352,046 research outputs found
W. F. Mitchell
No full textEarlier this year, an article was published in the News Bulletin
(February 2012) on the background of Captain Boyns Hedley
Hocking, a dentist who became one of the first casualties in the
bombing of Darwin in 1942. The author, W F Mitchell, has kindly
provided a summary of the 70th anniversary activities held in
Darwin in February 2012 to commemorate this significant event in
the Northern Territory?s historyDate:2012-09News Bulletin no. 413, p. 36 - 37
Assessing the George W. Bush Presidency: A Tale of Two Terms
Full text linkIn one of the first volumes assessing the full two terms of the George W. Bush presidency, Wroe and Herbert have gathered the work of leading American and European scholars. In fifteen succinct and incisive chapters, authorities such as Jim Pfiffner, John Maltese, Graham Wilson and Alan Gitelson offer assessments of the Bush administration's successes and failures. Extensive attention is paid to Bush's foreign policy, including 'The War on Terror' but the focus is broadened to absorb not only the Bush Doctrine and its repercussions, but also his trade and homeland security policies. The president's domestic leadership in economics and social policy is investigated, as are his dealings as president with the other institutions of the U.S. political system. The result is a comprehensive guide to the Bush presidency and its legacy
Electronic health records and improved nursing management of chronic obstructive pulmonary disease [Corrigendum]
No full textLiu F, Zou Y, Huang Q, Zheng L, Wang W. Patient Preference and Adherence. 2015;9:495–500.On page 495, author affiliations and correspondence sections “The First Affiliated College of Medicine, Zhejiang University” should be “The First Affiliated Hospital, College of Medicine, Zhejiang University”.Read the original articl
Analyse des signaux multicomposante à modulation de fréquence linéaire par la transformation de Teager-Huang-Hough
Full text linkA novel detection approach of linear FM (LFM) signals, with single or multiple components, in the time-frequency plane of Teager-Huang (TH) transform is presented. The detection scheme that combines TH transform and Hough transform is referred to as Teager-Huang-Hough (THH) transform. The input signal is mapped into the time-frequency plane by using TH transform followed by the application of Hough transform to recognize time-frequency components. LFM components are detected and their parameters are estimated from peaks and their locations in the Hough space. Advantages of THH transform over Hough transform of Wigner-Ville distribution (WVD) are: 1) cross-terms free detection and estimation, and 2) good time and frequency resolutions. No assumptions are made about the number of components of the LFM signals and their models. THH transform is illustrated on multicomponent LFM signals in free and noisy environments and the results compared with WVD-Hough and pseudo-WVD-Hough transforms
Fluorescence-based methods to study rapid dynamics and conformational flexibility in peptides
Full text linkIntramolecular collision of polypeptides is the primary step in protein folding, the
dynamics of which is of importance for understanding this fascinating topic. In this thesis
the rapid dynamics and flexibility of several sets of peptides were experimentally
investigated with a fluorescence-based method, where the long-lived, hydrophilic
fluorophore, 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO), was employed, which can be
selectively and efficiently quenched by tryptophan (Trp) through contact. An asparagine
derivative, Fmoc-DBO, was synthesized and applied to standard solid-phase peptide
synthesis to obtain DBO/Trp-labeled peptides. The end-to-end collision rates can then be
directly related to the intramolecular quenching of DBO by Trp. [Hudgins, R. R.; Huang,
F.; Gramlich, G.; Nau, W. M. J. Am. Chem. Soc. 2002, 124, 556-564 (Appendix I); Nau,
W. M.; Huang, F.; Wang, X.; Bakirci, H.; Gramlich, G.; Marquez, C. Chimia 2003, 57,
161-167 (Appendix III); Marquez, C.; Huang, F.; Nau, W. M. IEEE Trans. Nanobiosci.
2004, 3, 39-45 (Appendix V)]
This method has been further improved by establishing a dual quencher system, i.e.,
tyrosine (Tyr) was employed as an additional quencher, which can react with DBO upon
contact but with a lower efficiency than Trp. The combination of two probe/quencher
pairs with different quenching efficiency as well as the theoretical results for
intermolecular diffusion allows the extrapolation of the microscopic rate constants for
formation and dissociation of the end-to-end encounter complex even in the absence of
diffusion-controlled quenching. [Nau, W. M.; Huang, F.; Wang, X.; Bakirci, H.;
Gramlich, G.; Marquez, C. Chimia 2003, 57, 161-167 (Appendix III); Huang, F.; Hudgins,
R. R.; Nau, W. M. 2004, Submitted for publication (Appendix VI)]
We first applied this fluorescence-based method to measure the end-to-end collision
rate constants in flexible Gly-Ser peptides with varying length. The results suggest that the
behavior of real peptides deviates significantly from that of the ideal chain model and the
speed limit for protein folding should be faster than that reported previously. [Hudgins, R.
