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Caracterização química e avaliação da atividade biológica do extrato da raiz da Zanha golungensis (Sapindaceae)
No full textDesde os tempos antigos, o ser humano recorreu sempre aos produtos naturais como principal fonte primordial para a prevenção e tratamento de várias doenças. Estudos mostram que, nos países em desenvolvimento, 80% da população mundial recorre à medicina tradicional por ser considerada mais acessível, segura, eficaz e por apresentar menos reações adversas.
Em África, Zanha golungensis é utilizada tanto para fins alimentares como medicinais, nomeadamente no tratamento de várias enfermidades, como a malária, diarreia, dores de dentes, entorses, problemas respiratórios. O objectivo deste trabalho centra-se na caracterização do perfil químico e avaliação da atividade biológica do extrato da raiz da Z. golungensis, usada no tratamento da asma, segundo os praticantes da medicina tradicional em Nampula, na zona norte de Moçambique.
Para a caracterização dos compostos fenólicos foi usado o método HPLC-DAD-ESI/MS, onde foram identificados três compostos fenólicos com a mesma estrutura principal de crisoeriol, nomeadamente Crisoeriol-rhamnosyl-dirutinosideo, crisoeriol-dirhamnosyl-rutinosideo e crisoeriol-rhamnosyl-rutinosideo.
Verificou-se que o extrato apresentou atividade com a CMI de 10 mg/mL frente as bactérias Gram-negativo de origem clínica, e de origem alimentar, com CMI de 5mg/mL frente a Escherichia coli e CMI de 10mg/mL frente Pseudomona aeruginosa e Salmonella enterocolítica.
No que respeita à capacidade anti-inflamatória, o extrato apresentou um IC50 de 231,76±8,44 μg/mL, inibindo a produção de óxido nítrico (NO). Em relação à atividade antiproliferativa, o extrato demonstrou capacidade de inibir a proliferação de todas as linhas celulares tumorais em estudo. Contudo, o extrato não apresentou atividade antiproliferativa frente as linhas celulares não tumorais Vero.
No que concerne à atividade antioxidante, o extrato revelou capacidade de inibir a formação de substâncias reativas ao ácido tiobarbitúrico.
Os resultados obtidos indicam que a raiz da Z. golungensis possui atividade biológicas, o que comprova os seus efeitos benéficos no contexto da medicina tradicional em Moçambique.Since ancient times, human beings have resorted to natural products as the primary source for the prevention and treatment of various diseases. Studies show that, in developing countries, 80% of the world's population resorts to traditional medicine because it is considered more accessible, safe, effective and presents fewer adverse reactions.
In Africa, Zanha golungensis is used for both food and medicinal purposes, particularly in treating various illnesses, such as malaria, diarrhea, toothaches, sprains, and respiratory problems. The objective of this work focuses on characterizing the chemical profile and evaluating the biological activity of Z. golungensis root extract, used to treat asthma, according to traditional medicine practitioners in Nampula, in the north of Mozambique.
For the characterization of phenolic compounds, the HPLC-DAD-ESI/MS method was used, where three phenolic compounds with the same main structure of chrysoeriol were identified, namely Chrysoeriol-rhamnosyl-dirutinoside, chrysoeriol-dirhamnosyl-rutinoside and chrysoeriol- rhamnosyl-rutinoside.
It was found that the extract showed activity with a MIC of 10 mg/mL against Gram- negative bacteria of clinical origin and food origin, with a MIC of 5 mg/mL against Escherichia coli and a MIC of 10 mg/mL against Pseudomona aeruginosa and enterocolitic Salmonella.
Regarding anti-inflammatory capacity, the extract presented an IC50 of 231.76±8.44 μg/mL, inhibiting the production of nitric oxide (NO). Regarding antiproliferative activity, the extract demonstrated the ability to inhibit the proliferation of all tumor cell lines under study. However, the extract did not show antiproliferative activity against Vero non-tumor cell lines.
Regarding antioxidant activity, the extract revealed the ability to inhibit the formation of substances reactive to thiobarbituric acid.
