12,796 research outputs found
Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense
No full textAbstract not availableYves S.-Y. Hsieh, Cheng Chien, Sylvian K.-S. Liao, Shih-Fen Liao, Wei-Ting Hung, Wen-Bin Yang, Chih-Chien Lin, Ting-Jen Rachel Cheng, Chia-Chuan Chang, Jim-Min Fang and Chi-Huey Won
Opposite effects of low and high dose supplementation of vitamin E on survival of MRL/lpr mice
No full textsj-docx-1-jvm-10.1177_13567667231193436 - Supplemental material for The longer the better? The impact of online review length on tourist trust and visit intention
No full textSupplemental material, sj-docx-1-jvm-10.1177_13567667231193436 for The longer the better? The impact of online review length on tourist trust and visit intention by Chien-Jung Molly Huang, Shih-Chieh Chuang, Yin-Hui Cheng and Chia-Chen Hsieh in Journal of Vacation Marketing</p
sj-docx-1-tam-10.1177_17588359241246427 – Supplemental material for Assessing the effectiveness of targeted agents in adjuvant therapy for patients with metastatic colorectal cancer undergoing surgical resection: a retrospective cohort study
No full textSupplemental material, sj-docx-1-tam-10.1177_17588359241246427 for Assessing the effectiveness of targeted agents in adjuvant therapy for patients with metastatic colorectal cancer undergoing surgical resection: a retrospective cohort study by Yi-Chia Su, Chih-Chien Wu, Yu-Hsun Chen, Chien-Chou Su, Yu-Ching Chang, Meng-Che Hsieh and Yea-Huei Kao Yang in Therapeutic Advances in Medical Oncology</p
Low and high levels of α-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-γ, IκBα, and apoptotic pathway in activated splenocytes
No full textTiming of saccadic eye movements during an accumulative visual search task
No full textThe quality of visual performance depends on how efficiently saccades can be programmed. During each intersaccadic pause, the visual system needs to evaluate the fixated content and also determine where to look next. Most prior studies focused only on the spatial element of saccadic decisions but ignored the effect of time. A good search strategy should be able to apportion time between saccade production rate and the accuracy of target selection to maximize the acquisition of information. The current work is interested in how time is used in saccadic planning and how people decide when to look next. To answer these questions, a novel experiment was designed where subjects were asked to search through arrays of targets (thin circles containing oriented lines) embedded in non-targets (thicker circles), either to estimate a statistical property of the targets (mean orientation of the lines), or to just look at the targets. Varying the visual similarity of targets and non-targets had large effects on both the probability of landing on a target and the number of circles fixated per second in both estimation and the look-only tasks. Also, the eye dwelled longer on targets than on distractors even in the look-only task, where there was no need to evaluate target content. Saccadic dwell times, however, were about the same, regardless of whether the eye moved next to a target or to a distractor. The results show that the timing of saccades depends on (1) the currently fixated content, (2) accumulated evidence in eccentric vision and also (3) an internal timer. The strategy, which incorporates these three factors rather than simply relies on any one of them, may guarantee efficient use of time in saccadic planning.Ph. D.Includes bibliographical referencesby Chia-Chien W
