45,024 research outputs found
HU, JUN-ZHI
No full text本篇論文的目的，在提出以電腦輔助設計(Computer Aided Design) 來簡化設計過程
。同時製作一個小型的繪圖核心系統(GKS,Graphical Kerrel System) 作為電腦輔助
設計的基本繪圖工具。
電腦輔助設計部分，是用Bezier Curve 的Fitting Mode，所以使用者祇要將所要曲線
上的已知數點，透過本系統的Point Editor 輸入電腦，就可以逼近想要的曲線。這些
曲線用來設計一件物體的剖面和切面，再利用一、曲面旋轉，二、直軸設計和三、自
然軸設計，這三種設計方法，就可以將想要的物體，以網狀線條顯示在螢光幕上。當
然，一件完整的物體，有時是好幾件更小的物體所組成的，所以本系統提供管理物體
之間的資料結構的功能，使用者可以單獨地設計物體各部份，再銜接起來，成為一個
複雜、完整的個體。
繪圖核心系統部份，是依據Clnternational Standards Organization (ISO) 所定的
國際標準，而設計的一套繪圖系統，在這套系統中，所有的繪圖指令如畫線等都經過
標準化，而趨向一致，使繪圖系統和機器硬體無關，增進系統的可攜性。
以上這些功能，都己經IBM-PC 上，用C Language 設計完成
Xi jun ji qun yun dong zhong shui dong xiang hu zuo yong de yan jiu
No full textZhai, He = 细菌集群运动中水动相互作用的研究 / 翟翯.Thesis M.Phil. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 54-59).Abstracts also in Chinese.Title from PDF title page (viewed on 08, November, 2016).Zhai, He = Xi jun ji qun yun dong zhong shui dong xiang hu zuo yong de yan jiu / Zhai He
Nazeris luoi Hu & Li, sp. n.
No full textNazeris luoi Hu & Li, sp. n. (Figs. 7–12) Type material. Holotype: male, labeled ' China: Guangxi Province / Jinxiu County / Dayaoshan N. R. / 16 km / alt. 850–950 m / 24 -VII- 2011 / HU & YIN leg. Paratypes: 3 males, 6 females, same labeled data as holotype; 1 male, 1 female, same data, except alt. 800–950 m / 29 -VII- 2011 / HU & YIN leg. Description. Body length 4.3–5.4 mm; forebody length 2.6–2.7 mm. Male. Body (Fig. 7) reddish brown, with abdominal segment VII somewhat darker, antennal segments (except for basal two ones), maxillary palpi and legs (except for coxae) yellow. Head about as long as wide; postocular portion 1.85 times as long as eye length; with umbilicate punctation coarse and dense. Antennae slender; relative length (width) of each antennomere from I to XI as 34.0 (8.0): 12.0 (6.0): 22.0 (4.5): 19.0 (5.0): 18.0 (5.0): 18.0 (5.0): 16.0 (5.0): 15.0 (5.0): 15.0 (5.0): 13.0 (5.5): 17.0 (6.0). Pronotum longer than wide (length/width = 1.17), narrower than (pronotum/head = 0.88) and as long as head; prosternum with strong longitudinal median carina extending to anterior margin. Elytra shorter than wide (length/ width = 0.93), shorter (elytra/pronotum = 0.78) and narrower (elytra/pronotum = 0.97) than pronotum. Abdomen elongate, tergites lacking microsculpture. Sternite VII (Fig. 8) with posterior margin slightly emarginated at middle, area anterior to emargination not depressed. Sternite VIII (Fig. 9) with posterior margin triangularly concaved at middle. Aedeagus (Figs. 10–12) well sclerotized; median lobe with lateral margins angularly expanded laterally twice near apex in dorsal or ventral view, with pair of round laminae near apical fourth on dorsal side and apical tubercles on ventral side, with truncate apex; dorso-lateral apophysis strong, distinctly narrowed below apices, slightly curved mesally in dorsal or ventral view and distinctly curved dorsally in lateral view, extending much beyond apex of median lobe. Female. Sternites VII and VIII simple. Other characters similar to those of male. Distribution. South China: Guangxi. Remarks. Sharing with N. fujianensis a similar general appearance, but can be separated by the postocular portion being 1.85 times as long as eye length (1.54 times in N. fujianensis), and aedeagus with the dorso-lateral apophysis lacking mesal process at apical third, while N. fujianensis has the dorso-lateral apophysis with a long mesal process at apical third (Hu et al. 2010: 353, fig. 7). Etymology. The species is named in honor of Bao-Ting Luo (Administration of Dayaoshan National Nature Reserve) who helped a lot during our collection in Guangxi.Published as part of Hu, Jia-Yao, Li, Li-Zhen & Zhao, Mei-Jun, 2012, Six new species of Nazeris Fauvel (Coleoptera, Staphylinidae, Paederinae) from Guangxi, South China, pp. 35-44 in Zootaxa 3399 on page 37, DOI: 10.5281/zenodo.20874
Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia
Full text linkOverexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process. However, c-jun expression has not been investigated in acute myeloid leukemia (AML) cells containing the most common chromosomal translocations. t(8;21) is one of the most common AML-associated translocation and results in the AML1-ETO fusion protein. Overexpression of AML1-ETO in NIH3T3 cells leads to increased phosphorylation of Ser63 in c-Jun, which is generally JNK dependent. The role of the JNK signaling pathway for the functional properties of AML1-ETO is, however, unknown.
