local public authorities in New Jersey since October 2017 collected through the implementation of information and communication technologies (ICT) to facilitate the freedom of information request process. The data was collected using an open-source web interface that allowed users to submit an OPRA request to public authorities, with responses stored in a database and made available via the internet. After their request received a response, users were asked to answer a single survey question describing the status of their request, with their answer used to classify the request. Descriptive statistics, tables and frequencies were produced for the dataset and are included in this article. These data will assist state policymakers and other interested parties with assessing trends in OPRA requests across multiple types of public authorities & geographic regions. These data can inform more efficient government records management procedures, foster civic engagement by increasing government transparency and can inform the development of possible reforms to the OPRA law by showing trends in requests & responses that can be used to evaluate the law's implementation throughout the state.Peer reviewe
A critical analysis of the combined usage of protein localization prediction methods: Increasing the number of independent data sets can reduce the accuracy of predicted mitochondrial localization
No full textIn the absence of a comprehensive experimentally derived mitochondrial proteome, several bioinformatic approaches have been developed to aid the identification of novel mitochondrial disease genes within mapped nuclear genetic loci. Often, many classifiers are combined to increase the sensitivity and specificity of the predictions. Here we show that the greatest sensitivity and specificity are obtained by using a combination of seven carefully selected classifiers. We also show that increasing the number of independent prediction methods can paradoxically decrease the accuracy of predicting mitochondrial localization. This approach will help to accelerate the identification of new mitochondrial disease genes by providing a principled way for the selection for combination of appropriate prediction methods of mitochondrial localization of proteins
Human liver stem cells originate from the canals of hering
No full textLetter to the EditorNimantha De Alwis, Gavin Hudson, Alastair D. Burt, Christopher P. Day and Patrick F. Chinner
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