The Pharmaceutical Research of Wu-Chia-Pi
No full text五加皮藥材，其來源依藥學文獻均指為五加科(Araliaceae)五加屬A(Acanthopanax)若干種植物乾燥之根皮。我國本草將五加列於神農本草經草木部下品，自唐新修本草移附木部上品後，歷代諸家本草如開寶、嘉祐、圖經、証類、精要、圖考及長編等皆言五加皮，自古用於怯風濕，壯筋骨，活血，去瘀。治風寒濕痺，筋骨攣急，腰痛，陽痿，腳弱，小兒行遲，水腫，腳氣，瘡疽腫毒，跌打損傷諸症
五加皮藥材之來源植物甚多且復雜，一般文獻皆以細柱五加Acanthopanax listylu W.W. SMITH、無梗五加A. sessiliflorus (RUPR. et MAXIM.) SEEM、刺五加A. senticous (RUPR. et MAXIM.) HARMS、糙葉五加A. henryi (OLIV.) HARMS、輪葉五加A. verticillatus HOO為其代表，且為浸製五加皮酒之原料，時常飲之有強壯之功，為吾人酒宴乃至日常保健之飲料，關係國民健康至鉅。近年來報載五加皮酒有毒之說，甚受全國人士之重視與關懷。據那琦初步研究結果，南五加皮之原植物為五加屬植物無毒，北五加皮之原植物為杠柳有毒，隨後甘偉松等嘗著五加皮之藥用植物學考察。關於台灣地區所產本屬植物之本草學、生藥學之研究尚未見正式報告，著者因而進行本研究。
著者就採得之標本與市場品，進行五加之本草考察，以闡明其藥名、形態、種類、產地、性味、功能、修治、方用、禁忌、釀酒等歷史淵源，更而進行五加屬藥用植物等藥學之探討，以闡明其分類關係，五加藥材部分學者分隸於Acanthopanax MIQ.，Elentherococcus MAXIM.，Evodiopanax NAKAI，今統歸隸於五加屬植物，我國產30餘種植物予以索引敘述，並分辨刺五加(A. senticous HARMS)與杠柳(Periploca sepium BUNGE)比較解剖組織研究，以求証其真偽，有助於藥材之成分、藥理毒性及臨床應用等植物資源之開發。
Wu-Chia-Pi as a medical material, according to medical literature, can be derived from and referred to the dried root bark of those various plants of Acanthopanax species of Araliaceae, Family. The Chinese Pent¡¦ao lists Wu-Chia-Pi in Shen-Nung Pents’ao-Ching as Hsia-Ping under the category of Wood. Since the T’ang Dynasty Hsin-Hsiou-Pents¡¦ao moved it as Sang-Ping under the category of Wood, many schools of Pents¡¦ao in the succeeding dynasties, such as Kai-Pao, Chia-You, Tu-Ching, Cheng-Lay and Chang-Pian have all made mention of Wu-Chia-Pi, which has since ancient times been used to get rid of rheumatism, enhance the sinews and bones, activate blood circulation, remove blood clots, treat wind colds waist pain, impotence, and such symptoms as broken bones and injuries.
The plant sources of the medical material of Wu-Chia-Pi are quite numerous and complicated. The regular Wu-Chia-Pi can be represented by Acanthopanax gracilistylus W.W. SMITH, A. sessiliflorus SEEM, A. senticous HARMS, A. henryi HARMS and A. verticilatus Hoo, which can also serve as the raw materials for brewing Wu-Chia-Pi wine, which can function to strengthen the body if it is often taken and can also serve as healthful drink in banquets or in our daily lives; therefore, it has much to do with the health of the people. In recent years, there have been some newspaper report about the theories that Wu-Chia-Pi wine has poison in it, making it of great importance and concern by the Chinese people. As a result, several years ago the Legislative Yuan through the Monopoly Bureau prohibited the making and marketing of this wine. According to the study of Dr. Na-Chi, the plant of Nan-Wu-Chia-Pi is the poisonless Acanthopanax genus, whereas the original plant of the Pe-Wu-Chia-Pi is the poisonous Periploca sepium. Later professor, Wei-Song-Kang and others tried to investigate the medi-cal material of Wu-Chia-Pi. As for the locally grown plants of this genus in Taiwan areas, there is still no formal report about the science of Pents’ao and the science of raw medical for such plants, promptimg this author to conduct this research.
