987 research outputs found
A machine learning approach for prediction of DNA and peptide HPLC retention times
Get PDFHigh performance liquid chromatography (HPLC) has become one of the most efficient methods for
the separation of biomolecules. It is an important tool in DNA purification after synthesis as well as DNA quantification.
In both cases the separability of different oligonucleotides is essential. The prediction of oligonucleotide retention
times prior to the experiment may detect superimposed nucleotides and thereby help to avoid futile experiments.
In 2002 Gilar et al. proposed a simple mathematical model for the prediction of DNA retention times,
that reliably works at high temperatures only (at least 70°C).
To cover a wider temperature rang we incorporated DNA secondary structure information in addition to base composition and length.
We used support vector regression (SVR) for the model generation and retention time prediction.
A similar problem arises in shotgun proteomics. Here HPLC coupled to a mass spectrometer (MS) is used to analyze
complex peptide mixtures (thousands of peptides). Predicting peptide retention times can be used to validate
tandem-MS peptide identifications made by search engines like SEQUEST.
Recently several methods including multiple linear regression and artificial neural networks were proposed, but SVR has not been used so far
Profit as Social Rent: Embeddedness and Stratification in Markets
No full textThis article shows how research on the social structure of markets may contribute to the analysis the growing income inequality in contemporary capitalist economies. The author proposes a theoretical link between embeddedness and social stratification by discussing the role of institutions and networks in markets for the distribution of economic profits between firms. The author claims that we must understand profit and free competition as opposites, as economic theory does. In the main part of the article the author illustrates six typical mechanisms of rent extraction from networks or formal and symbolic rules that embed markets. They emerge from material as well as symbolical access to and influence on the orientation of other market actors. Social structures in markets lead to unequal chances for rent extraction, even if actors produce them for coordination rather than for accumulation purposes. This is how market sociology and theory of capitalism can be linked more closely
Hybrid threats, cyber warfare and NATO's comprehensive approach for countering 21st century threats - mapping the new frontier of global risk and security management
No full textThe author examines NATO's comprehensive conceptual framework (the Capstone Concept) for identifying and discussing emerging threats to international peace and security including cyber war and possible multi-stakeholder responses. Article by Sascha-Dominik bachmann, Senior Lectuer in Law, School of Law, University of Portsmouth
Hybrid threats, cyber warfare and NATO's comprehensive approach for countering 21st century threats - mapping the new frontier of global risk and security management
Get PDFThe author examines NATO's comprehensive conceptual framework (the Capstone Concept) for identifying and discussing emerging threats to international peace and security including cyber war and possible multi-stakeholder responses. Article by Sascha-Dominik bachmann, Senior Lectuer in Law, School of Law, University of Portsmouth
Emissions trading systems with cap adjustments
No full textAbstractEmissions Trading Systems (ETSs) with fixed caps lack provisions to address systematic imbalances in the supply and demand of permits due to changes in the state of the regulated economy. We propose a mechanism which adjusts the allocation of permits based on the current bank of permits. The mechanism spans the spectrum between a pure quantity instrument and a pure price instrument. We solve the firms׳ emissions control problem and obtain an explicit dependency between the key policy stringency parameter—the adjustment rate—and the firms׳ abatement and trading strategies. We present an analytical tool for selecting the optimal adjustment rate under both risk-neutrality and risk-aversion, which provides an analytical basis for the regulator׳s choice of a responsive ETS policy
Armed with swords and scales ::law, culture, and local courtrooms in London, 1860-1913 /
