15,037 research outputs found
Letter from John P. John to Joseph R. Goodman, 1942
No full textLetter from John P. John to Joseph R. Goodman: "Here are a couple of letters Caleb received concerning the Japanese situation. I have already sent him a condensed record of their general text. Probably more material will be coming in from time to time and we will forward it to you. I guess this is sufficient since Caleb has spoken with you in detail about the problem and where he is to be contacted in the east. Louise Thompson and I are holding things down while Caleb is away and can be contacted here by mail for anything."Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition
No full textSteroid hormones are associated with the risk of postmenopausal breast cancer and evidence suggests that increased concentrations of oestrogens from peripheral aromatisation in adipose tissue partly explains the association between body mass index (BMI) and risk of postmenopausal breast cancer. This study examined the associations between circulating concentrations of steroid hormones and anthropometric measurements in a sample of naturally postmenopausal women from the Melbourne Collaborative Cohort Study, not using hormone replacement therapy.
We measured plasma concentration of total oestradiol, oestrone sulphate, dehydroepiandrosterone sulphate, androstenedione, testosterone and sex hormone binding globulin (SHBG) and calculated concentration of free oestradiol. Body measurements included height, weight, BMI, waist circumference, fat mass and fat-free mass, the last two estimated by bioelectrical impedance analysis. BMI was positively associated with both oestrogens and androgens and negatively with SHBG. Fat mass was the principal measure responsible for the association observed between body size and total oestradiol. The associations between oestrone sulphate and androgens and body size were mainly with waist circumference.
The associations between oestrogens and body size were close to null for the first 6 years since menopause and became positive thereafter. Our results are compatible with the hypothesis that after the menopause excess fat mass increases oestrogen concentrations through the peripheral aromatisation of androgens in adipose tissue. This effect requires around 6 years to be detectable by way of circulating steroid hormone levels.Laura Baglietto, Dallas R. English, John L. Hopper, Robert J. MacInnis, Howard A. Morris, Wayne D. Tilley, Kavitha Krishnan and Graham G. Gile
Changes of North Atlantic plate motion in early Paleogene driven by Icelandic plume:Insights from kinematic and stratigraphic constraints
No full textMantle convection is a fundamental process that shapes the Earth's surface by providing the driving and resisting forces for horizontal motion of tectonic plates, as well as for inducing non-isostatic vertical motion commonly termed “dynamic topography”. Growing observational constraints of past plate motion and dynamic topography have led to better understanding of the history of surface expression induced by mantle flow. Often these two surface motion signals are studied separately. However, the existence of a thin, mechanically weak asthenosphere allows geodynamicists to link horizontal and vertical motion changes together via mantle flow properties in the context of pressure-driven Poiseuille-type flow. In this paper, we utilize publicly available geologic and geophysical datasets to study early Paleogene plate kinematics and spatiotemporal evolution of dynamic topography in the North Atlantic region. We find that the North America (NAM) and Greenland (GRN) plates experienced a rapid kinematic change around late Paleocene–early Eocene, coinciding with episodes of surface uplift inferred from stage-resolution stratigraphic information around the North Atlantic, Labrador Sea and Baffin Bay. We quantitatively tie these surface motion signals together to underlying asthenospheric flow processes by estimating torque variations on NAM and GRN. These are parameterized in terms of reconstructed kinematic changes as well as predicted Poiseuille-type flow induced by increasing Icelandic plume flux and speedup of Farallon slab. Our analysis indicates (1) that the torque-change associated with the Icelandic plume flux closely resembles the ones inferred from kinematic reconstructions, and (2) that the inclusion of slab effects does not modify significantly such a scenario. Our findings shed light on the role of asthenospheric channelized flow generated by the Icelandic plume in influencing the early Paleogene North Atlantic surface dynamics
R Code and Output Supporting: Do Capture and Survey Methods Influence Whether Marked Animals are Representative of Unmarked Animals?
No full textThe archive consists of 9 files:
1. WA_elk.R = R code used to analyze elk resighting data.
2. WA_elk.html = html output resulting from running the R code in WA_elk.R.
3. Mtg_AK_WA.R = R code used to analyze mountain goat resighting data.
4. Mtg_AK_WA.html = html output resulting from running the R code in Mtg_AK_WA.R.
5. Moose_MN.R = R code used to analyze moose resighting data.
6. Moose_MN.html = html output resulting from running the R code in Moose_MN.R.
7. sightdat.csv = resighting data collected from moose in Minnesota between 2004 and 2007.