Using the collected samples and those products sold on the market, the author conducted the investigation of Wu-Chia Pents’ao in order to elucidate the medical names, patterns, varieties, places of origin, characteristic flavors, functions, and such wine brewing as the historical derivation. Furthermore, explorations is msde of the medical science of the plant genus of Wu-Chia in order to elucidate its categorical relationship. Scholars have categorized the part of Wu-Chia medical material into Acanthopanax MIQ, Eleutherococcus MAXIM, Evodiopanax NAKAT Now, it is categorized under the plant genus of Wu-Chia, in which there are some 30 kinds of plants grown in our country, which are placed in index for description. In addition to this, distinction is made between A. senticous HARMS and Periploca sepium BGE in order to compare their analytical compostion, to substantiate the true and the false ones, which will be helpful to the understanding of the ingredients of the medical material, the medicinal toxicity, and the resource development of those plants in clinical applications
The effects of vitamin E on the progress of autoimmune disease in autoimmune–prone mice fed fresh oil or frying oil diet
No full text本研究係探討維生素E的補充對自體免疫鼠病情的影響，分別對攝食炸油（10%炸油+5%新鮮大豆油）或一般低油（5%新鮮大豆油）的自體免疫鼠MRL/lpr或NZB/W F1鼠，添加5倍或10倍的維生素E (all-rac-alpha-tocopheryl acetate, alpha-TOC)，追蹤小鼠自體抗體生成、尿蛋白和生命期之變化。並探討是否經由影響氧化壓力、免疫細胞族群、脂肪酸組成，進而影響發炎反應等機轉，以了解維生素E對自體免疫疾病的利弊。實驗飼料包括：炸油 (SF)、炸油補充10倍維生素E (SFE10, SF + 550mg/kg)、低油 (E1)、低油補充10倍維生素E (E10, 5%新鮮油+ alpha-TOC 500mg/kg) 或缺乏維生素E (E0)。結果顯示，炸油添加10倍維生素E對MRL/lpr與NZB/W F1自體免疫小鼠，有益於延緩小鼠病情惡化，在NZB/W F1鼠延長生命期達顯著差異。缺乏維生素E與炸油飲食，皆會造成紅血球溶血增加與組織TBARS上升，炸油補充維生素E，可顯著增加組織中維生素E含量，降低組織TBARS與紅血球溶血率，抗雙股DNA抗體生成較低，但新鮮油添加維生素E則無顯著變化。雖然缺乏維生素E增加組織氧化壓力，但抑制B細胞增生反應，降低自體抗體生成。在脂肪酸組成方面，SFE10飲食會抑制脾臟細胞脂肪酸LA衍生成AA，可能降低促發炎介質PGE2衍生，但本實驗結果未達顯著性。對免疫細胞的影響，E0與SF飲食，增加T細胞比例，促進IL-2分泌。SFE10組、E10組或ED組均顯著抑制IFN-gamma與IL-6的分泌，減少MHC II的表現，可能為降低自體抗體生成的原因。E10會降低NZB/W F1鼠脾臟細胞自發性IL-2的分泌，與前報導MRL/lpr鼠動物及細胞實驗，高劑量維生素E顯著抑制鼠脾臟細胞IL-2的分泌結果一致。
因此，由體外添加維生素E細胞培養，探討高劑量抑制IL-2分泌的影響機制，是否透過增加Th1的細胞凋亡或抑制IL-2的訊息傳遞。故利用OVA-specific Tg轉殖小鼠分離培養已分化的Th1與Th2細胞，探討The purpose of this study was to investigate the effect of vitamin E supplementation on the autoimmune disease in NZB/W F1 female mice. The animal model and cell culture experiments were conducted to extend the mechanism of vitamin E supplementation in different dietary condition. The mice were fed an AIN-76 diet containing either 10 % oxidized frying oil+5 % fresh oil (SF), SF supplemented with all-rac-alpha-tocopheryl acetate at a level of 550 mg/kg diet (SFE10), 5 % fresh oil (E1), E1 supplemented with all-rac-alpha-tocopheryl acetate at 500 mg/kg (E10) or vitamin E deficiency (E0) respectively. The results showed that both MRL/lpr and NZB/W F1 mice fed the SFE10 diet convalesced growth and food intake. NZB/W F1 mice fed the SFE10 