No full textIn the mid-eighteenth century, author and magistrate Henry Fielding adjudicated cases of theft, assault, and public disorder from his London home on Bow Street. By the middle of the nineteenth century, Fielding's modest 'police office' had expanded to become the most prolific court system in Britain and the cornerstone of criminal and civil justice in the metropolis. Sascha Auerbach examines the fascinating history of this institution through the lens of 'courtroom culture' - the combination of formal statute and informal custom that guided everyday practice in the London Police Courts. He offers a new model for understanding the relationship between law, culture, and society in modern Britain and illuminates how the local courtroom became a crucial part of everyday life and thoroughly entangled with popular representations of justice and morality
Management of Anterior Urethral Strictures in Adults: A Survey of Contemporary Practice in Germany
No full text<b><i>Introduction:</i></b> Treatment methods of anterior urethral strictures in adults have undergone considerable changes in the recent past. Our goal was to determine national practice patterns among German urologists and to compare results with the results of prior international surveys. <b><i>Methods:</i></b> We conducted a survey on the management of urethral strictures among German urologists. <b><i>Results:</i></b> Eight hundred forty-five urologists, representing about 14.6% of German urologists, answered the survey. Most common procedures were direct vision internal urethrotomy (DVIU; 87.2%), blind internal urethrotomy (57.5%), dilatation (56.3%), ventral buccal mucosa graft urethroplasty (31.6%) and excision and primary anastomosis (28.9%). In case of a 3.5-cm bulbar stricture and in the case of a 1-cm bulbar stricture after 2 failed DVIUs, a consecutive urethroplasty was significantly more often favoured compared to transurethral treatment options (44.9 vs. 21.3% and 59.4 vs. 8.3%, both <i>p</i> < 0.001). <b><i>Conclusion:</i></b> Open urethral reconstruction reveals to be a more common method in practice nowadays. Adherence to recommended treatment algorithms improved in comparison to prior surveys.</jats:p
Ungleichheit: Interdisziplinäre Perspektiven auf Ursachen und Implikationen
No full textDas vorliegende Arbeitspapier untersucht Ungleichheit aus verschiedenen interdisziplinären Perspektiven auf Ursachen und Implikationen.
Inhaltsverzeichnis:
Philipp Harms, Claudia Landwehr, Mario Scharfbillig, Daniel Schunk: Ungleichheit: Interdisziplinäre Perspektiven auf Ursachen und Implikationen - Einleitung
Konstantin M. Wacker: Warum wir Ungleichheit verringern müssen, um globale Armut bis 2030 zu beenden
Joachim Klose: Heimatverlust als Indikator zunehmender Ungleichheit
Gunnar Otte: Bildungsforschung und Bildungsreformen
Sibylle Kalmbach: Bildungsgerechtigkeit und Ungleichheit im Hochschulbereich – am Beispiel von Stipendien
Claudia Landwehr und Oliver Tüscher: Ursachen ungleicher politischer Beteiligung
Michael Edinger: Gleicher Zugang zur Macht? Über soziale Schließungsprozesse in der Politik
Sascha Huber: Wählermobilisierung und Ungleichheit in Deutschland: Ein Feldexperiment zur Steigerung der Wahlbeteiligung bei der Landtagswahl in Baden-Württemberg 2016
Tonio Rieger: Der ganzheitliche Ansatz zur Bekämpfung von Langzeitarbeitslosigkei
Building blocks for the educational web: Elena's smart space for learning
No full textBernd Simon, Stefan Sobernig, Fridolin Wild, Sandra Aguirre, Stefan Brantner, Peter Dolog, Gustaf Neumann, Gernot Huber, Tomaz Klobucar, Sascha Markus, Zoltán Miklós, Wolfgang Nejdl, Daniel Olmedilla, Joaquin Salvachua, Michael Sintek, and Thomas Zillinger. Building blocks for the educational web: Elena's smart space for learning. In IEEE International Conference on Advanced Learning Technologies (ICALT 2006), Kerkrade, The Netherlands, 2006. IEEE Computer Society.This case study summarizes the demonstration of a semantic network of interoperable educational systems referred to as Smart Space for Learning. We started connecting several educational nodes in projects such as Elena, Prolearn, and Icamp. Integration was achieved by using the interaction standard SQI, common schemas for querying and results presentation, and query exchange language, e.g. QEL. The paper particularly focuses on how heterogeneous nodes can be made interoperable by reusing generalizations of mediating components –building blocks for a Smart Space for LearningThis work has been sponsored by the EU project ELENA & TENCompetenc
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