8. MTG_Sight_Alaska.csv = resighting data collected from mountain goats in Alaska.
9. NE_MN_Map.pdf = map of collection region for moose resighting data.These files contain R code (along with associated output from running the code) supporting all results reported in "Do Capture and Survey Methods Influence Whether Marked Animals are Representative of Unmarked Animals?" in Wildlife Society Bulletin. The lead author wrote this code to analyze multi-year re-sighting data collected from moose (Alces alces) in Minnesota, elk (Cervus elaphus) in Washington, and mountain goats (Oreamnos americanus) in Washington and Alaska, to evaluate whether detection probabilities increased or decreased as a function of time since animals were captured.Fieberg, John R; White, Kevin S. (2015). R Code and Output Supporting: Do Capture and Survey Methods Influence Whether Marked Animals are Representative of Unmarked Animals?. Retrieved from the University Digital Conservancy, http://dx.doi.org/10.13020/D6Z597
Circulating steroid hormone levels and risk of breast cancer for postmenopausal women
No full textLink to a related website: https://cebp.aacrjournals.org/content/cebp/19/2/492.full.pdf, Open Access via UnpaywallEpidemiologic studies have consistently reported that endogenous steroid hormone levels are associated with postmenopausal breast cancer risk, but little is known on the associations by tumor grade, hormone receptor status, or age at diagnosis. We performed a case-cohort study of naturally postmenopausal women within the Melbourne Collaborative Cohort Study that included a random sample of 857 women and 197 breast cancer cases diagnosed during a mean of 9.2 years of follow-up. Concentrations of total estradiol, estrone sulfate, testosterone, DHEA sulfate, androstenedione, and sex hormone binding globulin were measured in plasma collected at baseline before diagnosis; free estradiol plasma concentration was calculated. Cox regression was used to estimate associations adjusted for known and potential confounders. The HR for breast cancer comparing fourth and first quartiles was 1.44 [95% confidence interval (95% CI), 0.89-2.35] for total estradiol, 1.75 (95% CI, 1.06, 2.89) for free estradiol, 2.05 (95% CI, 1.24-3.37) for estrone sulfate, 1.25 (95% CI, 0.78-2.01) for testosterone, 1.41 (95% CI, 0.88-2.27) for DHEA sulfate, 1.49 (95% CI, 0.91-2.44) for androstenedione, and 0.33 (95% CI, 0.19-0.55) for sex hormone binding globulin. These associations did not differ by tumor grade and estrogen receptor/progesterone receptor status (all test for heterogeneity, P > 0.05). Risks associated with estrogen and androgen levels were stronger at older ages (test for interaction across age groups, P = 0.59 for total estradiol and P = 0.01 for testosterone). Our prospective study confirms earlier findings and suggests that the associations of endogenous hormones with postmenopausal breast cancer risk are independent of tumor grade, and hormone receptor status and might increase in strength with age. Cancer Epidemiol Biomarkers Prev; 19(2); 492–502Laura Baglietto, Gianluca Severi, Dallas R. English, Kavitha Krishnan, John L. Hopper, Catriona McLean, Howard A. Morris, Wayne D. Tilley and Graham G. Gile
Local Author Talk with John Grabowski
No full textOn Wednesday, April 10 2024, meet author John J. Grabowski and hear about his recent book titled Cleveland Cultural Gardens: A Landscape of Diversity. From their beginnings as private farmland to their current form as monuments to cultural and ethnic diversity, the unique collection of landscaped, themed gardens that compose Cleveland’s Cultural Gardens holds a rich history. Honoring and embodying the cultural heritages of a region through the beauty of shared outdoor spaces, John J. Grabowski guides readers through this story, using both archival images and Lauren R. Pacini’s stunning contemporary photography.