R.; Huang, F.; Gramlich, G.; Nau, W. M. J. Am. Chem. Soc. 2002, 124, 556-564
(Appendix I)]
We also investigated the end-to-end collision rates of another series of peptides
composed of different types of amino acids in the backbone but with identical length. The
experimental results have led to a conformational flexibility scale for amino acids in peptides and suggested that the flexibility of peptides is mainly determined by the atoms
and groups in close proximity to the backbone, while the more remote atoms and groups
have a smaller effect on the peptide dynamics due to their larger conformational space.
[Huang, F.; Nau, W. M. Angew. Chem. Int. Ed. 2003, 42, 2269-2272 (Appendix II);
Huang, F.; Nau, W. M. Res. Chem. Intermed. 2004, submitted for publication (Appendix
VII)]
Further investigations on peptides derived from the N-terminal b-hairpin of
ubiquitin were also carried out. The end-to-end collision rates in these peptides showed
significant dependence on the secondary structure, i.e., the turn segment is much more
flexible than the strand segments, which supports a previous proposal that the b-turn is the
initiator for the formation of the whole b-hairpin. Activation energies for end-to-end
collision of these peptides showed a good agreement with the collision rate constants,
which indicates that the activation energy may also be a measure of the flexibility of
peptides although it is not as sensitive as the collision rate. [Huang, F.; Hudgins, R. R.;
Nau, W. M. 2004, Submitted for publication (Appendix VI)]
Additionally, to get more detailed structural information of our peptides and to
reveal the underlying reasons for the deviation of the experimental length dependence of
end-to-end collision rates from the theoretical prediction, intramolecular fluorescence
resonance energy transfer (FRET) was applied as an independent approach to investigate
the dynamics in peptide chains. Two energy donor/acceptor pairs with small Förster
critical radius, where either naphthalene or Trp serves as energy donor and DBO as energy
acceptor, were employed. Energy transfer between naphthalene and DBO was first
investigated at a very short distance, where DBO and naphthalene were separated by
dimethylsiloxy. It was found that the Dexter mechanism might dominate in this system
due to the close proximity of donor and acceptor, the high flexibility of the tether, and the
nonviscous solvent employed. [Pischel, U.; Huang, F.; Nau, W. M. Photochem. Photobiol.
Sci. 2004, 3, 305-310 (Appendix IV)] However, when naphthalene and DBO were
covalently attached to the opposite ends of peptides and studied in water, control
experiments in the presence of cucurbit[7]uril as an encapsulating host suggested that
FRET was the dominant mechanism, which allowed us to apply the FRET technique to
recover the intramolecular end-to-end distance distribution and diffusion coefficient by
means of global analysis. In the investigation with naphthalene/DBO energy donor/acceptor pair, slower diffusion coefficients in shorter chains were found for the
series of flexible Gly-Ser peptides, suggesting that shorter chains may exhibit a larger
internal friction limiting the conformational change. Additionally, the intramolecular
energy transfer efficiency have been measured with the Trp/DBO pair and the effective
average end-to-end distances were calculated, which provided a lower limit for the mean
end-to-end distance of peptides for the global data analysis and offered a complementary
approach to interpret the end-to-end collision rates determined with the same pair but
based on a collision-induced quenching mechanism. [Huang, F.; Wang, X.; Haas, E.; Nau,
W. M. 2004, In preparation (Appendix VIII)]
The fluorescence-based method based on contact quenching mechanism has some
other potential applications. It has potential to be applied for high-throughput screening of
protease activity and to investigate the helix-coil transition in peptides
Alex Huang
No full textDr. Alex Huang received combined B.S./M.S. from University of Chicago, M.D./Ph.D. from Johns Hopkins University, fulfilled his pediatric residency at Johns Hopkins, completed a Pediatric Hematology/Oncology fellowship at Johns Hopkins / NCI, and a postdoctoral fellowship at the National Institute of Allergy and Infectious Diseases. Currently, he is a tenured Professor of Pediatrics, Pathology, Biomedical Engineering and General Medical Sciences at Case Western Reserve University. Dr. Huang holds the endowed Theresia G. & Stuart F. Kline Family Foundation Chair in Pediatric Oncology and serves as Director of the Center for Pediatric Immunotherapy at Rainbow Babies & Children’s Hospital as well as Director of the Medical Scientist Training Program at Case Western Reserve University School of Medicine.