In the present study we found high expression levels of c-jun mRNA in t(8;21), t(15;17) or inv(16) positive patient cells by microarray analysis. Within t(8;21) positive patient samples, there was a correlation between AML1-ETO and c-jun mRNA expression levels. In myeloid U937 cells, c-jun mRNA and c-Jun protein expression levels increased upon induction of AML1-ETO. AML1-ETO transactivated the human c-jun promoter through the proximal AP-1 site via activating the JNK signaling pathway. JNK targets c-Jun and ATF-2, which also bind to the proximal AP-1 site in U937 cells, were also phosphorylated upon AML1-ETO induction. Furthermore, AML1-ETO induction increased the DNA binding capacity of c-Jun and ATF-2 to the proximal AP-1 site of the c-jun promoter, which might result in their enhanced transactivation capacities.
Interference with JNK and c-Jun activation by using JIP-1 or a JNK inhibitor reduced the transactivation capacity of AML1-ETO on the c-jun promoter and the pro-apoptotic function of AML1-ETO in U937 cells. AML1-ETO seems to activate the JNK signaling pathway by inducing the expression of a cytoplasmic factor, possibly G-CSF, because supernatant of AML1-ETO expressing cells was sufficient to induce phosphorylation of JNK and c-Jun in wildtype U937 cells.
This data demonstrates a novel mechanism of how AML1-ETO might exert positive effects on target gene expression and identifies the proto-oncogene c-jun as a common target gene in AML patient cells.Überexpression des Proto-Onkogens c-jun und konstitutive Aktivierung des Jun NH2-terminalen Kinase (JNK)-Signaltransduktionsweges sind wichtig für die leukämische Transformation in der Chronischen Myeloischen Leukämie. Die Expression von c-jun bei Akuter Myeloischer Leukämie (AML) mit den häufigsten reziproken Translokationen ist jedoch unbekannt. Bei einer der häufigsten AML Translokation t(8;21) wurde in Fibroblastenzellen gezeigt, daß das AML1-ETO-Fusionsgen die Phosphorylierung des Serin 63 in c-Jun erhöht. Die Rolle des JNK-Signalweges, der c-Jun am Serin 63 phosphorylieren kann, für die Funktion von AML1-ETO wurde bisher jedoch nicht untersucht. Weiterhin kann aktiviertes c-Jun durch eine positive Rückkoppelungsschleife über den c-jun Promotor zur Erhöhung der c-Jun Expression führen.
In der vorliegenden Arbeit konnten wir zeigen, daß AML Patientenzellen mit den häufigen Translokationen: t(8;21), t(15;17) oder inv(16) mehr c-jun mRNA besitzen im Vergleich zu Knochenmarkszellen gesunder Probanden. Weiterhin fanden wir eine hohe Korrelation zwischen der AML1-ETO und der c-jun mRNA bei t(8;21) positiven Patientenzellen. Induktion von AML1-ETO in der myeloischen U937 Zellinie erhöhte sowohl c-jun mRNA als auch c-Jun Proteinexpression. Damit konnten wir zeigen, daß AML1-ETO die Erhöhung der c-jun Expression bewirkt. Wir untersuchten den molekularen Mechanismus in U937 Zellen mittels transienter Transfektionen und fanden, daß AML1-ETO den c-jun Promotor durch die proximale AP-1 Seite transaktiviert. Diese Transaktivierung erfolgte indirekt über Aktivierung des JNK-Signaltransduktionsweges durch AML1-ETO. AML1-ETO-Induktion führte auch zur Phosphorylierung der JNK-Zielproteine c-Jun und ATF-2. Diese konnten im Gelretardierungsassay an die proximale AP-1 Seite des c-jun Promotors binden und wurden durch AML1-ETO-Induktion in ihrer Bindungsfähigkeit verstärkt. Deshalb nehmen wir an, daß die Transaktivierungskapazität des c-jun Promotors durch AML1-ETO über die Aktivierung des JNK-Signalweges läuft
Sustaining Elderly Engagement in IoT-Based Health Self-Monitoring through Incentives and Family Involvement
No full textNazeris dayaoensis Hu & Li, sp. n.