The results obtained indicate that the root of Z. golungensis has biological activity, which proves its beneficial effects in the context of traditional medicine in Mozambique
Caracterização química e avaliação da atividade biológica do extrato da raiz da Zanha golungensis (Sapindaceae)
Full text linkDesde os tempos antigos, o ser humano recorreu sempre aos produtos naturais como principal fonte primordial para a prevenção e tratamento de várias doenças. Estudos mostram que, nos países em desenvolvimento, 80% da população mundial recorre à medicina tradicional por ser considerada mais acessível, segura, eficaz e por apresentar menos reações adversas.
Em África, Zanha golungensis é utilizada tanto para fins alimentares como medicinais, nomeadamente no tratamento de várias enfermidades, como a malária, diarreia, dores de dentes, entorses, problemas respiratórios. O objectivo deste trabalho centra-se na caracterização do perfil químico e avaliação da atividade biológica do extrato da raiz da Z. golungensis, usada no tratamento da asma, segundo os praticantes da medicina tradicional em Nampula, na zona norte de Moçambique.
Para a caracterização dos compostos fenólicos foi usado o método HPLC-DAD-ESI/MS, onde foram identificados três compostos fenólicos com a mesma estrutura principal de crisoeriol, nomeadamente Crisoeriol-rhamnosyl-dirutinosideo, crisoeriol-dirhamnosyl-rutinosideo e crisoeriol-rhamnosyl-rutinosideo.
Verificou-se que o extrato apresentou atividade com a CMI de 10 mg/mL frente as bactérias Gram-negativo de origem clínica, e de origem alimentar, com CMI de 5mg/mL frente a Escherichia coli e CMI de 10mg/mL frente Pseudomona aeruginosa e Salmonella enterocolítica.
No que respeita à capacidade anti-inflamatória, o extrato apresentou um IC50 de 231,76±8,44 μg/mL, inibindo a produção de óxido nítrico (NO). Em relação à atividade antiproliferativa, o extrato demonstrou capacidade de inibir a proliferação de todas as linhas celulares tumorais em estudo. Contudo, o extrato não apresentou atividade antiproliferativa frente as linhas celulares não tumorais Vero.
No que concerne à atividade antioxidante, o extrato revelou capacidade de inibir a formação de substâncias reativas ao ácido tiobarbitúrico.
Os resultados obtidos indicam que a raiz da Z. golungensis possui atividade biológicas, o que comprova os seus efeitos benéficos no contexto da medicina tradicional em Moçambique.Since ancient times, human beings have resorted to natural products as the primary source for the prevention and treatment of various diseases. Studies show that, in developing countries, 80% of the world's population resorts to traditional medicine because it is considered more accessible, safe, effective and presents fewer adverse reactions.
In Africa, Zanha golungensis is used for both food and medicinal purposes, particularly in treating various illnesses, such as malaria, diarrhea, toothaches, sprains, and respiratory problems. The objective of this work focuses on characterizing the chemical profile and evaluating the biological activity of Z. golungensis root extract, used to treat asthma, according to traditional medicine practitioners in Nampula, in the north of Mozambique.
For the characterization of phenolic compounds, the HPLC-DAD-ESI/MS method was used, where three phenolic compounds with the same main structure of chrysoeriol were identified, namely Chrysoeriol-rhamnosyl-dirutinoside, chrysoeriol-dirhamnosyl-rutinoside and chrysoeriol- rhamnosyl-rutinoside.
It was found that the extract showed activity with a MIC of 10 mg/mL against Gram- negative bacteria of clinical origin and food origin, with a MIC of 5 mg/mL against Escherichia coli and a MIC of 10 mg/mL against Pseudomona aeruginosa and enterocolitic Salmonella.
Regarding anti-inflammatory capacity, the extract presented an IC50 of 231.76±8.44 μg/mL, inhibiting the production of nitric oxide (NO). Regarding antiproliferative activity, the extract demonstrated the ability to inhibit the proliferation of all tumor cell lines under study. However, the extract did not show antiproliferative activity against Vero non-tumor cell lines.
Regarding antioxidant activity, the extract revealed the ability to inhibit the formation of substances reactive to thiobarbituric acid.
The results obtained indicate that the root of Z. golungensis has biological activity, which proves its beneficial effects in the context of traditional medicine in Mozambique
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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