Prior to 2023, Dr. Huang served as the Director of Pediatric Hematology-Oncology Fellowship Program at University Hospital’s Rainbow Babies & Children’s for 17 years. Dr. Huang oversees immune-based cancer therapeutics as co-leader of Immune Oncology Scientific Program at Case Comprehensive Cancer Center. Nationally, he is an elected member of the NCI’s Pediatric and Adolescent Solid Tumor Steering Committee (PASTSC) and a steering member of the Coalition for Pediatric Medical Research. Dr. Huang’s research focuses on exploiting the tumor immune microenvironment to control pediatric and AYA cancers.https://openworks.mdanderson.org/kleinermanbios/1003/thumbnail.jp
Aceria gallae T. Huang 1996
No full textAceria gallae T. Huang, 1996 (Fig. 2) Aceria gallae T. Huang, 1996: 82, fig. 1 Female: (n= 4) Body worm-like, 123 long; prodorsal shield 23 long, 27 wide, anterior lobe present; prodorsal shield design with median lines complete, admedian line from basal one-fourth to half, concave at basal twofifths and convex at basal one-third, submedian lines convex at half; scapular tubercles set at prodorsal shield rear margin, setae (sc) 22 long, directed backward, sct-sct 14 apart; leg segments normal, foretibial seta (1 ') absent; 1 st coxal setae (1 b) 7 long, 1 bt- 1 bt 6 apart, 2 nd coxal setae (1 a) 11 long, 1 at- 1 at 7 apart, 3 rd coxal setae (2 a) 16 long, 2 at- 2 at 17 apart; solenidion ending as a knob; empodium simple, 4 -rayed. Opisthosoma: with about 78 microtuberculate rings, rear rings broader than anterior rings; first 3 rings 4 long; lateral setae (c 2) 15 long, c 2 t-c 2t 36 apart, c 2t \dt 37, c 2 t-dt 19; 1 st ventral setae (d) 21 long, dt-dt 28 apart, dt\et 31, dt-et 21; 2 nd ventral setae (e) 6 long, et-et 18 apart, et\ft 43, et-ft 39; 3 rd ventral setae (f) 20 long, ft-ft 14 apart; setae h 1 present. Coverflap: 17 wide, 11 long, with about 8 longitudinal lines, genital setae (3 a) 5 long, 3 at- 3 at 11 apart. Male: not seen. Specimens examined: 4 females, Tucheng, Taipei; 23 -Dec.- 1995, G. S. Tung; 5 females, Jhushan, Nantou, 20 -Aug.- 1995, K. W. Huang; 10 -Dec.- 1998, Dakan, Taichung, K. W. Huang; ex. Cordia dichotoma Forst. (Boraginaceae). Relation to host: Mites form cylindrical galls on the upper surface of leaf and erineum on the lower surface. Distribution: Taiwan.Published as part of Huang, Kun-Wei, 2008, Aceria (Acarina: Eriophyoidea) in Taiwan: five new species and plant abnormalities caused by sixteen species, pp. 1-30 in Zootaxa 1829 on pages 5-7, DOI: 10.5281/zenodo.18316
Wang W, Xiong Z, Huang D, Li Y, Huang Y, Guo Y, Andreacchio A, Canavese F, Chen S. Risk factors for unsuccessful reduction of chronic Monteggia fractures in children treated surgically. Bone Jt Open. 2024 Jul 12;5(7):581-591. doi: 10.1302/2633-1462.57.BJO-2024-0004.R2. PMID: 38991554; PMCID: PMC11247538.
No full textAims
To investigate the risk factors for unsuccessful radial head reduction (RHR) in children with chronic Monteggia fractures (CMFs) treated surgically.
Methods
A total of 209 children (mean age 6.84 years (SD 2.87)), who underwent surgical reatment for CMFs between March 2015 and March 2023 at six institutions, were retrospectively reviewed. Assessed risk factors included age, sex, laterality, dislocation direction and distance, preoperative proximal radial metaphysis width, time from injury to surgery, reduction method, annular ligament reconstruction, radiocapitellar joint fixation, ulnar osteotomy, site of ulnar osteotomy, preoperative and postoperative ulnar angulation, ulnar fixation method, progressive ulnar distraction, and postoperative cast immobilization. Independent-samples t-test, chi-squared test, and logistic regression analysis were used to identify the risk factors associated with unsuccessful RHR.
Results
Redislocation occurred during surgery in 48 patients (23%), and during follow-up in 44 (21.1%). The mean follow-up of patients with successful RHR was 13.25 months (6 to 78). According to the univariable analysis, time from injury to surgery (p = 0.002) and preoperative dislocation distance (p = 0.042) were identified as potential risk factors for unsuccessful RHR. However, only time from injury to surgery (p = 0.007) was confirmed as a risk factor by logistic regression analysis. Receiver operating characteristic curve analysis and chi-squared test confirmed that a time from injury to surgery greater than 1.75 months increased the rate of unsuccessful RHR above the cutoff (p = 0.002).