No full textNazeris dayaoensis Hu & Li, sp. n. (Figs. 1–6) Type material. Holotype: male, labeled ' China: Guangxi Province / Jinxiu County / Dayaoshan N. R. / Shengtangshan / alt. 1650–1800 m / 26 -VII- 2011 / HU Jia-Yao leg.' Paratypes: 11 males, 10 females, same label data as holotype; 1 male, 1 female, same data, except 'alt. 1900 m, 25 -VII- 2011 / PENG Zhong leg.; 1 male, same data, except alt. 1900 m, 26 -VII- 2011 / PENG Zhong leg.; 8 males, 13 females, same data, except 7 km / alt. 1200–1400 m / 22 - VII- 2011 / HU & YIN leg.; 4 females, same data, except 7 km / alt. 1200–1400 m / 22 -VII- 2011 / PENG Zhong leg.; 4 males, 3 females, same data, except Yinshan Station / alt. 1200 m, 23 -VII- 2011 / PENG Zhong leg. Description. Body length 4.2–5.4 mm; forebody length 2.4–2.5 mm. Male. Body (Fig. 1) reddish brown, with abdominal segment VII somewhat darker, antennal segments (except for basal two ones), maxillary palpi and legs (except for coxae) yellow. Head about as long as wide; postocular portion 1.73 times as long as eye length; with umbilicate punctation coarse and dense. Antennae slender; relative length (width) of each antennomere from I to XI as 34.0 (9.0): 12.0 (6.0): 20.0 (4.0): 17.0 (4.5): 17.0 (4.5): 17.0 (4.5): 15.0 (4.5): 14.0 (4.0): 14.0 (4.0): 13.0 (5.0): 16.0 (5.5). Pronotum longer than wide (length/width = 1.15), narrower than (pronotum/head = 0.88) and as long as head; prosternum with strong longitudinal median carina extending to anterior margin. Elytra shorter than wide (length/ width = 0.96), shorter (elytra/pronotum = 0.81) and narrower (elytra/pronotum = 0.96) than pronotum. Abdomen elongate, tergites lacking microsculpture. Sternite VII (Fig. 2) with posterior margin slightly emarginated at middle, area anterior to emargination not depressed. Sternite VIII (Fig. 3) with posterior margin triangularly concaved at middle. Aedeagus (Figs. 4–6) well sclerotized; median lobe with lateral sides nearly parallel in apical half, and abruptly constricted to sharp apex in dorsal or ventral view, with pair of round semi-membranous lateral projections near apical third; dorso-lateral apophysis very slender, slightly curved mesally in dorsal or ventral view and slightly curved dorsally in lateral view, extending to level of apex of median lobe. Female. Sternites VII and VIII simple. Other characters similar to those of male. Distribution. South China: Guangxi. Remarks. Similar to N. fujianensis Hu et al. from Fujian in sharing a similar general appearance, but can be readily separated by the postocular portion being 1.73 times as long as eye length (1.54 times in N. fujianensis), and aedeagus with the dorso-lateral apophysis lacking mesal process at apical third, while N. fujianensis has the dorsolateral apophysis with a long mesal process at apical third (Hu et al. 2010: 353, fig. 7). Etymology. The specific name is derived from the name of the type locality: Dayao Mountain.Published as part of Hu, Jia-Yao, Li, Li-Zhen & Zhao, Mei-Jun, 2012, Six new species of Nazeris Fauvel (Coleoptera, Staphylinidae, Paederinae) from Guangxi, South China, pp. 35-44 in Zootaxa 3399 on pages 36-37, DOI: 10.5281/zenodo.20874
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