184 research outputs found
Pedagogy, medical education and cinema: a possible encounter
No full textWritten for the 15° years of the JMM, the article analyzes the relationship between Pedagogy, medical education and film language, retracing the scientific and professional relationship that binds the Author with the Journal and its editors
Comparison of population and family-based methods for genetic association analysis in the presence of interacting loci
No full textTest to Identify Co-Localization of Genetic Association Signals Across Multiple Traits Using Summary Statistics
No full textTesting the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
No full textVariations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern, and T1D results from a cellular (T lymphocyte) response, we hypothesised that alleles predisposing to atopy could be protective for T1D and transmitted less often than the expected 50% from heterozygous parents to offspring with T1D. We genotyped seven exonic single nucleotide polymorphisms (SNPs) and the -3223 C>T SNP in the putative promoter region of IL4RA in up to 3475 T1D families, including 1244 Finnish T1D families. Only the -3223 C>T SNP showed evidence of negative association (P=0.014). There was some evidence for an interaction between -3233 C>T and the T1D locus IDDM2 in the insulin gene region (P=0.001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one
Defining aetiological variants within the HLA class II region that can lead to the development of Graves' disease
No full textVEGF non-angiogenic functions in adult organ homeostasis: therapeutic implications
No full textVascular endothelial growth factor (VEGF) is best known as an angiogenic factor essential for embryonic vasculogenesis and postnatal angiogenesis. Considerable evidence has accumulated that VEGF also has non-angiogenic functions. Early studies demonstrated that VEGF transcripts are ubiquitously expressed, and the phosphorylation of VEGF receptor is detectable in adult organs that have no feature of angiogenesis. Recent clinical studies showed that the inhibition of VEGF signaling results in diverse angiogenesis-irrelevant side effects involving the dysfunctions of many organs, suggesting non-angiogenic roles of VEGF in the regulation of organ homeostasis. On the other hand, VEGF stimulates endothelial cells (ECs) to express intercellular adhesion molecules that mediate physical interactions with adjacent tissue cells, or secreted various multifunctional substances that affect the functions of surrounding organs. Furthermore, very recent studies including ours have revealed VEGF as a potent agonist for endothelial exocytosis of Weibel-Palade bodies in which thrombogenic and inflammatory factors are stored. In this brief review, we highlight the importance of VEGF non-angiogenic functions in the modulation of tissue repair and organ regeneration, vascular homeostasis, and inflammation, and propose that the non-angiogenic functions are primarily mediated through the substances released from ECs.Genetics & HeredityMedicine, Research & ExperimentalSCI(E)PubMed9REVIEW7635-6458
Common allelic variants of exons 10, 12 and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the UK
No full textThyroglobulin (Tg) is a major autoantigen for autoimmune thyroid disease (AITD). The Tg gene ( Tg) has been mapped to chromosome 8q24, which has recently been linked in two independent studies to AITD. Association of specific alleles of microsatellite markers within Tg itself supports a role for Tg as a good candidate susceptibility locus for AITD. Resequencing of the Tg exons has led to the identification of a number of novel single nucleotide polymorphisms, four of which have been reported to be associated with AITD. Resequencing of Tg in Caucasian subjects in the United Kingdom (UK) has confirmed the presence of four single nucleotide polymorphisms in exons 10, 12, and 33. However, in the largest case-control association study to date with adequate power to detect the reported effect if present, we found no evidence for association of the Tg DNA variants with AITD in the UK. These data suggest that the recently identified single nucleotide polymorphisms do not have a causal role for AITD in the UK. At this stage, we cannot exclude the Tg region as harboring a susceptibility locus for AITD, and only large scale sequencing and fine mapping of the region, including neighboring genes, will allow us to identify any potential causal variants within this region
Dataset for a machine learning tool to improve lymph node staging with FDG-PET/CT
No full textThis upload provides Open Data associated with the publication "A machine learning tool to improve prediction of mediastinal lymph node metastases in non-small cell lung cancer using routinely obtainable [18F]FDG-PET/CT parameters" by Rogasch JMM et al. (2022).
The upload contains the anonymized dataset with 10 features necessary for the final GBM model that was presented in the publication. However, the original full dataset with 40 features was excluded from this Open Data repository because it may not comply with strict rules of data anonymization. The full dataset can be obtained from the corresponding author ([email protected]) upon reasonable request.
Besides the dataset, this upload provides the original python and R scripts that were used as well as their output.
A description of all files can be found in "content_description_2022_11_19.txt".
A user-friendly web tool that implements the final machine learning model can be found here: PET_LN_calculato
ANALISA KEBUTUHAN STEAM DI STASIUN STERILIZER DENGAN SISTIM PEREBUSAN 90 MENIT DI PT.ASN (Agro Sinergi Nusantara)
No full textIncreasing the performance of a machine in an industry engaged in palm oil processing is very meaningful in optimizing production activities to achieve good final results so as to increase industrial productivity. The process of boiling oil palm bunches is a very significant process that ensures the quality of palm oil produced in CPO processing. The use of saturated steam allows the formation of a hydrolysis/evaporation process of water in the fruit, if using dry steam it will cause the skin to burn, thus limiting evaporation of water in the fruit flesh and can also complicate the compression process. Therefore, controlling the quality of steam which is used as a source of boiling heat is very important in order to get perfect boiling results. From the above review, the author makes an analysis of the need for steam at the sterilizer statio
Role of mitofusin 2 in cardiovascular oxidative injury
No full textMitochondria are highly dynamic organelles with constant shape changes regulated by fusion and fission events. In addition to regulating mitochondrial morphology, mitochondrial fusion/fission is involved in fundamental mitochondrial biological processes, including mitochondrial metabolism, energization, respiration, mitochondrial membrane potential, and mtDNA stability. Dysfunction of mitochondrial dynamics has been implicated in various human diseases, especially in neurodegenerative diseases. Emerging evidence indicates that impaired expression of mitochondrial fusion proteins or their malfunction participates in oxidative stress-induced cardiovascular injury. This review will focus on recent advances of mitochondrial fusion in regulating various cellular processes in cardiovascular system.Genetics & HeredityMedicine, Research & ExperimentalSCI(E)PubMed6REVIEW10987-9918
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