To see the video of this presentation, click Link to Full Text in the upper right corner
Circulating insulin-like growth factor-I and binding protein-3 and the risk of breast cancer
No full text© 2007 American Association for Cancer ResearchFour meta-analyses and literature reviews have concluded that a positive association exists between circulating levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and breast cancer risk for premenopausal but not postmenopausal women. Recently, a large prospective study reported an association with IGF-I and IGFBP-3 concentration for breast cancer diagnosed after, but not before, the age of 50 years; and in a large cohort of primarily premenopausal women, IGF-I and IGFBP-3 were not associated with breast cancer risk. We did a case-cohort study within the Melbourne Collaborative Cohort Study, which included a random sample of 1,901 women (subcohort) and 423 breast cancer cases diagnosed during a mean of 9.1 years of follow-up. IGF-I and IGFBP-3 concentrations were measured in plasma collected at baseline. The association between quartiles of IGF concentration and breast cancer risk was tested using a Cox model adjusted for known and potential confounders. The hazard ratio (HR) for breast cancer comparing the fourth with the first quartiles was 1.20 [95% confidence interval (95% CI), 0.87-1.65] for IGF-I and 1.09 (95% CI, 0.78-1.53) for IGFBP-3. Both associations varied with age: for IGF-I, the HRs for breast cancer comparing the fourth with the first quartiles were 0.60 (95% CI, 0.25-1.45) before age 50 and 1.61 (95% CI, 1.04-2.51) after age 60 (test for the log-linear trend of HR according to age, P = 0.05); for IGFBP-3, the HRs were 0.79 (95% CI, 0.34-1.83) before age 50 and 1.62 (95% CI, 1.03-2.55) after age 60 (test for log-linear trend, P = 0.08). IGF-I and IGFBP-3 were positively associated with breast cancer risk in older women but not in younger women. More prospective studies are needed to clarify the age dependence of the association between IGF-I and IGFBP-3 and breast cancer.Laura Baglietto, Dallas R. English, John L. Hopper, Howard A. Morris, Wayne D. Tilley and Graham G. Gile
Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival
No full textOBJECTIVE: To describe survival outcomes with noninvasive ventilation (NIV) for full ventilatory support, and a mechanically assisted cough and oximetry protocol in a series of patients with Duchenne muscular dystrophy.
METHODS: We monitored end-tidal carbon dioxide (PETCO2), SpO2, vital capacity, maximum insufflation capacity, and cough peak flow. Nocturnal NIV was initiated for symptomatic hypoventilation. An oximeter and mechanically assisted cough device were prescribed when the pa- tient’s maximum assisted cough peak flow fell below 300 L/min. Patients used up to continuous NIV and mechanically assisted cough to return SpO2 to > 95% during intercurrent respiratory infections or as otherwise needed. We recorded respiratory and cardiac hospitalizations and mortality, and quantified survival by duration of continuous NIV dependence (ie, unable to maintain oxygenation without the ventilator).
RESULTS: With advancing Duchenne muscular dystrophy, 101 nocturnal-only NIV users extended their NIV use throughout the daytime hours and required it continuously for 7.4 +- 6.1 years to 30.1 +- 6.1 years of age, with 56 patients still alive. Twenty-six of the 101 became continuously dependent without requiring hospitalization. Eight tracheostomized users were decannulated to NIV. Thirty-one consecutive unweanable intubated patients were extubated to NIV plus mechanically assisted cough. Of the 67 deaths (including 8 patients who died from heart failure before requiring ventilator use), 34 (52%) were probably cardiac, 14 (21%) were probably respiratory, and 19 (27%) were of unknown or other etiology.
CONCLUSIONS: Continuous NIV along with mechanically assisted cough and oximetry as needed can prolong life and obviate tracheotomy in patients with Duchenne muscular dystrophy. Unweanable patients can be decannulated and extubated to NIV plus mechanically assisted cough.Peer reviewe
Letter from John R. Cox to Hayao (Sam) and Toshiko Chuman
No full textA letter to Hayao (Sam) Chuman and Toshiko Chuman (nee Nakamura) from John R. Cox, Major, Infantry Commanding with the Army's 7th Psychological Operations Battalion. The letter regards Hayao and Toshiko's son's appointment to the Battalion in Vietnam, and what that appointment entails.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Modelling the composition of melts formed during continental breakup of the Southeast Greenland margin
No full textWe have developed a generic dynamic model of extension of the lithosphere, which predicts major element composition and volume of melt generated from initial extension to steady state seafloor spreading. Stokes equations for non-Newtonian flow are solved and the mantle melts by decompression. Strengthening of the mantle due to dehydration as melting progresses is included. The composition is then empirically related to depletion. Using a crystallisation algorithm, the predicted primary melt composition was compared with mean North Atlantic mid-ocean ridge basalt (MORB). At steady state, using half spreading rates from 10 to 20 mm yr? 1 and mantle potential temperatures of 1300 to 1325 °C we predict a major element composition that is within the variation in the mean of North Atlantic MORB.This model is applied to the Southeast Greenland margin, which has extensive coverage of seismic and ODP core data. These data have been interpreted to indicate an initial pulse of magmatism on rifting that rapidly decayed to leave oceanic crustal thickness of 8 to 11 km. This pattern of melt production can be recreated by introducing an initial hot layer of asthenosphere beneath the continental lithosphere and by having a period of fast spreading during early opening. The hot layer was convected through the melt region giving a pulse of high magnesian and low silica melt during the early rifting process. The predicted major element composition of primary melts generated are in close agreement with primary melts from the Southeast Greenland margin. The observed variations in major element composition are reproduced without a mantle source composition anomaly.<br/
- …