Conclusion
Time from injury to surgery is the primary independent risk factor for unsuccessful RHR in surgically treated children with CMFs, particularly in those with a time from injury to surgery of more than 1.75 months. No other factors were found to influence the
incidence of unsuccessful RHR. Surgical reduction of paediatric CMFs should be performed within the first two months of injury whenever possible
Coccobius abdominis Huang 1994
No full textCoccobius abdominis Huang 1994 (Figs 1–9) Coccobius abdominis Huang, 1994: 161. Material examined. Holotype female. China: Fujian, Fuzhou, Jinshan, 1987 (coll. Nai-Quan Lin), by yellow pan trap, (FAFU). Paratypes. 1 ♀, China: Fujian, Fuzhou, Forest Park, 23 June 1989 (coll. Zhi-Shan Wu), by sweeping; 1 ♀, China: Fujian, Fuzhou, Forest Park, 5 November 1989 (coll. Jian-Qing Huang), by yellow sticky trap, (FAFU). Additional specimen, 1 ♀, China: Fujian, Fuzhou, Jinshan, 30 September 2013 (coll. Zhu-Hong Wang), ex. diaspidid scale on bamboo. Female. Body length: 0.59 (0.65–0.79) mm. Colour. Head and mesosoma dark brown, metasoma pale yellow; mandible dark brown to black brown. Antenna with basal three-fifths of scape dark brown, apex of scape pale brown, pedicel and flagellum pale yellow. Wings hyaline. Legs pale yellow, fore coxae dark basally and hind coxae slightly darkened basally. Third valvula pale yellow. Head. Vertex with reticulate sculpture; eyes finely setose; Antennal scape about 3.78 × (3.57 –4.00×) as long as wide; pedicel 1.50 × (1.40 ×) as long as wide, 0.89 × (0.87–0.90 ×) as long as F 1; F 1 subequal in length to F 2, 0.88 × (0.89 ×) as long as F 3; F 1 –F 3 2.00×, 1.78 × and 1.73 × as long as wide respectively, each with 2 or 3 longitudinal sensilla; clava shorter than funicle; C 1 1.32 × (1.47–1.54 ×) as long as wide, subequal in length to F 3; C 2 2.05 × (2.36–2.66 ×) as long as wide, 1.54 × (1.44–1.78 ×) as long as C 1, each with 3 or 4 longitudinal sensilla. Mesosoma. Mid-lobe of mesoscutum mostly with irregularly hexagonal cells or reticulation, except transverse reticulation posterolaterally, with 22 (14–20) setae; distance between axillae 2.82 × (3.00×) length of an axilla; mesoscutellum 0.75 × (0.86 ×) as long as mid–lobe of mesoscutum, with longitudinal reticulation medially and irregularly hexagonal cells or reticulation laterally, with 2 pairs of setae, and placoid sensilla closer to fore pair of setae than to hind pair; metanotum with faint reticulation medially; propodeum reticulate except faint medially; mesopostphragma, measured from apex of mesoscutellum, 1.39 × (1.11–1.32 ×) as long as mesoscutellum. Fore wing 3.04 × (3.03–3.35 ×) as long as maximum width of wing disc; marginal fringe 0.35 × (0.26–0.35 ×) as long as maximum width of disc; submarginal vein shorter than marginal vein, with 7 (7 or 8) setae; marginal vein with 9 (8 or 9) setae along anterior margin; postmarginal vein absent; wing disc densely setose with narrow asetose area posterobasally. Metasoma. Metasoma slightly shorter than mesosoma; tergites 1–7 with setae as follows: T 1 –T4, 1+ 1 each; T5, 2+ 2; T6, 4 between cercal plates; T7, 7 in two rows; ovipositor basally located at T 3, slightly projecting beyond apex of metasoma, 1.41 × (1.42 ×) as long as mid tibia, third valvula 1.94 × (1.47–1.57 ×) as long as mid basitarsus. Male. Unknown. Host. An unidentified Diaspididae (Hemiptera) scale on bamboo. Distribution. China (Fujian). Diagnosis. Coccobius abdominis differs from other species of the genus by the head and mesosoma being dark brown and the metasoma completely pale yellow in combination with the antennal pedicel and flagellum being pale yellow.Published as part of Wang, Zhu-Hong, Huang, Jian & Polaszek, Andrew, 2014, Three new species of Coccobius Ratzeburg (Hymenoptera, Aphelinidae) and redescription of C. abdominis Huang and C. furviflagellatus Huang from China, pp. 460-472 in Zootaxa 3774 (5) on pages 462-463, DOI: 10.11646/zootaxa.3774.5.4, http://zenodo.org/record/22456
- …
