309,994 research outputs found
A new look at the pathogenesis of asthma
No full textAsthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell response, but in general targeting this component of the disease with selective therapies has been disappointing and most therapy still relies on bronchodilators and corticosteroids rather than treating underlying disease mechanisms. With the disappointing outcomes of targeting individual Th-2 cytokines or manipulating T-cells, the time has come to re-evaluate the direction of research in this disease. A case is made that asthma has its origins in the airways themselves involving defective structural and functional behaviour of the epithelium in relation to environmental insults. Specifically, a defect in barrier function and an impaired innate immune response to viral infection may provide the substrate upon which allergic sensitization takes place. Once sensitized, the repeated allergen exposure will lead to disease persistence. These mechanisms could also be used to explain airway wall remodelling and the susceptibility of the asthmatic lung to exacerbations provoked by respiratory viruses, air pollution episodes and exposure to biologically active allergens. Variable activation of this epithelial-mesenchymal trophic unit could also lead to the emergence of different asthma phenotypes and a more targeted approach to the treatment of these. It also raises the possibility of developing treatments that increase the lung's resistance to the inhaled environment rather than concentrating all efforts on trying to suppress inflammation once it has become established.<br/
δ Orionis: Further temporal variability and evidence for small-scale structure in the interstellar medium
No full textWe report here the detection of both spatial and temporal variations in interstellar absorption in the line of sight to δ Orionis. First, we present new high-resolution (R≈110 000) observations of the interstellar D lines of Na i towards both δ Ori A and C. Comparison of these spectra highlights variations in absorption between the two stars, indicative of small-scale spatial structure in the interstellar medium in this direction over distances of less than ≈15 000 au (the projected separation of the two stars). Components with the largest Na i column densities and lowest velocity dispersions are, in general, found to be subject to the greatest differences; in fact the narrowest component detected is only observed in one of the sightlines. This effect has also been reported by Meyer & Blades. Secondly, we present new ultra-high-resolution (R≈900 000) Na i D1 observations and high-resolution (R≈110 000) Ca ii H & K observations of δ Ori A which, through ultra-high-resolution work conducted between 1994 and 2000, has been shown to exhibit a time-variable interstellar Na i absorption component. These new observations, while revealing the further reduction in intensity of the time-variable Na i absorption, indicate constant Ca ii absorption over the same period. This results in a dramatic reduction in the Na°/Ca+ abundance ratio, perhaps indicating the line of sight to be gradually probing a less-dense outer region of an absorbing filament
Designing a Metadata-Enabled Namespace for Enhancing Resource Discovery in Knowledge Bases [Version presented at the International Conference]
No full textThe proliferation of digitized resources accessible via Internet and Intranet knowledge bases, and a pressing need to develop more sophisticated tools for the identification and retrieval of electronic resources, both general purpose and domain-specific metadata schemes have assumed a particular prominence. While recent work emanating from the World Wide Web Consortium (W3C) has focused on the Resource Description Framework (RDF), and metadata maps or “crosswalks” have been created to support the interoperability of metadata standards -- thus converting metatags from diverse domains from simply “machine-readable” to “machine-understandable” -- the next iteration, to “human-understandable”, remains a challenge. This apparent gap provides a framework for three-phase research (Howarth, 2000, 1999) to develop a tool which will provide a “human-understandable” front-end search assist to any XML-compliant metadata scheme. Findings from phase one, the analyses and mapping of eight metadata schemes, identify the particular challenges of designing a common “namespace”, populated with element tags which are appropriately descriptive, yet readily understood by a lay searcher, when there is little congruence within, and a high degree of variability across, the metadata schemes under study. Implications for the subsequent design and testing of both the proposed “metalevel ontology” (phase two), and the prototype search assist tool (phase three) are examined
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
British poetry in the age of modernism
No full textIf Modernist poetry dominated the early twentieth century, what did it mean for British poets like Thomas Hardy, Edward Thomas and Wilfred Owen not to be Modernist? This is the first critical account of how non-Modernist poetry responded to the Modernist revolution. Peter Howarth uncovers the origins of the battles over poetic style still being fought today, and connects the early twentieth-century controversy about poetic form with contemporary social and political developments and the trauma of the First World War. Howarth argues that at the heart of the division between modern and traditional poetic form are different ideas of freedom, power and individuality. Scholars and students of twentieth-century poetry will find this an informative and inspiring account of the themes and debates that have shaped British poetry of the last hundred years
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Da "un magnifico errore" a "una comunità d'interazione dinamica". I codici di catalogazione angloamericani e l'evoluzione della catalogazione sociale : Lectio magistralis in Biblioteconomia
No full textLa catalogazione sociale è considerata come una tendenza recente del controllo bibliografico. Questo saggio sostiene invece che il coinvolgimento degli utenti nella descrizione e nell'aggiunta di termini del linguaggio naturale rientra nel processo logico di sviluppo dei codici e degli standard di catalogazione. Il saggio ricostruisce la storia delle regole di catalogazione angloamericane a partire dalla metà dell'Ottocento evidenziando un impegno costante verso la cooperazione. Una collaborazione tra catalogatori professionisti e "catalogatori sociali" sembra una alleanza crescente e positiva
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
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