diet had lower anti-dsDNA IgG antibody level and longer life span than those fed the SF diets. The vitamin E supplementation in the oxidized oil significantly decreased TBARS values in the kidney and spleen of NZB/W F1 mice. The RBC hemolysis and TBARS values were increase in mice fed the ED diet. IFN-gamma and IL-6 production by mitogen-stimulated splenocytes decreased in mice fed on the SFE10, E10 and E0 diets. The IL-2 secretion by PHA-stimulation significantly increased in the SFE10 and E0 groups. The splenocytes from mice fed on the E0 diet have lower proliferative responses by PHA and LPS stimulation. The percentage of T cells significantly increased while major histocompatibility complex (MHC) class II-bearing cells decresed in the spleens of the SFE10 and E0 groups. The SFE10 group had significantly higher LA composition and tended to have lower AA and urinary bicycle-PGE2 than those of the SF diet group. We previously demonstrated that high dose of alpha-tocopherol succinate inhibited IL-2 mRNA expression and production in PHA-activated splenocytes of MRL/lpr mice. The na第一章、文獻回顧1
第一節、全身性紅斑狼瘡之簡介1
一、免疫系統自體辨識機轉的建立與失調1
二、致病因素與自體免疫疾病之分類2
三、疾病特徵與臨床治療3
四、實驗動物模式3
五、淋巴球在自體免疫之角色7
六、細胞凋亡在自體免疫之角色11
第二節、自體免疫疾病之相關研究13
一、限制熱量攝取13
二、動情激素13
三、前列腺素14
四、膳食油脂15
五、抗氧化劑16
第三節、維生素E之簡介18
一、維生素E的發現與歷史18
二、維生素E的化學性質19
三、維生素E的吸收與分佈20
四、維生素E的建議攝取量與安全性20
第四節、維生素E的生理角色 20
一、維生素E的抗氧化角色 21
二、維生素E對心血管疾病之調節22
三、維生素E對前列腺素之調節 22
四、維生素E對免疫功能之調節 23
五、維生素E對細胞訊息之調節 25
1. protein kinase C之角色 25
2. NF-kappaB之角色 26
3. PPARs之角色 27
六、維生素E與細胞凋亡之關係 29
第五節、研究動機 30
第六節、實驗假說 31
第二章、補充維生素E對攝食炸油飲食之自體免疫鼠病情的影響32
第一節、前言 32
第二節、材料與方法 33
一、實驗設計 33
二、動物飼養 33
三、病情指標之測定 36
四、統計方法 38
第三節、結果 38
一、補充維生素E與不同油脂飲食對MRL/lpr雌鼠病情的影響 38
二、補充維生素E與不同油脂飲食對NZB/W F1雌鼠病情的影響 45
第四節、討論 51
第三章、補充維生素E對攝食炸油飲食之NZB/W F1雌鼠免疫調節的影響 52
第一節、前言 52
第二節、材料與方法 53
一、實驗設計 53
二、動物飼養 54
三、病情指標之測定 54
四、動物犧牲及樣品收集與分析 54
五、統計方法 63
第三節、結果 64
一、 生長及攝食狀況 64
二、 病情指標 68
三、 組織氧化壓力 68
四、 組織脂肪酸組成 73
五、 體內PGE2代謝情況 78
六、 免疫細胞之反應 81
1. 脾臟細胞增生反應 81
2. 細胞表面標記 82
3. 細胞激素分泌 83
第四節、討論 87
第四章、維生素E缺乏或高量補充對低油飲食之NZB/W F1雌鼠病情的影響 90
第一節、前言 90
第二節、材料與方法 91
一、實驗設計 91
二、動物飼養 91
三、病情指標之測定 93
四、動物犧牲及樣品收集與分析 93
五、統計方法 93
第三節、結果 93
一、生長及攝食狀況 93
二、病情指標 97
三、組織氧化壓力 97
四、肝臟脂肪酸組成 105
五、體內PGE2代謝情況 106
六、免疫細胞之反應 108
1. 脾臟細胞增生反應 108
2. 細胞表面標記 109
3. 細胞激素分泌 110
第四節、討論 113
第五章、以體外模式探討不同劑量維生素E對脾臟細胞的影響 117
第一節、前言 117
第二節、材料與方法 117
一、免疫細胞處理維生素E之吸收試驗 117
二、維生素E對脾臟細胞增生能力的影響 119
三、維生素E對細胞表面抗原之分析 119
四、維生素E對脾臟細胞激素分泌的影響 119
五、OVA-Tg BALB/c mice脾臟Th1與Th2細胞的建立 119
第三節、結果 121
一、Jurkat細胞對不同型式維生素E之攝入實驗 121
二、維生素E對脾臟細胞增生能力的影響 123
三、維生素E對脾臟細胞細胞族群分佈的影響 123
四、維生素E對脾臟細胞激素分泌的影響 123
五、維生素E對脾臟已分化的Th1與Th2細胞分泌細胞激素的影響128
第四節、 討論 131
第六章、高劑量維生素E對免疫細胞IL-2分泌的影響機制探討 134
第一節、前言 134
第二節、材料與方法 134
一、有無氧化壓力下，維生素E對細胞凋亡的影響 134
二、維生素E經由PPA
A Screening Platform for Compounds with Potential Immuno-regulatory Activities Using Human Cord Blood Mononuclear Cells
No full text- …
